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Protein

Jun dimerization protein 2

Gene

Jdp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Jun dimerization protein 2
Gene namesi
Name:Jdp2
Synonyms:Jdp-2, Jundm2, Jundp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi621611. Jdp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Jun dimerization protein 2PRO_0000331132Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki65 – 65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei148 – 1481Phosphothreonine; by MAPK8By similarity

Post-translational modificationi

Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.By similarity
Polyubiquitinated; probably by IRF2BP1.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ78E65.
PRIDEiQ78E65.

Expressioni

Gene expression databases

GenevisibleiQ78E65. RN.

Interactioni

Subunit structurei

Interacts with IRF2BP1 (By similarity). Forms homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG (By similarity). Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer.By similarity2 Publications

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

BioGridi250557. 1 interaction.
STRINGi10116.ENSRNOP00000011339.

Structurei

3D structure databases

ProteinModelPortaliQ78E65.
SMRiQ78E65. Positions 73-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 13564bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni74 – 9623Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni100 – 12829Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110847.
HOGENOMiHOG000034126.
HOVERGENiHBG057870.
InParanoidiQ78E65.
KOiK09033.
OMAiXESERLE.
OrthoDBiEOG70S777.
PhylomeDBiQ78E65.
TreeFamiTF326301.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029819. JDP2.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF10. PTHR23351:SF10. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q78E65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPGQIPDPS VTAGSLPGLG PLTGLPSSAL TTEELKYADI RNIGAMIAPL
60 70 80 90 100
HFLEVKLGKR PQPVKSELDE EEERRKRRRE KNKVAAARCR NKKKERTEFL
110 120 130 140 150
QRESERLELM NAELKTQIEE LKLERQQLIL MLNRHRPTCI VRTDSVRTPE
160
SEGNPLLEQL DKK
Length:163
Mass (Da):18,675
Last modified:July 5, 2004 - v1
Checksum:iA8AB65A7D20564F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53449 mRNA. Translation: AAC02258.1.
RefSeqiNP_446346.1. NM_053894.1.
XP_008762957.1. XM_008764735.1.
UniGeneiRn.10721.

Genome annotation databases

EnsembliENSRNOT00000011339; ENSRNOP00000011339; ENSRNOG00000008224.
GeneIDi116674.
KEGGirno:116674.
UCSCiRGD:621611. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53449 mRNA. Translation: AAC02258.1.
RefSeqiNP_446346.1. NM_053894.1.
XP_008762957.1. XM_008764735.1.
UniGeneiRn.10721.

3D structure databases

ProteinModelPortaliQ78E65.
SMRiQ78E65. Positions 73-135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250557. 1 interaction.
STRINGi10116.ENSRNOP00000011339.

Proteomic databases

PaxDbiQ78E65.
PRIDEiQ78E65.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011339; ENSRNOP00000011339; ENSRNOG00000008224.
GeneIDi116674.
KEGGirno:116674.
UCSCiRGD:621611. rat.

Organism-specific databases

CTDi122953.
RGDi621611. Jdp2.

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110847.
HOGENOMiHOG000034126.
HOVERGENiHBG057870.
InParanoidiQ78E65.
KOiK09033.
OMAiXESERLE.
OrthoDBiEOG70S777.
PhylomeDBiQ78E65.
TreeFamiTF326301.

Miscellaneous databases

PROiQ78E65.

Gene expression databases

GenevisibleiQ78E65. RN.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029819. JDP2.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF10. PTHR23351:SF10. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions."
    Aronheim A., Zandi E., Hennemann H., Elledge S.J., Karin M.
    Mol. Cell. Biol. 17:3094-3102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH JUN; JUNB AND JUND, DNA-BINDING.
    Tissue: Pituitary.
  2. "The ras recruitment system, a novel approach to the study of protein-protein interactions."
    Broder Y.C., Katz S., Aronheim A.
    Curr. Biol. 8:1121-1124(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CEBPG.

Entry informationi

Entry nameiJDP2_RAT
AccessioniPrimary (citable) accession number: Q78E65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.