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Protein

Proto-oncogene tyrosine-protein kinase ROS

Gene

Ros1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1, and PLCG2.5 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by dephosphorylation by PTPN6.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1973ATPPROSITE-ProRule annotation1
Active sitei2072Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1944 – 1952ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB
  • cell growth Source: UniProtKB
  • cell proliferation Source: UniProtKB
  • columnar/cuboidal epithelial cell development Source: UniProtKB
  • negative regulation of gene expression Source: MGI
  • peptidyl-tyrosine autophosphorylation Source: MGI
  • protein phosphorylation Source: UniProtKB
  • regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • regulation of phosphate transport Source: MGI
  • regulation of TOR signaling Source: UniProtKB
  • signal transduction by protein phosphorylation Source: MGI
  • spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene tyrosine-protein kinase ROS (EC:2.7.10.1)
Alternative name(s):
Proto-oncogene c-Ros
Proto-oncogene c-Ros-1
Receptor tyrosine kinase c-ros oncogene 1
c-Ros receptor tyrosine kinase
Gene namesi
Name:Ros1
Synonyms:Ros, Ros-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:97999. Ros1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 1854ExtracellularSequence analysisAdd BLAST1826
Transmembranei1855 – 1875HelicalSequence analysisAdd BLAST21
Topological domaini1876 – 2340CytoplasmicSequence analysisAdd BLAST465

GO - Cellular componenti

  • cell surface Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • perinuclear region of cytoplasm Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are viable and healthy. Females display normal fertility while males are sterile due a non-cell autonomous defect in sperm maturation. It is associated with the absence of tall columnar epithelial cells with long microvilli in the proximal part of the caput epididymidis.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2267Y → F: Abrogates interaction with PTPN6. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Chemistry databases

ChEMBLiCHEMBL2034802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000027811529 – 2340Proto-oncogene tyrosine-protein kinase ROSAdd BLAST2312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...)Sequence analysis1
Glycosylationi334N-linked (GlcNAc...)Sequence analysis1
Glycosylationi362N-linked (GlcNAc...)Sequence analysis1
Glycosylationi935N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1011N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1243N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1676N-linked (GlcNAc...)Sequence analysis1
Modified residuei2267Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei2327Phosphotyrosine; by autocatalysisBy similarity1

Post-translational modificationi

Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2267 and/or Tyr-2327 recruits PTPN11 (By similarity). Phosphorylation at Tyr-2267 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation. Phosphorylation at Tyr-2267 stimulates the kinase activity and the activation of the ERK1 signaling cascade.By similarity1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ78DX7.
PRIDEiQ78DX7.

PTM databases

iPTMnetiQ78DX7.
PhosphoSitePlusiQ78DX7.

Expressioni

Tissue specificityi

Expressed by epithelial cells of the caput epididymis (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000019893.
CleanExiMM_ROS1.
ExpressionAtlasiQ78DX7. baseline and differential.
GenevisibleiQ78DX7. MM.

Interactioni

Subunit structurei

Interacts with PTPN11; may activate the PI3 kinase-mTOR signaling pathway. Interacts with VAV3; constitutive interaction mediating VAV3 phosphorylation (By similarity). Interacts with PTPN6 (via SH2 1 domain); the interaction is direct and promotes ROS1 dephosphorylation.By similarity1 Publication

GO - Molecular functioni

  • protein phosphatase binding Source: UniProtKB

Protein-protein interaction databases

MINTiMINT-192643.
STRINGi10090.ENSMUSP00000020045.

Chemistry databases

BindingDBiQ78DX7.

Structurei

3D structure databases

ProteinModelPortaliQ78DX7.
SMRiQ78DX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 206Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini207 – 295Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST89
Domaini567 – 667Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST101
Domaini943 – 1038Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini1039 – 1146Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST108
Domaini1442 – 1549Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST108
Domaini1550 – 1649Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST100
Domaini1651 – 1744Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST94
Domaini1745 – 1846Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST102
Domaini1938 – 2216Protein kinasePROSITE-ProRule annotationAdd BLAST279

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
Contains 9 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQAA. Eukaryota.
ENOG410XSTC. LUCA.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000137937.
HOVERGENiHBG058631.
InParanoidiQ78DX7.
KOiK05088.
OMAiQQDALSF.
OrthoDBiEOG091G003T.
PhylomeDBiQ78DX7.
TreeFamiTF351636.

Family and domain databases

CDDicd00063. FN3. 8 hits.
Gene3Di2.120.10.30. 3 hits.
2.60.40.10. 9 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000033. LDLR_classB_rpt.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 9 hits.
SM00135. LY. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 9 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q78DX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNICWLTLK LVKFVVLGCI IWISVAQSTV LSSCLTSCVT NLGRQLDSGT
60 70 80 90 100
RYNLSEACIH GCQFWNSVDQ ETCALKCNDT YATICERESC EVGCSNAEGS
110 120 130 140 150
YEEEVLESTE LPTAPFASSI GSHGVTLRWN PANISGVKYI IQWKYAQLPG
160 170 180 190 200
SWTFTETVSK LSYTVEPLHP FTEYIFRVVW IFTAQLHLYS PPSPSYRTHP
210 220 230 240 250
YGVPETAPLI LNMESWSPDT VEVSWAPPHF PGGPILGYNL RLISKNQKLD
260 270 280 290 300
SGTQRTSFQF YSTLPNTTYR FSIAAVNEVG EGPEAESTVT TPSPSVQEEE
310 320 330 340 350
QWLFLSRKTS LRKRSLKYLV DEAHCLWSDA IHHNITGISV YAQQQVVYFS
360 370 380 390 400
EGTVIWMKGA ANMSDVSDLR IFYQGSGLVS SISIDWLYQR MYFIMDKLVY
410 420 430 440 450
VCELKNCSNL EEITPFSLIA PQKVVVDSYN GYLFYLLRDG IYRVNLPLPS
460 470 480 490 500
GRDTKAVRIV ESGTLKDFAV KPQSKRIIYF NDTMQLFMST FLDGSAFHRV
510 520 530 540 550
LPWVPLVTVK SFACENNDFL ITDGKAIFQQ DSLSFNEFIV GCDLSHIEEF
560 570 580 590 600
GFGNLVIFGS SVQSYPLPGH PQEVSVLFGS REALIQWTPP ALAIGASPSA
610 620 630 640 650
WQNWTYEVKV YSQDILEITQ VFSNISGTML NVPELQSSTK YTVSVRASSP
660 670 680 690 700
KGPGPWSAPS VGTTLVPATE PPFIMAVKED GLWSKPLCSF GPGEFLSSDV
710 720 730 740 750
GNVSDMDWYN NSLYYSDTKG NVYVRPLNGM DISENYHIPS IVGAGALAFE
760 770 780 790 800
WLGHFLYWAG KTYVIQRQSV LTGHTDIVTH VKLLVNDMAV DSVGGYLYWT
810 820 830 840 850
TLYSVESTRL NGESSLVLQA QPWLSGKKVI ALTLDLSDGL LYWLVQDNQC
860 870 880 890 900
IHLYTAVLRG WSGGDATITE FAAWSTSEIS QNALMYYSGR LFWINGFRII
910 920 930 940 950
TAQEIGQRTS VSVSEPAKFN QFTIIQTSLK PLPGNFSSTP KVIPDPVQES
960 970 980 990 1000
SFRIEGHTSS FQILWNEPPA VDWGIVFYSV EFSTHSKFLI IEQQSLPIFT
1010 1020 1030 1040 1050
VEGLEPYTLF NLSVTPYTYW GKGQKTSLSF RAPESVPSAP ENPRIFILSS
1060 1070 1080 1090 1100
GRYTKKNEVV VEFRWNKPKH ENGVLTKFEI FYHISKQSGT NRSTEDWMSA
1110 1120 1130 1140 1150
SVIPPVMSFQ LEAVSPEYTV AFQVRVFTSK GPGPFSDIVM SKTSEIKPCP
1160 1170 1180 1190 1200
YLISLLGNKI VFLDMDQNQV LWTFSLEGDV STVGYTTDDE MGYFAQGDTL
1210 1220 1230 1240 1250
FLLNLRNHSS SKLFQDALVS DIRVIAVDWI ARHLYFALKA SQNGTQIFNV
1260 1270 1280 1290 1300
DLEHKVKSPR EVKTCKAHTT IISFSIYPLL SRLYWTEVSD LGHQMFYCNI
1310 1320 1330 1340 1350
SNHTSQHVLQ PKASNQHGRS QCSCNVTESE LSGAMTVDTS DPDRPWIYFT
1360 1370 1380 1390 1400
KRQEIWAMDL EGCQCWKVIM VPTIPGKRII SLTVDGEFIY WIMKTKDDAQ
1410 1420 1430 1440 1450
IYQAKKGSGA ILSQVKASRS KHILAYSSAL QPFPDKAYLS LASDMVEATI
1460 1470 1480 1490 1500
LYATNTSLTL KLPPVKTNLT WHGITHPTST YLIYYMEANR ANSSDRRHKM
1510 1520 1530 1540 1550
LESQENVARI EGLQPFSMYM IQIAVKNYYS EPLEHLPLGK EIQGQTKSGV
1560 1570 1580 1590 1600
PGAVCHINAT VLSDTSLHVF WTESHKPNGP KESVRYQLVM SYLAPIPETP
1610 1620 1630 1640 1650
LRQGEFPSAK LSLLITKLSG GQLYVMKVLA CHPEEMWCTE SHPVSVNMFD
1660 1670 1680 1690 1700
TPEKPSALVP ENTSLQLDWK ARSNVNLTGF WFELQKWKYN EFYHVKASCS
1710 1720 1730 1740 1750
QGPVYVCNIT DLQPYTSYNI RVVVVYTTGE NSSSIPESFK TKAGVPSKPG
1760 1770 1780 1790 1800
IPKLLEGSKN SIQWEKAEDN GSRLMYYTLE VRKGISNDSQ NQSSRWKVVF
1810 1820 1830 1840 1850
NGSCSSICTW RSKNLKGTFQ FRAVAANEIG LGEYSEISED ITLVEDGVWI
1860 1870 1880 1890 1900
TETSFILTII VGIFLVATVP LTFVWHRSLK SHKASKEGLS VLNDNDKELA
1910 1920 1930 1940 1950
ELRGLAAGVG LANACYAVHT VPTQEEIENL PAFPREKLSL RLLLGSGAFG
1960 1970 1980 1990 2000
EVYEGTAIDI LGVGSGEIKV AVKTLKKGST DQEKIEFLKE AHLMSKFNHP
2010 2020 2030 2040 2050
NILKQLGVCL LGEPQYIILE LMEGGDLLSY LRKARGTTFH GPSLTLLDLV
2060 2070 2080 2090 2100
ELCVDISKGC VYLEQMHFIH RDLAARNCLV SVKDYTSPRV VKIGDFGLAR
2110 2120 2130 2140 2150
EIYKNDYYRK RGEGLLPVRW MAPENLMDGI FTSQSDVWSF GILVWEILTL
2160 2170 2180 2190 2200
GHQPYPAHSN LDVLNYVQAG GRLEPPRNCP DDLWNLMSQC WAQEPDQRPT
2210 2220 2230 2240 2250
FHNIQNQLQL FRNVFLNNVS HCGEAAPTGG VINKGFEGED DEMVTLNSDD
2260 2270 2280 2290 2300
TMPVALMETK NQEGLNYMVL ATKCSQGEGS YEGPLGPKEL GSCDLKKDKK
2310 2320 2330 2340
QPQADKDFCQ EPQVAYGSPG LSEGLNYACL AHSEHGDVSE
Length:2,340
Mass (Da):261,967
Last modified:July 5, 2004 - v1
Checksum:iA3A670B0C4151D7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27Q → L in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti109 – 111TEL → QAI in AAA50600 (PubMed:8544427).Curated3
Sequence conflicti329D → Y in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti419I → V in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti591A → P in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti595G → P in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti631 – 632NV → KL in AAA50600 (PubMed:8544427).Curated2
Sequence conflicti642 – 645TVSV → PFSC in AAA50600 (PubMed:8544427).Curated4
Sequence conflicti656W → G in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti671 – 672PP → LL in AAA50600 (PubMed:8544427).Curated2
Sequence conflicti830I → V in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti1050S → R in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti1066N → D in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti1085S → F in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti1235Y → C in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti1276I → T in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti1371V → L in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti1428 – 1429SA → FR in AAA50600 (PubMed:8544427).Curated2
Sequence conflicti1486 – 1487ME → IK in AAA50600 (PubMed:8544427).Curated2
Sequence conflicti1541 – 1545EIQGQ → RFKDK in AAA50600 (PubMed:8544427).Curated5
Sequence conflicti1585 – 1592RYQLVMSY → AISWLMSD in AAA50600 (PubMed:8544427).Curated8
Sequence conflicti1669W → R in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti1778T → S in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti1893N → S in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti1917 – 1918AV → GI in AAA50600 (PubMed:8544427).Curated2
Sequence conflicti2087S → N in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti2118V → A in AAA50600 (PubMed:8544427).Curated1
Sequence conflicti2270 – 2272LAT → VPQ in AAA50600 (PubMed:8544427).Curated3
Sequence conflicti2333S → R in AAA50600 (PubMed:8544427).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81650 mRNA. Translation: CAA57310.1.
U15443 mRNA. Translation: AAA50600.1.
CCDSiCCDS23838.1.
RefSeqiNP_035412.2. NM_011282.2.
UniGeneiMm.236163.

Genome annotation databases

EnsembliENSMUST00000020045; ENSMUSP00000020045; ENSMUSG00000019893.
GeneIDi19886.
KEGGimmu:19886.
UCSCiuc007fbb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81650 mRNA. Translation: CAA57310.1.
U15443 mRNA. Translation: AAA50600.1.
CCDSiCCDS23838.1.
RefSeqiNP_035412.2. NM_011282.2.
UniGeneiMm.236163.

3D structure databases

ProteinModelPortaliQ78DX7.
SMRiQ78DX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-192643.
STRINGi10090.ENSMUSP00000020045.

Chemistry databases

BindingDBiQ78DX7.
ChEMBLiCHEMBL2034802.

PTM databases

iPTMnetiQ78DX7.
PhosphoSitePlusiQ78DX7.

Proteomic databases

PaxDbiQ78DX7.
PRIDEiQ78DX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020045; ENSMUSP00000020045; ENSMUSG00000019893.
GeneIDi19886.
KEGGimmu:19886.
UCSCiuc007fbb.1. mouse.

Organism-specific databases

CTDi6098.
MGIiMGI:97999. Ros1.

Phylogenomic databases

eggNOGiENOG410IQAA. Eukaryota.
ENOG410XSTC. LUCA.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000137937.
HOVERGENiHBG058631.
InParanoidiQ78DX7.
KOiK05088.
OMAiQQDALSF.
OrthoDBiEOG091G003T.
PhylomeDBiQ78DX7.
TreeFamiTF351636.

Miscellaneous databases

PROiQ78DX7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019893.
CleanExiMM_ROS1.
ExpressionAtlasiQ78DX7. baseline and differential.
GenevisibleiQ78DX7. MM.

Family and domain databases

CDDicd00063. FN3. 8 hits.
Gene3Di2.120.10.30. 3 hits.
2.60.40.10. 9 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000033. LDLR_classB_rpt.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 9 hits.
SM00135. LY. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 9 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiROS1_MOUSE
AccessioniPrimary (citable) accession number: Q78DX7
Secondary accession number(s): Q60705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.