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Protein

Polyprotein p42

Gene

M

Organism
Influenza C virus (strain C/California/1978)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Ion channel, which might have a role in genome packaging and uncoating processes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Viral ion channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Polyprotein p42
Cleaved into the following 2 chains:
Alternative name(s):
CM1'
p31
Gene namesi
Name:M
OrganismiInfluenza C virus (strain C/California/1978)
Taxonomic identifieri203224 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus C
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 238CytoplasmicSequence analysisAdd BLAST238
Transmembranei239 – 259Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini260 – 288ExtracellularSequence analysisAdd BLAST29
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 374CytoplasmicSequence analysisAdd BLAST65

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host endoplasmic reticulum, Host membrane, Membrane, Viral matrix protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004088761 – 374Polyprotein p42Add BLAST374
ChainiPRO_00002694571 – 259Protein M1'Add BLAST259
ChainiPRO_0000269904260 – 374Protein CM2Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi270N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Lipidationi324S-palmitoyl cysteine; by hostBy similarity1
Modified residuei337Phosphoserine; by hostBy similarity1
Modified residuei362Phosphoserine; by hostBy similarity1

Post-translational modificationi

Palmitoylated.By similarity
N-glycosylated.By similarity
Ser-337 is the major site of phosphorylation, Ser-362 being a minor one.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei259 – 260Cleavage; by host signal peptidase2

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Homotetramer; disulfide-linked.By similarity

Structurei

3D structure databases

SMRiQ788J5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the influenza C protein M1 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR004271. CM1.
IPR004267. CM2.
PfamiView protein in Pfam
PF03026. CM1. 1 hit.
PF03021. CM2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform p42 (identifier: Q788J5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHEILIAET EAFLKNVAPE TRTAIISAIT GGKSACKSAA KLIKNEHLPL
60 70 80 90 100
MSGEATTMHI VMRCLYPEIK PWKKASDMLN KATSSLKKSE GRDIRKQMKA
110 120 130 140 150
AGDFLGVESM MKMRAFRDDQ IMEMVEEVYD HPDDYTPDIR IGTITAWLRC
160 170 180 190 200
KNKKSERYRS NVSESGRTAL KIHEVRKAST AMNEIAGITG LGEEALSLQR
210 220 230 240 250
QTESLAILCN HTFGSNIMRP HLEKAIKGVE GRVGEMGRMA MKWLVVIIYF
260 270 280 290 300
SITSKPASAC NLKTCLNLFN NTDAVTVHCF NENQGYMLTL ASLGLGIITM
310 320 330 340 350
LYLLVKIIIE LVNGFVLGRW ERWCGDIKTT IMPEIDSMEK DIALSRERLD
360 370
LGEDAPDETD NSPIPFSNDG IFEI
Note: Produced by unspliced mRNA.
Length:374
Mass (Da):41,787
Last modified:January 9, 2007 - v2
Checksum:i0DCC08483B054379
GO
Isoform M1 (identifier: Q788J5-2) [UniParc]FASTAAdd to basket
Also known as: CM1

The sequence of this isoform differs from the canonical sequence as follows:
     243-374: Missing.

Show »
Length:242
Mass (Da):26,985
Checksum:iAD39D9054A189D95
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022112243 – 374Missing in isoform M1. CuratedAdd BLAST132

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000608 Genomic RNA. Translation: BAA75836.1.
AB000608 Genomic RNA. Translation: BAA75837.1.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMAT_INCCA
AccessioniPrimary (citable) accession number: Q788J5
Secondary accession number(s): Q9WAD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 9, 2007
Last modified: May 10, 2017
This is version 40 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families