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Q786F2

- HEMA_MEASC

UniProt

Q786F2 - HEMA_MEASC

Protein

Hemagglutinin glycoprotein

Gene

H

Organism
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hemagglutinin

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin glycoprotein
    Gene namesi
    Name:H
    OrganismiMeasles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus)
    Taxonomic identifieri645098 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeMorbillivirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000008699: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 617617Hemagglutinin glycoproteinPRO_0000394712Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi168 – 1681N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi187 – 1871N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi200 – 2001N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi215 – 2151N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi238 – 2381N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi416 – 4161N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with human MCP/CD46 antigen and SLAMF1 By similarity. Interacts with human PVRL4; this interaction allows virus infection of the respiratory epithelium.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PVRL4Q96NY82EBI-5323300,EBI-4314784From a different organism.
    SLAMF1Q132912EBI-5323300,EBI-4315002From a different organism.

    Protein-protein interaction databases

    DIPiDIP-59438N.
    IntActiQ786F2. 2 interactions.

    Structurei

    Secondary structure

    1
    617
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi157 – 1593
    Helixi162 – 1654
    Beta strandi194 – 1985
    Helixi206 – 2116
    Beta strandi215 – 22410
    Beta strandi227 – 23711
    Beta strandi249 – 26113
    Beta strandi264 – 2674
    Beta strandi269 – 27911
    Beta strandi281 – 2833
    Beta strandi287 – 2915
    Beta strandi296 – 3005
    Beta strandi304 – 3074
    Beta strandi318 – 3247
    Beta strandi333 – 3397
    Beta strandi346 – 3505
    Beta strandi355 – 3595
    Beta strandi362 – 37211
    Helixi374 – 38411
    Turni389 – 3935
    Beta strandi394 – 3963
    Helixi400 – 4034
    Beta strandi408 – 4169
    Beta strandi418 – 4214
    Beta strandi425 – 4306
    Beta strandi442 – 4454
    Beta strandi451 – 4566
    Turni460 – 4623
    Beta strandi466 – 4716
    Beta strandi482 – 4865
    Beta strandi495 – 4973
    Beta strandi508 – 5114
    Beta strandi515 – 5173
    Beta strandi519 – 5213
    Beta strandi523 – 5319
    Beta strandi537 – 5437
    Beta strandi548 – 5514
    Beta strandi563 – 5653
    Beta strandi568 – 5736
    Beta strandi576 – 58510
    Beta strandi588 – 5903
    Beta strandi594 – 60411

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GJTX-ray3.10A156-617[»]
    ProteinModelPortaliQ786F2.
    SMRiQ786F2. Positions 157-607.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737IntravirionSequence AnalysisAdd
    BLAST
    Topological domaini59 – 617559Virion surfaceSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821Helical; Note=Membrane anchorSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR000665. Hemagglutn-neuramid.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00423. HN. 1 hit.
    [Graphical view]
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q786F2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPQRDRINA FYKDNPHPKG SRIVINREHL MIDRPYVLLA VLFVMFLSLI    50
    GLLAIAGIRL HRAAIYTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG 100
    DEVGLRTPQR FTDLVKFISD KIKFLNPDRE YDFRDLTWCI NPPERIKLDY 150
    DQYCADVAAE ELMNALVNST LLEARATNQF LAVSKGNCSG PTTIRGQFSN 200
    MSLSLLDLYL SRGYNVSSIV TMTSQGMYGG TYLVGKPNLS SKGSELSQLS 250
    MHRVFEVGVI RNPGLGAPVF HMTNYFEQPV SNDFSNCMVA LGELKFAALC 300
    HREDSITIPY QGSGKGVSFQ LVKLGVWKSP TDMRSWVPLS TDDPVIDRLY 350
    LSSHRGVIAD NQAKWAVPTT RTDDKLRMET CFQQACKGKN QALCENPEWA 400
    PLKDNRIPSY GVLSVNLSLT VELKIKIASG FGPLITHGSG MDLYKTNHNN 450
    VYWLTIPPMK NLALGVINTL EWIPRFKVSP NLFTVPIKEA GEDCHAPTYL 500
    PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY YVYSPSRSFS 550
    YFYPFRLPIK GVPIELQVEC FTWDKKLWCR HFCVLADSES GGHITHSGMV 600
    GMGVSCTVTR EDGTNRR 617
    Length:617
    Mass (Da):69,174
    Last modified:March 2, 2010 - v1
    Checksum:i7E877598258DEC5E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016162 Genomic RNA. Translation: BAA34982.1.
    PIRiPQ0377.
    PQ0381.
    RefSeqiNP_056923.1. NC_001498.1.

    Genome annotation databases

    GeneIDi1489801.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016162 Genomic RNA. Translation: BAA34982.1 .
    PIRi PQ0377.
    PQ0381.
    RefSeqi NP_056923.1. NC_001498.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GJT X-ray 3.10 A 156-617 [» ]
    ProteinModelPortali Q786F2.
    SMRi Q786F2. Positions 157-607.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59438N.
    IntActi Q786F2. 2 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1489801.

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR000665. Hemagglutn-neuramid.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00423. HN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative nucleotide sequence analyses of the entire genomes of B95a cell-isolated and vero cell-isolated measles viruses from the same patient."
      Takeuchi K., Miyajima N., Kobune F., Tashiro M.
      Virus Genes 20:253-257(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. Cited for: INTERACTION WITH HUMAN PVRL4.

    Entry informationi

    Entry nameiHEMA_MEASC
    AccessioniPrimary (citable) accession number: Q786F2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Caution

    Morbiliviruses hemagglutinins have no neuraminidase activity.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3