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Q786F2 (HEMA_MEASC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemagglutinin glycoprotein
Gene names
Name:H
OrganismMeasles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) [Reference proteome]
Taxonomic identifier645098 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeMorbillivirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length617 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis By similarity.

Subunit structure

Interacts with human MCP/CD46 antigen and SLAMF1 By similarity. Interacts with human PVRL4; this interaction allows virus infection of the respiratory epithelium. Ref.2

Subcellular location

Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the paramyxoviruses hemagglutinin-neuraminidase family. Non-sialidase subfamily.

Caution

Morbiliviruses hemagglutinins have no neuraminidase activity.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PVRL4Q96NY82EBI-5323300,EBI-4314784From a different organism.
SLAMF1Q132912EBI-5323300,EBI-4315002From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 617617Hemagglutinin glycoprotein
PRO_0000394712

Regions

Topological domain1 – 3737Intravirion Potential
Transmembrane38 – 5821Helical; Note=Membrane anchor; Potential
Topological domain59 – 617559Virion surface Potential

Amino acid modifications

Glycosylation1681N-linked (GlcNAc...); by host Potential
Glycosylation1871N-linked (GlcNAc...); by host Potential
Glycosylation2001N-linked (GlcNAc...); by host Potential
Glycosylation2151N-linked (GlcNAc...); by host Potential
Glycosylation2381N-linked (GlcNAc...); by host Potential
Glycosylation4161N-linked (GlcNAc...); by host Potential

Secondary structure

.................................................................................... 617
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q786F2 [UniParc].

Last modified March 2, 2010. Version 1.
Checksum: 7E877598258DEC5E

FASTA61769,174
        10         20         30         40         50         60 
MSPQRDRINA FYKDNPHPKG SRIVINREHL MIDRPYVLLA VLFVMFLSLI GLLAIAGIRL 

        70         80         90        100        110        120 
HRAAIYTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG DEVGLRTPQR FTDLVKFISD 

       130        140        150        160        170        180 
KIKFLNPDRE YDFRDLTWCI NPPERIKLDY DQYCADVAAE ELMNALVNST LLEARATNQF 

       190        200        210        220        230        240 
LAVSKGNCSG PTTIRGQFSN MSLSLLDLYL SRGYNVSSIV TMTSQGMYGG TYLVGKPNLS 

       250        260        270        280        290        300 
SKGSELSQLS MHRVFEVGVI RNPGLGAPVF HMTNYFEQPV SNDFSNCMVA LGELKFAALC 

       310        320        330        340        350        360 
HREDSITIPY QGSGKGVSFQ LVKLGVWKSP TDMRSWVPLS TDDPVIDRLY LSSHRGVIAD 

       370        380        390        400        410        420 
NQAKWAVPTT RTDDKLRMET CFQQACKGKN QALCENPEWA PLKDNRIPSY GVLSVNLSLT 

       430        440        450        460        470        480 
VELKIKIASG FGPLITHGSG MDLYKTNHNN VYWLTIPPMK NLALGVINTL EWIPRFKVSP 

       490        500        510        520        530        540 
NLFTVPIKEA GEDCHAPTYL PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY 

       550        560        570        580        590        600 
YVYSPSRSFS YFYPFRLPIK GVPIELQVEC FTWDKKLWCR HFCVLADSES GGHITHSGMV 

       610 
GMGVSCTVTR EDGTNRR 

« Hide

References

[1]"Comparative nucleotide sequence analyses of the entire genomes of B95a cell-isolated and vero cell-isolated measles viruses from the same patient."
Takeuchi K., Miyajima N., Kobune F., Tashiro M.
Virus Genes 20:253-257(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Adherens junction protein nectin-4 is the epithelial receptor for measles virus."
Muhlebach M.D., Mateo M., Sinn P.L., Prufer S., Uhlig K.M., Leonard V.H., Navaratnarajah C.K., Frenzke M., Wong X.X., Sawatsky B., Ramachandran S., McCray P.B. Jr., Cichutek K., von Messling V., Lopez M., Cattaneo R.
Nature 480:530-533(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HUMAN PVRL4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB016162 Genomic RNA. Translation: BAA34982.1.
PIRPQ0377.
PQ0381.
RefSeqNP_056923.1. NC_001498.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4GJTX-ray3.10A156-617[»]
ProteinModelPortalQ786F2.
SMRQ786F2. Positions 157-607.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-59438N.
IntActQ786F2. 2 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1489801.

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR000665. Hemagglutn-neuramid.
IPR011040. Sialidases.
[Graphical view]
PfamPF00423. HN. 1 hit.
[Graphical view]
SUPFAMSSF50939. SSF50939. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEMA_MEASC
AccessionPrimary (citable) accession number: Q786F2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 2, 2010
Last modified: June 11, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references