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Protein

Hemagglutinin glycoprotein

Gene

H

Organism
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin glycoprotein
Gene namesi
Name:H
OrganismiMeasles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus)
Taxonomic identifieri645098 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeMorbillivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008699 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37IntravirionSequence analysisAdd BLAST37
Transmembranei38 – 58Helical; Note=Membrane anchorSequence analysisAdd BLAST21
Topological domaini59 – 617Virion surfaceSequence analysisAdd BLAST559

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003947121 – 617Hemagglutinin glycoproteinAdd BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi168N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi187N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi200N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi215N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi238N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi416N-linked (GlcNAc...); by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with human MCP/CD46 antigen and SLAMF1 (By similarity). Interacts with human NECTIN4; this interaction allows virus infection of the respiratory epithelium.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NECTIN4Q96NY82EBI-5323300,EBI-4314784From a different organism.
SLAMF1Q132912EBI-5323300,EBI-4315002From a different organism.

Protein-protein interaction databases

DIPiDIP-59438N.
IntActiQ786F2. 2 interactors.

Structurei

Secondary structure

1617
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi157 – 159Combined sources3
Helixi162 – 165Combined sources4
Beta strandi194 – 198Combined sources5
Helixi206 – 211Combined sources6
Beta strandi215 – 224Combined sources10
Beta strandi227 – 237Combined sources11
Beta strandi249 – 261Combined sources13
Beta strandi264 – 267Combined sources4
Beta strandi269 – 279Combined sources11
Beta strandi281 – 283Combined sources3
Beta strandi287 – 291Combined sources5
Beta strandi296 – 300Combined sources5
Beta strandi304 – 307Combined sources4
Beta strandi318 – 324Combined sources7
Beta strandi333 – 339Combined sources7
Beta strandi346 – 350Combined sources5
Beta strandi355 – 359Combined sources5
Beta strandi362 – 372Combined sources11
Helixi374 – 384Combined sources11
Turni389 – 393Combined sources5
Beta strandi394 – 396Combined sources3
Helixi400 – 403Combined sources4
Beta strandi408 – 416Combined sources9
Beta strandi418 – 421Combined sources4
Beta strandi425 – 430Combined sources6
Beta strandi442 – 445Combined sources4
Beta strandi451 – 456Combined sources6
Turni460 – 462Combined sources3
Beta strandi466 – 471Combined sources6
Beta strandi482 – 486Combined sources5
Beta strandi495 – 497Combined sources3
Beta strandi508 – 511Combined sources4
Beta strandi515 – 517Combined sources3
Beta strandi519 – 521Combined sources3
Beta strandi523 – 531Combined sources9
Beta strandi537 – 543Combined sources7
Beta strandi548 – 551Combined sources4
Beta strandi563 – 565Combined sources3
Beta strandi568 – 573Combined sources6
Beta strandi576 – 585Combined sources10
Beta strandi588 – 590Combined sources3
Beta strandi594 – 604Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GJTX-ray3.10A156-617[»]
ProteinModelPortaliQ786F2.
SMRiQ786F2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK19378.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn/HN.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q786F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPQRDRINA FYKDNPHPKG SRIVINREHL MIDRPYVLLA VLFVMFLSLI
60 70 80 90 100
GLLAIAGIRL HRAAIYTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG
110 120 130 140 150
DEVGLRTPQR FTDLVKFISD KIKFLNPDRE YDFRDLTWCI NPPERIKLDY
160 170 180 190 200
DQYCADVAAE ELMNALVNST LLEARATNQF LAVSKGNCSG PTTIRGQFSN
210 220 230 240 250
MSLSLLDLYL SRGYNVSSIV TMTSQGMYGG TYLVGKPNLS SKGSELSQLS
260 270 280 290 300
MHRVFEVGVI RNPGLGAPVF HMTNYFEQPV SNDFSNCMVA LGELKFAALC
310 320 330 340 350
HREDSITIPY QGSGKGVSFQ LVKLGVWKSP TDMRSWVPLS TDDPVIDRLY
360 370 380 390 400
LSSHRGVIAD NQAKWAVPTT RTDDKLRMET CFQQACKGKN QALCENPEWA
410 420 430 440 450
PLKDNRIPSY GVLSVNLSLT VELKIKIASG FGPLITHGSG MDLYKTNHNN
460 470 480 490 500
VYWLTIPPMK NLALGVINTL EWIPRFKVSP NLFTVPIKEA GEDCHAPTYL
510 520 530 540 550
PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY YVYSPSRSFS
560 570 580 590 600
YFYPFRLPIK GVPIELQVEC FTWDKKLWCR HFCVLADSES GGHITHSGMV
610
GMGVSCTVTR EDGTNRR
Length:617
Mass (Da):69,174
Last modified:March 2, 2010 - v1
Checksum:i7E877598258DEC5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016162 Genomic RNA. Translation: BAA34982.1.
PIRiPQ0377.
PQ0381.
RefSeqiNP_056923.1. NC_001498.1.

Genome annotation databases

GeneIDi1489801.
KEGGivg:1489801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016162 Genomic RNA. Translation: BAA34982.1.
PIRiPQ0377.
PQ0381.
RefSeqiNP_056923.1. NC_001498.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GJTX-ray3.10A156-617[»]
ProteinModelPortaliQ786F2.
SMRiQ786F2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59438N.
IntActiQ786F2. 2 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489801.
KEGGivg:1489801.

Phylogenomic databases

KOiK19378.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn/HN.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHEMA_MEASC
AccessioniPrimary (citable) accession number: Q786F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 2, 2010
Last modified: November 2, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Morbiliviruses hemagglutinins have no neuraminidase activity.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.