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Q786F2

- HEMA_MEASC

UniProt

Q786F2 - HEMA_MEASC

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Protein

Hemagglutinin glycoprotein

Gene

H

Organism
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis (By similarity).By similarity

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: InterPro

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin glycoprotein
Gene namesi
Name:H
OrganismiMeasles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus)
Taxonomic identifieri645098 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeMorbillivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000008699: Genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737IntravirionSequence AnalysisAdd
BLAST
Transmembranei38 – 5821Helical; Note=Membrane anchorSequence AnalysisAdd
BLAST
Topological domaini59 – 617559Virion surfaceSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Hemagglutinin glycoproteinPRO_0000394712Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi168 – 1681N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi187 – 1871N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi200 – 2001N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi215 – 2151N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi238 – 2381N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi416 – 4161N-linked (GlcNAc...); by hostSequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with human MCP/CD46 antigen and SLAMF1 (By similarity). Interacts with human PVRL4; this interaction allows virus infection of the respiratory epithelium.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PVRL4Q96NY82EBI-5323300,EBI-4314784From a different organism.
SLAMF1Q132912EBI-5323300,EBI-4315002From a different organism.

Protein-protein interaction databases

DIPiDIP-59438N.
IntActiQ786F2. 2 interactions.

Structurei

Secondary structure

1
617
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi157 – 1593Combined sources
Helixi162 – 1654Combined sources
Beta strandi194 – 1985Combined sources
Helixi206 – 2116Combined sources
Beta strandi215 – 22410Combined sources
Beta strandi227 – 23711Combined sources
Beta strandi249 – 26113Combined sources
Beta strandi264 – 2674Combined sources
Beta strandi269 – 27911Combined sources
Beta strandi281 – 2833Combined sources
Beta strandi287 – 2915Combined sources
Beta strandi296 – 3005Combined sources
Beta strandi304 – 3074Combined sources
Beta strandi318 – 3247Combined sources
Beta strandi333 – 3397Combined sources
Beta strandi346 – 3505Combined sources
Beta strandi355 – 3595Combined sources
Beta strandi362 – 37211Combined sources
Helixi374 – 38411Combined sources
Turni389 – 3935Combined sources
Beta strandi394 – 3963Combined sources
Helixi400 – 4034Combined sources
Beta strandi408 – 4169Combined sources
Beta strandi418 – 4214Combined sources
Beta strandi425 – 4306Combined sources
Beta strandi442 – 4454Combined sources
Beta strandi451 – 4566Combined sources
Turni460 – 4623Combined sources
Beta strandi466 – 4716Combined sources
Beta strandi482 – 4865Combined sources
Beta strandi495 – 4973Combined sources
Beta strandi508 – 5114Combined sources
Beta strandi515 – 5173Combined sources
Beta strandi519 – 5213Combined sources
Beta strandi523 – 5319Combined sources
Beta strandi537 – 5437Combined sources
Beta strandi548 – 5514Combined sources
Beta strandi563 – 5653Combined sources
Beta strandi568 – 5736Combined sources
Beta strandi576 – 58510Combined sources
Beta strandi588 – 5903Combined sources
Beta strandi594 – 60411Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GJTX-ray3.10A156-617[»]
ProteinModelPortaliQ786F2.
SMRiQ786F2. Positions 157-607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q786F2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPQRDRINA FYKDNPHPKG SRIVINREHL MIDRPYVLLA VLFVMFLSLI
60 70 80 90 100
GLLAIAGIRL HRAAIYTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG
110 120 130 140 150
DEVGLRTPQR FTDLVKFISD KIKFLNPDRE YDFRDLTWCI NPPERIKLDY
160 170 180 190 200
DQYCADVAAE ELMNALVNST LLEARATNQF LAVSKGNCSG PTTIRGQFSN
210 220 230 240 250
MSLSLLDLYL SRGYNVSSIV TMTSQGMYGG TYLVGKPNLS SKGSELSQLS
260 270 280 290 300
MHRVFEVGVI RNPGLGAPVF HMTNYFEQPV SNDFSNCMVA LGELKFAALC
310 320 330 340 350
HREDSITIPY QGSGKGVSFQ LVKLGVWKSP TDMRSWVPLS TDDPVIDRLY
360 370 380 390 400
LSSHRGVIAD NQAKWAVPTT RTDDKLRMET CFQQACKGKN QALCENPEWA
410 420 430 440 450
PLKDNRIPSY GVLSVNLSLT VELKIKIASG FGPLITHGSG MDLYKTNHNN
460 470 480 490 500
VYWLTIPPMK NLALGVINTL EWIPRFKVSP NLFTVPIKEA GEDCHAPTYL
510 520 530 540 550
PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY YVYSPSRSFS
560 570 580 590 600
YFYPFRLPIK GVPIELQVEC FTWDKKLWCR HFCVLADSES GGHITHSGMV
610
GMGVSCTVTR EDGTNRR
Length:617
Mass (Da):69,174
Last modified:March 2, 2010 - v1
Checksum:i7E877598258DEC5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016162 Genomic RNA. Translation: BAA34982.1.
PIRiPQ0377.
PQ0381.
RefSeqiNP_056923.1. NC_001498.1.

Genome annotation databases

GeneIDi1489801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016162 Genomic RNA. Translation: BAA34982.1 .
PIRi PQ0377.
PQ0381.
RefSeqi NP_056923.1. NC_001498.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GJT X-ray 3.10 A 156-617 [» ]
ProteinModelPortali Q786F2.
SMRi Q786F2. Positions 157-607.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59438N.
IntActi Q786F2. 2 interactions.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1489801.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative nucleotide sequence analyses of the entire genomes of B95a cell-isolated and vero cell-isolated measles viruses from the same patient."
    Takeuchi K., Miyajima N., Kobune F., Tashiro M.
    Virus Genes 20:253-257(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Cited for: INTERACTION WITH HUMAN PVRL4.

Entry informationi

Entry nameiHEMA_MEASC
AccessioniPrimary (citable) accession number: Q786F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 2, 2010
Last modified: November 26, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Morbiliviruses hemagglutinins have no neuraminidase activity.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3