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Q783Y1

- HN_SENDA

UniProt

Q783Y1 - HN_SENDA

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Protein

Hemagglutinin-neuraminidase

Gene
HN
Organism
Sendai virus (strain Hamamatsu) (SeV)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Short name:
HN protein
Gene namesi
Name:HN
OrganismiSendai virus (strain Hamamatsu) (SeV)
Taxonomic identifieri302271 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRespirovirus
Virus hostiCavia cutleri (Guinea pig) [TaxID: 10144]
Cricetidae sp. (Hamster) [TaxID: 36483]
Mus musculus (Mouse) [TaxID: 10090]
Rattus norvegicus (Rat) [TaxID: 10116]
ProteomesiUP000007191: Genome, UP000008510: Genome, UP000008857: Genome

Subcellular locationi

Virion membrane; Single-pass type II membrane protein Reviewed prediction. Host cell membrane; Single-pass type II membrane protein Reviewed prediction
Note: Folded in the endoplasmic reticulum By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737Intravirion By similarityAdd
BLAST
Transmembranei38 – 5821Helical; By similarityAdd
BLAST
Topological domaini59 – 575517Virion surface By similarityAdd
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 575575Hemagglutinin-neuraminidasePRO_0000142636Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi77 – 771N-linked (GlcNAc...); by host By similarity
Disulfide bondi129 – 129Interchain Reviewed prediction
Glycosylationi499 – 4991N-linked (GlcNAc...); by host By similarity
Glycosylationi511 – 5111N-linked (GlcNAc...); by host By similarity

Post-translational modificationi

N-glycosylated; glycans consist of a mixture of high mannose-type oligosaccharides and of complex-type oligosaccharides By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homotetramer; composed of disulfide-linked homodimers. Interacts with F protein trimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ783Y1.
SMRiQ783Y1. Positions 144-572.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 145Incorporation in virion By similarity
Regioni59 – 14082Involved in interaction with F protein By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q783Y1-1 [UniParc]FASTAAdd to Basket

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MDGDRSKRDS YWSTSPGGST TKLVSDSERS GKVDTWLLIL AFTQWALSIA    50
TVIICIVIAA RQGYSMERYS MTVEALNTSN KEVKESLTSL IRQEVITRAV 100
NIQSSVQTGI PVLLNKNSRD VIQLIEKSCN RQELTQLCDS TIAVHHAEGI 150
APLEPHSFWR CPAGEPYLSS DPEVSLLPGP SLLSGSTTIS GCVRLPSLSI 200
GEAIYAYSSN LITQGCADIG KSYQVLQLGY ISLNSDMFPD LNPVVSHTYD 250
INDNRKSCSV VATGTRGYQL CSMPTVDERT DYSSDGIEDL VLDILDLKGR 300
TKSHRYSNSE IDLDHPFSAL YPSVGSGIAT EGSLIFLGYG GLTTPLQGDT 350
KCRIQGCQQV SQDTCNEALK ITWLGGKQVV SVLIQVNDYL SERPRIRVTT 400
VPITQNYLGA EGRLLKLGDQ VYIYTRSSGW HSQLQIGVLD VSHPLTISWT 450
PHEALSRPGN EDCNWYNTCP KECISGVYTD AYPLSPDAAN VATVTLYANT 500
SRVNPTIMYS NTTNIINMLR IKDVKLEAAY TTTSCITHFG KGYCFHIIEI 550
NQKSLNTLQP MLFKTSIPKL CKAES 575
Length:575
Mass (Da):63,212
Last modified:July 5, 2004 - v1
Checksum:iBDA9E1B72431058A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti461 – 4611E → G in strain: Isolate E30cl2; egg passage attenuated.
Natural varianti462 – 4621D → G in strain: Isolate E30cl2, Isolate E50cl9 and Isolate E30M15cl5; egg passage attenuated.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57213 Genomic RNA. Translation: CAA40499.1.
AB039658 Genomic RNA. Translation: BAB20025.1.
AB065186 Genomic RNA. Translation: BAC79131.1.
AB065187 Genomic RNA. Translation: BAC07511.1.
AB065188 Genomic RNA. Translation: BAC79139.1.
AB065189 Genomic RNA. Translation: BAC79147.1.
PIRiS14532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57213 Genomic RNA. Translation: CAA40499.1 .
AB039658 Genomic RNA. Translation: BAB20025.1 .
AB065186 Genomic RNA. Translation: BAC79131.1 .
AB065187 Genomic RNA. Translation: BAC07511.1 .
AB065188 Genomic RNA. Translation: BAC79139.1 .
AB065189 Genomic RNA. Translation: BAC79147.1 .
PIRi S14532.

3D structure databases

ProteinModelPortali Q783Y1.
SMRi Q783Y1. Positions 144-572.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A field isolate of Sendai virus: its high virulence to mice and genetic divergence from prototype strains."
    Sakaguchi T., Fujii Y., Kiyotani K., Sasaki M., Yoshida T.
    Arch. Virol. 135:159-164(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Conserved and non-conserved regions in the Sendai virus genome: evolution of a gene possessing overlapping reading frames."
    Fujii Y., Kiyotani K., Yoshida T., Sakaguchi T.
    Virus Genes 22:47-52(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "Involvement of the leader sequence in Sendai virus pathogenesis revealed by recovery of a pathogenic field isolate from cDNA."
    Fujii Y., Sakaguchi T., Kiyotani K., Huang C., Fukuhara N., Egi Y., Yoshida T.
    J. Virol. 76:8540-8547(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate E15cl2.
  4. "Identification of mutations associated with attenuation of virulence of a field Sendai virus isolate by egg passage."
    Fujii Y., Sakaguchi T., Kiyotani K., Huang C., Fukuhara N., Yoshida T.
    Virus Genes 25:189-193(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate E15cl2, Isolate E30cl2 and Isolate E30M15cl5.
  5. Fujii Y., Kiyotani K., Huang C., Fukuhara N., Egi K., Yoshida T., Sakaguchi T.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate E50cl9.

Entry informationi

Entry nameiHN_SENDA
AccessioniPrimary (citable) accession number: Q783Y1
Secondary accession number(s): Q7T415, Q7TB20, Q82459
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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