Hemagglutinin-neuraminidase - Sendai virus (strain Hamamatsu) (SeV)

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Q783Y1 (HN_SENDA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 63. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Hemagglutinin-neuraminidase
Short name=HN protein
EC=3.2.1.18

Gene names

Name:

Organism

Sendai virus (strain Hamamatsu) (SeV) [Complete proteome]

Taxonomic identifier

302271 [NCBI]

Taxonomic lineage

Viruses › ssRNA negative-strand viruses › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Respirovirus ›

Virus host

Cavia cutleri (Guinea pig) [TaxID: 10144]
Cricetidae sp. (Hamster) [TaxID: 36483]
Mus musculus (Mouse) [TaxID: 10090]
Rattus norvegicus (Rat) [TaxID: 10116]

Protein attributes

Sequence length	575 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity. Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.
Catalytic activity	Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Subunit structure	Homotetramer; composed of disulfide-linked homodimers. Interacts with F protein trimer By similarity.
Subcellular location	Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein Potential. Note: Folded in the endoplasmic reticulum By similarity.
Post-translational modification	N-glycosylated; glycans consist of a mixture of high mannose-type oligosaccharides and of complex-type oligosaccharides By similarity.
Sequence similarities	Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Ontologies

Keywords
Biological process	Host-virus interaction Viral attachment to host cell Virus entry into host cell
Cellular component	Host cell membrane Host membrane Membrane Viral envelope protein Virion
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Hemagglutinin Hydrolase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell Inferred from electronic annotation. Source: UniProtKB-KW viral infectious cycle Inferred from electronic annotation. Source: InterPro
Cellular_component	host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: UniProtKB-KW virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	exo-alpha-(2->3)-sialidase activity Inferred from electronic annotation. Source: EC exo-alpha-(2->6)-sialidase activity Inferred from electronic annotation. Source: EC exo-alpha-(2->8)-sialidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 575

575

Hemagglutinin-neuraminidase

PRO_0000142636

Regions

Topological domain

1 – 37

Intravirion By similarity

Transmembrane

38 – 58

Helical; By similarity

Topological domain

59 – 575

517

Virion surface By similarity

Region

10 – 14

Incorporation in virion By similarity

Region

59 – 140

Involved in interaction with F protein By similarity

Amino acid modifications

Glycosylation

N-linked (GlcNAc...); by host By similarity

Glycosylation

499

N-linked (GlcNAc...); by host By similarity

Glycosylation

511

N-linked (GlcNAc...); by host By similarity

Disulfide bond

129

Interchain Potential

Natural variations

Natural variant

461

E → G in strain: Isolate E30cl2; egg passage attenuated.

Natural variant

462

D → G in strain: Isolate E30cl2, Isolate E50cl9 and Isolate E30M15cl5; egg passage attenuated.

Sequences

Sequence

Length

Mass (Da)

Tools

Q783Y1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: BDA9E1B72431058A
Show »

FASTA

575

63,212

        10         20         30         40         50         60 
MDGDRSKRDS YWSTSPGGST TKLVSDSERS GKVDTWLLIL AFTQWALSIA TVIICIVIAA 

        70         80         90        100        110        120 
RQGYSMERYS MTVEALNTSN KEVKESLTSL IRQEVITRAV NIQSSVQTGI PVLLNKNSRD 

       130        140        150        160        170        180 
VIQLIEKSCN RQELTQLCDS TIAVHHAEGI APLEPHSFWR CPAGEPYLSS DPEVSLLPGP 

       190        200        210        220        230        240 
SLLSGSTTIS GCVRLPSLSI GEAIYAYSSN LITQGCADIG KSYQVLQLGY ISLNSDMFPD 

       250        260        270        280        290        300 
LNPVVSHTYD INDNRKSCSV VATGTRGYQL CSMPTVDERT DYSSDGIEDL VLDILDLKGR 

       310        320        330        340        350        360 
TKSHRYSNSE IDLDHPFSAL YPSVGSGIAT EGSLIFLGYG GLTTPLQGDT KCRIQGCQQV 

       370        380        390        400        410        420 
SQDTCNEALK ITWLGGKQVV SVLIQVNDYL SERPRIRVTT VPITQNYLGA EGRLLKLGDQ 

       430        440        450        460        470        480 
VYIYTRSSGW HSQLQIGVLD VSHPLTISWT PHEALSRPGN EDCNWYNTCP KECISGVYTD 

       490        500        510        520        530        540 
AYPLSPDAAN VATVTLYANT SRVNPTIMYS NTTNIINMLR IKDVKLEAAY TTTSCITHFG 

       550        560        570 
KGYCFHIIEI NQKSLNTLQP MLFKTSIPKL CKAES

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References

[1]	"A field isolate of Sendai virus: its high virulence to mice and genetic divergence from prototype strains." Sakaguchi T., Fujii Y., Kiyotani K., Sasaki M., Yoshida T. Arch. Virol. 135:159-164(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]	"Conserved and non-conserved regions in the Sendai virus genome: evolution of a gene possessing overlapping reading frames." Fujii Y., Kiyotani K., Yoshida T., Sakaguchi T. Virus Genes 22:47-52(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]	"Involvement of the leader sequence in Sendai virus pathogenesis revealed by recovery of a pathogenic field isolate from cDNA." Fujii Y., Sakaguchi T., Kiyotani K., Huang C., Fukuhara N., Egi Y., Yoshida T. J. Virol. 76:8540-8547(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. Strain: Isolate E15cl2.
[4]	"Identification of mutations associated with attenuation of virulence of a field Sendai virus isolate by egg passage." Fujii Y., Sakaguchi T., Kiyotani K., Huang C., Fukuhara N., Yoshida T. Virus Genes 25:189-193(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. Strain: Isolate E15cl2, Isolate E30cl2 and Isolate E30M15cl5.
[5]	Fujii Y., Kiyotani K., Huang C., Fukuhara N., Egi K., Yoshida T., Sakaguchi T. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. Strain: Isolate E50cl9.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X57213 Genomic RNA. Translation: CAA40499.1. AB039658 Genomic RNA. Translation: BAB20025.1. AB065186 Genomic RNA. Translation: BAC79131.1. AB065187 Genomic RNA. Translation: BAC07511.1. AB065188 Genomic RNA. Translation: BAC79139.1. AB065189 Genomic RNA. Translation: BAC79147.1.
PIR	S14532.
3D structure databases
ProteinModelPortal	Q783Y1.
SMR	Q783Y1. Positions 144-572.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.120.10.10. 1 hit.
InterPro	IPR000665. Hemagglutn-neuramid. IPR016285. Hemagglutn-neuramid_paramyxo. IPR011040. Sialidases. [Graphical view]
Pfam	PF00423. HN. 1 hit. [Graphical view]
PIRSF	PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAM	SSF50939. Sialidase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HN_SENDA

Accession

Primary (citable) accession number: Q783Y1
Secondary accession number(s): Q7T415, Q7TB20, Q82459

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

Entry information

Relevant documents