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Q783Y1

- HN_SENDA

UniProt

Q783Y1 - HN_SENDA

Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Sendai virus (strain Hamamatsu) (SeV)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.By similarity
    Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hemagglutinin, Hydrolase

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin-neuraminidase (EC:3.2.1.18)
    Short name:
    HN protein
    Gene namesi
    Name:HN
    OrganismiSendai virus (strain Hamamatsu) (SeV)
    Taxonomic identifieri302271 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRespirovirus
    Virus hostiCavia cutleri (Guinea pig) [TaxID: 10144]
    Cricetidae sp. (Hamster) [TaxID: 36483]
    Mus musculus (Mouse) [TaxID: 10090]
    Rattus norvegicus (Rat) [TaxID: 10116]
    ProteomesiUP000007191: Genome, UP000008510: Genome, UP000008857: Genome

    Subcellular locationi

    Virion membrane Curated; Single-pass type II membrane protein Curated. Host cell membrane Curated; Single-pass type II membrane protein Curated
    Note: Folded in the endoplasmic reticulum.By similarity

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 575575Hemagglutinin-neuraminidasePRO_0000142636Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi77 – 771N-linked (GlcNAc...); by hostBy similarity
    Disulfide bondi129 – 129InterchainSequence Analysis
    Glycosylationi499 – 4991N-linked (GlcNAc...); by hostBy similarity
    Glycosylationi511 – 5111N-linked (GlcNAc...); by hostBy similarity

    Post-translational modificationi

    N-glycosylated; glycans consist of a mixture of high mannose-type oligosaccharides and of complex-type oligosaccharides.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homotetramer; composed of disulfide-linked homodimers. Interacts with F protein trimer By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ783Y1.
    SMRiQ783Y1. Positions 144-572.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737IntravirionBy similarityAdd
    BLAST
    Topological domaini59 – 575517Virion surfaceBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni10 – 145Incorporation in virionBy similarity
    Regioni59 – 14082Involved in interaction with F proteinBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00423. HN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q783Y1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGDRSKRDS YWSTSPGGST TKLVSDSERS GKVDTWLLIL AFTQWALSIA    50
    TVIICIVIAA RQGYSMERYS MTVEALNTSN KEVKESLTSL IRQEVITRAV 100
    NIQSSVQTGI PVLLNKNSRD VIQLIEKSCN RQELTQLCDS TIAVHHAEGI 150
    APLEPHSFWR CPAGEPYLSS DPEVSLLPGP SLLSGSTTIS GCVRLPSLSI 200
    GEAIYAYSSN LITQGCADIG KSYQVLQLGY ISLNSDMFPD LNPVVSHTYD 250
    INDNRKSCSV VATGTRGYQL CSMPTVDERT DYSSDGIEDL VLDILDLKGR 300
    TKSHRYSNSE IDLDHPFSAL YPSVGSGIAT EGSLIFLGYG GLTTPLQGDT 350
    KCRIQGCQQV SQDTCNEALK ITWLGGKQVV SVLIQVNDYL SERPRIRVTT 400
    VPITQNYLGA EGRLLKLGDQ VYIYTRSSGW HSQLQIGVLD VSHPLTISWT 450
    PHEALSRPGN EDCNWYNTCP KECISGVYTD AYPLSPDAAN VATVTLYANT 500
    SRVNPTIMYS NTTNIINMLR IKDVKLEAAY TTTSCITHFG KGYCFHIIEI 550
    NQKSLNTLQP MLFKTSIPKL CKAES 575
    Length:575
    Mass (Da):63,212
    Last modified:July 5, 2004 - v1
    Checksum:iBDA9E1B72431058A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti461 – 4611E → G in strain: Isolate E30cl2; egg passage attenuated.
    Natural varianti462 – 4621D → G in strain: Isolate E30cl2, Isolate E50cl9 and Isolate E30M15cl5; egg passage attenuated.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57213 Genomic RNA. Translation: CAA40499.1.
    AB039658 Genomic RNA. Translation: BAB20025.1.
    AB065186 Genomic RNA. Translation: BAC79131.1.
    AB065187 Genomic RNA. Translation: BAC07511.1.
    AB065188 Genomic RNA. Translation: BAC79139.1.
    AB065189 Genomic RNA. Translation: BAC79147.1.
    PIRiS14532.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57213 Genomic RNA. Translation: CAA40499.1 .
    AB039658 Genomic RNA. Translation: BAB20025.1 .
    AB065186 Genomic RNA. Translation: BAC79131.1 .
    AB065187 Genomic RNA. Translation: BAC07511.1 .
    AB065188 Genomic RNA. Translation: BAC79139.1 .
    AB065189 Genomic RNA. Translation: BAC79147.1 .
    PIRi S14532.

    3D structure databases

    ProteinModelPortali Q783Y1.
    SMRi Q783Y1. Positions 144-572.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00423. HN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A field isolate of Sendai virus: its high virulence to mice and genetic divergence from prototype strains."
      Sakaguchi T., Fujii Y., Kiyotani K., Sasaki M., Yoshida T.
      Arch. Virol. 135:159-164(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Conserved and non-conserved regions in the Sendai virus genome: evolution of a gene possessing overlapping reading frames."
      Fujii Y., Kiyotani K., Yoshida T., Sakaguchi T.
      Virus Genes 22:47-52(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "Involvement of the leader sequence in Sendai virus pathogenesis revealed by recovery of a pathogenic field isolate from cDNA."
      Fujii Y., Sakaguchi T., Kiyotani K., Huang C., Fukuhara N., Egi Y., Yoshida T.
      J. Virol. 76:8540-8547(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate E15cl2.
    4. "Identification of mutations associated with attenuation of virulence of a field Sendai virus isolate by egg passage."
      Fujii Y., Sakaguchi T., Kiyotani K., Huang C., Fukuhara N., Yoshida T.
      Virus Genes 25:189-193(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate E15cl2, Isolate E30cl2 and Isolate E30M15cl5.
    5. Fujii Y., Kiyotani K., Huang C., Fukuhara N., Egi K., Yoshida T., Sakaguchi T.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate E50cl9.

    Entry informationi

    Entry nameiHN_SENDA
    AccessioniPrimary (citable) accession number: Q783Y1
    Secondary accession number(s): Q7T415, Q7TB20, Q82459
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3