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Protein

Immediate-early protein 2

Gene

U90/U87/U86

Organism
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional transactivator.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processHost-virus interaction, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Immediate-early protein 2
Short name:
IE2
Gene namesi
Name:U90/U87/U86
Synonyms:BCLF0
OrganismiHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Taxonomic identifieri10370 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009295 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002602251 – 1500Immediate-early protein 2Add BLAST1500

Proteomic databases

PRIDEiQ77Z83

Interactioni

Subunit structurei

Interacts with human UBE2I in the nucleus. Although this interaction does not promote IE2 sumoylation, it represses transactivation activity (By similarity).By similarity

Structurei

Secondary structure

11500
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1335 – 1345Combined sources11
Beta strandi1352 – 1358Combined sources7
Helixi1364 – 1376Combined sources13
Beta strandi1381 – 1384Combined sources4
Beta strandi1389 – 1391Combined sources3
Helixi1399 – 1409Combined sources11
Helixi1412 – 1419Combined sources8
Beta strandi1436 – 1444Combined sources9
Helixi1445 – 1461Combined sources17
Turni1463 – 1465Combined sources3
Beta strandi1466 – 1474Combined sources9
Helixi1481 – 1483Combined sources3
Helixi1484 – 1495Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WX8X-ray2.50A/B/C/D1324-1500[»]
SMRiQ77Z83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1024 – 1072Interaction with human UBE2IBy similarityAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi713 – 1141Ser-richAdd BLAST429

Domaini

The C-terminus binds to a DNA fragment that contains the transcription initiation site and an upstream sequence of the IEA promoter.

Keywords - Domaini

Repeat

Phylogenomic databases

OrthoDBiVOG0900005Z

Family and domain databases

InterProiView protein in InterPro
IPR005028 Herpes_IE2_3
PfamiView protein in Pfam
PF03361 Herpes_IE2_3, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q77Z83-1) [UniParc]FASTAAdd to basket
Also known as: IE2 protein, Protein U90-U86/87

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPAKPSGNN MGSNDERMQD YRPDPMMEES IKEILEESLM CDTSFDDLII
60 70 80 90 100
PGLESFGLII PESSNNIESN NVEEGSDGEL KTLAEQKCKQ GNDNDVIQSA
110 120 130 140 150
MKLSGLYCDA DITHTQPLSD NTHQDPIYSQ ESRIFTKTIQ DPRIVAQTHR
160 170 180 190 200
QCTSSASNLQ SNESGSTQVR FASELPNQLL QPMYTSHNQN ANLQNNFTSL
210 220 230 240 250
PYQPYHDPYR DIESSYRESR NTNRGYDYNF RHHPYRPRGG NGKYNYYNPN
260 270 280 290 300
SKYQQPYKRC FTRTYNRRGR GHRSYDCSDR SADLPYEHYT YPNYEQQNPD
310 320 330 340 350
PRMNNYKDFT QLTNKFNFES YDYSMAFSTD STHVQSDNYN HPTKAQTIPE
360 370 380 390 400
TTKTKKHEAT KDNETSTENQ VLTPDVISLS YRPSSYKMDI IKKIYDTDVI
410 420 430 440 450
PLPKEALTAN GSNRDVDIQK YKKAHIRCRS VQKKKERSSQ TNKHDENHAS
460 470 480 490 500
SRSDLKERKS NENEDKAVTK ARDFSKLNPL LSPLPLTPEP AIDFADHTDK
510 520 530 540 550
FYSTPEFNQI QQNLHRSKTS LQDTVPISKH TPRAPTKDNS YKKHHDSKDN
560 570 580 590 600
YPKMKHSPGR TTSKKNTTNS NGHQNFKEVS VKNVSGKATS TSPKSKTHHY
610 620 630 640 650
SSSSDEEGQY KSPVKTIIQS PSPYCKLKNP SIMDKNSAKN HTASADKNLT
660 670 680 690 700
DNSPIRSNLN PTAFNKSNSN KSITDSTSNS DECTDRKPNC NSTKNESKDP
710 720 730 740 750
NRTCGKNSDK HLSKSCTMAS KRAPSRASSR ASSRDSSRAS SRASSRASSR
760 770 780 790 800
DSSRASSRAS SRDSSRASSR ASSRASSKAS SRASSRASSR ASSRDSSRAS
810 820 830 840 850
SKASSRASSR DSSRASSRAS SRASSKASSR ASSRASSRAS SRDSSRASSK
860 870 880 890 900
ASSRASSRDS SRASSRDSSR DSSRASSRAS SRDSSRASSK ASRKASSRAS
910 920 930 940 950
SRASSRASSK ASGKASSEAS SRASSRNSSR ASSRASSRAS SRDSSRASSR
960 970 980 990 1000
ASSRDSSRAS SKASRKASSR ASSRASSREL RQIYCDSNKR QTPPHDTSIN
1010 1020 1030 1040 1050
TKFEISEIKF RCGEDLNFYK NTAARLQCFN HNDQFYNPRF RPHIRTNRKK
1060 1070 1080 1090 1100
SESTNDTDSE SSMSRCKSHC RNSPDSLTVV RRKKHKSGSS SISSSIEENC
1110 1120 1130 1140 1150
RSNSHIVTGK EKFTPFYYQS SRTRSSSSSS SSSASLSCSK STLKTCRKTQ
1160 1170 1180 1190 1200
YKDNKQIKSK SDSKHKTTNM SSDYESNRHA DVFKNSPEAG EKFPLHNSSP
1210 1220 1230 1240 1250
FNTHEQSNHS ENAIDEEQKK APNITTSHLQ GKQNVRLHNT KKCKKKRPRD
1260 1270 1280 1290 1300
DDSDSSIKNF CKKRISGAQK TESEVSEPDD LCYRDYVRLK ERKVSEKFKI
1310 1320 1330 1340 1350
HRGRVATKDF QKLFRNTMRA FEYKQIPKKP CNEKNLKEAV YDICCNGLSN
1360 1370 1380 1390 1400
NAAIIMYFTR SKKVAQIIKI MQKELMIRPN ITVSEAFKMN HAPPKYYDKD
1410 1420 1430 1440 1450
EIKRFIQLQK QGPQELWDKF ENNTTHDLFT RHSDVKTMII YAATPIDFVG
1460 1470 1480 1490 1500
AVKTCNKYAK DNPKEIVLRV CSIIDGDNPI SIYNPISKEF KSKFSTLSKC
Length:1,500
Mass (Da):168,789
Last modified:July 22, 2008 - v2
Checksum:i4EB4BBD1F25B39C0
GO
Isoform 2 (identifier: Q69567-1) [UniParc]FASTAAdd to basket
Also known as: IE1 protein, Protein U90-U89
The sequence of this isoform can be found in the external entry Q69567.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:941
Mass (Da):104,648
GO
Isoform 3 (identifier: Q77Z83-2) [UniParc]FASTAAdd to basket
Also known as: IE-100

The sequence of this isoform differs from the canonical sequence as follows:
     614-1230: Missing.

Note: No experimental confirmation available.
Show »
Length:883
Mass (Da):101,975
Checksum:iE65CA34D1DAF6821
GO
Isoform 4 (identifier: Q77Z83-3) [UniParc]FASTAAdd to basket
Also known as: IE-55

The sequence of this isoform differs from the canonical sequence as follows:
     170-1230: Missing.

Note: No experimental confirmation available.
Show »
Length:439
Mass (Da):50,240
Checksum:i6D775570FB4889C8
GO

Sequence cautioni

The sequence CAA58335 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136T → S in CAA58335 (PubMed:7747482).Curated1
Sequence conflicti143 – 144RI → L in CAA58335 (PubMed:7747482).Curated2
Sequence conflicti206H → R in AAB67722 (Ref. 2) Curated1
Sequence conflicti675D → N in AAB67722 (Ref. 2) Curated1
Sequence conflicti696E → D in AAB67722 (Ref. 2) Curated1
Sequence conflicti755 – 802Missing in CAA58335 (PubMed:7747482).CuratedAdd BLAST48
Sequence conflicti755 – 802Missing in AAA68477 (PubMed:7941342).CuratedAdd BLAST48
Sequence conflicti918E → K in AAB67722 (Ref. 2) Curated1
Sequence conflicti958R → G in AAB67722 (Ref. 2) Curated1
Sequence conflicti1169N → D in AAB67722 (Ref. 2) Curated1
Sequence conflicti1430T → S in AAB67722 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034764170 – 1230Missing in isoform 4. CuratedAdd BLAST1061
Alternative sequenceiVSP_034763614 – 1230Missing in isoform 3. CuratedAdd BLAST617

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83413 Genomic DNA Translation: CAA58335.1 Sequence problems.
AF015297 mRNA Translation: AAB67722.1
AF015298 Genomic DNA Translation: AAB69858.1
U13194 Genomic DNA Translation: AAA68477.1
PIRiT03824

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIE2_HHV6U
AccessioniPrimary (citable) accession number: Q77Z83
Secondary accession number(s): O42080, Q69471, Q69564
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 22, 2008
Last modified: May 23, 2018
This is version 46 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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