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Protein

Protein Rev

Gene

rev

Organism
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

HIV-1 lineages are divided in three main groups, M (for Major), O (for Outlier), and N (for New, or Non-M, Non-O). The vast majority of strains found worldwide belong to the group M. Group O seems to be endemic to and largely confined to Cameroon and neighboring countries in West Central Africa, where these viruses represent a small minority of HIV-1 strains. The group N is represented by a limited number of isolates from Cameroonian persons. The group M is further subdivided in 9 clades or subtypes (A to D, F to H, J and K).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-bindingUniRule annotationSAAS annotation
Biological processHost-virus interactionUniRule annotation, mRNA transportUniRule annotationSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RevUniRule annotationSAAS annotation
Alternative name(s):
ART/TRSUniRule annotation
Anti-repression transactivatorUniRule annotation
Regulator of expression of viral proteinsUniRule annotation
Gene namesi
Name:revUniRule annotationImported
OrganismiHuman immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)Imported
Taxonomic identifieri11706 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000105453 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasmUniRule annotationSAAS annotation, Host nucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3852.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5Phosphoserine; by host CK2UniRule annotation1
Modified residuei8Phosphoserine; by host CK2UniRule annotation1
Modified residuei92Phosphoserine; by hostUniRule annotation1
Modified residuei99Phosphoserine; by hostUniRule annotation1

Post-translational modificationi

Asymmetrically arginine dimethylated at one site by host PRMT6. Methylation impairs the RNA-binding activity and export of viral RNA from the nucleus to the cytoplasm.UniRule annotation
Phosphorylated by protein kinase CK2. Presence of, and maybe binding to the N-terminus of the regulatory beta subunit of CK2 is necessary for CK2-mediated Rev's phosphorylation.UniRule annotation

Keywords - PTMi

MethylationUniRule annotation, PhosphoproteinUniRule annotation

Interactioni

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

IntActiQ77YF8. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ77YF8.
SMRiQ77YF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni18 – 26HomomultimerizationUniRule annotation9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 50Nuclear localization signal and RNA-binding (RRE)UniRule annotationAdd BLAST17
Motifi73 – 84Nuclear export signal and binding to XPO1UniRule annotationAdd BLAST12

Domaini

The RNA-binding motif binds to the RRE, a 240 bp stem-and-loop structure present in incompletely spliced viral pre-mRNAs. This region also contains the NLS which mediates nuclear localization via KPNB1 binding and, when the N-terminal sequence is present, nucleolar targeting. These overlapping functions prevent Rev bound to RRE from undesirable return to the nucleus. When Rev binds the RRE, the NLS becomes masked while the NES remains accessible. The leucine-rich NES mediates binding to human XPO1.UniRule annotation

Sequence similaritiesi

Belongs to the HIV-1 REV protein family.UniRule annotation

Family and domain databases

HAMAPiMF_04077. REV_HIV1. 1 hit.
InterProiView protein in InterPro
IPR000625. REV_protein.
PfamiView protein in Pfam
PF00424. REV. 1 hit.

Sequencei

Sequence statusi: Complete.

Q77YF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRSGDSDE ELIRTVRLIK LLYQSNPPPN PEGTRQARRN RRRRWRERQR
60 70 80 90 100
QIHSISERIL GTYLGRSAEP VPLQLPPLER LTLDCNEDCG TSGTQGVGSP
110
QILVESPTVL ESGTKE
Length:116
Mass (Da):13,075
Last modified:July 5, 2004 - v1
Checksum:i4BCF5059C9A7F3B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033819 Genomic RNA. Translation: AAC82592.1.
RefSeqiNP_057854.1. NC_001802.1.

Genome annotation databases

GeneIDi155908.

Similar proteinsi

Entry informationi

Entry nameiQ77YF8_HV1H2
AccessioniPrimary (citable) accession number: Q77YF8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: December 20, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported