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Protein

Protein Rev

Gene

rev

Organism
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-bindingUniRule annotationSAAS annotation
Biological processmRNA transportUniRule annotationSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RevUniRule annotationSAAS annotation
Alternative name(s):
Regulator of expression of viral proteinsUniRule annotation
Gene namesi
Name:revUniRule annotationImported
OrganismiHuman immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)Imported
Taxonomic identifieri11706 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000105453 Componenti: Genome

Subcellular locationi

  • Host cytoplasm UniRule annotation
  • host nucleolus UniRule annotation
  • host nucleolus SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasmUniRule annotationSAAS annotation, Host nucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3852.

Interactioni

Subunit structurei

Homomultimer; when bound to the RRE. Multimeric assembly is essential for activity.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ77YF8.
SMRiQ77YF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR000625. REV_protein.
PfamiView protein in Pfam
PF00424. REV. 1 hit.

Sequencei

Sequence statusi: Complete.

Q77YF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRSGDSDE ELIRTVRLIK LLYQSNPPPN PEGTRQARRN RRRRWRERQR
60 70 80 90 100
QIHSISERIL GTYLGRSAEP VPLQLPPLER LTLDCNEDCG TSGTQGVGSP
110
QILVESPTVL ESGTKE
Length:116
Mass (Da):13,075
Last modified:July 5, 2004 - v1
Checksum:i4BCF5059C9A7F3B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033819 Genomic RNA. Translation: AAC82592.1.
RefSeqiNP_057854.1. NC_001802.1.

Genome annotation databases

GeneIDi155908.

Similar proteinsi

Entry informationi

Entry nameiQ77YF8_HV1H2
AccessioniPrimary (citable) accession number: Q77YF8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported