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Protein

Protein G3

Gene

TG3L

Organism
Vaccinia virus (strain Tian Tan) (VACV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry. Also plays a role in cell-cell fusion (syncytium formation) (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processFusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Protein G3
Gene namesi
ORF Names:TG3L
OrganismiVaccinia virus (strain Tian Tan) (VACV)
Taxonomic identifieri10253 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000163220 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21Helical; Signal-anchorSequence analysisAdd BLAST21
Topological domaini22 – 111Virion surfaceSequence analysisAdd BLAST90

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002629271 – 111Protein G3Add BLAST111

Interactioni

Subunit structurei

Part of a stable entry-fusion complex (EFC) which is at least composed of proteins A16, A21, A28, G3, G9, H2, J5, and L5. Formation of the viral membrane is necessary for the assembly of the complex. Interacts with L5 (By similarity).By similarity

Structurei

3D structure databases

SMRiQ77TL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chordopoxvirinae G3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR010367. Poxvirus_G3.
PfamiView protein in Pfam
PF06129. Chordopox_G3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q77TL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLLYLILF LLFVCISYYF TYYPTNKLQA AVMETDRENA IIRQRNDEIP
60 70 80 90 100
TRTLDTAIFT DASTVASAQI HLYYNSNIGK IIMSLNGKKH TFNLYDDNDI
110
RTLLPILLLS K
Length:111
Mass (Da):12,803
Last modified:July 5, 2004 - v1
Checksum:i9BCD24ABADC2B07D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095689 Genomic DNA. Translation: AAF33939.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095689 Genomic DNA. Translation: AAF33939.1.

3D structure databases

SMRiQ77TL4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR010367. Poxvirus_G3.
PfamiView protein in Pfam
PF06129. Chordopox_G3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiG3_VACCT
AccessioniPrimary (citable) accession number: Q77TL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: March 15, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.