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Q77MS1

- RIR1_GAHVM

UniProt

Q77MS1 - RIR1_GAHVM

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Protein

Ribonucleoside-diphosphate reductase large subunit

Gene
MDV052
Organism
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei249 – 2491Substrate By similarity
Sitei265 – 2651Important for hydrogen atom transfer By similarity
Binding sitei295 – 2951Substrate; via amide nitrogen By similarity
Active sitei470 – 4701Proton acceptor By similarity
Active sitei472 – 4721Cysteine radical intermediate By similarity
Active sitei474 – 4741Proton acceptor By similarity
Sitei487 – 4871Important for hydrogen atom transfer By similarity
Sitei796 – 7961Important for electron transfer By similarity
Sitei797 – 7971Important for electron transfer By similarity
Sitei817 – 8171Interacts with thioredoxin/glutaredoxin By similarity
Sitei820 – 8201Interacts with thioredoxin/glutaredoxin By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase large subunit (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase large subunit
Gene namesi
Name:MDV052
OrganismiGallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Taxonomic identifieri10389 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
ProteomesiUP000008072: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 822822Ribonucleoside-diphosphate reductase large subunitPRO_0000406420Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi265 ↔ 487Redox-active By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ77MS1.

Interactioni

Subunit structurei

Heterodimer of a large and a small chain By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ77MS1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni264 – 2652Substrate binding By similarity
Regioni470 – 4745Substrate binding By similarity
Regioni651 – 6555Substrate binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi205 – 2095Poly-Ala

Sequence similaritiesi

Family and domain databases

InterProiIPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
PROSITEiPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q77MS1-1 [UniParc]FASTAAdd to Basket

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MDHSDVYEPY TFSGKHHVRM YDFSKLTPMW NKDASTPPRK FADMHIASTV    50
AMELYNIERE LLNMGHLSGM ETMMVDVRKS PEMIPSTINM RDHITRLVNK 100
MKPICRFDER LYSLCGELVH LRIELREVPL DTWLLSKKLN LKYEVVDNIR 150
RYRAHIEMDM LRFYGSIHPW LKRLGLQSAL KYEEYLVELE DGKKESLCQF 200
FVRLAAAAAT EASMKKPFMT TLTTGVANWR TTFTTFFLAL ANQLFVPSTP 250
CMLFLGREGT STASCYLMDP RTNNTQDTLK AITEDVVPHL LARGGIGISL 300
QHLNGKFGLM HVMKVLDSLV MAANVNESRP TGICVYLEPW HADIMSALNM 350
RGMVAAEESR RCDNVFLALW SCDLLFKRYL RHVNGEKNVI WTLFDSRASI 400
LTKLHSEEFE KEYERLESEG LGVASIPIRD MMFAIIKSAA STGSPFILFK 450
DACNRHYITN TQGDAIAGSN LCTEIIQKTD ANTNGVCSLA SINLARCVRN 500
IDGNRQFDFD ALRYAVRLAT VFVNAIMEGS DVPTEKSHSG RERNRSMGIG 550
VQGFHTAFLS MGLDLCDERA RSLNKLIFEF MLLEAMTVSC EFCERGLPPF 600
ADFSNSYYAR GRLHFDGWAN VELAAVEEWN MLRDRIVSAG LYNAQFIALM 650
PTAASAQVTE VSEGFSPLFS NMFSKVTSTG ELLRPNIQLM EELRTIYLDN 700
ENQRLATIAA LESANWNIQT ALGNKPECHS LLKYKTAFDY DQALLIDLCS 750
DRAPFVDQSQ SMTLFITETA DGTLLASRVM NLLLHAYKAG LKTGMYYCKI 800
RKATNAGVFC GDGELTCSSC VL 822
Length:822
Mass (Da):92,821
Last modified:October 13, 2009 - v1
Checksum:iA03EA8256609AC4A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF243438 Genomic DNA. Translation: AAG14232.1.
RefSeqiYP_001033968.1. NC_002229.3.

Genome annotation databases

GeneIDi4811513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF243438 Genomic DNA. Translation: AAG14232.1 .
RefSeqi YP_001033968.1. NC_002229.3.

3D structure databases

ProteinModelPortali Q77MS1.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q77MS1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4811513.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

InterProi IPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view ]
PRINTSi PR01183. RIBORDTASEM1.
TIGRFAMsi TIGR02506. NrdE_NrdA. 1 hit.
PROSITEi PS00089. RIBORED_LARGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of a very virulent Marek's disease virus."
    Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.
    J. Virol. 74:7980-7988(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRIR1_GAHVM
AccessioniPrimary (citable) accession number: Q77MS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 13, 2009
Last modified: May 14, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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