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Q77MS1

- RIR1_GAHVM

UniProt

Q77MS1 - RIR1_GAHVM

Protein

Ribonucleoside-diphosphate reductase large subunit

Gene

MDV052

Organism
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei249 – 2491SubstrateBy similarity
    Sitei265 – 2651Important for hydrogen atom transferBy similarity
    Binding sitei295 – 2951Substrate; via amide nitrogenBy similarity
    Active sitei470 – 4701Proton acceptorBy similarity
    Active sitei472 – 4721Cysteine radical intermediateBy similarity
    Active sitei474 – 4741Proton acceptorBy similarity
    Sitei487 – 4871Important for hydrogen atom transferBy similarity
    Sitei796 – 7961Important for electron transferBy similarity
    Sitei797 – 7971Important for electron transferBy similarity
    Sitei817 – 8171Interacts with thioredoxin/glutaredoxinBy similarity
    Sitei820 – 8201Interacts with thioredoxin/glutaredoxinBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase large subunit (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase large subunit
    Gene namesi
    Name:MDV052
    OrganismiGallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
    Taxonomic identifieri10389 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]
    ProteomesiUP000008072: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 822822Ribonucleoside-diphosphate reductase large subunitPRO_0000406420Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi265 ↔ 487Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ77MS1.

    Interactioni

    Subunit structurei

    Heterodimer of a large and a small chain.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ77MS1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni264 – 2652Substrate bindingBy similarity
    Regioni470 – 4745Substrate bindingBy similarity
    Regioni651 – 6555Substrate bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi205 – 2095Poly-Ala

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR013346. NrdE_NrdA.
    IPR000788. RNR_lg_C.
    IPR013509. RNR_lsu_N.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 1 hit.
    PF00317. Ribonuc_red_lgN. 1 hit.
    [Graphical view]
    PRINTSiPR01183. RIBORDTASEM1.
    TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
    PROSITEiPS00089. RIBORED_LARGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q77MS1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDHSDVYEPY TFSGKHHVRM YDFSKLTPMW NKDASTPPRK FADMHIASTV    50
    AMELYNIERE LLNMGHLSGM ETMMVDVRKS PEMIPSTINM RDHITRLVNK 100
    MKPICRFDER LYSLCGELVH LRIELREVPL DTWLLSKKLN LKYEVVDNIR 150
    RYRAHIEMDM LRFYGSIHPW LKRLGLQSAL KYEEYLVELE DGKKESLCQF 200
    FVRLAAAAAT EASMKKPFMT TLTTGVANWR TTFTTFFLAL ANQLFVPSTP 250
    CMLFLGREGT STASCYLMDP RTNNTQDTLK AITEDVVPHL LARGGIGISL 300
    QHLNGKFGLM HVMKVLDSLV MAANVNESRP TGICVYLEPW HADIMSALNM 350
    RGMVAAEESR RCDNVFLALW SCDLLFKRYL RHVNGEKNVI WTLFDSRASI 400
    LTKLHSEEFE KEYERLESEG LGVASIPIRD MMFAIIKSAA STGSPFILFK 450
    DACNRHYITN TQGDAIAGSN LCTEIIQKTD ANTNGVCSLA SINLARCVRN 500
    IDGNRQFDFD ALRYAVRLAT VFVNAIMEGS DVPTEKSHSG RERNRSMGIG 550
    VQGFHTAFLS MGLDLCDERA RSLNKLIFEF MLLEAMTVSC EFCERGLPPF 600
    ADFSNSYYAR GRLHFDGWAN VELAAVEEWN MLRDRIVSAG LYNAQFIALM 650
    PTAASAQVTE VSEGFSPLFS NMFSKVTSTG ELLRPNIQLM EELRTIYLDN 700
    ENQRLATIAA LESANWNIQT ALGNKPECHS LLKYKTAFDY DQALLIDLCS 750
    DRAPFVDQSQ SMTLFITETA DGTLLASRVM NLLLHAYKAG LKTGMYYCKI 800
    RKATNAGVFC GDGELTCSSC VL 822
    Length:822
    Mass (Da):92,821
    Last modified:October 13, 2009 - v1
    Checksum:iA03EA8256609AC4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF243438 Genomic DNA. Translation: AAG14232.1.
    RefSeqiYP_001033968.1. NC_002229.3.

    Genome annotation databases

    GeneIDi4811513.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF243438 Genomic DNA. Translation: AAG14232.1 .
    RefSeqi YP_001033968.1. NC_002229.3.

    3D structure databases

    ProteinModelPortali Q77MS1.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q77MS1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4811513.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    InterProi IPR013346. NrdE_NrdA.
    IPR000788. RNR_lg_C.
    IPR013509. RNR_lsu_N.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 1 hit.
    PF00317. Ribonuc_red_lgN. 1 hit.
    [Graphical view ]
    PRINTSi PR01183. RIBORDTASEM1.
    TIGRFAMsi TIGR02506. NrdE_NrdA. 1 hit.
    PROSITEi PS00089. RIBORED_LARGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of a very virulent Marek's disease virus."
      Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.
      J. Virol. 74:7980-7988(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRIR1_GAHVM
    AccessioniPrimary (citable) accession number: Q77MS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3