Q77MS0 (RIR2_GAHVM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonucleoside-diphosphate reductase small chain
EC=1.17.4.1

Alternative name(s):
Ribonucleotide reductase small subunit

Gene names

Name:

MDV053

Organism

Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) [Reference proteome]

Taxonomic identifier

10389 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Mardivirus › Gallid herpesvirus 2

Virus host

Gallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.
Catalytic activity	2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.
Cofactor	Binds 2 iron ions per subunit By similarity.
Pathway	Genetic information processing; DNA replication.
Subunit structure	Heterodimer of a large and a small chain By similarity.
Sequence similarities	Belongs to the ribonucleoside diphosphate reductase small chain family.

Ontologies

Keywords
Biological process	DNA replication
Developmental stage	Early protein
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-UniPathway deoxyribonucleoside diphosphate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	ribonucleoside-diphosphate reductase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Inferred from electronic annotation. Source: EC transition metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Ribonucleoside-diphosphate reductase small chain		PRO_0000406511
Sites
	Active site	138	1	By similarity
	Metal binding	101	1	Iron 1 By similarity
	Metal binding	131	1	Iron 1 By similarity
	Metal binding	131	1	Iron 2 By similarity
	Metal binding	134	1	Iron 1 By similarity
	Metal binding	194	1	Iron 2 By similarity
	Metal binding	228	1	Iron 2 By similarity
	Metal binding	231	1	Iron 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q77MS0 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: C1928938B22BD9F5	FASTA	343	39,060
	10 20 30 40 50 60 MSGPPSHEIG MLYSLAPSVD MKSENIEDLP SESIPTTNHC ASNYFYAPEC PDIGHLRALS 70 80 90 100 110 120 IMNRWTETEF VISDDLRDVS MLTEEERYFY RFLFTFLSAA DDLVNLNIDN LLGLFSQKDI 130 140 150 160 170 180 HHYYFEQECI EAVHSRAYSI IQLMLFDNDS LARAEYVKTS LNSPAIQSKL DWLNKRVIEC 190 200 210 220 230 240 SSIAEKYILM ILIEGIFFSA SFAAIAYLRI NNLFVVTCQI NNLISRDEAI HVEASCCIFK 250 260 270 280 290 300 NYLMGPKPSI GRVQELFKEA VQIECAFLRT AAPRNSQLLD VEAICSYVRY SADRLLKELD 310 320 330 340 MPPIYNEPKP TADFPLALMT ASNNTNFFER RNTAYSGSVS NDL

References

[1]	"The genome of a very virulent Marek's disease virus." Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F. J. Virol. 74:7980-7988(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF243438 Genomic DNA. Translation: AAG14233.1.
RefSeq	YP_001033969.1. NC_002229.3.
3D structure databases
HSSP	HSSP built from PDB template 1H0O based on UniProtKB P11157.
ProteinModelPortal	Q77MS0.
ModBase	Search...
Proteomic databases
PRIDE	Q77MS0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4811514.
Phylogenomic databases
ProtClustDB	CLSP2509600.
Enzyme and pathway databases
UniPathway	UPA00326.
Family and domain databases
Gene3D	1.10.620.20. 1 hit.
InterPro	IPR009078. Ferritin-like_SF. IPR012348. RNR-rel. IPR000358. RNR_small. [Graphical view]
PANTHER	PTHR23409. PTHR23409. 1 hit.
Pfam	PF00268. Ribonuc_red_sm. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
PROSITE	PS00368. RIBORED_SMALL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RIR2_GAHVM

Accession

Primary (citable) accession number: Q77MS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 5, 2011
Last sequence update:	October 13, 2009
Last modified:	May 1, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program