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Q77MS0

- RIR2_GAHVM

UniProt

Q77MS0 - RIR2_GAHVM

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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

MDV053

Organism
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011Iron 1PROSITE-ProRule annotation
Metal bindingi131 – 1311Iron 1PROSITE-ProRule annotation
Metal bindingi131 – 1311Iron 2By similarity
Metal bindingi134 – 1341Iron 1PROSITE-ProRule annotation
Active sitei138 – 1381PROSITE-ProRule annotation
Metal bindingi194 – 1941Iron 2By similarity
Metal bindingi228 – 2281Iron 2By similarity
Metal bindingi231 – 2311Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:MDV053
OrganismiGallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Taxonomic identifieri10389 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
ProteomesiUP000008072: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Ribonucleoside-diphosphate reductase small chainPRO_0000406511Add
BLAST

Proteomic databases

PRIDEiQ77MS0.

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Heterodimer of a large and a small chain.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ77MS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q77MS0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGPPSHEIG MLYSLAPSVD MKSENIEDLP SESIPTTNHC ASNYFYAPEC
60 70 80 90 100
PDIGHLRALS IMNRWTETEF VISDDLRDVS MLTEEERYFY RFLFTFLSAA
110 120 130 140 150
DDLVNLNIDN LLGLFSQKDI HHYYFEQECI EAVHSRAYSI IQLMLFDNDS
160 170 180 190 200
LARAEYVKTS LNSPAIQSKL DWLNKRVIEC SSIAEKYILM ILIEGIFFSA
210 220 230 240 250
SFAAIAYLRI NNLFVVTCQI NNLISRDEAI HVEASCCIFK NYLMGPKPSI
260 270 280 290 300
GRVQELFKEA VQIECAFLRT AAPRNSQLLD VEAICSYVRY SADRLLKELD
310 320 330 340
MPPIYNEPKP TADFPLALMT ASNNTNFFER RNTAYSGSVS NDL
Length:343
Mass (Da):39,060
Last modified:October 13, 2009 - v1
Checksum:iC1928938B22BD9F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF243438 Genomic DNA. Translation: AAG14233.1.
RefSeqiYP_001033969.1. NC_002229.3.

Genome annotation databases

GeneIDi4811514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF243438 Genomic DNA. Translation: AAG14233.1 .
RefSeqi YP_001033969.1. NC_002229.3.

3D structure databases

ProteinModelPortali Q77MS0.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q77MS0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4811514.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of a very virulent Marek's disease virus."
    Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.
    J. Virol. 74:7980-7988(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRIR2_GAHVM
AccessioniPrimary (citable) accession number: Q77MS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 13, 2009
Last modified: November 26, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3