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Q77MS0

- RIR2_GAHVM

UniProt

Q77MS0 - RIR2_GAHVM

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Protein
Ribonucleoside-diphosphate reductase small chain
Gene
MDV053
Organism
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011Iron 1 By similarity
Metal bindingi131 – 1311Iron 1 By similarity
Metal bindingi131 – 1311Iron 2 By similarity
Metal bindingi134 – 1341Iron 1 By similarity
Active sitei138 – 1381 By similarity
Metal bindingi194 – 1941Iron 2 By similarity
Metal bindingi228 – 2281Iron 2 By similarity
Metal bindingi231 – 2311Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
  2. deoxyribonucleoside diphosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:MDV053
OrganismiGallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Taxonomic identifieri10389 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
ProteomesiUP000008072: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Ribonucleoside-diphosphate reductase small chain
PRO_0000406511Add
BLAST

Proteomic databases

PRIDEiQ77MS0.

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Heterodimer of a large and a small chain By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ77MS0.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q77MS0-1 [UniParc]FASTAAdd to Basket

« Hide

MSGPPSHEIG MLYSLAPSVD MKSENIEDLP SESIPTTNHC ASNYFYAPEC    50
PDIGHLRALS IMNRWTETEF VISDDLRDVS MLTEEERYFY RFLFTFLSAA 100
DDLVNLNIDN LLGLFSQKDI HHYYFEQECI EAVHSRAYSI IQLMLFDNDS 150
LARAEYVKTS LNSPAIQSKL DWLNKRVIEC SSIAEKYILM ILIEGIFFSA 200
SFAAIAYLRI NNLFVVTCQI NNLISRDEAI HVEASCCIFK NYLMGPKPSI 250
GRVQELFKEA VQIECAFLRT AAPRNSQLLD VEAICSYVRY SADRLLKELD 300
MPPIYNEPKP TADFPLALMT ASNNTNFFER RNTAYSGSVS NDL 343
Length:343
Mass (Da):39,060
Last modified:October 13, 2009 - v1
Checksum:iC1928938B22BD9F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF243438 Genomic DNA. Translation: AAG14233.1.
RefSeqiYP_001033969.1. NC_002229.3.

Genome annotation databases

GeneIDi4811514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF243438 Genomic DNA. Translation: AAG14233.1 .
RefSeqi YP_001033969.1. NC_002229.3.

3D structure databases

ProteinModelPortali Q77MS0.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q77MS0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4811514.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of a very virulent Marek's disease virus."
    Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.
    J. Virol. 74:7980-7988(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRIR2_GAHVM
AccessioniPrimary (citable) accession number: Q77MS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 13, 2009
Last modified: May 14, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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