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Q77MS0

- RIR2_GAHVM

UniProt

Q77MS0 - RIR2_GAHVM

Protein

Ribonucleoside-diphosphate reductase small chain

Gene

MDV053

Organism
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi101 – 1011Iron 1PROSITE-ProRule annotation
    Metal bindingi131 – 1311Iron 1PROSITE-ProRule annotation
    Metal bindingi131 – 1311Iron 2By similarity
    Metal bindingi134 – 1341Iron 1PROSITE-ProRule annotation
    Active sitei138 – 1381PROSITE-ProRule annotation
    Metal bindingi194 – 1941Iron 2By similarity
    Metal bindingi228 – 2281Iron 2By similarity
    Metal bindingi231 – 2311Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:MDV053
    OrganismiGallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
    Taxonomic identifieri10389 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]
    ProteomesiUP000008072: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Ribonucleoside-diphosphate reductase small chainPRO_0000406511Add
    BLAST

    Proteomic databases

    PRIDEiQ77MS0.

    Expressioni

    Keywords - Developmental stagei

    Early protein

    Interactioni

    Subunit structurei

    Heterodimer of a large and a small chain.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ77MS0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q77MS0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGPPSHEIG MLYSLAPSVD MKSENIEDLP SESIPTTNHC ASNYFYAPEC    50
    PDIGHLRALS IMNRWTETEF VISDDLRDVS MLTEEERYFY RFLFTFLSAA 100
    DDLVNLNIDN LLGLFSQKDI HHYYFEQECI EAVHSRAYSI IQLMLFDNDS 150
    LARAEYVKTS LNSPAIQSKL DWLNKRVIEC SSIAEKYILM ILIEGIFFSA 200
    SFAAIAYLRI NNLFVVTCQI NNLISRDEAI HVEASCCIFK NYLMGPKPSI 250
    GRVQELFKEA VQIECAFLRT AAPRNSQLLD VEAICSYVRY SADRLLKELD 300
    MPPIYNEPKP TADFPLALMT ASNNTNFFER RNTAYSGSVS NDL 343
    Length:343
    Mass (Da):39,060
    Last modified:October 13, 2009 - v1
    Checksum:iC1928938B22BD9F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF243438 Genomic DNA. Translation: AAG14233.1.
    RefSeqiYP_001033969.1. NC_002229.3.

    Genome annotation databases

    GeneIDi4811514.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF243438 Genomic DNA. Translation: AAG14233.1 .
    RefSeqi YP_001033969.1. NC_002229.3.

    3D structure databases

    ProteinModelPortali Q77MS0.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q77MS0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4811514.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of a very virulent Marek's disease virus."
      Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.
      J. Virol. 74:7980-7988(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRIR2_GAHVM
    AccessioniPrimary (citable) accession number: Q77MS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3