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Q77MS0 (RIR2_GAHVM) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:MDV053
OrganismGallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) [Reference proteome]
Taxonomic identifier10389 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
Virus hostGallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small chain By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Ribonucleoside-diphosphate reductase small chain
PRO_0000406511

Sites

Active site1381 By similarity
Metal binding1011Iron 1 By similarity
Metal binding1311Iron 1 By similarity
Metal binding1311Iron 2 By similarity
Metal binding1341Iron 1 By similarity
Metal binding1941Iron 2 By similarity
Metal binding2281Iron 2 By similarity
Metal binding2311Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q77MS0 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: C1928938B22BD9F5

FASTA34339,060
        10         20         30         40         50         60 
MSGPPSHEIG MLYSLAPSVD MKSENIEDLP SESIPTTNHC ASNYFYAPEC PDIGHLRALS 

        70         80         90        100        110        120 
IMNRWTETEF VISDDLRDVS MLTEEERYFY RFLFTFLSAA DDLVNLNIDN LLGLFSQKDI 

       130        140        150        160        170        180 
HHYYFEQECI EAVHSRAYSI IQLMLFDNDS LARAEYVKTS LNSPAIQSKL DWLNKRVIEC 

       190        200        210        220        230        240 
SSIAEKYILM ILIEGIFFSA SFAAIAYLRI NNLFVVTCQI NNLISRDEAI HVEASCCIFK 

       250        260        270        280        290        300 
NYLMGPKPSI GRVQELFKEA VQIECAFLRT AAPRNSQLLD VEAICSYVRY SADRLLKELD 

       310        320        330        340 
MPPIYNEPKP TADFPLALMT ASNNTNFFER RNTAYSGSVS NDL 

« Hide

References

[1]"The genome of a very virulent Marek's disease virus."
Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.
J. Virol. 74:7980-7988(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF243438 Genomic DNA. Translation: AAG14233.1.
RefSeqYP_001033969.1. NC_002229.3.

3D structure databases

ProteinModelPortalQ77MS0.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ77MS0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4811514.

Phylogenomic databases

ProtClustDBCLSP2509600.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_GAHVM
AccessionPrimary (citable) accession number: Q77MS0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 13, 2009
Last modified: December 11, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways