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Protein

Endolysin

Gene

R

Organism
Salmonella phage HK620 (Bacteriophage HK620)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Endolysin with transglycosylase activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.UniRule annotation

Catalytic activityi

Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei19UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzymeUniRule annotation, LyaseUniRule annotation
Biological processCytolysis, Host cell lysis by virusUniRule annotation, Viral release from host cell

Protein family/group databases

CAZyiGH104. Glycoside Hydrolase Family 104.

Names & Taxonomyi

Protein namesi
Recommended name:
EndolysinUniRule annotation (EC:4.2.2.n2UniRule annotation)
Alternative name(s):
Lysis proteinUniRule annotation
LysozymeUniRule annotation
TransglycosylaseUniRule annotation
Gene namesi
Name:RImported
OrganismiSalmonella phage HK620 (Bacteriophage HK620)Imported
Taxonomic identifieri155148 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeP22virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000000725 Componenti: Genome

Subcellular locationi

  • Host cytoplasm UniRule annotation
  • Note: The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ77IT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000W9.

Family and domain databases

CDDicd00736. bacteriophage_lambda_lysozyme. 1 hit.
HAMAPiMF_04109. ENDOLYSIN_LAMBDA. 1 hit.
InterProiView protein in InterPro
IPR034691. Endolysin_lambda_type.
IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom_sf.
PfamiView protein in Pfam
PF00959. Phage_lysozyme. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Q77IT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEINNQRKA FLDMLAWSEG TDNGRQKTRN HGYDVIVGGE LFTDYSDHPR
60 70 80 90 100
KLVTLNPKLK STAAGRYQLL SRWWDAYRKQ LGLKDFSPKS QDAVALQQIK
110 120 130 140 150
ERGALPMIDR GDIRQAIDRC SNIWASLPGA GYGQFEHKAD SLIAKFKEAG

GTVREIEV
Length:158
Mass (Da):17,853
Last modified:July 5, 2004 - v1
Checksum:iCB5CA3FAB7150038
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF335538 Genomic DNA. Translation: AAK28884.1.
RefSeqiNP_112069.1. NC_002730.1.

Genome annotation databases

GeneIDi920973.
KEGGivg:920973.

Similar proteinsi

Entry informationi

Entry nameiQ77IT9_BPHK6
AccessioniPrimary (citable) accession number: Q77IT9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported