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Q77DB4

- VP24_EBORR

UniProt

Q77DB4 - VP24_EBORR

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Protein

Membrane-associated protein VP24

Gene

VP24

Organism
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Interferon antiviral system evasion

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated protein VP24
Gene namesi
Name:VP24
ORF Names:REBOVgp6
OrganismiReston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
Taxonomic identifieri386032 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
Sus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000007207: Genome

Subcellular locationi

Virion membrane By similarity; Peripheral membrane protein By similarity. Host cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Host endomembrane system By similarity; Peripheral membrane protein By similarity
Note: In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place (By similarity).By similarity

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
  3. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Membrane-associated protein VP24PRO_0000245068Add
BLAST

Interactioni

Subunit structurei

Binds to host importin alpha-1/KPNA1.By similarity

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR009433. Filo_VP24.
[Graphical view]
PfamiPF06389. Filo_VP24. 1 hit.
[Graphical view]
PIRSFiPIRSF011355. VP24. 1 hit.

Sequencei

Sequence statusi: Complete.

Q77DB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKATGRYNL VPPKKDMEKG VIFSDLCNFL ITQTLQGWKV YWAGIEFDVS
60 70 80 90 100
QKGMALLTRL KTNDFAPAWA MTRNLFPHLF QNPNSVIQSP IWALRVILAA
110 120 130 140 150
GLQDQLLDHS LVEPLTGALG LISDWLLTTT STHFNLRTRS VKDQLSLRML
160 170 180 190 200
SLIRSNILQF INKLDALHVV NYNGLLSSIE IGTSTHTIII TRTNMGFLVE
210 220 230 240 250
VQEPDKSAMN SKRPGPVKFS LLHESAFKPF TRVPQSGMQS LIMEFNSLLA

I
Length:251
Mass (Da):28,169
Last modified:February 21, 2006 - v1
Checksum:iDB8F144CA8FB2509
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522874 Genomic RNA. Translation: AAN04453.1.
AY769362 Genomic RNA. Translation: AAV48580.1.
RefSeqiNP_690586.1. NC_004161.1.

Genome annotation databases

GeneIDi955193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522874 Genomic RNA. Translation: AAN04453.1 .
AY769362 Genomic RNA. Translation: AAV48580.1 .
RefSeqi NP_690586.1. NC_004161.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 955193.

Family and domain databases

InterProi IPR009433. Filo_VP24.
[Graphical view ]
Pfami PF06389. Filo_VP24. 1 hit.
[Graphical view ]
PIRSFi PIRSF011355. VP24. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of an isolate from the 1989/90 epizootic of Ebola virus Reston among macaques imported into the United States."
    Groseth A., Stroeher U., Theriault S., Feldmann H.
    Virus Res. 87:155-163(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus Zaire."
    Boehmann Y., Enterlein S., Randolf A., Muehlberger E.I.
    Virology 332:406-417(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP24_EBORR
AccessioniPrimary (citable) accession number: Q77DB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: February 21, 2006
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3