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Protein

Protein E7

Gene

E7

Organism
Human papillomavirus type 16
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ActivatorSAAS annotation

Keywords - Biological processi

G1/S host cell cycle checkpoint dysregulation by virusSAAS annotation, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virusSAAS annotation, Modulation of host cell cycle by virus, Transcription, Transcription regulationSAAS annotation, Viral immunoevasion

Keywords - Ligandi

DNA-bindingSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein E7SAAS annotation
Gene namesi
Name:E7Imported
OrganismiHuman papillomavirus type 16Imported
Taxonomic identifieri333760 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cytoplasm SAAS annotation
  • Host nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasmSAAS annotation, Host nucleusSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ778G6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the papillomaviridae E7 protein family.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Family and domain databases

HAMAPiMF_04004. PPV_E7.
InterProiIPR000148. Papilloma_E7.
[Graphical view]
PfamiPF00527. E7. 1 hit.
[Graphical view]
PIRSFiPIRSF003407. Papvi_E7. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q778G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGDTPTLHE YMLDLQPETT DLYCYEQLND SSEEEDEIDG PAGQAEPDRA
60 70 80 90
HYNIVTFCCK CDSTLRLCVQ STHVDIRTLE DLLMGTLGIV CPICSQKP
Length:98
Mass (Da):11,022
Last modified:May 10, 2005 - v1
Checksum:i9BD612534CD2C9EB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei98 – 981Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ388068 Genomic DNA. Translation: CAB45129.1.
RefSeqiNP_041326.1. NC_001526.2.

Genome annotation databases

GeneIDi1489079.
KEGGivg:1489079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ388068 Genomic DNA. Translation: CAB45129.1.
RefSeqiNP_041326.1. NC_001526.2.

3D structure databases

ProteinModelPortaliQ778G6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489079.
KEGGivg:1489079.

Family and domain databases

HAMAPiMF_04004. PPV_E7.
InterProiIPR000148. Papilloma_E7.
[Graphical view]
PfamiPF00527. E7. 1 hit.
[Graphical view]
PIRSFiPIRSF003407. Papvi_E7. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Analysis of human papillomavirus type 16 E6 variants in relation to p53 codon 72 polymorphism genotypes in cervical carcinogenesis."
    van Duin M., Snijders P.J., Vossen M.T., Klaassen E., Voorhorst F., Verheijen R.H., Helmerhorst T.J., Meijer C.J., Walboomers J.M.
    J. Gen. Virol. 81:317-325(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AFG7611TImported.

Entry informationi

Entry nameiQ778G6_HPV16
AccessioniPrimary (citable) accession number: Q778G6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: July 6, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.