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Protein
Submitted name:

Gag protein

Gene

gag

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interactionSAAS annotation, Virus exit from host cellSAAS annotation

Keywords - Ligandi

Metal-binding, RNA-bindingSAAS annotation, Viral nucleoproteinUniRule annotation, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Gag proteinImported
Gene namesi
Name:gagImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cytoplasm SAAS annotation
  • Host nucleus SAAS annotation
  • Virion UniRule annotation
  • Host nucleus UniRule annotation
  • Host cytoplasm UniRule annotation
  • Virion SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinUniRule annotationSAAS annotation, Host cytoplasmUniRule annotationSAAS annotation, Host nucleusUniRule annotationSAAS annotation, Virion

PTM / Processingi

Post-translational modificationi

Gag-Pol polyprotein: Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ77697.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini381 – 39616CCHC-typeInterPro annotationAdd
BLAST
Domaini403 – 41816CCHC-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains CCHC-type zinc fingers.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR000721. Gag_p24.
IPR014817. Gag_p6.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_HIV/RSV.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF08705. Gag_p6. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
PRINTSiPR00234. HIV1MATRIX.
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q77697-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARASVLSG GKLDAWEKIR LRPGGKKKYR LKHLVWASRE LERFALNPSL
60 70 80 90 100
LETAGGCQQL MEQLQAHLRT GSEELKSLFN TIATLWCVHQ RIDIKDTKEA
110 120 130 140 150
LDKIEVIQNK SKTAAATGSS SQNYPIVQNA QGQMTHQSMS PRTLNAWVKV
160 170 180 190 200
IEEKAFSPEV IPMFTALSEG ATPQDLNMML NIVGGHQAAM QMLKDTINEE
210 220 230 240 250
AAEWDRVHPV HAGPIPPGQM REPRGSDIAG TTSTLQEQIG WMTSNPPVPV
260 270 280 290 300
GEIYKRWIVL GLNKIVRMYS PVSILDIRQG PKEPFRDYVD RFFKTLRAEQ
310 320 330 340 350
ATQEVKNWMT ETLLVQNANP DCKSILRALG PGATLEEMMT ACQGVGGPGH
360 370 380 390 400
KARVLAEAMS QVQQSNIMMQ RGNFRGQRTI KCFNCGKEGH LARNCKAPRK
410 420 430 440 450
RGCWKCGKEG HQMKDCTERQ ANFLGKIWPS SKGRPGNFPQ SRPEPTAPPA
460 470 480
ESFGMREEIT SSPKQEPRDK GLYPPLASLK S
Length:481
Mass (Da):53,563
Last modified:November 1, 1996 - v1
Checksum:i5D99F40EF4618DFC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11755 Genomic DNA. Translation: AAA44312.1.
PIRiS49086.

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11755 Genomic DNA. Translation: AAA44312.1.
PIRiS49086.

3D structure databases

ProteinModelPortaliQ77697.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR000721. Gag_p24.
IPR014817. Gag_p6.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_HIV/RSV.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF08705. Gag_p6. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
PRINTSiPR00234. HIV1MATRIX.
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Phylogenetic analysis of gag genes from 70 international HIV-1 isolates provides evidence for multiple genotypes."
    Louwagie J.J., McCutchan F., Brennan T., Peeters M., Brennan, T, Sanders-Buel E., Eddy G., van der Groen G., Fransen K., Gershy-Damet M., Deleys R., Burke D.
    AIDS 7:769-780(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CI20Imported.
    Tissue: BloodImported.

Entry informationi

Entry nameiQ77697_9HIV1
AccessioniPrimary (citable) accession number: Q77697
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.