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Protein

Major capsid protein L1

Gene

L1

Organism
Human papillomavirus type 6
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral penetration into host cytoplasm, Virus endocytosis by hostUniRule annotationSAAS annotation, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid protein L1UniRule annotationSAAS annotation
Gene namesi
Name:L1UniRule annotationImported
OrganismiHuman papillomavirus type 6Imported
Taxonomic identifieri31552 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Proteomesi
  • UP000104012 Componenti: Genome
  • UP000168705 Componenti: Genome
  • UP000130240 Componenti: Genome
  • UP000141032 Componenti: Genome
  • UP000175509 Componenti: Genome
  • UP000160109 Componenti: Genome
  • UP000100753 Componenti: Genome
  • UP000161820 Componenti: Genome
  • UP000171490 Componenti: Genome
  • UP000119984 Componenti: Genome
  • UP000129028 Componenti: Genome
  • UP000155066 Componenti: Genome
  • UP000126400 Componenti: Genome
  • UP000137308 Componenti: Genome
  • UP000165242 Componenti: Genome
  • UP000119424 Componenti: Genome
  • UP000129810 Componenti: Genome
  • UP000108211 Componenti: Genome
  • UP000161428 Componenti: Genome
  • UP000158894 Componenti: Genome
  • UP000097268 Componenti: Genome
  • UP000121396 Componenti: Genome
  • UP000168150 Componenti: Genome
  • UP000102668 Componenti: Genome
  • UP000125003 Componenti: Genome
  • UP000160227 Componenti: Genome
  • UP000120049 Componenti: Genome
  • UP000170026 Componenti: Genome
  • UP000160115 Componenti: Genome
  • UP000107205 Componenti: Genome
  • UP000166540 Componenti: Genome
  • UP000147114 Componenti: Genome
  • UP000144754 Componenti: Genome
  • UP000120692 Componenti: Genome
  • UP000165199 Componenti: Genome
  • UP000173025 Componenti: Genome
  • UP000147643 Componenti: Genome
  • UP000120749 Componenti: Genome
  • UP000154982 Componenti: Genome
  • UP000159267 Componenti: Genome
  • UP000168671 Componenti: Genome
  • UP000159161 Componenti: Genome
  • UP000116306 Componenti: Genome
  • UP000146511 Componenti: Genome
  • UP000130794 Componenti: Genome
  • UP000175292 Componenti: Genome
  • UP000149492 Componenti: Genome
  • UP000103085 Componenti: Genome
  • UP000160855 Componenti: Genome
  • UP000117658 Componenti: Genome
  • UP000148353 Componenti: Genome
  • UP000103599 Componenti: Genome
  • UP000104379 Componenti: Genome
  • UP000142315 Componenti: Genome
  • UP000132344 Componenti: Genome
  • UP000169220 Componenti: Genome
  • UP000173459 Componenti: Genome
  • UP000145238 Componenti: Genome
  • UP000162616 Componenti: Genome
  • UP000101371 Componenti: Genome
  • UP000142050 Componenti: Genome
  • UP000156003 Componenti: Genome
  • UP000130719 Componenti: Genome
  • UP000156390 Componenti: Genome
  • UP000147176 Componenti: Genome
  • UP000166520 Componenti: Genome
  • UP000131275 Componenti: Genome
  • UP000120498 Componenti: Genome
  • UP000113073 Componenti: Genome
  • UP000131260 Componenti: Genome
  • UP000113782 Componenti: Genome
  • UP000107142 Componenti: Genome
  • UP000121569 Componenti: Genome
  • UP000150196 Componenti: Genome
  • UP000104660 Componenti: Genome
  • UP000101624 Componenti: Genome
  • UP000126280 Componenti: Genome
  • UP000136481 Componenti: Genome
  • UP000171112 Componenti: Genome
  • UP000152558 Componenti: Genome
  • UP000160584 Componenti: Genome
  • UP000154868 Componenti: Genome
  • UP000112107 Componenti: Genome
  • UP000156145 Componenti: Genome
  • UP000102939 Componenti: Genome
  • UP000144421 Componenti: Genome
  • UP000110791 Componenti: Genome
  • UP000130211 Componenti: Genome
  • UP000172825 Componenti: Genome
  • UP000118952 Componenti: Genome
  • UP000149731 Componenti: Genome
  • UP000157357 Componenti: Genome
  • UP000119860 Componenti: Genome
  • UP000096308 Componenti: Genome
  • UP000105441 Componenti: Genome
  • UP000139192 Componenti: Genome
  • UP000107996 Componenti: Genome
  • UP000139334 Componenti: Genome
  • UP000172045 Componenti: Genome
  • UP000113613 Componenti: Genome
  • UP000111123 Componenti: Genome
  • UP000139729 Componenti: Genome
  • UP000102108 Componenti: Genome
  • UP000160463 Componenti: Genome
  • UP000099521 Componenti: Genome
  • UP000099304 Componenti: Genome
  • UP000106462 Componenti: Genome
  • UP000124489 Componenti: Genome
  • UP000170701 Componenti: Genome
  • UP000165891 Componenti: Genome
  • UP000139714 Componenti: Genome
  • UP000146905 Componenti: Genome
  • UP000104087 Componenti: Genome
  • UP000104825 Componenti: Genome
  • UP000109162 Componenti: Genome
  • UP000103640 Componenti: Genome
  • UP000112542 Componenti: Genome
  • UP000140487 Componenti: Genome
  • UP000098197 Componenti: Genome
  • UP000138745 Componenti: Genome
  • UP000097181 Componenti: Genome
  • UP000129691 Componenti: Genome
  • UP000143572 Componenti: Genome
  • UP000149220 Componenti: Genome
  • UP000138774 Componenti: Genome
  • UP000098718 Componenti: Genome
  • UP000097839 Componenti: Genome
  • UP000146999 Componenti: Genome
  • UP000147917 Componenti: Genome
  • UP000143495 Componenti: Genome
  • UP000155899 Componenti: Genome
  • UP000134217 Componenti: Genome
  • UP000127633 Componenti: Genome
  • UP000158762 Componenti: Genome
  • UP000133639 Componenti: Genome
  • UP000150997 Componenti: Genome
  • UP000113024 Componenti: Genome
  • UP000142344 Componenti: Genome
  • UP000143867 Componenti: Genome
  • UP000146204 Componenti: Genome
  • UP000138232 Componenti: Genome

Subcellular locationi

  • Host nucleus SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleusUniRule annotationSAAS annotation, T=7 icosahedral capsid proteinUniRule annotationSAAS annotation, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi171Interchain (with Cys-423)UniRule annotation
Disulfide bondi423Interchain (with Cys-171)UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Expressioni

Keywords - Developmental stagei

Late proteinUniRule annotation

Structurei

3D structure databases

SMRiQ775J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the papillomaviridae L1 protein family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di2.60.175.20. 1 hit.
HAMAPiMF_04002. PPV_L1. 1 hit.
InterProiView protein in InterPro
IPR002210. Capsid_L1_Papillomavir.
IPR036973. Capsid_L1_sf_Papillomavir.
IPR011222. dsDNA_vir_gr_I_capsid.
PfamiView protein in Pfam
PF00500. Late_protein_L1. 1 hit.
PRINTSiPR00865. HPVCAPSIDL1.
SUPFAMiSSF88648. SSF88648. 1 hit.

Sequencei

Sequence statusi: Complete.

Q775J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRPSDSTVY VPPPNPVSKV VATDAYVTRT NIFYHASSSR LLAVGHPYFS
60 70 80 90 100
IKRANKTVVP KVSGYQYRVF KVVLPDPNKF ALPDSSLFDP TTQRLVWACT
110 120 130 140 150
GLEVGRGQPL GVGVSGHPFL NKYDDVENSG SGGNPGQDNR VNVGMDYKQT
160 170 180 190 200
QLCMVGCAPP LGEHWGKGKQ CTNTPVQAGD CPPLELITSV IQDGDMVDTG
210 220 230 240 250
FGAMNFADLQ TNKSDVPIDI CGTTCKYPDY LQMAADPYGD RLFFFLRKEQ
260 270 280 290 300
MFARHFFNRA GEVGEPVPDT LIIKGSGNRT SVGSSIYVNT PSGSLVSSEA
310 320 330 340 350
QLFNKPYWLQ KAQGHNNGIC WGNQLFVTVV DTTRSTNMTL CASVTTSSTY
360 370 380 390 400
TNSDYKEYMR HVEEYDLQFI FQLCSITLSA EVMAYIHTMN PSVLEDWNFG
410 420 430 440 450
LSPPPNGTLE DTYRYVQSQA ITCQKPTPEK EKPDPYKNLS FWEVNLKEKF
460 470 480 490 500
SSELDQYPLG RKFLLQSGYR GRSSIRTGVK RPAVSKASAA PKRKRAKTKR
Length:500
Mass (Da):55,597
Last modified:July 5, 2004 - v1
Checksum:iB6168D0F76A287F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067036 Genomic DNA. Translation: AAC80439.1.
AF067037 Genomic DNA. Translation: AAC80440.1.
AF067038 Genomic DNA. Translation: AAC80441.1.
AF067043 Genomic DNA. Translation: AAC80446.1.
AF067050 Genomic DNA. Translation: AAC80453.1.
AY015006 Genomic DNA. Translation: AAK01850.1.
AF335604 Genomic DNA. Translation: AAK21270.1.
JN252314 Genomic DNA. Translation: AFL91935.1.
JN252316 Genomic DNA. Translation: AFL91953.1.
JN252321 Genomic DNA. Translation: AFL91998.1.
JN252322 Genomic DNA. Translation: AFL92007.1.
JN252323 Genomic DNA. Translation: AFL92016.1.
KU298876 Genomic DNA. Translation: ALT54559.1.
KU298877 Genomic DNA. Translation: ALT54568.1.
KU298878 Genomic DNA. Translation: ALT54577.1.
KX514423 Genomic DNA. Translation: ARQ82663.1.
KX514427 Genomic DNA. Translation: ARQ82696.1.
FM876129 Genomic DNA. Translation: CAS89460.1.
FM876130 Genomic DNA. Translation: CAS89461.1.
FM876131 Genomic DNA. Translation: CAS89462.1.
FM876132 Genomic DNA. Translation: CAS89463.1.
FM876133 Genomic DNA. Translation: CAS89464.1.
FM876134 Genomic DNA. Translation: CAS89465.1.
FM876135 Genomic DNA. Translation: CAS89466.1.
FM876136 Genomic DNA. Translation: CAS89467.1.
FM876137 Genomic DNA. Translation: CAS89468.1.
FM876138 Genomic DNA. Translation: CAS89469.1.
FM876139 Genomic DNA. Translation: CAS89470.1.
FM876140 Genomic DNA. Translation: CAS89471.1.
FM876141 Genomic DNA. Translation: CAS89472.1.
FM876142 Genomic DNA. Translation: CAS89473.1.
FM876143 Genomic DNA. Translation: CAS89474.1.
FM876144 Genomic DNA. Translation: CAS89475.1.
FM876145 Genomic DNA. Translation: CAS89476.1.
FM876146 Genomic DNA. Translation: CAS89477.1.
FM876147 Genomic DNA. Translation: CAS89478.1.
FM876148 Genomic DNA. Translation: CAS89479.1.
FM876149 Genomic DNA. Translation: CAS89480.1.
FM876150 Genomic DNA. Translation: CAS89481.1.
FM876151 Genomic DNA. Translation: CAS89482.1.
FM876152 Genomic DNA. Translation: CAS89483.1.
FM876153 Genomic DNA. Translation: CAS89484.1.
FM876154 Genomic DNA. Translation: CAS89485.1.
FM876155 Genomic DNA. Translation: CAS89486.1.
FM876157 Genomic DNA. Translation: CAS89488.1.
FM876158 Genomic DNA. Translation: CAS89489.1.
FM876159 Genomic DNA. Translation: CAS89490.1.
FM876161 Genomic DNA. Translation: CAS89492.1.
FM876162 Genomic DNA. Translation: CAS89493.1.
FM876163 Genomic DNA. Translation: CAS89494.1.
FM876164 Genomic DNA. Translation: CAS89495.1.
FM876165 Genomic DNA. Translation: CAS89496.1.
FM897134 Genomic DNA. Translation: CAU03651.1.
FM897135 Genomic DNA. Translation: CAU03652.1.
FM897136 Genomic DNA. Translation: CAU03653.1.
FM897137 Genomic DNA. Translation: CAU03654.1.
FM897138 Genomic DNA. Translation: CAU03655.1.
FM897139 Genomic DNA. Translation: CAU03656.1.
FM897140 Genomic DNA. Translation: CAU03657.1.
FM897141 Genomic DNA. Translation: CAU03658.1.
FM897142 Genomic DNA. Translation: CAU03659.1.
FM897143 Genomic DNA. Translation: CAU03660.1.
FM897144 Genomic DNA. Translation: CAU03661.1.
FM897148 Genomic DNA. Translation: CAU03665.1.
FM897149 Genomic DNA. Translation: CAU03666.1.
FM897150 Genomic DNA. Translation: CAU03667.1.
FM897151 Genomic DNA. Translation: CAU03668.1.
FM897152 Genomic DNA. Translation: CAU03669.1.
FM897153 Genomic DNA. Translation: CAU03670.1.
FM897154 Genomic DNA. Translation: CAU03671.1.
FM897155 Genomic DNA. Translation: CAU03672.1.
FM897156 Genomic DNA. Translation: CAU03673.1.
FM897157 Genomic DNA. Translation: CAU03674.1.
FM897158 Genomic DNA. Translation: CAU03675.1.
FM897159 Genomic DNA. Translation: CAU03676.1.
FM897160 Genomic DNA. Translation: CAU03677.1.
FM897161 Genomic DNA. Translation: CAU03678.1.
FM897162 Genomic DNA. Translation: CAU03679.1.
FM897163 Genomic DNA. Translation: CAU03680.1.
FM897164 Genomic DNA. Translation: CAU03681.1.
FM897165 Genomic DNA. Translation: CAU03682.1.
FR751320 Genomic DNA. Translation: CBY85394.1.
FR751322 Genomic DNA. Translation: CBY85412.1.
FR751323 Genomic DNA. Translation: CBY85421.1.
FR751324 Genomic DNA. Translation: CBY85430.1.
FR751325 Genomic DNA. Translation: CBY85439.1.
FR751326 Genomic DNA. Translation: CBY85448.1.
FR751329 Genomic DNA. Translation: CBY85475.1.
FR751330 Genomic DNA. Translation: CBY85484.1.
FR751331 Genomic DNA. Translation: CBY85493.1.
FR751332 Genomic DNA. Translation: CBY85502.1.
FR751333 Genomic DNA. Translation: CBY85511.1.
FR751334 Genomic DNA. Translation: CBY85520.1.
FR751335 Genomic DNA. Translation: CBY85529.1.
FR751336 Genomic DNA. Translation: CBY85538.1.
FR751337 Genomic DNA. Translation: CBY85547.1.
FR751338 Genomic DNA. Translation: CBY85556.1.
HE599226 Genomic DNA. Translation: CCD42057.1.
HE599227 Genomic DNA. Translation: CCD42066.1.
HE599228 Genomic DNA. Translation: CCD42075.1.
HE599229 Genomic DNA. Translation: CCD42084.1.
HE599230 Genomic DNA. Translation: CCD42093.1.
HE599231 Genomic DNA. Translation: CCD42102.1.
HE599232 Genomic DNA. Translation: CCD42111.1.
HE599233 Genomic DNA. Translation: CCD42120.1.
HE599234 Genomic DNA. Translation: CCD42129.1.
HE599235 Genomic DNA. Translation: CCD42138.1.
HE599236 Genomic DNA. Translation: CCD42147.1.
HE599237 Genomic DNA. Translation: CCD42156.1.
HE599238 Genomic DNA. Translation: CCD42165.1.
HE599239 Genomic DNA. Translation: CCD42174.1.
HE599240 Genomic DNA. Translation: CCD42183.1.
HE599241 Genomic DNA. Translation: CCD42192.1.
HE599242 Genomic DNA. Translation: CCD42201.1.
HE599243 Genomic DNA. Translation: CCD42210.1.
HE599244 Genomic DNA. Translation: CCD42219.1.
HE599245 Genomic DNA. Translation: CCD42228.1.
HE599246 Genomic DNA. Translation: CCD42237.1.
HE962026 Genomic DNA. Translation: CCJ09331.1.
HE962028 Genomic DNA. Translation: CCJ09349.1.
HE962029 Genomic DNA. Translation: CCJ09358.1.
HE962030 Genomic DNA. Translation: CCJ09367.1.
HE962031 Genomic DNA. Translation: CCJ09376.1.
HE962032 Genomic DNA. Translation: CCJ09385.1.
HG793809 Genomic DNA. Translation: CDK36508.1.
HG793810 Genomic DNA. Translation: CDK36517.1.
HG793811 Genomic DNA. Translation: CDK36526.1.
HG793812 Genomic DNA. Translation: CDK36535.1.
HG793815 Genomic DNA. Translation: CDK36562.1.
HG793816 Genomic DNA. Translation: CDK36571.1.
HG793817 Genomic DNA. Translation: CDK36580.1.
HG793818 Genomic DNA. Translation: CDK36589.1.
HG793820 Genomic DNA. Translation: CDK36607.1.
HG793821 Genomic DNA. Translation: CDK36616.1.
HG793822 Genomic DNA. Translation: CDK36625.1.
HG793823 Genomic DNA. Translation: CDK36634.1.
HG793825 Genomic DNA. Translation: CDK36652.1.
HG793826 Genomic DNA. Translation: CDK36661.1.
HG793827 Genomic DNA. Translation: CDK36670.1.
HG793830 Genomic DNA. Translation: CDK36697.1.
HG793832 Genomic DNA. Translation: CDK36715.1.
HG793834 Genomic DNA. Translation: CDK36733.1.
HG793835 Genomic DNA. Translation: CDK36742.1.
HG793837 Genomic DNA. Translation: CDK36760.1.
HG793838 Genomic DNA. Translation: CDK36769.1.
HG793839 Genomic DNA. Translation: CDK36778.1.
HG793840 Genomic DNA. Translation: CDK36787.1.
HG793841 Genomic DNA. Translation: CDK36796.1.
HG793842 Genomic DNA. Translation: CDK36805.1.
HG793843 Genomic DNA. Translation: CDK36814.1.
HG793844 Genomic DNA. Translation: CDK36823.1.
HG793846 Genomic DNA. Translation: CDK36841.1.
HG793847 Genomic DNA. Translation: CDK36850.1.
HG793848 Genomic DNA. Translation: CDK36859.1.
HG793849 Genomic DNA. Translation: CDK36868.1.
HG793853 Genomic DNA. Translation: CDK36904.1.
HG793854 Genomic DNA. Translation: CDK36913.1.
HG793855 Genomic DNA. Translation: CDK36922.1.
HG793857 Genomic DNA. Translation: CDK36940.1.
HG793858 Genomic DNA. Translation: CDK36949.1.
HG793859 Genomic DNA. Translation: CDK36958.1.
HG793862 Genomic DNA. Translation: CDK36985.1.
HG793863 Genomic DNA. Translation: CDK36994.1.
HG793864 Genomic DNA. Translation: CDK37003.1.
HG793865 Genomic DNA. Translation: CDK37012.1.
HG793866 Genomic DNA. Translation: CDK37021.1.
HG793869 Genomic DNA. Translation: CDK37048.1.
HG793870 Genomic DNA. Translation: CDK37057.1.
HG793871 Genomic DNA. Translation: CDK37066.1.
HG793872 Genomic DNA. Translation: CDK37075.1.
HG793873 Genomic DNA. Translation: CDK37084.1.
HG793874 Genomic DNA. Translation: CDK37093.1.
HG793875 Genomic DNA. Translation: CDK37102.1.
HG793876 Genomic DNA. Translation: CDK37111.1.
HG793877 Genomic DNA. Translation: CDK37120.1.
HG793882 Genomic DNA. Translation: CDK37165.1.
HG793883 Genomic DNA. Translation: CDK37174.1.
HG793884 Genomic DNA. Translation: CDK37183.1.
HG793886 Genomic DNA. Translation: CDK37201.1.
HG793887 Genomic DNA. Translation: CDK37210.1.
HG793888 Genomic DNA. Translation: CDK37219.1.
HG793895 Genomic DNA. Translation: CDK37282.1.
HG793896 Genomic DNA. Translation: CDK37291.1.
HG793897 Genomic DNA. Translation: CDK37300.1.
HG793898 Genomic DNA. Translation: CDK37309.1.
HG793899 Genomic DNA. Translation: CDK37318.1.
HG793902 Genomic DNA. Translation: CDK37345.1.
HG793906 Genomic DNA. Translation: CDK37381.1.
HG793907 Genomic DNA. Translation: CDK37390.1.
HG793908 Genomic DNA. Translation: CDK37399.1.
HG793909 Genomic DNA. Translation: CDK37408.1.
HG793910 Genomic DNA. Translation: CDK37417.1.
HG793912 Genomic DNA. Translation: CDK37435.1.
HG793913 Genomic DNA. Translation: CDK37444.1.
HG793914 Genomic DNA. Translation: CDK37453.1.
HG793915 Genomic DNA. Translation: CDK37462.1.
HG793916 Genomic DNA. Translation: CDK37471.1.
HG793921 Genomic DNA. Translation: CDK37516.1.
HG793922 Genomic DNA. Translation: CDK37525.1.
HG793923 Genomic DNA. Translation: CDK37534.1.
HG793924 Genomic DNA. Translation: CDK37543.1.
HG793926 Genomic DNA. Translation: CDK37561.1.
HG793927 Genomic DNA. Translation: CDK37570.1.
HG793929 Genomic DNA. Translation: CDK37588.1.
HG793930 Genomic DNA. Translation: CDK37597.1.
HG793931 Genomic DNA. Translation: CDK37606.1.
HG793932 Genomic DNA. Translation: CDK37615.1.
HG793933 Genomic DNA. Translation: CDK37624.1.
HG793934 Genomic DNA. Translation: CDK37633.1.
HG793935 Genomic DNA. Translation: CDK37642.1.
HG793936 Genomic DNA. Translation: CDK37651.1.
HG793937 Genomic DNA. Translation: CDK37660.1.
HG793938 Genomic DNA. Translation: CDK37669.1.
HG793939 Genomic DNA. Translation: CDK37678.1.

Similar proteinsi

Entry informationi

Entry nameiQ775J6_9PAPI
AccessioniPrimary (citable) accession number: Q775J6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported