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Protein

Tail fiber receptor-binding protein

Gene

mtd

Organism
Bordetella phage BPP-1
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Tail fiber protein located at the distal ends of the fibers that binds to the adhesion receptors on the host surface, thereby determining the host range. The phage can alter its tropism by modifying this protein. Variants are expressed through a diversity-generating retroelement (DGR) that creates mutant copies of a template repeat and replaces the end of the tail fiber receptor-binding protein with these sequences, thus changing the host range. Milliards of variants of the fiber receptor-binding protein can be created with this system.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral attachment to host adhesion receptor, Viral attachment to host cell, Viral receptor tropism switching, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Tail fiber receptor-binding proteinCurated
Alternative name(s):
Major tropism determinant protein1 Publication
Gene namesi
Name:mtdImported
OrganismiBordetella phage BPP-1Imported
Taxonomic identifieri194699 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridae
Virus hostiBordetella bronchiseptica (Alcaligenes bronchisepticus) [TaxID: 518]
Proteomesi
  • UP000001765 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Viral tail fiber protein, Viral tail protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004329581 – 381Tail fiber receptor-binding proteinAdd BLAST381

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

DIPiDIP-46043N.

Structurei

Secondary structure

1381
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 16Combined sources5
Beta strandi25 – 28Combined sources4
Turni29 – 32Combined sources4
Beta strandi33 – 36Combined sources4
Beta strandi39 – 41Combined sources3
Beta strandi45 – 47Combined sources3
Helixi50 – 53Combined sources4
Beta strandi66 – 71Combined sources6
Beta strandi74 – 77Combined sources4
Beta strandi81 – 85Combined sources5
Beta strandi88 – 94Combined sources7
Beta strandi107 – 114Combined sources8
Beta strandi119 – 123Combined sources5
Turni133 – 135Combined sources3
Beta strandi136 – 147Combined sources12
Beta strandi151 – 154Combined sources4
Helixi164 – 166Combined sources3
Beta strandi172 – 177Combined sources6
Beta strandi182 – 185Combined sources4
Turni186 – 188Combined sources3
Beta strandi189 – 194Combined sources6
Helixi200 – 203Combined sources4
Beta strandi210 – 212Combined sources3
Beta strandi215 – 217Combined sources3
Turni223 – 226Combined sources4
Helixi238 – 247Combined sources10
Helixi255 – 262Combined sources8
Beta strandi273 – 275Combined sources3
Helixi290 – 293Combined sources4
Beta strandi303 – 305Combined sources3
Beta strandi307 – 317Combined sources11
Beta strandi326 – 329Combined sources4
Beta strandi332 – 334Combined sources3
Beta strandi336 – 342Combined sources7
Helixi348 – 350Combined sources3
Beta strandi374 – 379Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YU0X-ray1.56A1-381[»]
1YU1X-ray2.07A1-381[»]
1YU2X-ray1.86A1-381[»]
1YU3X-ray2.52A1-381[»]
1YU4X-ray1.87A/B/C1-381[»]
2IOUX-ray3.16A/B/C/D/E/F5-380[»]
ProteinModelPortaliQ775D6.
SMRiQ775D6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ775D6.

Family & Domainsi

Domaini

The C-terminus contains a variable sequence in which nucleotide subtitutions can be introduced at 23 sites by the DGR.1 Publication

Family and domain databases

InterProiIPR016187. CTDL_fold.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.

Sequencei

Sequence statusi: Complete.

Q775D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAVQFRGG TTAQHATFTG AAREITVDTD KNTVVVHDGA TAGGFPLARH
60 70 80 90 100
DLVKTAFIKA DKSAVAFTRT GNATASIKAG TIVEVNGKLV QFTADTAITM
110 120 130 140 150
PALTAGTDYA IYVCDDGTVR ADSNFSAPTG YTSTTARKVG GFHYAPGSNA
160 170 180 190 200
AAQAGGNTTA QINEYSLWDI KFRPAALDPR GMTLVAGAFW ADIYLLGVNH
210 220 230 240 250
LTDGTSKYNV TIADGSASPK KSTKFGGDGS AAYSDGAWYN FAEVMTHHGK
260 270 280 290 300
RLPNYNEFQA LAFGTTEATS SGGTDVPTTG VNGTGATSAW NIFTSKWGVV
310 320 330 340 350
QASGCLWTWG NEFGGVNGAS EYTANTGGRG SVYAQPAAAL FGGAWNGTSL
360 370 380
SGSRAALWYS GPSFSFAFFG ARGVCDHLIL E
Length:381
Mass (Da):39,524
Last modified:July 5, 2004 - v1
Checksum:iD40DC9AE0133206D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029185 Genomic DNA. Translation: AAR97674.1.
RefSeqiNP_958677.1. NC_005357.1.

Genome annotation databases

GeneIDi2717224.
KEGGivg:2717224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029185 Genomic DNA. Translation: AAR97674.1.
RefSeqiNP_958677.1. NC_005357.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YU0X-ray1.56A1-381[»]
1YU1X-ray2.07A1-381[»]
1YU2X-ray1.86A1-381[»]
1YU3X-ray2.52A1-381[»]
1YU4X-ray1.87A/B/C1-381[»]
2IOUX-ray3.16A/B/C/D/E/F5-380[»]
ProteinModelPortaliQ775D6.
SMRiQ775D6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46043N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2717224.
KEGGivg:2717224.

Miscellaneous databases

EvolutionaryTraceiQ775D6.

Family and domain databases

InterProiIPR016187. CTDL_fold.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFIBD_BPBPP
AccessioniPrimary (citable) accession number: Q775D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2015
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.