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Protein

Protein K7

Gene

MVA028R

Organism
Vaccinia virus (strain Ankara) (VACV)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation. Contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein K7
Gene namesi
Ordered Locus Names:MVA028R, ACAM3000_MVA_028
OrganismiVaccinia virus (strain Ankara) (VACV)
Taxonomic identifieri126794 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000172909 Componenti: Genome
  • UP000159908 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000996071 – 149Protein K7Add BLAST149

Interactioni

Subunit structurei

Interacts with DDDX3; this interaction inhibits DDX3 and suppresses DDX3-mediated IFN-beta promoter induction. Interacts with TRAF6 and IRAK2; these interactions suppress TLR-dependent NF-KappaB activation (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ76ZX2.
SMRiQ76ZX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR009174. Orthopox_K7.
IPR022819. Poxvirus.
PfamiView protein in Pfam
PF06227. Poxvirus. 1 hit.
PIRSFiPIRSF003764. VAC_K7R. 1 hit.

Sequencei

Sequence statusi: Complete.

Q76ZX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKLDYEDA VFYFVDDDKI CSRDSIIDLI DEYITWRNHV IVFNKDITSC
60 70 80 90 100
GRLYKELMKF DDVAIRYYGI DKINEIVEAM SEGDHYINFT KVHDQESLFA
110 120 130 140
TIGICAKITE HWGYKKISES RFQSLGNITD LMTDDNINIL ILFLEKKLN
Length:149
Mass (Da):17,468
Last modified:July 5, 2004 - v1
Checksum:iB3E972A93DF97DC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94848 Genomic DNA. Translation: AAB96484.1.
AY603355 Genomic DNA. Translation: AAT10426.1.
RefSeqiYP_232921.1. NC_006998.1.

Genome annotation databases

GeneIDi3707496.
KEGGivg:3707496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94848 Genomic DNA. Translation: AAB96484.1.
AY603355 Genomic DNA. Translation: AAT10426.1.
RefSeqiYP_232921.1. NC_006998.1.

3D structure databases

ProteinModelPortaliQ76ZX2.
SMRiQ76ZX2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3707496.
KEGGivg:3707496.

Family and domain databases

InterProiView protein in InterPro
IPR009174. Orthopox_K7.
IPR022819. Poxvirus.
PfamiView protein in Pfam
PF06227. Poxvirus. 1 hit.
PIRSFiPIRSF003764. VAC_K7R. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiK7_VACCA
AccessioniPrimary (citable) accession number: Q76ZX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: February 15, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.