Q76RE7DUT_VACCADeoxyuridine 5'-triphosphate nucleotidohydrolasedUTPase3.6.1.23dUTP pyrophosphataseOPG046DUTF2LMVA030LACAM3000_MVA_030Vaccinia virus (strain Ankara)VACVVirusesVaridnaviriaBamfordviraeNucleocytoviricotaPokkesviricetesChitoviralesPoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virusHomo sapiensHumanThe complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.dUTP + H2O = diphosphate + dUMP + H(+)Expressed in the early phase of the viral replicative cycle.Belongs to the dUTPase family.Was originally thought to be a protease-like protein (pseudoprotease).Early proteinHydrolaseMagnesiumMetal-bindingNucleotide metabolismMg(2+)dUTPdUTPdUTPdUTPdUTPdUTPMFNMNINSPVRFVKETNRAKSPTRQSPGAAGYDLYSAYDYTIPPGERQLIKTDISMSMPKICYGRIAPRSGLSLKGIDIGGGVIDEDYRGNIGVILINNGKCTFNVNTGDRIAQLIYQRIYYPELEEVQSLDSTNRGDQGFGSTGLR
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