Reviewed,
UniProtKB/Swiss-Prot Q76RE7 (DUT_VACCA)
Last modified
December 15, 2009.
Version 20.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Deoxyuridine 5'-triphosphate nucleotidohydrolase Short name=dUTPase EC=3.6.1.23 Alternative name(s): dUTP pyrophosphatase | ||||
| Gene names |
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| Organism | Vaccinia virus (strain Ankara) (VACV) | ||||
| Taxonomic identifier | 126794 [NCBI] | ||||
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus › Vaccinia virus | ||||
| Virus host | Homo sapiens (Human) [TaxID: 9606] |
Protein attributes
| Sequence length | 147 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. |
| Catalytic activity | dUTP + H2O = dUMP + diphosphate. |
| Sequence similarities | Belongs to the dUTPase family. |
| Caution | Was originally thought to be a protease-like protein (pseudoprotease). |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide metabolism |
| Molecular function | Hydrolase |
| Gene Ontology (GO) | |
| Biological process | dUTP metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | dUTP diphosphatase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 147 | 147 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | PRO_0000182939 | |||
Sequences
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References
| [1] | "The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses." Antoine G., Scheiflinger F., Dorner F., Falkner F.G. Virology 244:365-396(1998) [PubMed: 9601507] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J., Khristova M., Wohlhueter R.M. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate Acambis 3000. |
Cross-references
Sequence databases | |
|---|---|
| U94848 Genomic DNA. Translation: AAB96413.1. AY603355 Genomic DNA. Translation: AAT10428.1. | |
| PIR | PRVZ7F. G42506. |
3D structure databases | |
| SMR | Q76RE7. Positions 7-131. |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR008180. DeoxyUTP_pyroPase_dom. IPR008181. dUTP_pyrophosphatase_subfam_1. [Graphical view] |
| Pfam | PF00692. dUTPase. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DUT_VACCA | ||||||||
| Accession | Primary (citable) accession number: Q76RE7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||

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