Q76NV1 (DYRK1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable serine/threonine-protein kinase dyrk1
EC=2.7.12.1

Alternative name(s):
Dual specificity tyrosine-phosphorylation regulated kinase 1

Gene names

Name:	dyrk1
ORF Names:	DDB_G0277485

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	836 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular space Inferred from direct assay. Source: dictyBase
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine/tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 836	836	Probable serine/threonine-protein kinase dyrk1		PRO_0000358884
Regions
	Domain	304 – 624	321	Protein kinase
	Nucleotide binding	310 – 318	9	ATP By similarity
	Compositional bias	40 – 69	30	Poly-Gln
	Compositional bias	72 – 105	34	Poly-Gln
	Compositional bias	107 – 132	26	Poly-Asn
	Compositional bias	135 – 205	71	Poly-Asn
	Compositional bias	208 – 263	56	Poly-Asn
	Compositional bias	264 – 267	4	Poly-Thr
	Compositional bias	271 – 276	6	Poly-Asn
	Compositional bias	688 – 717	30	Poly-Gln
	Compositional bias	788 – 813	26	Poly-Asn
	Compositional bias	832 – 835	4	Poly-Asn
Sites
	Active site	432	1	Proton acceptor By similarity
	Binding site	333	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q76NV1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 245A628226397C63	FASTA	836	97,098
	10 20 30 40 50 60 MDSDAKSRND APIIKLSIDL IKTYKHINQV YYTAKAKKKQ QAQQQAQQQA QQLQQQAQQQ 70 80 90 100 110 120 QHQLQQQQQL LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QYQQQHNNNI NNNNNNSNIN 130 140 150 160 170 180 NKNNNNNNTN FNTSNNNNNT NNNSNNNSNN NNSNNNNNNN NINNINNINI NNKNNNNNNN 190 200 210 220 230 240 NNNNINNINN NNNKNNNNNN NNNNNDDNNN INNNNSNNNN NNNNNNNNNN NNNNNNNNNN 250 260 270 280 290 300 NSNNNNNNNN LNNNNSNNNY NNNTTTTSSS NNNNNNKQSK YNDGYDDENA DYIVRIGEVF 310 320 330 340 350 360 VDRFEIISSL GKGSFGQVVK AFDSVLKEYV AIKIIKNKVP FYNQALIEIR LLELMNNKDP 370 380 390 400 410 420 EDQYKIIKLK HHFKFRNHLC IVTELLSYNL YDLLRNTHFH GVSLNLIKKF AHQILTALFF 430 440 450 460 470 480 MSTPEVDVIH CDLKPENILL RNPKRSAIKI IDFGSSCHSN ERMYKYIQSR FYRSPEILLE 490 500 510 520 530 540 LEYSFSIDMW SLGCILVEMH VGEPLFSGQN EQDQLTKIIE VLDLPPSHMI DSSPKAKKFF 550 560 570 580 590 600 TKDPINSTYQ LKKNEKLKTN VEFCKKKLSE IIGVETGGPQ SRRKNEPGHA LVDYLKFLDL 610 620 630 640 650 660 IEKMLIYDPQ KRITPLEALQ HSFFLTDETS QPPQQQSQQQ SQQQSQQQSQ QQSQQQSQQR 670 680 690 700 710 720 RQSNTDNNFS NNNPINNYNS PSSKSPHQQL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQTYS 730 740 750 760 770 780 PTTQQSNHKL VDQMKKASMK DKSPHSNISN ILNDSEEDNS KVHINSNTSD NMQARINFQV 790 800 810 820 830 ENQSNIYNNN NNNNNNNNNN NNNNNSNNYN NSNELSPNPP ILPNLKDLLP HNNNNI

References

[1]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000020 Genomic DNA. Translation: EAL68705.1.
RefSeq	XP_642598.1. XM_637506.1.
3D structure databases
HSSP	HSSP built from PDB template 1WBP based on UniProtKB Q96SB4.
ProteinModelPortal	Q76NV1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0229429; DDB0229429; DDB_G0277485.
GeneID	8621015.
GenomeReviews	Gene locus dyrk1 in contig CM000151_GR.
KEGG	ddi:DDB_G0277485.
Organism-specific databases
dictyBase	DDB_G0277485. dyrk1.
Phylogenomic databases
eggNOG	KOG0667.
GeneTree	EPrGT00060000009507.
HOGENOM	HBG755340.
OMA	DDENADY.
PhylomeDB	Q76NV1.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR002290. Ser/Thr_kinase_dom. [Graphical view]
KO	K08825.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DYRK1_DICDI

Accession

Primary (citable) accession number: Q76NV1
Secondary accession number(s): Q54ZP4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	July 5, 2004
Last modified:	November 16, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)