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Q76NM3

- Q76NM3_PLAF7

UniProt

Q76NM3 - Q76NM3_PLAF7

Protein
Submitted name:

L-lactate dehydrogenase

Gene

PfLDH

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. L-lactate dehydrogenase activity Source: GeneDB_Pfalciparum

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. glycolytic process Source: GeneDB_Pfalciparum

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Enzyme and pathway databases

    SABIO-RKQ76NM3.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    L-lactate dehydrogenaseImported (EC:1.1.1.27Imported)
    Gene namesi
    Name:PfLDHImported
    ORF Names:PF13_0141Imported
    OrganismiPlasmodium falciparum (isolate 3D7)Imported
    Taxonomic identifieri36329 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
    ProteomesiUP000001450: Chromosome 13

    Organism-specific databases

    EuPathDBiPlasmoDB:PF3D7_1324900.

    Interactioni

    Protein-protein interaction databases

    IntActiQ76NM3. 1 interaction.
    STRINGi5833.PF13_0141-1.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZH2X-ray2.10A/B/C/D1-316[»]
    ProteinModelPortaliQ76NM3.
    SMRiQ76NM3. Positions 2-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000213794.
    KOiK00016.
    OMAiYGQNDIC.
    PhylomeDBiQ76NM3.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q76NM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPKAKIVLV GSGMIGGVMA TLIVQKNLGD VVLFDIVKNM PHGKALDTSH    50
    TNVMAYSNCK VSGSNTYDDL AGADVVIVTA GFTKAPGKSD KEWNRDDLLP 100
    LNNKIMIEIG GHIKKNCPNA FIIVVTNPVD VMVQLLHQHS GVPKNKIIGL 150
    GGVLDTSRLK YYISQKLNVC PRDVNAHIVG AHGNKMVLLK RYITVGGIPL 200
    QEFINNKLIS DAELEAIFDR TVNTALEIVN LHASPYVAPA AAIIEMAESY 250
    LKDLKKVLIC STLLEGQYGH SDIFGGTPVV LGANGVEQVI ELQLNSEEKA 300
    KFDEAIAETK RMKALA 316
    Length:316
    Mass (Da):34,108
    Last modified:July 5, 2004 - v1
    Checksum:iD25EB863954B8FC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844509 Genomic DNA. Translation: CAD52397.1.
    RefSeqiXP_001349989.1. XM_001349953.1.

    Genome annotation databases

    EnsemblProtistsiPF13_0141:mRNA; PF13_0141:pep; PF13_0141.
    GeneIDi814112.
    KEGGipfa:PF13_0141.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844509 Genomic DNA. Translation: CAD52397.1 .
    RefSeqi XP_001349989.1. XM_001349953.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZH2 X-ray 2.10 A/B/C/D 1-316 [» ]
    ProteinModelPortali Q76NM3.
    SMRi Q76NM3. Positions 2-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q76NM3. 1 interaction.
    STRINGi 5833.PF13_0141-1.

    Chemistry

    BindingDBi Q76NM3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi PF13_0141:mRNA ; PF13_0141:pep ; PF13_0141 .
    GeneIDi 814112.
    KEGGi pfa:PF13_0141.

    Organism-specific databases

    EuPathDBi PlasmoDB:PF3D7_1324900.

    Phylogenomic databases

    HOGENOMi HOG000213794.
    KOi K00016.
    OMAi YGQNDIC.
    PhylomeDBi Q76NM3.

    Enzyme and pathway databases

    SABIO-RK Q76NM3.

    Miscellaneous databases

    PROi Q76NM3.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate 3D7Imported.
    2. "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
      Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z.
      , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
      Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate 3D7Imported.
    3. "Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase by a DNA aptamer."
      Cheung Y.W., Kwok J., Law A.W., Watt R.M., Kotaka M., Tanner J.A.
      Proc. Natl. Acad. Sci. U.S.A. 110:15967-15972(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).

    Entry informationi

    Entry nameiQ76NM3_PLAF7
    AccessioniPrimary (citable) accession number: Q76NM3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3