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Q76NM3

- Q76NM3_PLAF7

UniProt

Q76NM3 - Q76NM3_PLAF7

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Protein
Submitted name:

L-lactate dehydrogenase

Gene

PfLDH

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. L-lactate dehydrogenase activity Source: GeneDB_Pfalciparum

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. glycolytic process Source: GeneDB_Pfalciparum
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Enzyme and pathway databases

SABIO-RKQ76NM3.

Names & Taxonomyi

Protein namesi
Submitted name:
L-lactate dehydrogenaseImported (EC:1.1.1.27Imported)
Gene namesi
Name:PfLDHImported
ORF Names:PF13_0141Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1324900.

Interactioni

Protein-protein interaction databases

IntActiQ76NM3. 1 interaction.
STRINGi5833.PF13_0141-1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZH2X-ray2.10A/B/C/D1-316[»]
ProteinModelPortaliQ76NM3.
SMRiQ76NM3. Positions 2-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213794.
InParanoidiQ76NM3.
OMAiYGQNDIC.
PhylomeDBiQ76NM3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q76NM3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPKAKIVLV GSGMIGGVMA TLIVQKNLGD VVLFDIVKNM PHGKALDTSH
60 70 80 90 100
TNVMAYSNCK VSGSNTYDDL AGADVVIVTA GFTKAPGKSD KEWNRDDLLP
110 120 130 140 150
LNNKIMIEIG GHIKKNCPNA FIIVVTNPVD VMVQLLHQHS GVPKNKIIGL
160 170 180 190 200
GGVLDTSRLK YYISQKLNVC PRDVNAHIVG AHGNKMVLLK RYITVGGIPL
210 220 230 240 250
QEFINNKLIS DAELEAIFDR TVNTALEIVN LHASPYVAPA AAIIEMAESY
260 270 280 290 300
LKDLKKVLIC STLLEGQYGH SDIFGGTPVV LGANGVEQVI ELQLNSEEKA
310
KFDEAIAETK RMKALA
Length:316
Mass (Da):34,108
Last modified:July 5, 2004 - v1
Checksum:iD25EB863954B8FC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA. Translation: CAD52397.1.
RefSeqiXP_001349989.1. XM_001349953.1.

Genome annotation databases

EnsemblProtistsiPF13_0141:mRNA; PF13_0141:pep; PF13_0141.
GeneIDi814112.
KEGGipfa:PF13_0141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA. Translation: CAD52397.1 .
RefSeqi XP_001349989.1. XM_001349953.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZH2 X-ray 2.10 A/B/C/D 1-316 [» ]
ProteinModelPortali Q76NM3.
SMRi Q76NM3. Positions 2-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q76NM3. 1 interaction.
STRINGi 5833.PF13_0141-1.

Chemistry

BindingDBi Q76NM3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi PF13_0141:mRNA ; PF13_0141:pep ; PF13_0141 .
GeneIDi 814112.
KEGGi pfa:PF13_0141.

Organism-specific databases

EuPathDBi PlasmoDB:PF3D7_1324900.

Phylogenomic databases

HOGENOMi HOG000213794.
InParanoidi Q76NM3.
OMAi YGQNDIC.
PhylomeDBi Q76NM3.

Enzyme and pathway databases

SABIO-RK Q76NM3.

Miscellaneous databases

PROi Q76NM3.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.
  2. "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
    Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z.
    , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
    Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.
  3. "Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase by a DNA aptamer."
    Cheung Y.W., Kwok J., Law A.W., Watt R.M., Kotaka M., Tanner J.A.
    Proc. Natl. Acad. Sci. U.S.A. 110:15967-15972(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).

Entry informationi

Entry nameiQ76NM3_PLAF7
AccessioniPrimary (citable) accession number: Q76NM3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3