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Q76NM3

- Q76NM3_PLAF7

UniProt

Q76NM3 - Q76NM3_PLAF7

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Protein
Submitted name: L-lactate dehydrogenase
Gene
PfLDH, PF13_0141
Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. L-lactate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Enzyme and pathway databases

SABIO-RKQ76NM3.

Names & Taxonomyi

Protein namesi
Submitted name:
L-lactate dehydrogenaseImported (EC:1.1.1.27Imported)
Gene namesi
Name:PfLDHImported
ORF Names:PF13_0141Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1324900.

Interactioni

Protein-protein interaction databases

IntActiQ76NM3. 1 interaction.
STRINGi5833.PF13_0141-1.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZH2X-ray2.10A/B/C/D1-316[»]
ProteinModelPortaliQ76NM3.
SMRiQ76NM3. Positions 2-316.

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213794.
KOiK00016.
OMAiYGQNDIC.
PhylomeDBiQ76NM3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q76NM3-1 [UniParc]FASTAAdd to Basket

« Hide

MAPKAKIVLV GSGMIGGVMA TLIVQKNLGD VVLFDIVKNM PHGKALDTSH    50
TNVMAYSNCK VSGSNTYDDL AGADVVIVTA GFTKAPGKSD KEWNRDDLLP 100
LNNKIMIEIG GHIKKNCPNA FIIVVTNPVD VMVQLLHQHS GVPKNKIIGL 150
GGVLDTSRLK YYISQKLNVC PRDVNAHIVG AHGNKMVLLK RYITVGGIPL 200
QEFINNKLIS DAELEAIFDR TVNTALEIVN LHASPYVAPA AAIIEMAESY 250
LKDLKKVLIC STLLEGQYGH SDIFGGTPVV LGANGVEQVI ELQLNSEEKA 300
KFDEAIAETK RMKALA 316
Length:316
Mass (Da):34,108
Last modified:July 5, 2004 - v1
Checksum:iD25EB863954B8FC1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844509 Genomic DNA. Translation: CAD52397.1.
RefSeqiXP_001349989.1. XM_001349953.1.

Genome annotation databases

EnsemblProtistsiPF13_0141:mRNA; PF13_0141:pep; PF13_0141.
GeneIDi814112.
KEGGipfa:PF13_0141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844509 Genomic DNA. Translation: CAD52397.1 .
RefSeqi XP_001349989.1. XM_001349953.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZH2 X-ray 2.10 A/B/C/D 1-316 [» ]
ProteinModelPortali Q76NM3.
SMRi Q76NM3. Positions 2-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q76NM3. 1 interaction.
STRINGi 5833.PF13_0141-1.

Chemistry

BindingDBi Q76NM3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi PF13_0141:mRNA ; PF13_0141:pep ; PF13_0141 .
GeneIDi 814112.
KEGGi pfa:PF13_0141.

Organism-specific databases

EuPathDBi PlasmoDB:PF3D7_1324900.

Phylogenomic databases

HOGENOMi HOG000213794.
KOi K00016.
OMAi YGQNDIC.
PhylomeDBi Q76NM3.

Enzyme and pathway databases

SABIO-RK Q76NM3.

Miscellaneous databases

PROi Q76NM3.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.
  2. "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
    Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z.
    , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
    Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.
  3. "Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase by a DNA aptamer."
    Cheung Y.W., Kwok J., Law A.W., Watt R.M., Kotaka M., Tanner J.A.
    Proc. Natl. Acad. Sci. U.S.A. 110:15967-15972(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).

Entry informationi

Entry nameiQ76NM3_PLAF7
AccessioniPrimary (citable) accession number: Q76NM3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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