Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q76NI1 (VKIND_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein very KIND
Alternative name(s):
Cerebral protein 9
KIND domain-containing protein 1
Kinase non-catalytic C-lobe domain-containing protein 1
Ras-GEF domain-containing family member 2
Gene names
Name:KNDC1
Synonyms:C10orf23, KIAA1768, RASGEF2, VKIND
ORF Names:hucep-9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1749 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable guanine nucleotide exchange factor (GEF).

Tissue specificity

Expressed specifically in the cerebral cortex. Ref.1

Sequence similarities

Contains 2 KIND domains.

Contains 1 N-terminal Ras-GEF domain.

Contains 1 Ras-GEF domain.

Sequence caution

The sequence BAB21859.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI17339.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q76NI1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q76NI1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
     1194-1206: VMYAERWGLEPCT → ASGLRAPLCPVRQ
     1207-1749: Missing.
Isoform 3 (identifier: Q76NI1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
Isoform 4 (identifier: Q76NI1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1130-1396: ELEQQLMMEK...PREAEEDARP → VSPRPWHCRV...LSCRLLACTL
     1397-1749: Missing.
Isoform 5 (identifier: Q76NI1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1258: Missing.
Isoform 6 (identifier: Q76NI1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1584: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 17491749Protein very KIND
PRO_0000307141

Regions

Domain37 – 217181KIND 1
Domain444 – 608165KIND 2
Domain1246 – 1371126N-terminal Ras-GEF
Domain1468 – 1719252Ras-GEF
Coiled coil1133 – 119058 Potential
Compositional bias724 – 885162Pro-rich

Natural variations

Alternative sequence1 – 15841584Missing in isoform 6.
VSP_028592
Alternative sequence1 – 12581258Missing in isoform 5.
VSP_028593
Alternative sequence1 – 6565Missing in isoform 2 and isoform 3.
VSP_028594
Alternative sequence1130 – 1396267ELEQQ…EDARP → VSPRPWHCRVGQGVSFQQSF LVTAGDRWHRVPRAPNRVTL VLVPPPRGCQDGQGPLPGLS STSRDRLVCTGAPGGSTSED REGLFSHGRPGDGFTGGPSM LVTRLRSVVFSVGQAQPPGP WAASLCSERKHQKRLPSKSR LGLVAAAWSGLSGQQCHPGS GAAATPPWPAGRGGLRPGSP GCRRGLQSSGRKVGPVTHSP DLGCILESPGTPGWMTGGAQ WPSAPGTSPTTVCLELSHRG KPPPASGHRSPSWGSSLLLS CRLLACTL in isoform 4.
VSP_028595
Alternative sequence1194 – 120613VMYAE…LEPCT → ASGLRAPLCPVRQ in isoform 2.
VSP_028596
Alternative sequence1207 – 1749543Missing in isoform 2.
VSP_028597
Alternative sequence1397 – 1749353Missing in isoform 4.
VSP_028598
Natural variant4361E → G. Ref.1
Corresponds to variant rs3810964 [ dbSNP | Ensembl ].
VAR_035358
Natural variant5811G → S.
Corresponds to variant rs35152544 [ dbSNP | Ensembl ].
VAR_035359
Natural variant7171L → P. Ref.1
Corresponds to variant rs2998139 [ dbSNP | Ensembl ].
VAR_035360
Natural variant10381R → W.
Corresponds to variant rs35604376 [ dbSNP | Ensembl ].
VAR_061786
Natural variant13321A → T.
Corresponds to variant rs11101642 [ dbSNP | Ensembl ].
VAR_051902

Experimental info

Sequence conflict3461L → P in BAD12625. Ref.1
Sequence conflict8061V → D in BAD12625. Ref.1
Sequence conflict9251A → G in BAD12625. Ref.1
Sequence conflict9711E → G in BAD12625. Ref.1
Sequence conflict10721S → P in BAD12625. Ref.1
Sequence conflict10841A → V in BAD12625. Ref.1
Sequence conflict12601A → T in BAD12625. Ref.1
Sequence conflict13151I → T in BAD12625. Ref.1
Sequence conflict14681S → G in BAD12625. Ref.1
Sequence conflict16241K → R in BAD12625. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: FB5F6C6692BBCB06

FASTA1,749191,397
        10         20         30         40         50         60 
MQAMDPAAAD LYEEDGKDLD FYDFEPLPTL PEDEENVSLA DILSLRDRGL SEQEAWAVCL 

        70         80         90        100        110        120 
ECSLSMRSVA HAAIFQSLCI TPDTLAFNTS GNVCFMEQLS DDPEGAFVPP EFDVTGNTFE 

       130        140        150        160        170        180 
AHIYSLGATL KAALEYVAEP TLEPRLSQDL EALLSRMQAE DPGDRPDLES IIALCEEKLQ 

       190        200        210        220        230        240 
LTSSCRVCRS LSAVGRRVLS IESFGALQDV SESSWRERPA PGNAGPRRPP GDPSTDPEVL 

       250        260        270        280        290        300 
PTPEGPESET SRGPRASPTK ALLSTPVRNG ESHSREGLAG LVLDAERTLG ELDRDALRRS 

       310        320        330        340        350        360 
RLRKVQTFPR LLSDSPEATL CLPLTRGKSQ LPISELFSPD PRKAFLDRKN GLSSFQAQPK 

       370        380        390        400        410        420 
CRLWPEQEPE HQLGRVPCAG RSTDRGPGVP GSPGQPETSH PSQGPAEAPA DPRDASGEAQ 

       430        440        450        460        470        480 
TPRDDERIPE GARQLESAAA EQWVSLQDLL SQLGRPFREY ELWALCLACL RALQTRPEHP 

       490        500        510        520        530        540 
AYLCLDSVLV AEDGAVLFQP PPANGSYDSF FLAPELAEER LVTEKASVYC VAAVLWTAAK 

       550        560        570        580        590        600 
FSVPRNHKLA LPRRLKTLLL DMARRSAPER PSAAEAIKVC GSYLLQRGMD SRKILAHLRA 

       610        620        630        640        650        660 
SICQVYQEEE TISLQNAFSV VELKPSVAPA PEPSPGFLPV NSDTGLVAVP GPVPGQHPCG 

       670        680        690        700        710        720 
EEATQLPAAF TSEATHFKPI VLAQNASVAR DQPALAQEES EERGGQREGE GEEKLSLEAH 

       730        740        750        760        770        780 
AGSPSLKTPD GPVPGPGPQG AAPEPLGASV QRDSAQGRPC PPPQAPANQP EGASSAAPGS 

       790        800        810        820        830        840 
PVPAPPTKAS ALPVEQGPAE PIPPGVASGG LRPDALGPTT AHHGPRHPPK PPRSKATERP 

       850        860        870        880        890        900 
GQEPEGPGAT PAGERDDQSP DSVPERPRPA DRRLCLPCVD ASPLPGRTAC PSLQEATRLI 

       910        920        930        940        950        960 
QEEFAFDGYL DNGLEALIMG EYIFALKDLT FATFCGAISE KFCDLYWDEK LLQNLFKVVN 

       970        980        990       1000       1010       1020 
GQASPSPSTA EEAGSQLEGS QSPRSPSSKR PSLHRLGKEK PAMARTSSRA PCSPTSVSDV 

      1030       1040       1050       1060       1070       1080 
DSDALSRGNF EVGFRPQRSV KAERAQQPEA GEDRRPAGGA SDVEAVTRLA RSKGVGPALS 

      1090       1100       1110       1120       1130       1140 
PGPAGFQSCS PGWCSAFYEA DCFGADVHNY VKDLGRQQAD GALPDAQSPE LEQQLMMEKR 

      1150       1160       1170       1180       1190       1200 
NYRKTLKFYQ KLLQKEKRNK GSDVKTMLSK LKGQLEEMKS RVQFLSLVKK YLQVMYAERW 

      1210       1220       1230       1240       1250       1260 
GLEPCTLPVI VNIAAAPCDT LDFSPLDESS SLIFYNVNKH PGGRQKARIL QAGTPLGLMA 

      1270       1280       1290       1300       1310       1320 
YLYSSDAFLE GYVQQFLYTF RYFCTPHDFL HFLLDRINST LTRAHQDPTS TFTKIYRRSL 

      1330       1340       1350       1360       1370       1380 
CVLQAWVEDC YAVDFPRNSG LLGKLEDFIS SKILPLDGSA KHLLGLLEVG MDRRAEGNPR 

      1390       1400       1410       1420       1430       1440 
GTDLENPREA EEDARPFNAL CKRLSEDGIS RKSFPWRLPR GNGLVLPPHK ERPYTIAAAL 

      1450       1460       1470       1480       1490       1500 
PKPCFLEDFY GPCAKTSEKG PYFLTEYSTH QLFSQLTLLQ QELFQKCHPV HFLNSRALGV 

      1510       1520       1530       1540       1550       1560 
MDKSTAIPKA SSSESLSAKT CSLFLPNYVQ DKYLLQLLRN ADDVSTWVAA EIVTSHTSKL 

      1570       1580       1590       1600       1610       1620 
QVNLLSKFLL IAKSCYEQRN FATAMQILSG LEHLAVRQSP AWRILPAKIA EVMEELKAVE 

      1630       1640       1650       1660       1670       1680 
VFLKSDSLCL MEGRRFRAQP TLPSAHLLAM HIQQLETGGF TMTNGAHRWS KLRNIAKVVS 

      1690       1700       1710       1720       1730       1740 
QVHAFQENPY TFSPDPKLQS YLKQRIARFS GADISTLAAD SRANFHQVSS EKHSRKIQDK 


LRRMKATFQ 

« Hide

Isoform 2 [UniParc].

Checksum: 631124F7586C846F
Show »

FASTA1,141122,639
Isoform 3 [UniParc].

Checksum: 2FE7062F7447A263
Show »

FASTA1,684184,133
Isoform 4 [UniParc].

Checksum: 898CFE93F843B2E5
Show »

FASTA1,397148,552
Isoform 5 [UniParc].

Checksum: A8F9C33FB112DCA3
Show »

FASTA49155,823
Isoform 6 [UniParc].

Checksum: EC85325473AD06D2
Show »

FASTA16518,783

References

« Hide 'large scale' references
[1]"Molecular cloning of a novel gene which is specifically expressed in human cerebral cortex."
Yoshimoto M., Yazaki M., Matsumoto K., Takayama K.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, VARIANTS GLY-436 AND PRO-717.
Tissue: Brain cortex.
[2]"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6).
Tissue: Brain and Cerebellum.
[4]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The nucleotide sequence of a long cDNA clone isolated from human spleen."
Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 579-1749 (ISOFORM 4).
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB000781 mRNA. Translation: BAD12625.1.
AB051555 mRNA. Translation: BAB21859.1. Different initiation.
AK057756 mRNA. Translation: BAB71561.1.
AK131205 mRNA. Translation: BAD18397.1.
AL445199 Genomic DNA. Translation: CAM24665.1.
AL445199 Genomic DNA. Translation: CAI17339.1. Sequence problems.
AK074179 mRNA. Translation: BAB85005.1.
CCDSCCDS7674.1. [Q76NI1-1]
RefSeqNP_689856.6. NM_152643.6. [Q76NI1-1]
UniGeneHs.530685.

3D structure databases

ProteinModelPortalQ76NI1.
SMRQ76NI1. Positions 1508-1703.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124529. 2 interactions.
IntActQ76NI1. 2 interactions.
STRING9606.ENSP00000304437.

PTM databases

PhosphoSiteQ76NI1.

Polymorphism databases

DMDM160013711.

Proteomic databases

PaxDbQ76NI1.
PRIDEQ76NI1.

Protocols and materials databases

DNASU85442.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304613; ENSP00000304437; ENSG00000171798. [Q76NI1-1]
ENST00000368571; ENSP00000357560; ENSG00000171798. [Q76NI1-2]
GeneID85442.
KEGGhsa:85442.
UCSCuc001llz.1. human. [Q76NI1-1]
uc001lma.1. human. [Q76NI1-2]
uc001lmb.1. human. [Q76NI1-4]

Organism-specific databases

CTD85442.
GeneCardsGC10P134974.
HGNCHGNC:29374. KNDC1.
HPAHPA039624.
neXtProtNX_Q76NI1.
PharmGKBPA134983621.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81994.
HOVERGENHBG108658.
OrthoDBEOG7P5T00.
PhylomeDBQ76NI1.
TreeFamTF336009.

Gene expression databases

ArrayExpressQ76NI1.
BgeeQ76NI1.
CleanExHS_KNDC1.
GenevestigatorQ76NI1.

Family and domain databases

Gene3D1.10.840.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR011019. KIND.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view]
PfamPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTSM00750. KIND. 2 hits.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMSSF48366. SSF48366. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEPS51377. KIND. 2 hits.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKNDC1. human.
GenomeRNAi85442.
NextBio76025.
PROQ76NI1.

Entry information

Entry nameVKIND_HUMAN
AccessionPrimary (citable) accession number: Q76NI1
Secondary accession number(s): B0QZC5 expand/collapse secondary AC list , Q5T233, Q6ZNH8, Q8TEE5, Q96LV7, Q9C095
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: July 9, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM