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Protein

Kinase non-catalytic C-lobe domain-containing protein 1

Gene

KNDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Kinase non-catalytic C-lobe domain-containing protein 1Imported
Short name:
KIND domain-containing protein 11 Publication
Alternative name(s):
Cerebral protein 91 Publication
Protein very KINDBy similarity
Short name:
v-KINDBy similarity
Ras-GEF domain-containing family member 2Imported
Gene namesi
Name:KNDC1Imported
Synonyms:C10orf23, KIAA1768, RASGEF2, VKINDBy similarity
ORF Names:hucep-91 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000171798.17
HGNCiHGNC:29374 KNDC1
MIMi616237 gene
neXtProtiNX_Q76NI1

Subcellular locationi

Keywords - Cellular componenti

Cell projection

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171798
PharmGKBiPA134983621

Polymorphism and mutation databases

BioMutaiKNDC1
DMDMi160013711

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003071411 – 1749Kinase non-catalytic C-lobe domain-containing protein 1Add BLAST1749

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei964PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ76NI1
PeptideAtlasiQ76NI1
PRIDEiQ76NI1

PTM databases

iPTMnetiQ76NI1
PhosphoSitePlusiQ76NI1

Expressioni

Tissue specificityi

Expressed specifically in the cerebral cortex.1 Publication

Gene expression databases

BgeeiENSG00000171798
CleanExiHS_KNDC1
GenevisibleiQ76NI1 HS

Organism-specific databases

HPAiHPA039624

Interactioni

Subunit structurei

Interacts (via KIND2) with MAP2; the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124529, 3 interactors
IntActiQ76NI1, 3 interactors
STRINGi9606.ENSP00000304437

Structurei

3D structure databases

ProteinModelPortaliQ76NI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 217KIND 1PROSITE-ProRule annotationAdd BLAST181
Domaini444 – 608KIND 2PROSITE-ProRule annotationAdd BLAST165
Domaini1246 – 1371N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST126
Domaini1468 – 1719Ras-GEFPROSITE-ProRule annotationAdd BLAST252

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1133 – 1190Sequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi724 – 885Pro-richAdd BLAST162

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410II5U Eukaryota
ENOG410XQ1A LUCA
GeneTreeiENSGT00390000011408
HOVERGENiHBG108658
InParanoidiQ76NI1
OMAiTSGNVCF
OrthoDBiEOG091G06SI
PhylomeDBiQ76NI1
TreeFamiTF336009

Family and domain databases

CDDicd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR011019 KIND_dom
IPR029899 KNDC1
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
PANTHERiPTHR21560 PTHR21560, 1 hit
PfamiView protein in Pfam
PF16474 KIND, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00750 KIND, 2 hits
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF48366 SSF48366, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51377 KIND, 2 hits
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q76NI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQAMDPAAAD LYEEDGKDLD FYDFEPLPTL PEDEENVSLA DILSLRDRGL
60 70 80 90 100
SEQEAWAVCL ECSLSMRSVA HAAIFQSLCI TPDTLAFNTS GNVCFMEQLS
110 120 130 140 150
DDPEGAFVPP EFDVTGNTFE AHIYSLGATL KAALEYVAEP TLEPRLSQDL
160 170 180 190 200
EALLSRMQAE DPGDRPDLES IIALCEEKLQ LTSSCRVCRS LSAVGRRVLS
210 220 230 240 250
IESFGALQDV SESSWRERPA PGNAGPRRPP GDPSTDPEVL PTPEGPESET
260 270 280 290 300
SRGPRASPTK ALLSTPVRNG ESHSREGLAG LVLDAERTLG ELDRDALRRS
310 320 330 340 350
RLRKVQTFPR LLSDSPEATL CLPLTRGKSQ LPISELFSPD PRKAFLDRKN
360 370 380 390 400
GLSSFQAQPK CRLWPEQEPE HQLGRVPCAG RSTDRGPGVP GSPGQPETSH
410 420 430 440 450
PSQGPAEAPA DPRDASGEAQ TPRDDERIPE GARQLESAAA EQWVSLQDLL
460 470 480 490 500
SQLGRPFREY ELWALCLACL RALQTRPEHP AYLCLDSVLV AEDGAVLFQP
510 520 530 540 550
PPANGSYDSF FLAPELAEER LVTEKASVYC VAAVLWTAAK FSVPRNHKLA
560 570 580 590 600
LPRRLKTLLL DMARRSAPER PSAAEAIKVC GSYLLQRGMD SRKILAHLRA
610 620 630 640 650
SICQVYQEEE TISLQNAFSV VELKPSVAPA PEPSPGFLPV NSDTGLVAVP
660 670 680 690 700
GPVPGQHPCG EEATQLPAAF TSEATHFKPI VLAQNASVAR DQPALAQEES
710 720 730 740 750
EERGGQREGE GEEKLSLEAH AGSPSLKTPD GPVPGPGPQG AAPEPLGASV
760 770 780 790 800
QRDSAQGRPC PPPQAPANQP EGASSAAPGS PVPAPPTKAS ALPVEQGPAE
810 820 830 840 850
PIPPGVASGG LRPDALGPTT AHHGPRHPPK PPRSKATERP GQEPEGPGAT
860 870 880 890 900
PAGERDDQSP DSVPERPRPA DRRLCLPCVD ASPLPGRTAC PSLQEATRLI
910 920 930 940 950
QEEFAFDGYL DNGLEALIMG EYIFALKDLT FATFCGAISE KFCDLYWDEK
960 970 980 990 1000
LLQNLFKVVN GQASPSPSTA EEAGSQLEGS QSPRSPSSKR PSLHRLGKEK
1010 1020 1030 1040 1050
PAMARTSSRA PCSPTSVSDV DSDALSRGNF EVGFRPQRSV KAERAQQPEA
1060 1070 1080 1090 1100
GEDRRPAGGA SDVEAVTRLA RSKGVGPALS PGPAGFQSCS PGWCSAFYEA
1110 1120 1130 1140 1150
DCFGADVHNY VKDLGRQQAD GALPDAQSPE LEQQLMMEKR NYRKTLKFYQ
1160 1170 1180 1190 1200
KLLQKEKRNK GSDVKTMLSK LKGQLEEMKS RVQFLSLVKK YLQVMYAERW
1210 1220 1230 1240 1250
GLEPCTLPVI VNIAAAPCDT LDFSPLDESS SLIFYNVNKH PGGRQKARIL
1260 1270 1280 1290 1300
QAGTPLGLMA YLYSSDAFLE GYVQQFLYTF RYFCTPHDFL HFLLDRINST
1310 1320 1330 1340 1350
LTRAHQDPTS TFTKIYRRSL CVLQAWVEDC YAVDFPRNSG LLGKLEDFIS
1360 1370 1380 1390 1400
SKILPLDGSA KHLLGLLEVG MDRRAEGNPR GTDLENPREA EEDARPFNAL
1410 1420 1430 1440 1450
CKRLSEDGIS RKSFPWRLPR GNGLVLPPHK ERPYTIAAAL PKPCFLEDFY
1460 1470 1480 1490 1500
GPCAKTSEKG PYFLTEYSTH QLFSQLTLLQ QELFQKCHPV HFLNSRALGV
1510 1520 1530 1540 1550
MDKSTAIPKA SSSESLSAKT CSLFLPNYVQ DKYLLQLLRN ADDVSTWVAA
1560 1570 1580 1590 1600
EIVTSHTSKL QVNLLSKFLL IAKSCYEQRN FATAMQILSG LEHLAVRQSP
1610 1620 1630 1640 1650
AWRILPAKIA EVMEELKAVE VFLKSDSLCL MEGRRFRAQP TLPSAHLLAM
1660 1670 1680 1690 1700
HIQQLETGGF TMTNGAHRWS KLRNIAKVVS QVHAFQENPY TFSPDPKLQS
1710 1720 1730 1740
YLKQRIARFS GADISTLAAD SRANFHQVSS EKHSRKIQDK LRRMKATFQ
Length:1,749
Mass (Da):191,397
Last modified:October 23, 2007 - v2
Checksum:iFB5F6C6692BBCB06
GO
Isoform 2 (identifier: Q76NI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
     1194-1206: VMYAERWGLEPCT → ASGLRAPLCPVRQ
     1207-1749: Missing.

Show »
Length:1,141
Mass (Da):122,639
Checksum:i631124F7586C846F
GO
Isoform 3 (identifier: Q76NI1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Show »
Length:1,684
Mass (Da):184,133
Checksum:i2FE7062F7447A263
GO
Isoform 4 (identifier: Q76NI1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1130-1396: ELEQQLMMEK...PREAEEDARP → VSPRPWHCRV...LSCRLLACTL
     1397-1749: Missing.

Show »
Length:1,397
Mass (Da):148,552
Checksum:i898CFE93F843B2E5
GO
Isoform 5 (identifier: Q76NI1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1258: Missing.

Show »
Length:491
Mass (Da):55,823
Checksum:iA8F9C33FB112DCA3
GO
Isoform 6 (identifier: Q76NI1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1584: Missing.

Show »
Length:165
Mass (Da):18,783
Checksum:iEC85325473AD06D2
GO

Sequence cautioni

The sequence BAB21859 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI17339 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti346L → P in BAD12625 (Ref. 1) Curated1
Sequence conflicti806V → D in BAD12625 (Ref. 1) Curated1
Sequence conflicti925A → G in BAD12625 (Ref. 1) Curated1
Sequence conflicti971E → G in BAD12625 (Ref. 1) Curated1
Sequence conflicti1072S → P in BAD12625 (Ref. 1) Curated1
Sequence conflicti1084A → V in BAD12625 (Ref. 1) Curated1
Sequence conflicti1260A → T in BAD12625 (Ref. 1) Curated1
Sequence conflicti1315I → T in BAD12625 (Ref. 1) Curated1
Sequence conflicti1468S → G in BAD12625 (Ref. 1) Curated1
Sequence conflicti1624K → R in BAD12625 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035358436E → G1 PublicationCorresponds to variant dbSNP:rs3810964Ensembl.1
Natural variantiVAR_035359581G → S. Corresponds to variant dbSNP:rs35152544Ensembl.1
Natural variantiVAR_035360717L → P1 PublicationCorresponds to variant dbSNP:rs2998139Ensembl.1
Natural variantiVAR_0617861038R → W. Corresponds to variant dbSNP:rs35604376Ensembl.1
Natural variantiVAR_0519021332A → T. Corresponds to variant dbSNP:rs11101642Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0285921 – 1584Missing in isoform 6. 1 PublicationAdd BLAST1584
Alternative sequenceiVSP_0285931 – 1258Missing in isoform 5. 1 PublicationAdd BLAST1258
Alternative sequenceiVSP_0285941 – 65Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST65
Alternative sequenceiVSP_0285951130 – 1396ELEQQ…EDARP → VSPRPWHCRVGQGVSFQQSF LVTAGDRWHRVPRAPNRVTL VLVPPPRGCQDGQGPLPGLS STSRDRLVCTGAPGGSTSED REGLFSHGRPGDGFTGGPSM LVTRLRSVVFSVGQAQPPGP WAASLCSERKHQKRLPSKSR LGLVAAAWSGLSGQQCHPGS GAAATPPWPAGRGGLRPGSP GCRRGLQSSGRKVGPVTHSP DLGCILESPGTPGWMTGGAQ WPSAPGTSPTTVCLELSHRG KPPPASGHRSPSWGSSLLLS CRLLACTL in isoform 4. 1 PublicationAdd BLAST267
Alternative sequenceiVSP_0285961194 – 1206VMYAE…LEPCT → ASGLRAPLCPVRQ in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0285971207 – 1749Missing in isoform 2. 1 PublicationAdd BLAST543
Alternative sequenceiVSP_0285981397 – 1749Missing in isoform 4. 1 PublicationAdd BLAST353

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000781 mRNA Translation: BAD12625.1
AB051555 mRNA Translation: BAB21859.1 Different initiation.
AK057756 mRNA Translation: BAB71561.1
AK131205 mRNA Translation: BAD18397.1
AL445199 Genomic DNA Translation: CAM24665.1
AL445199 Genomic DNA Translation: CAI17339.1 Sequence problems.
AK074179 mRNA Translation: BAB85005.1
CCDSiCCDS7674.1 [Q76NI1-1]
RefSeqiNP_689856.6, NM_152643.7 [Q76NI1-1]
UniGeneiHs.530685

Genome annotation databases

EnsembliENST00000304613; ENSP00000304437; ENSG00000171798 [Q76NI1-1]
ENST00000368571; ENSP00000357560; ENSG00000171798 [Q76NI1-2]
GeneIDi85442
KEGGihsa:85442
UCSCiuc001llz.2 human [Q76NI1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKNDC1_HUMAN
AccessioniPrimary (citable) accession number: Q76NI1
Secondary accession number(s): B0QZC5
, Q5T233, Q6ZNH8, Q8TEE5, Q96LV7, Q9C095
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: April 25, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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