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Q76NI1

- VKIND_HUMAN

UniProt

Q76NI1 - VKIND_HUMAN

Protein

Protein very KIND

Gene

KNDC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Probable guanine nucleotide exchange factor (GEF).

    GO - Molecular functioni

    1. protein serine/threonine kinase activity Source: Ensembl
    2. Ras guanyl-nucleotide exchange factor activity Source: Ensembl

    GO - Biological processi

    1. cerebellar granule cell differentiation Source: Ensembl
    2. positive regulation of protein phosphorylation Source: Ensembl
    3. regulation of dendrite morphogenesis Source: Ensembl
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein very KIND
    Alternative name(s):
    Cerebral protein 9
    KIND domain-containing protein 1
    Kinase non-catalytic C-lobe domain-containing protein 1
    Ras-GEF domain-containing family member 2
    Gene namesi
    Name:KNDC1
    Synonyms:C10orf23, KIAA1768, RASGEF2, VKIND
    ORF Names:hucep-9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:29374. KNDC1.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. guanyl-nucleotide exchange factor complex Source: Ensembl
    3. neuronal cell body Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134983621.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17491749Protein very KINDPRO_0000307141Add
    BLAST

    Proteomic databases

    PaxDbiQ76NI1.
    PRIDEiQ76NI1.

    PTM databases

    PhosphoSiteiQ76NI1.

    Expressioni

    Tissue specificityi

    Expressed specifically in the cerebral cortex.1 Publication

    Gene expression databases

    ArrayExpressiQ76NI1.
    BgeeiQ76NI1.
    CleanExiHS_KNDC1.
    GenevestigatoriQ76NI1.

    Organism-specific databases

    HPAiHPA039624.

    Interactioni

    Protein-protein interaction databases

    BioGridi124529. 2 interactions.
    IntActiQ76NI1. 2 interactions.
    STRINGi9606.ENSP00000304437.

    Structurei

    3D structure databases

    ProteinModelPortaliQ76NI1.
    SMRiQ76NI1. Positions 1508-1703.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 217181KIND 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini444 – 608165KIND 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1246 – 1371126N-terminal Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini1468 – 1719252Ras-GEFPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1133 – 119058Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi724 – 885162Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 KIND domains.PROSITE-ProRule annotation
    Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG81994.
    HOVERGENiHBG108658.
    OrthoDBiEOG7P5T00.
    PhylomeDBiQ76NI1.
    TreeFamiTF336009.

    Family and domain databases

    Gene3Di1.10.840.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR011019. KIND.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view]
    PfamiPF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view]
    SMARTiSM00750. KIND. 2 hits.
    SM00229. RasGEFN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 3 hits.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS51377. KIND. 2 hits.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q76NI1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQAMDPAAAD LYEEDGKDLD FYDFEPLPTL PEDEENVSLA DILSLRDRGL     50
    SEQEAWAVCL ECSLSMRSVA HAAIFQSLCI TPDTLAFNTS GNVCFMEQLS 100
    DDPEGAFVPP EFDVTGNTFE AHIYSLGATL KAALEYVAEP TLEPRLSQDL 150
    EALLSRMQAE DPGDRPDLES IIALCEEKLQ LTSSCRVCRS LSAVGRRVLS 200
    IESFGALQDV SESSWRERPA PGNAGPRRPP GDPSTDPEVL PTPEGPESET 250
    SRGPRASPTK ALLSTPVRNG ESHSREGLAG LVLDAERTLG ELDRDALRRS 300
    RLRKVQTFPR LLSDSPEATL CLPLTRGKSQ LPISELFSPD PRKAFLDRKN 350
    GLSSFQAQPK CRLWPEQEPE HQLGRVPCAG RSTDRGPGVP GSPGQPETSH 400
    PSQGPAEAPA DPRDASGEAQ TPRDDERIPE GARQLESAAA EQWVSLQDLL 450
    SQLGRPFREY ELWALCLACL RALQTRPEHP AYLCLDSVLV AEDGAVLFQP 500
    PPANGSYDSF FLAPELAEER LVTEKASVYC VAAVLWTAAK FSVPRNHKLA 550
    LPRRLKTLLL DMARRSAPER PSAAEAIKVC GSYLLQRGMD SRKILAHLRA 600
    SICQVYQEEE TISLQNAFSV VELKPSVAPA PEPSPGFLPV NSDTGLVAVP 650
    GPVPGQHPCG EEATQLPAAF TSEATHFKPI VLAQNASVAR DQPALAQEES 700
    EERGGQREGE GEEKLSLEAH AGSPSLKTPD GPVPGPGPQG AAPEPLGASV 750
    QRDSAQGRPC PPPQAPANQP EGASSAAPGS PVPAPPTKAS ALPVEQGPAE 800
    PIPPGVASGG LRPDALGPTT AHHGPRHPPK PPRSKATERP GQEPEGPGAT 850
    PAGERDDQSP DSVPERPRPA DRRLCLPCVD ASPLPGRTAC PSLQEATRLI 900
    QEEFAFDGYL DNGLEALIMG EYIFALKDLT FATFCGAISE KFCDLYWDEK 950
    LLQNLFKVVN GQASPSPSTA EEAGSQLEGS QSPRSPSSKR PSLHRLGKEK 1000
    PAMARTSSRA PCSPTSVSDV DSDALSRGNF EVGFRPQRSV KAERAQQPEA 1050
    GEDRRPAGGA SDVEAVTRLA RSKGVGPALS PGPAGFQSCS PGWCSAFYEA 1100
    DCFGADVHNY VKDLGRQQAD GALPDAQSPE LEQQLMMEKR NYRKTLKFYQ 1150
    KLLQKEKRNK GSDVKTMLSK LKGQLEEMKS RVQFLSLVKK YLQVMYAERW 1200
    GLEPCTLPVI VNIAAAPCDT LDFSPLDESS SLIFYNVNKH PGGRQKARIL 1250
    QAGTPLGLMA YLYSSDAFLE GYVQQFLYTF RYFCTPHDFL HFLLDRINST 1300
    LTRAHQDPTS TFTKIYRRSL CVLQAWVEDC YAVDFPRNSG LLGKLEDFIS 1350
    SKILPLDGSA KHLLGLLEVG MDRRAEGNPR GTDLENPREA EEDARPFNAL 1400
    CKRLSEDGIS RKSFPWRLPR GNGLVLPPHK ERPYTIAAAL PKPCFLEDFY 1450
    GPCAKTSEKG PYFLTEYSTH QLFSQLTLLQ QELFQKCHPV HFLNSRALGV 1500
    MDKSTAIPKA SSSESLSAKT CSLFLPNYVQ DKYLLQLLRN ADDVSTWVAA 1550
    EIVTSHTSKL QVNLLSKFLL IAKSCYEQRN FATAMQILSG LEHLAVRQSP 1600
    AWRILPAKIA EVMEELKAVE VFLKSDSLCL MEGRRFRAQP TLPSAHLLAM 1650
    HIQQLETGGF TMTNGAHRWS KLRNIAKVVS QVHAFQENPY TFSPDPKLQS 1700
    YLKQRIARFS GADISTLAAD SRANFHQVSS EKHSRKIQDK LRRMKATFQ 1749
    Length:1,749
    Mass (Da):191,397
    Last modified:October 23, 2007 - v2
    Checksum:iFB5F6C6692BBCB06
    GO
    Isoform 2 (identifier: Q76NI1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-65: Missing.
         1194-1206: VMYAERWGLEPCT → ASGLRAPLCPVRQ
         1207-1749: Missing.

    Show »
    Length:1,141
    Mass (Da):122,639
    Checksum:i631124F7586C846F
    GO
    Isoform 3 (identifier: Q76NI1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-65: Missing.

    Show »
    Length:1,684
    Mass (Da):184,133
    Checksum:i2FE7062F7447A263
    GO
    Isoform 4 (identifier: Q76NI1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1130-1396: ELEQQLMMEK...PREAEEDARP → VSPRPWHCRV...LSCRLLACTL
         1397-1749: Missing.

    Show »
    Length:1,397
    Mass (Da):148,552
    Checksum:i898CFE93F843B2E5
    GO
    Isoform 5 (identifier: Q76NI1-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1258: Missing.

    Show »
    Length:491
    Mass (Da):55,823
    Checksum:iA8F9C33FB112DCA3
    GO
    Isoform 6 (identifier: Q76NI1-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1584: Missing.

    Show »
    Length:165
    Mass (Da):18,783
    Checksum:iEC85325473AD06D2
    GO

    Sequence cautioni

    The sequence BAB21859.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI17339.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti346 – 3461L → P in BAD12625. 1 PublicationCurated
    Sequence conflicti806 – 8061V → D in BAD12625. 1 PublicationCurated
    Sequence conflicti925 – 9251A → G in BAD12625. 1 PublicationCurated
    Sequence conflicti971 – 9711E → G in BAD12625. 1 PublicationCurated
    Sequence conflicti1072 – 10721S → P in BAD12625. 1 PublicationCurated
    Sequence conflicti1084 – 10841A → V in BAD12625. 1 PublicationCurated
    Sequence conflicti1260 – 12601A → T in BAD12625. 1 PublicationCurated
    Sequence conflicti1315 – 13151I → T in BAD12625. 1 PublicationCurated
    Sequence conflicti1468 – 14681S → G in BAD12625. 1 PublicationCurated
    Sequence conflicti1624 – 16241K → R in BAD12625. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti436 – 4361E → G.1 Publication
    Corresponds to variant rs3810964 [ dbSNP | Ensembl ].
    VAR_035358
    Natural varianti581 – 5811G → S.
    Corresponds to variant rs35152544 [ dbSNP | Ensembl ].
    VAR_035359
    Natural varianti717 – 7171L → P.1 Publication
    Corresponds to variant rs2998139 [ dbSNP | Ensembl ].
    VAR_035360
    Natural varianti1038 – 10381R → W.
    Corresponds to variant rs35604376 [ dbSNP | Ensembl ].
    VAR_061786
    Natural varianti1332 – 13321A → T.
    Corresponds to variant rs11101642 [ dbSNP | Ensembl ].
    VAR_051902

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 15841584Missing in isoform 6. 1 PublicationVSP_028592Add
    BLAST
    Alternative sequencei1 – 12581258Missing in isoform 5. 1 PublicationVSP_028593Add
    BLAST
    Alternative sequencei1 – 6565Missing in isoform 2 and isoform 3. 2 PublicationsVSP_028594Add
    BLAST
    Alternative sequencei1130 – 1396267ELEQQ…EDARP → VSPRPWHCRVGQGVSFQQSF LVTAGDRWHRVPRAPNRVTL VLVPPPRGCQDGQGPLPGLS STSRDRLVCTGAPGGSTSED REGLFSHGRPGDGFTGGPSM LVTRLRSVVFSVGQAQPPGP WAASLCSERKHQKRLPSKSR LGLVAAAWSGLSGQQCHPGS GAAATPPWPAGRGGLRPGSP GCRRGLQSSGRKVGPVTHSP DLGCILESPGTPGWMTGGAQ WPSAPGTSPTTVCLELSHRG KPPPASGHRSPSWGSSLLLS CRLLACTL in isoform 4. 1 PublicationVSP_028595Add
    BLAST
    Alternative sequencei1194 – 120613VMYAE…LEPCT → ASGLRAPLCPVRQ in isoform 2. 1 PublicationVSP_028596Add
    BLAST
    Alternative sequencei1207 – 1749543Missing in isoform 2. 1 PublicationVSP_028597Add
    BLAST
    Alternative sequencei1397 – 1749353Missing in isoform 4. 1 PublicationVSP_028598Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000781 mRNA. Translation: BAD12625.1.
    AB051555 mRNA. Translation: BAB21859.1. Different initiation.
    AK057756 mRNA. Translation: BAB71561.1.
    AK131205 mRNA. Translation: BAD18397.1.
    AL445199 Genomic DNA. Translation: CAM24665.1.
    AL445199 Genomic DNA. Translation: CAI17339.1. Sequence problems.
    AK074179 mRNA. Translation: BAB85005.1.
    CCDSiCCDS7674.1. [Q76NI1-1]
    RefSeqiNP_689856.6. NM_152643.6. [Q76NI1-1]
    UniGeneiHs.530685.

    Genome annotation databases

    EnsembliENST00000304613; ENSP00000304437; ENSG00000171798. [Q76NI1-1]
    ENST00000368571; ENSP00000357560; ENSG00000171798. [Q76NI1-2]
    GeneIDi85442.
    KEGGihsa:85442.
    UCSCiuc001llz.1. human. [Q76NI1-1]
    uc001lma.1. human. [Q76NI1-2]
    uc001lmb.1. human. [Q76NI1-4]

    Polymorphism databases

    DMDMi160013711.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000781 mRNA. Translation: BAD12625.1 .
    AB051555 mRNA. Translation: BAB21859.1 . Different initiation.
    AK057756 mRNA. Translation: BAB71561.1 .
    AK131205 mRNA. Translation: BAD18397.1 .
    AL445199 Genomic DNA. Translation: CAM24665.1 .
    AL445199 Genomic DNA. Translation: CAI17339.1 . Sequence problems.
    AK074179 mRNA. Translation: BAB85005.1 .
    CCDSi CCDS7674.1. [Q76NI1-1 ]
    RefSeqi NP_689856.6. NM_152643.6. [Q76NI1-1 ]
    UniGenei Hs.530685.

    3D structure databases

    ProteinModelPortali Q76NI1.
    SMRi Q76NI1. Positions 1508-1703.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124529. 2 interactions.
    IntActi Q76NI1. 2 interactions.
    STRINGi 9606.ENSP00000304437.

    PTM databases

    PhosphoSitei Q76NI1.

    Polymorphism databases

    DMDMi 160013711.

    Proteomic databases

    PaxDbi Q76NI1.
    PRIDEi Q76NI1.

    Protocols and materials databases

    DNASUi 85442.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304613 ; ENSP00000304437 ; ENSG00000171798 . [Q76NI1-1 ]
    ENST00000368571 ; ENSP00000357560 ; ENSG00000171798 . [Q76NI1-2 ]
    GeneIDi 85442.
    KEGGi hsa:85442.
    UCSCi uc001llz.1. human. [Q76NI1-1 ]
    uc001lma.1. human. [Q76NI1-2 ]
    uc001lmb.1. human. [Q76NI1-4 ]

    Organism-specific databases

    CTDi 85442.
    GeneCardsi GC10P134974.
    HGNCi HGNC:29374. KNDC1.
    HPAi HPA039624.
    neXtProti NX_Q76NI1.
    PharmGKBi PA134983621.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81994.
    HOVERGENi HBG108658.
    OrthoDBi EOG7P5T00.
    PhylomeDBi Q76NI1.
    TreeFami TF336009.

    Miscellaneous databases

    ChiTaRSi KNDC1. human.
    GenomeRNAii 85442.
    NextBioi 76025.
    PROi Q76NI1.

    Gene expression databases

    ArrayExpressi Q76NI1.
    Bgeei Q76NI1.
    CleanExi HS_KNDC1.
    Genevestigatori Q76NI1.

    Family and domain databases

    Gene3Di 1.10.840.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR011019. KIND.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view ]
    Pfami PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view ]
    SMARTi SM00750. KIND. 2 hits.
    SM00229. RasGEFN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 3 hits.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS51377. KIND. 2 hits.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel gene which is specifically expressed in human cerebral cortex."
      Yoshimoto M., Yazaki M., Matsumoto K., Takayama K.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, VARIANTS GLY-436 AND PRO-717.
      Tissue: Brain cortex.
    2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6).
      Tissue: Brain and Cerebellum.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 579-1749 (ISOFORM 4).
      Tissue: Spleen.

    Entry informationi

    Entry nameiVKIND_HUMAN
    AccessioniPrimary (citable) accession number: Q76NI1
    Secondary accession number(s): B0QZC5
    , Q5T233, Q6ZNH8, Q8TEE5, Q96LV7, Q9C095
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3