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Q76N32

- CEP68_HUMAN

UniProt

Q76N32 - CEP68_HUMAN

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Protein
Centrosomal protein of 68 kDa
Gene
CEP68, KIAA0582
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. centrosome organization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 68 kDa
Short name:
Cep68
Gene namesi
Name:CEP68
Synonyms:KIAA0582
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:29076. CEP68.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134991391.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757Centrosomal protein of 68 kDa
PRO_0000089494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei478 – 4781Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ76N32.
PaxDbiQ76N32.
PRIDEiQ76N32.

PTM databases

PhosphoSiteiQ76N32.

Expressioni

Gene expression databases

ArrayExpressiQ76N32.
BgeeiQ76N32.
CleanExiHS_CEP68.
GenevestigatoriQ76N32.

Organism-specific databases

HPAiHPA040493.
HPA040620.

Interactioni

Protein-protein interaction databases

BioGridi116789. 2 interactions.
IntActiQ76N32. 1 interaction.
MINTiMINT-7034577.
STRINGi9606.ENSP00000367229.

Structurei

3D structure databases

ProteinModelPortaliQ76N32.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi532 – 5376Poly-Ser

Phylogenomic databases

eggNOGiNOG44343.
HOVERGENiHBG050898.
InParanoidiQ76N32.
KOiK16764.
OMAiLSFQAEY.
OrthoDBiEOG7NW68J.
PhylomeDBiQ76N32.
TreeFamiTF333570.

Family and domain databases

InterProiIPR026696. AKAP6/CEP68.
[Graphical view]
PANTHERiPTHR14514. PTHR14514. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q76N32-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALGEEKAEA EASEDTKAQS YGRGSCRERE LDIPGPMSGE QPPRLEAEGG    50
LISPVWGAEG IPAPTCWIGT DPGGPSRAHQ PQASDANREP VAERSEPALS 100
GLPPATMGSG DLLLSGESQV EKTKLSSSEE FPQTLSLPRT TTICSGHDAD 150
TEDDPSLADL PQALDLSQQP HSSGLSCLSQ WKSVLSPGSA AQPSSCSISA 200
SSTGSSLQGH QERAEPRGGS LAKVSSSLEP VVPQEPSSVV GLGPRPQWSP 250
QPVFSGGDAS GLGRRRLSFQ AEYWACVLPD SLPPSPDRHS PLWNPNKEYE 300
DLLDYTYPLR PGPQLPKHLD SRVPADPVLQ DSGVDLDSFS VSPASTLKSP 350
TNVSPNCPPA EATALPFSGP REPSLKQWPS RVPQKQGGMG LASWSQLAST 400
PRAPGSRDAR WERREPALRG AKDRLTIGKH LDMGSPQLRT RDRGWPSPRP 450
EREKRTSQSA RRPTCTESRW KSEEEVESDD EYLALPARLT QVSSLVSYLG 500
SISTLVTLPT GDIKGQSPLE VSDSDGPASF PSSSSQSQLP PGAALQGSGD 550
PEGQNPCFLR SFVRAHDSAG EGSLGSSQAL GVSSGLLKTR PSLPARLDRW 600
PFSDPDVEGQ LPRKGGEQGK ESLVQCVKTF CCQLEELICW LYNVADVTDH 650
GTAARSNLTS LKSSLQLYRQ FKKDIDEHQS LTESVLQKGE ILLQCLLENT 700
PVLEDVLGRI AKQSGELESH ADRLYDSILA SLDMLAGCTL IPDKKPMAAM 750
EHPCEGV 757
Length:757
Mass (Da):81,102
Last modified:April 26, 2005 - v2
Checksum:i3FC969065CD5D2D7
GO
Isoform 2 (identifier: Q76N32-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     492-628: Missing.

Note: No experimental confirmation available.

Show »
Length:620
Mass (Da):67,040
Checksum:iB4E2D7D474AD4134
GO

Sequence cautioni

The sequence BAA25508.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271R → G.
Corresponds to variant rs12611491 [ dbSNP | Ensembl ].
VAR_050794
Natural varianti74 – 741G → S.1 Publication
Corresponds to variant rs7572857 [ dbSNP | Ensembl ].
VAR_022363
Natural varianti397 – 3971L → P.
Corresponds to variant rs35501092 [ dbSNP | Ensembl ].
VAR_050795
Natural varianti462 – 4621R → C.
Corresponds to variant rs35694840 [ dbSNP | Ensembl ].
VAR_050796
Natural varianti473 – 4731E → Q.
Corresponds to variant rs35089924 [ dbSNP | Ensembl ].
VAR_050797

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei492 – 628137Missing in isoform 2.
VSP_013476Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011154 mRNA. Translation: BAA25508.2. Different initiation.
AC007386 Genomic DNA. Translation: AAF03518.2.
AK299373 mRNA. Translation: BAG61363.1.
CH471053 Genomic DNA. Translation: EAW99926.1.
CH471053 Genomic DNA. Translation: EAW99927.1.
CH471053 Genomic DNA. Translation: EAW99928.1.
CH471053 Genomic DNA. Translation: EAW99929.1.
BC002982 mRNA. Translation: AAH02982.1.
BC004873 mRNA. Translation: AAH04873.1.
CCDSiCCDS1880.2. [Q76N32-1]
RefSeqiNP_055962.2. NM_015147.2. [Q76N32-1]
XP_005264275.1. XM_005264218.2. [Q76N32-1]
UniGeneiHs.709257.

Genome annotation databases

EnsembliENST00000260569; ENSP00000260569; ENSG00000011523. [Q76N32-2]
ENST00000377990; ENSP00000367229; ENSG00000011523. [Q76N32-1]
GeneIDi23177.
KEGGihsa:23177.
UCSCiuc002sdk.4. human. [Q76N32-2]
uc002sdl.4. human. [Q76N32-1]

Polymorphism databases

DMDMi62899863.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011154 mRNA. Translation: BAA25508.2 . Different initiation.
AC007386 Genomic DNA. Translation: AAF03518.2 .
AK299373 mRNA. Translation: BAG61363.1 .
CH471053 Genomic DNA. Translation: EAW99926.1 .
CH471053 Genomic DNA. Translation: EAW99927.1 .
CH471053 Genomic DNA. Translation: EAW99928.1 .
CH471053 Genomic DNA. Translation: EAW99929.1 .
BC002982 mRNA. Translation: AAH02982.1 .
BC004873 mRNA. Translation: AAH04873.1 .
CCDSi CCDS1880.2. [Q76N32-1 ]
RefSeqi NP_055962.2. NM_015147.2. [Q76N32-1 ]
XP_005264275.1. XM_005264218.2. [Q76N32-1 ]
UniGenei Hs.709257.

3D structure databases

ProteinModelPortali Q76N32.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116789. 2 interactions.
IntActi Q76N32. 1 interaction.
MINTi MINT-7034577.
STRINGi 9606.ENSP00000367229.

PTM databases

PhosphoSitei Q76N32.

Polymorphism databases

DMDMi 62899863.

Proteomic databases

MaxQBi Q76N32.
PaxDbi Q76N32.
PRIDEi Q76N32.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000260569 ; ENSP00000260569 ; ENSG00000011523 . [Q76N32-2 ]
ENST00000377990 ; ENSP00000367229 ; ENSG00000011523 . [Q76N32-1 ]
GeneIDi 23177.
KEGGi hsa:23177.
UCSCi uc002sdk.4. human. [Q76N32-2 ]
uc002sdl.4. human. [Q76N32-1 ]

Organism-specific databases

CTDi 23177.
GeneCardsi GC02P065283.
HGNCi HGNC:29076. CEP68.
HPAi HPA040493.
HPA040620.
neXtProti NX_Q76N32.
PharmGKBi PA134991391.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44343.
HOVERGENi HBG050898.
InParanoidi Q76N32.
KOi K16764.
OMAi LSFQAEY.
OrthoDBi EOG7NW68J.
PhylomeDBi Q76N32.
TreeFami TF333570.

Miscellaneous databases

GeneWikii CEP68.
GenomeRNAii 23177.
NextBioi 44621.
PROi Q76N32.

Gene expression databases

ArrayExpressi Q76N32.
Bgeei Q76N32.
CleanExi HS_CEP68.
Genevestigatori Q76N32.

Family and domain databases

InterProi IPR026696. AKAP6/CEP68.
[Graphical view ]
PANTHERi PTHR14514. PTHR14514. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-74.
    Tissue: Lymph.
  7. "Proteomic characterization of the human centrosome by protein correlation profiling."
    Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
    Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Lymphoblast.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-478, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiCEP68_HUMAN
AccessioniPrimary (citable) accession number: Q76N32
Secondary accession number(s): B4DRQ1
, D6W5F1, D6W5F2, O60326, Q9BQ18, Q9UDM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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