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Q76N32 (CEP68_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Centrosomal protein of 68 kDa

Short name=Cep68
Gene names
Name:CEP68
Synonyms:KIAA0582
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length757 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome Ref.7.

Sequence caution

The sequence BAA25508.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityAlternative splicing
Polymorphism
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcentrosome organization

Inferred from mutant phenotype PubMed 18042621. Source: UniProtKB

   Cellular_componentcentrosome

Inferred from direct assay PubMed 18042621PubMed 21399614. Source: UniProtKB

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q76N32-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q76N32-2)

The sequence of this isoform differs from the canonical sequence as follows:
     492-628: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 757757Centrosomal protein of 68 kDa
PRO_0000089494

Regions

Compositional bias532 – 5376Poly-Ser

Amino acid modifications

Modified residue4781Phosphoserine Ref.8

Natural variations

Alternative sequence492 – 628137Missing in isoform 2.
VSP_013476
Natural variant271R → G.
Corresponds to variant rs12611491 [ dbSNP | Ensembl ].
VAR_050794
Natural variant741G → S. Ref.6
Corresponds to variant rs7572857 [ dbSNP | Ensembl ].
VAR_022363
Natural variant3971L → P.
Corresponds to variant rs35501092 [ dbSNP | Ensembl ].
VAR_050795
Natural variant4621R → C.
Corresponds to variant rs35694840 [ dbSNP | Ensembl ].
VAR_050796
Natural variant4731E → Q.
Corresponds to variant rs35089924 [ dbSNP | Ensembl ].
VAR_050797

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 26, 2005. Version 2.
Checksum: 3FC969065CD5D2D7

FASTA75781,102
        10         20         30         40         50         60 
MALGEEKAEA EASEDTKAQS YGRGSCRERE LDIPGPMSGE QPPRLEAEGG LISPVWGAEG 

        70         80         90        100        110        120 
IPAPTCWIGT DPGGPSRAHQ PQASDANREP VAERSEPALS GLPPATMGSG DLLLSGESQV 

       130        140        150        160        170        180 
EKTKLSSSEE FPQTLSLPRT TTICSGHDAD TEDDPSLADL PQALDLSQQP HSSGLSCLSQ 

       190        200        210        220        230        240 
WKSVLSPGSA AQPSSCSISA SSTGSSLQGH QERAEPRGGS LAKVSSSLEP VVPQEPSSVV 

       250        260        270        280        290        300 
GLGPRPQWSP QPVFSGGDAS GLGRRRLSFQ AEYWACVLPD SLPPSPDRHS PLWNPNKEYE 

       310        320        330        340        350        360 
DLLDYTYPLR PGPQLPKHLD SRVPADPVLQ DSGVDLDSFS VSPASTLKSP TNVSPNCPPA 

       370        380        390        400        410        420 
EATALPFSGP REPSLKQWPS RVPQKQGGMG LASWSQLAST PRAPGSRDAR WERREPALRG 

       430        440        450        460        470        480 
AKDRLTIGKH LDMGSPQLRT RDRGWPSPRP EREKRTSQSA RRPTCTESRW KSEEEVESDD 

       490        500        510        520        530        540 
EYLALPARLT QVSSLVSYLG SISTLVTLPT GDIKGQSPLE VSDSDGPASF PSSSSQSQLP 

       550        560        570        580        590        600 
PGAALQGSGD PEGQNPCFLR SFVRAHDSAG EGSLGSSQAL GVSSGLLKTR PSLPARLDRW 

       610        620        630        640        650        660 
PFSDPDVEGQ LPRKGGEQGK ESLVQCVKTF CCQLEELICW LYNVADVTDH GTAARSNLTS 

       670        680        690        700        710        720 
LKSSLQLYRQ FKKDIDEHQS LTESVLQKGE ILLQCLLENT PVLEDVLGRI AKQSGELESH 

       730        740        750 
ADRLYDSILA SLDMLAGCTL IPDKKPMAAM EHPCEGV 

« Hide

Isoform 2 [UniParc].

Checksum: B4E2D7D474AD4134
Show »

FASTA62067,040

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-74.
Tissue: Lymph.
[7]"Proteomic characterization of the human centrosome by protein correlation profiling."
Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Lymphoblast.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-478, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB011154 mRNA. Translation: BAA25508.2. Different initiation.
AC007386 Genomic DNA. Translation: AAF03518.2.
AK299373 mRNA. Translation: BAG61363.1.
CH471053 Genomic DNA. Translation: EAW99926.1.
CH471053 Genomic DNA. Translation: EAW99927.1.
CH471053 Genomic DNA. Translation: EAW99928.1.
CH471053 Genomic DNA. Translation: EAW99929.1.
BC002982 mRNA. Translation: AAH02982.1.
BC004873 mRNA. Translation: AAH04873.1.
CCDSCCDS1880.2. [Q76N32-1]
RefSeqNP_055962.2. NM_015147.2. [Q76N32-1]
XP_005264275.1. XM_005264218.2. [Q76N32-1]
UniGeneHs.709257.

3D structure databases

ProteinModelPortalQ76N32.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116789. 2 interactions.
IntActQ76N32. 1 interaction.
MINTMINT-7034577.
STRING9606.ENSP00000367229.

PTM databases

PhosphoSiteQ76N32.

Polymorphism databases

DMDM62899863.

Proteomic databases

MaxQBQ76N32.
PaxDbQ76N32.
PRIDEQ76N32.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000260569; ENSP00000260569; ENSG00000011523. [Q76N32-2]
ENST00000377990; ENSP00000367229; ENSG00000011523. [Q76N32-1]
GeneID23177.
KEGGhsa:23177.
UCSCuc002sdk.4. human. [Q76N32-2]
uc002sdl.4. human. [Q76N32-1]

Organism-specific databases

CTD23177.
GeneCardsGC02P065283.
HGNCHGNC:29076. CEP68.
HPAHPA040493.
HPA040620.
neXtProtNX_Q76N32.
PharmGKBPA134991391.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44343.
HOVERGENHBG050898.
InParanoidQ76N32.
KOK16764.
OMALSFQAEY.
OrthoDBEOG7NW68J.
PhylomeDBQ76N32.
TreeFamTF333570.

Gene expression databases

ArrayExpressQ76N32.
BgeeQ76N32.
CleanExHS_CEP68.
GenevestigatorQ76N32.

Family and domain databases

InterProIPR026696. AKAP6/CEP68.
[Graphical view]
PANTHERPTHR14514. PTHR14514. 1 hit.
ProtoNetSearch...

Other

GeneWikiCEP68.
GenomeRNAi23177.
NextBio44621.
PROQ76N32.

Entry information

Entry nameCEP68_HUMAN
AccessionPrimary (citable) accession number: Q76N32
Secondary accession number(s): B4DRQ1 expand/collapse secondary AC list , D6W5F1, D6W5F2, O60326, Q9BQ18, Q9UDM9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM