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Q76N32

- CEP68_HUMAN

UniProt

Q76N32 - CEP68_HUMAN

Protein

Centrosomal protein of 68 kDa

Gene

CEP68

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein domain specific binding Source: UniProtKB
    2. protein kinase binding Source: UniProtKB

    GO - Biological processi

    1. centriole-centriole cohesion Source: UniProtKB
    2. centrosome organization Source: UniProtKB
    3. protein localization to organelle Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centrosomal protein of 68 kDa
    Short name:
    Cep68
    Gene namesi
    Name:CEP68
    Synonyms:KIAA0582
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:29076. CEP68.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134991391.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 757757Centrosomal protein of 68 kDaPRO_0000089494Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei478 – 4781Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ76N32.
    PaxDbiQ76N32.
    PRIDEiQ76N32.

    PTM databases

    PhosphoSiteiQ76N32.

    Expressioni

    Gene expression databases

    ArrayExpressiQ76N32.
    BgeeiQ76N32.
    CleanExiHS_CEP68.
    GenevestigatoriQ76N32.

    Organism-specific databases

    HPAiHPA040493.
    HPA040620.

    Interactioni

    Protein-protein interaction databases

    BioGridi116789. 2 interactions.
    IntActiQ76N32. 1 interaction.
    MINTiMINT-7034577.
    STRINGi9606.ENSP00000367229.

    Structurei

    3D structure databases

    ProteinModelPortaliQ76N32.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi532 – 5376Poly-Ser

    Phylogenomic databases

    eggNOGiNOG44343.
    HOVERGENiHBG050898.
    InParanoidiQ76N32.
    KOiK16764.
    OMAiLSFQAEY.
    OrthoDBiEOG7NW68J.
    PhylomeDBiQ76N32.
    TreeFamiTF333570.

    Family and domain databases

    InterProiIPR026696. AKAP6/CEP68.
    [Graphical view]
    PANTHERiPTHR14514. PTHR14514. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q76N32-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALGEEKAEA EASEDTKAQS YGRGSCRERE LDIPGPMSGE QPPRLEAEGG    50
    LISPVWGAEG IPAPTCWIGT DPGGPSRAHQ PQASDANREP VAERSEPALS 100
    GLPPATMGSG DLLLSGESQV EKTKLSSSEE FPQTLSLPRT TTICSGHDAD 150
    TEDDPSLADL PQALDLSQQP HSSGLSCLSQ WKSVLSPGSA AQPSSCSISA 200
    SSTGSSLQGH QERAEPRGGS LAKVSSSLEP VVPQEPSSVV GLGPRPQWSP 250
    QPVFSGGDAS GLGRRRLSFQ AEYWACVLPD SLPPSPDRHS PLWNPNKEYE 300
    DLLDYTYPLR PGPQLPKHLD SRVPADPVLQ DSGVDLDSFS VSPASTLKSP 350
    TNVSPNCPPA EATALPFSGP REPSLKQWPS RVPQKQGGMG LASWSQLAST 400
    PRAPGSRDAR WERREPALRG AKDRLTIGKH LDMGSPQLRT RDRGWPSPRP 450
    EREKRTSQSA RRPTCTESRW KSEEEVESDD EYLALPARLT QVSSLVSYLG 500
    SISTLVTLPT GDIKGQSPLE VSDSDGPASF PSSSSQSQLP PGAALQGSGD 550
    PEGQNPCFLR SFVRAHDSAG EGSLGSSQAL GVSSGLLKTR PSLPARLDRW 600
    PFSDPDVEGQ LPRKGGEQGK ESLVQCVKTF CCQLEELICW LYNVADVTDH 650
    GTAARSNLTS LKSSLQLYRQ FKKDIDEHQS LTESVLQKGE ILLQCLLENT 700
    PVLEDVLGRI AKQSGELESH ADRLYDSILA SLDMLAGCTL IPDKKPMAAM 750
    EHPCEGV 757
    Length:757
    Mass (Da):81,102
    Last modified:April 26, 2005 - v2
    Checksum:i3FC969065CD5D2D7
    GO
    Isoform 2 (identifier: Q76N32-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         492-628: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:620
    Mass (Da):67,040
    Checksum:iB4E2D7D474AD4134
    GO

    Sequence cautioni

    The sequence BAA25508.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271R → G.
    Corresponds to variant rs12611491 [ dbSNP | Ensembl ].
    VAR_050794
    Natural varianti74 – 741G → S.1 Publication
    Corresponds to variant rs7572857 [ dbSNP | Ensembl ].
    VAR_022363
    Natural varianti397 – 3971L → P.
    Corresponds to variant rs35501092 [ dbSNP | Ensembl ].
    VAR_050795
    Natural varianti462 – 4621R → C.
    Corresponds to variant rs35694840 [ dbSNP | Ensembl ].
    VAR_050796
    Natural varianti473 – 4731E → Q.
    Corresponds to variant rs35089924 [ dbSNP | Ensembl ].
    VAR_050797

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei492 – 628137Missing in isoform 2. 1 PublicationVSP_013476Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011154 mRNA. Translation: BAA25508.2. Different initiation.
    AC007386 Genomic DNA. Translation: AAF03518.2.
    AK299373 mRNA. Translation: BAG61363.1.
    CH471053 Genomic DNA. Translation: EAW99926.1.
    CH471053 Genomic DNA. Translation: EAW99927.1.
    CH471053 Genomic DNA. Translation: EAW99928.1.
    CH471053 Genomic DNA. Translation: EAW99929.1.
    BC002982 mRNA. Translation: AAH02982.1.
    BC004873 mRNA. Translation: AAH04873.1.
    CCDSiCCDS1880.2. [Q76N32-1]
    RefSeqiNP_055962.2. NM_015147.2. [Q76N32-1]
    XP_005264275.1. XM_005264218.2. [Q76N32-1]
    UniGeneiHs.709257.

    Genome annotation databases

    EnsembliENST00000260569; ENSP00000260569; ENSG00000011523. [Q76N32-2]
    ENST00000377990; ENSP00000367229; ENSG00000011523. [Q76N32-1]
    GeneIDi23177.
    KEGGihsa:23177.
    UCSCiuc002sdk.4. human. [Q76N32-2]
    uc002sdl.4. human. [Q76N32-1]

    Polymorphism databases

    DMDMi62899863.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011154 mRNA. Translation: BAA25508.2 . Different initiation.
    AC007386 Genomic DNA. Translation: AAF03518.2 .
    AK299373 mRNA. Translation: BAG61363.1 .
    CH471053 Genomic DNA. Translation: EAW99926.1 .
    CH471053 Genomic DNA. Translation: EAW99927.1 .
    CH471053 Genomic DNA. Translation: EAW99928.1 .
    CH471053 Genomic DNA. Translation: EAW99929.1 .
    BC002982 mRNA. Translation: AAH02982.1 .
    BC004873 mRNA. Translation: AAH04873.1 .
    CCDSi CCDS1880.2. [Q76N32-1 ]
    RefSeqi NP_055962.2. NM_015147.2. [Q76N32-1 ]
    XP_005264275.1. XM_005264218.2. [Q76N32-1 ]
    UniGenei Hs.709257.

    3D structure databases

    ProteinModelPortali Q76N32.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116789. 2 interactions.
    IntActi Q76N32. 1 interaction.
    MINTi MINT-7034577.
    STRINGi 9606.ENSP00000367229.

    PTM databases

    PhosphoSitei Q76N32.

    Polymorphism databases

    DMDMi 62899863.

    Proteomic databases

    MaxQBi Q76N32.
    PaxDbi Q76N32.
    PRIDEi Q76N32.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260569 ; ENSP00000260569 ; ENSG00000011523 . [Q76N32-2 ]
    ENST00000377990 ; ENSP00000367229 ; ENSG00000011523 . [Q76N32-1 ]
    GeneIDi 23177.
    KEGGi hsa:23177.
    UCSCi uc002sdk.4. human. [Q76N32-2 ]
    uc002sdl.4. human. [Q76N32-1 ]

    Organism-specific databases

    CTDi 23177.
    GeneCardsi GC02P065283.
    HGNCi HGNC:29076. CEP68.
    HPAi HPA040493.
    HPA040620.
    neXtProti NX_Q76N32.
    PharmGKBi PA134991391.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44343.
    HOVERGENi HBG050898.
    InParanoidi Q76N32.
    KOi K16764.
    OMAi LSFQAEY.
    OrthoDBi EOG7NW68J.
    PhylomeDBi Q76N32.
    TreeFami TF333570.

    Miscellaneous databases

    GeneWikii CEP68.
    GenomeRNAii 23177.
    NextBioi 44621.
    PROi Q76N32.

    Gene expression databases

    ArrayExpressi Q76N32.
    Bgeei Q76N32.
    CleanExi HS_CEP68.
    Genevestigatori Q76N32.

    Family and domain databases

    InterProi IPR026696. AKAP6/CEP68.
    [Graphical view ]
    PANTHERi PTHR14514. PTHR14514. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-74.
      Tissue: Lymph.
    7. "Proteomic characterization of the human centrosome by protein correlation profiling."
      Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
      Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Lymphoblast.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-478, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiCEP68_HUMAN
    AccessioniPrimary (citable) accession number: Q76N32
    Secondary accession number(s): B4DRQ1
    , D6W5F1, D6W5F2, O60326, Q9BQ18, Q9UDM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3