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Q76M96

- CCD80_HUMAN

UniProt

Q76M96 - CCD80_HUMAN

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Protein

Coiled-coil domain-containing protein 80

Gene

CCDC80

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Promotes cell adhesion and matrix assembly.By similarity

GO - Molecular functioni

  1. heparin binding Source: Ensembl

GO - Biological processi

  1. extracellular matrix organization Source: Ensembl
  2. positive regulation of cell-substrate adhesion Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 80
Alternative name(s):
Down-regulated by oncogenes protein 1
Up-regulated in BRS-3 deficient mouse homolog
Gene namesi
Name:CCDC80
Synonyms:DRO1, URB
ORF Names:HBE245
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30649. CCDC80.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: Ensembl
  2. interstitial matrix Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596470.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 950929Coiled-coil domain-containing protein 80PRO_0000282418Add
BLAST

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ76M96.
PaxDbiQ76M96.
PeptideAtlasiQ76M96.
PRIDEiQ76M96.

PTM databases

PhosphoSiteiQ76M96.

Expressioni

Tissue specificityi

Expressed in dermal papilla and dermal fibroblasts (at protein level). Expressed in heart, thymus, placenta, pancreas, colon, epithelium, spleen and osteoblasts.3 Publications

Inductioni

Down-regulated in cancer and after osteoblastic differentiation. Up-regulated by dihydrotestosterone (DHT).2 Publications

Gene expression databases

BgeeiQ76M96.
CleanExiHS_CCDC80.
ExpressionAtlasiQ76M96. baseline and differential.
GenevestigatoriQ76M96.

Organism-specific databases

HPAiCAB025158.
HPA002266.

Interactioni

Subunit structurei

Binds to various extracellular matrix proteins.By similarity

Protein-protein interaction databases

BioGridi127410. 1 interaction.
IntActiQ76M96. 3 interactions.
STRINGi9606.ENSP00000206423.

Structurei

3D structure databases

ProteinModelPortaliQ76M96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili560 – 58728Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi347 – 40458Thr-richAdd
BLAST
Compositional biasi486 – 610125Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the CCDC80 family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG42473.
GeneTreeiENSGT00730000110685.
HOVERGENiHBG104210.
InParanoidiQ76M96.
OMAiAMYEVID.
OrthoDBiEOG72G170.
PhylomeDBiQ76M96.
TreeFamiTF332926.

Family and domain databases

InterProiIPR025232. DUF4174.
[Graphical view]
PfamiPF13778. DUF4174. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q76M96-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTWRMGPRFT MLLAMWLVCG SEPHPHATIR GSHGGRKVPL VSPDSSRPAR
60 70 80 90 100
FLRHTGRSRG IERSTLEEPN LQPLQRRRSV PVLRLARPTE PPARSDINGA
110 120 130 140 150
AVRPEQRPAA RGSPREMIRD EGSSARSRML RFPSGSSSPN ILASFAGKNR
160 170 180 190 200
VWVISAPHAS EGYYRLMMSL LKDDVYCELA ERHIQQIVLF HQAGEEGGKV
210 220 230 240 250
RRITSEGQIL EQPLDPSLIP KLMSFLKLEK GKFGMVLLKK TLQVEERYPY
260 270 280 290 300
PVRLEAMYEV IDQGPIRRIE KIRQKGFVQK CKASGVEGQV VAEGNDGGGG
310 320 330 340 350
AGRPSLGSEK KKEDPRRAQV PPTRESRVKV LRKLAATAPA LPQPPSTPRA
360 370 380 390 400
TTLPPAPATT VTRSTSRAVT VAARPMTTTA FPTTQRPWTP SPSHRPPTTT
410 420 430 440 450
EVITARRPSV SENLYPPSRK DQHRERPQTT RRPSKATSLE SFTNAPPTTI
460 470 480 490 500
SEPSTRAAGP GRFRDNRMDR REHGHRDPNV VPGPPKPAKE KPPKKKAQDK
510 520 530 540 550
ILSNEYEEKY DLSRPTASQL EDELQVGNVP LKKAKESKKH EKLEKPEKEK
560 570 580 590 600
KKKMKNENAD KLLKSEKQMK KSEKKSKQEK EKSKKKKGGK TEQDGYQKPT
610 620 630 640 650
NKHFTQSPKK SVADLLGSFE GKRRLLLITA PKAENNMYVQ QRDEYLESFC
660 670 680 690 700
KMATRKISVI TIFGPVNNST MKIDHFQLDN EKPMRVVDDE DLVDQRLISE
710 720 730 740 750
LRKEYGMTYN DFFMVLTDVD LRVKQYYEVP ITMKSVFDLI DTFQSRIKDM
760 770 780 790 800
EKQKKEGIVC KEDKKQSLEN FLSRFRWRRR LLVISAPNDE DWAYSQQLSA
810 820 830 840 850
LSGQACNFGL RHITILKLLG VGEEVGGVLE LFPINGSSVV EREDVPAHLV
860 870 880 890 900
KDIRNYFQVS PEYFSMLLVG KDGNVKSWYP SPMWSMVIVY DLIDSMQLRR
910 920 930 940 950
QEMAIQQSLG MRCPEDEYAG YGYHSYHQGY QDGYQDDYRH HESYHHGYPY
Length:950
Mass (Da):108,174
Last modified:July 5, 2004 - v1
Checksum:i67A1D4A7DD907AA0
GO
Isoform 2 (identifier: Q76M96-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTSVHRKVDYTM

Show »
Length:961
Mass (Da):109,492
Checksum:i9EAE839A541AADF3
GO
Isoform 3 (identifier: Q76M96-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-865: Missing.

Show »
Length:85
Mass (Da):10,174
Checksum:iF43811D3541675A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti411 – 4111S → L in BAC11475. (PubMed:14702039)Curated
Sequence conflicti549 – 5491E → K in AAH86876. (PubMed:15489334)Curated
Sequence conflicti551 – 5511K → E in AAH86876. (PubMed:15489334)Curated
Sequence conflicti837 – 8371S → G in AAH73164. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 865865Missing in isoform 3. 1 PublicationVSP_024135Add
BLAST
Alternative sequencei1 – 11M → MTSVHRKVDYTM in isoform 2. 1 PublicationVSP_024136

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY333429 mRNA. Translation: AAQ96742.1.
AY548106 mRNA. Translation: AAS66643.1.
AY548107 mRNA. Translation: AAS66644.1.
AY526612 mRNA. Translation: AAS92235.1.
AB052098 mRNA. Translation: BAD05134.1.
AF506819 mRNA. Translation: AAM33633.1.
BX647817 mRNA. Translation: CAH56167.1.
BX647117 mRNA. Translation: CAH56178.1.
AL833034 mRNA. Translation: CAH56325.1.
CH471052 Genomic DNA. Translation: EAW79663.1.
CH471052 Genomic DNA. Translation: EAW79665.1.
BC042105 mRNA. Translation: AAH42105.1.
BC073164 mRNA. Translation: AAH73164.1.
BC086876 mRNA. Translation: AAH86876.1.
BC110842 mRNA. Translation: AAI10843.1.
BC116178 mRNA. Translation: AAI16179.1.
AK075210 mRNA. Translation: BAC11475.1.
CCDSiCCDS2968.1. [Q76M96-1]
RefSeqiNP_955805.1. NM_199511.2. [Q76M96-1]
NP_955806.1. NM_199512.2. [Q76M96-1]
XP_005247192.1. XM_005247135.1. [Q76M96-2]
UniGeneiHs.477128.

Genome annotation databases

EnsembliENST00000206423; ENSP00000206423; ENSG00000091986. [Q76M96-1]
ENST00000439685; ENSP00000411814; ENSG00000091986. [Q76M96-1]
GeneIDi151887.
KEGGihsa:151887.
UCSCiuc003dzf.3. human. [Q76M96-1]

Polymorphism databases

DMDMi74712933.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY333429 mRNA. Translation: AAQ96742.1 .
AY548106 mRNA. Translation: AAS66643.1 .
AY548107 mRNA. Translation: AAS66644.1 .
AY526612 mRNA. Translation: AAS92235.1 .
AB052098 mRNA. Translation: BAD05134.1 .
AF506819 mRNA. Translation: AAM33633.1 .
BX647817 mRNA. Translation: CAH56167.1 .
BX647117 mRNA. Translation: CAH56178.1 .
AL833034 mRNA. Translation: CAH56325.1 .
CH471052 Genomic DNA. Translation: EAW79663.1 .
CH471052 Genomic DNA. Translation: EAW79665.1 .
BC042105 mRNA. Translation: AAH42105.1 .
BC073164 mRNA. Translation: AAH73164.1 .
BC086876 mRNA. Translation: AAH86876.1 .
BC110842 mRNA. Translation: AAI10843.1 .
BC116178 mRNA. Translation: AAI16179.1 .
AK075210 mRNA. Translation: BAC11475.1 .
CCDSi CCDS2968.1. [Q76M96-1 ]
RefSeqi NP_955805.1. NM_199511.2. [Q76M96-1 ]
NP_955806.1. NM_199512.2. [Q76M96-1 ]
XP_005247192.1. XM_005247135.1. [Q76M96-2 ]
UniGenei Hs.477128.

3D structure databases

ProteinModelPortali Q76M96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127410. 1 interaction.
IntActi Q76M96. 3 interactions.
STRINGi 9606.ENSP00000206423.

PTM databases

PhosphoSitei Q76M96.

Polymorphism databases

DMDMi 74712933.

Proteomic databases

MaxQBi Q76M96.
PaxDbi Q76M96.
PeptideAtlasi Q76M96.
PRIDEi Q76M96.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000206423 ; ENSP00000206423 ; ENSG00000091986 . [Q76M96-1 ]
ENST00000439685 ; ENSP00000411814 ; ENSG00000091986 . [Q76M96-1 ]
GeneIDi 151887.
KEGGi hsa:151887.
UCSCi uc003dzf.3. human. [Q76M96-1 ]

Organism-specific databases

CTDi 151887.
GeneCardsi GC03M112323.
H-InvDB HIX0003550.
HGNCi HGNC:30649. CCDC80.
HPAi CAB025158.
HPA002266.
MIMi 608298. gene.
neXtProti NX_Q76M96.
PharmGKBi PA144596470.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42473.
GeneTreei ENSGT00730000110685.
HOVERGENi HBG104210.
InParanoidi Q76M96.
OMAi AMYEVID.
OrthoDBi EOG72G170.
PhylomeDBi Q76M96.
TreeFami TF332926.

Miscellaneous databases

ChiTaRSi CCDC80. human.
GeneWikii CCDC80.
GenomeRNAii 151887.
NextBioi 86811.
PROi Q76M96.
SOURCEi Search...

Gene expression databases

Bgeei Q76M96.
CleanExi HS_CCDC80.
ExpressionAtlasi Q76M96. baseline and differential.
Genevestigatori Q76M96.

Family and domain databases

InterProi IPR025232. DUF4174.
[Graphical view ]
Pfami PF13778. DUF4174. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "URB expression in human bone marrow stromal cells and during mouse development."
    Liu Y., Monticone M., Tonachini L., Mastrogiacomo M., Marigo V., Cancedda R., Castagnola P.
    Biochem. Biophys. Res. Commun. 322:497-507(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, TISSUE SPECIFICITY.
    Tissue: Hair follicle dermal papilla.
  2. "DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells."
    Bommer G.T., Jaeger C., Duerr E.M., Baehs S., Eichhorst S.T., Brabletz T., Hu G., Froehlich T., Arnold G., Kress D.C., Goeke B., Fearon E.R., Kolligs F.T.
    J. Biol. Chem. 280:7962-7975(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
    Tissue: Hair follicle dermal papilla.
  4. "A novel gene from human brain endothelial cell PCR select library."
    Yonezawa T., Ninomiya Y.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain endothelium.
  5. Guo J.H., Yu L.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon endothelium, Endometrium and Stomach.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain, Chondrosarcoma and PNS.
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-583 (ISOFORM 2).
    Tissue: Placenta.

Entry informationi

Entry nameiCCD80_HUMAN
AccessioniPrimary (citable) accession number: Q76M96
Secondary accession number(s): D3DN67
, Q5PR20, Q6GPG9, Q8IVT6, Q8NBV1, Q8NHY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3