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Q76M96

- CCD80_HUMAN

UniProt

Q76M96 - CCD80_HUMAN

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Protein
Coiled-coil domain-containing protein 80
Gene
CCDC80, DRO1, URB, HBE245
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Promotes cell adhesion and matrix assembly By similarity.

GO - Molecular functioni

  1. heparin binding Source: Ensembl

GO - Biological processi

  1. extracellular matrix organization Source: Ensembl
  2. positive regulation of cell-substrate adhesion Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 80
Alternative name(s):
Down-regulated by oncogenes protein 1
Up-regulated in BRS-3 deficient mouse homolog
Gene namesi
Name:CCDC80
Synonyms:DRO1, URB
ORF Names:HBE245
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30649. CCDC80.

Subcellular locationi

Secretedextracellular spaceextracellular matrix By similarity 1 Publication

GO - Cellular componenti

  1. basement membrane Source: Ensembl
  2. interstitial matrix Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596470.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 950929Coiled-coil domain-containing protein 80
PRO_0000282418Add
BLAST

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ76M96.
PaxDbiQ76M96.
PeptideAtlasiQ76M96.
PRIDEiQ76M96.

PTM databases

PhosphoSiteiQ76M96.

Expressioni

Tissue specificityi

Expressed in dermal papilla and dermal fibroblasts (at protein level). Expressed in heart, thymus, placenta, pancreas, colon, epithelium, spleen and osteoblasts.3 Publications

Inductioni

Down-regulated in cancer and after osteoblastic differentiation. Up-regulated by dihydrotestosterone (DHT).2 Publications

Gene expression databases

ArrayExpressiQ76M96.
BgeeiQ76M96.
CleanExiHS_CCDC80.
GenevestigatoriQ76M96.

Organism-specific databases

HPAiCAB025158.
HPA002266.

Interactioni

Subunit structurei

Binds to various extracellular matrix proteins By similarity.

Protein-protein interaction databases

BioGridi127410. 1 interaction.
IntActiQ76M96. 1 interaction.
STRINGi9606.ENSP00000206423.

Structurei

3D structure databases

ProteinModelPortaliQ76M96.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili560 – 58728 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi347 – 40458Thr-rich
Add
BLAST
Compositional biasi486 – 610125Lys-rich
Add
BLAST

Sequence similaritiesi

Belongs to the CCDC80 family.

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG42473.
HOVERGENiHBG104210.
InParanoidiQ76M96.
OMAiAMYEVID.
OrthoDBiEOG72G170.
PhylomeDBiQ76M96.
TreeFamiTF332926.

Family and domain databases

InterProiIPR025232. DUF4174.
[Graphical view]
PfamiPF13778. DUF4174. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q76M96-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTWRMGPRFT MLLAMWLVCG SEPHPHATIR GSHGGRKVPL VSPDSSRPAR    50
FLRHTGRSRG IERSTLEEPN LQPLQRRRSV PVLRLARPTE PPARSDINGA 100
AVRPEQRPAA RGSPREMIRD EGSSARSRML RFPSGSSSPN ILASFAGKNR 150
VWVISAPHAS EGYYRLMMSL LKDDVYCELA ERHIQQIVLF HQAGEEGGKV 200
RRITSEGQIL EQPLDPSLIP KLMSFLKLEK GKFGMVLLKK TLQVEERYPY 250
PVRLEAMYEV IDQGPIRRIE KIRQKGFVQK CKASGVEGQV VAEGNDGGGG 300
AGRPSLGSEK KKEDPRRAQV PPTRESRVKV LRKLAATAPA LPQPPSTPRA 350
TTLPPAPATT VTRSTSRAVT VAARPMTTTA FPTTQRPWTP SPSHRPPTTT 400
EVITARRPSV SENLYPPSRK DQHRERPQTT RRPSKATSLE SFTNAPPTTI 450
SEPSTRAAGP GRFRDNRMDR REHGHRDPNV VPGPPKPAKE KPPKKKAQDK 500
ILSNEYEEKY DLSRPTASQL EDELQVGNVP LKKAKESKKH EKLEKPEKEK 550
KKKMKNENAD KLLKSEKQMK KSEKKSKQEK EKSKKKKGGK TEQDGYQKPT 600
NKHFTQSPKK SVADLLGSFE GKRRLLLITA PKAENNMYVQ QRDEYLESFC 650
KMATRKISVI TIFGPVNNST MKIDHFQLDN EKPMRVVDDE DLVDQRLISE 700
LRKEYGMTYN DFFMVLTDVD LRVKQYYEVP ITMKSVFDLI DTFQSRIKDM 750
EKQKKEGIVC KEDKKQSLEN FLSRFRWRRR LLVISAPNDE DWAYSQQLSA 800
LSGQACNFGL RHITILKLLG VGEEVGGVLE LFPINGSSVV EREDVPAHLV 850
KDIRNYFQVS PEYFSMLLVG KDGNVKSWYP SPMWSMVIVY DLIDSMQLRR 900
QEMAIQQSLG MRCPEDEYAG YGYHSYHQGY QDGYQDDYRH HESYHHGYPY 950
Length:950
Mass (Da):108,174
Last modified:July 5, 2004 - v1
Checksum:i67A1D4A7DD907AA0
GO
Isoform 2 (identifier: Q76M96-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTSVHRKVDYTM

Show »
Length:961
Mass (Da):109,492
Checksum:i9EAE839A541AADF3
GO
Isoform 3 (identifier: Q76M96-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-865: Missing.

Show »
Length:85
Mass (Da):10,174
Checksum:iF43811D3541675A0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 865865Missing in isoform 3.
VSP_024135Add
BLAST
Alternative sequencei1 – 11M → MTSVHRKVDYTM in isoform 2.
VSP_024136

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti411 – 4111S → L in BAC11475. 1 Publication
Sequence conflicti549 – 5491E → K in AAH86876. 1 Publication
Sequence conflicti551 – 5511K → E in AAH86876. 1 Publication
Sequence conflicti837 – 8371S → G in AAH73164. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY333429 mRNA. Translation: AAQ96742.1.
AY548106 mRNA. Translation: AAS66643.1.
AY548107 mRNA. Translation: AAS66644.1.
AY526612 mRNA. Translation: AAS92235.1.
AB052098 mRNA. Translation: BAD05134.1.
AF506819 mRNA. Translation: AAM33633.1.
BX647817 mRNA. Translation: CAH56167.1.
BX647117 mRNA. Translation: CAH56178.1.
AL833034 mRNA. Translation: CAH56325.1.
CH471052 Genomic DNA. Translation: EAW79663.1.
CH471052 Genomic DNA. Translation: EAW79665.1.
BC042105 mRNA. Translation: AAH42105.1.
BC073164 mRNA. Translation: AAH73164.1.
BC086876 mRNA. Translation: AAH86876.1.
BC110842 mRNA. Translation: AAI10843.1.
BC116178 mRNA. Translation: AAI16179.1.
AK075210 mRNA. Translation: BAC11475.1.
CCDSiCCDS2968.1. [Q76M96-1]
RefSeqiNP_955805.1. NM_199511.2. [Q76M96-1]
NP_955806.1. NM_199512.2. [Q76M96-1]
XP_005247192.1. XM_005247135.1. [Q76M96-2]
UniGeneiHs.477128.

Genome annotation databases

EnsembliENST00000206423; ENSP00000206423; ENSG00000091986. [Q76M96-1]
ENST00000439685; ENSP00000411814; ENSG00000091986. [Q76M96-1]
GeneIDi151887.
KEGGihsa:151887.
UCSCiuc003dzf.3. human. [Q76M96-1]

Polymorphism databases

DMDMi74712933.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY333429 mRNA. Translation: AAQ96742.1 .
AY548106 mRNA. Translation: AAS66643.1 .
AY548107 mRNA. Translation: AAS66644.1 .
AY526612 mRNA. Translation: AAS92235.1 .
AB052098 mRNA. Translation: BAD05134.1 .
AF506819 mRNA. Translation: AAM33633.1 .
BX647817 mRNA. Translation: CAH56167.1 .
BX647117 mRNA. Translation: CAH56178.1 .
AL833034 mRNA. Translation: CAH56325.1 .
CH471052 Genomic DNA. Translation: EAW79663.1 .
CH471052 Genomic DNA. Translation: EAW79665.1 .
BC042105 mRNA. Translation: AAH42105.1 .
BC073164 mRNA. Translation: AAH73164.1 .
BC086876 mRNA. Translation: AAH86876.1 .
BC110842 mRNA. Translation: AAI10843.1 .
BC116178 mRNA. Translation: AAI16179.1 .
AK075210 mRNA. Translation: BAC11475.1 .
CCDSi CCDS2968.1. [Q76M96-1 ]
RefSeqi NP_955805.1. NM_199511.2. [Q76M96-1 ]
NP_955806.1. NM_199512.2. [Q76M96-1 ]
XP_005247192.1. XM_005247135.1. [Q76M96-2 ]
UniGenei Hs.477128.

3D structure databases

ProteinModelPortali Q76M96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127410. 1 interaction.
IntActi Q76M96. 1 interaction.
STRINGi 9606.ENSP00000206423.

PTM databases

PhosphoSitei Q76M96.

Polymorphism databases

DMDMi 74712933.

Proteomic databases

MaxQBi Q76M96.
PaxDbi Q76M96.
PeptideAtlasi Q76M96.
PRIDEi Q76M96.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000206423 ; ENSP00000206423 ; ENSG00000091986 . [Q76M96-1 ]
ENST00000439685 ; ENSP00000411814 ; ENSG00000091986 . [Q76M96-1 ]
GeneIDi 151887.
KEGGi hsa:151887.
UCSCi uc003dzf.3. human. [Q76M96-1 ]

Organism-specific databases

CTDi 151887.
GeneCardsi GC03M112323.
H-InvDB HIX0003550.
HGNCi HGNC:30649. CCDC80.
HPAi CAB025158.
HPA002266.
MIMi 608298. gene.
neXtProti NX_Q76M96.
PharmGKBi PA144596470.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42473.
HOVERGENi HBG104210.
InParanoidi Q76M96.
OMAi AMYEVID.
OrthoDBi EOG72G170.
PhylomeDBi Q76M96.
TreeFami TF332926.

Miscellaneous databases

ChiTaRSi CCDC80. human.
GeneWikii CCDC80.
GenomeRNAii 151887.
NextBioi 86811.
PROi Q76M96.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q76M96.
Bgeei Q76M96.
CleanExi HS_CCDC80.
Genevestigatori Q76M96.

Family and domain databases

InterProi IPR025232. DUF4174.
[Graphical view ]
Pfami PF13778. DUF4174. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "URB expression in human bone marrow stromal cells and during mouse development."
    Liu Y., Monticone M., Tonachini L., Mastrogiacomo M., Marigo V., Cancedda R., Castagnola P.
    Biochem. Biophys. Res. Commun. 322:497-507(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, TISSUE SPECIFICITY.
    Tissue: Hair follicle dermal papilla.
  2. "DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells."
    Bommer G.T., Jaeger C., Duerr E.M., Baehs S., Eichhorst S.T., Brabletz T., Hu G., Froehlich T., Arnold G., Kress D.C., Goeke B., Fearon E.R., Kolligs F.T.
    J. Biol. Chem. 280:7962-7975(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
    Tissue: Hair follicle dermal papilla.
  4. "A novel gene from human brain endothelial cell PCR select library."
    Yonezawa T., Ninomiya Y.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain endothelium.
  5. Guo J.H., Yu L.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon endothelium, Endometrium and Stomach.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain, Chondrosarcoma and PNS.
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-583 (ISOFORM 2).
    Tissue: Placenta.

Entry informationi

Entry nameiCCD80_HUMAN
AccessioniPrimary (citable) accession number: Q76M96
Secondary accession number(s): D3DN67
, Q5PR20, Q6GPG9, Q8IVT6, Q8NBV1, Q8NHY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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