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Q76M96

- CCD80_HUMAN

UniProt

Q76M96 - CCD80_HUMAN

Protein

Coiled-coil domain-containing protein 80

Gene

CCDC80

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Promotes cell adhesion and matrix assembly.By similarity

    GO - Molecular functioni

    1. heparin binding Source: Ensembl

    GO - Biological processi

    1. extracellular matrix organization Source: Ensembl
    2. positive regulation of cell-substrate adhesion Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 80
    Alternative name(s):
    Down-regulated by oncogenes protein 1
    Up-regulated in BRS-3 deficient mouse homolog
    Gene namesi
    Name:CCDC80
    Synonyms:DRO1, URB
    ORF Names:HBE245
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30649. CCDC80.

    Subcellular locationi

    GO - Cellular componenti

    1. basement membrane Source: Ensembl
    2. interstitial matrix Source: Ensembl

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA144596470.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 950929Coiled-coil domain-containing protein 80PRO_0000282418Add
    BLAST

    Post-translational modificationi

    Phosphorylated.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ76M96.
    PaxDbiQ76M96.
    PeptideAtlasiQ76M96.
    PRIDEiQ76M96.

    PTM databases

    PhosphoSiteiQ76M96.

    Expressioni

    Tissue specificityi

    Expressed in dermal papilla and dermal fibroblasts (at protein level). Expressed in heart, thymus, placenta, pancreas, colon, epithelium, spleen and osteoblasts.3 Publications

    Inductioni

    Down-regulated in cancer and after osteoblastic differentiation. Up-regulated by dihydrotestosterone (DHT).2 Publications

    Gene expression databases

    ArrayExpressiQ76M96.
    BgeeiQ76M96.
    CleanExiHS_CCDC80.
    GenevestigatoriQ76M96.

    Organism-specific databases

    HPAiCAB025158.
    HPA002266.

    Interactioni

    Subunit structurei

    Binds to various extracellular matrix proteins.By similarity

    Protein-protein interaction databases

    BioGridi127410. 1 interaction.
    IntActiQ76M96. 1 interaction.
    STRINGi9606.ENSP00000206423.

    Structurei

    3D structure databases

    ProteinModelPortaliQ76M96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili560 – 58728Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi347 – 40458Thr-richAdd
    BLAST
    Compositional biasi486 – 610125Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCDC80 family.Curated

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG42473.
    HOVERGENiHBG104210.
    InParanoidiQ76M96.
    OMAiAMYEVID.
    OrthoDBiEOG72G170.
    PhylomeDBiQ76M96.
    TreeFamiTF332926.

    Family and domain databases

    InterProiIPR025232. DUF4174.
    [Graphical view]
    PfamiPF13778. DUF4174. 3 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q76M96-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTWRMGPRFT MLLAMWLVCG SEPHPHATIR GSHGGRKVPL VSPDSSRPAR    50
    FLRHTGRSRG IERSTLEEPN LQPLQRRRSV PVLRLARPTE PPARSDINGA 100
    AVRPEQRPAA RGSPREMIRD EGSSARSRML RFPSGSSSPN ILASFAGKNR 150
    VWVISAPHAS EGYYRLMMSL LKDDVYCELA ERHIQQIVLF HQAGEEGGKV 200
    RRITSEGQIL EQPLDPSLIP KLMSFLKLEK GKFGMVLLKK TLQVEERYPY 250
    PVRLEAMYEV IDQGPIRRIE KIRQKGFVQK CKASGVEGQV VAEGNDGGGG 300
    AGRPSLGSEK KKEDPRRAQV PPTRESRVKV LRKLAATAPA LPQPPSTPRA 350
    TTLPPAPATT VTRSTSRAVT VAARPMTTTA FPTTQRPWTP SPSHRPPTTT 400
    EVITARRPSV SENLYPPSRK DQHRERPQTT RRPSKATSLE SFTNAPPTTI 450
    SEPSTRAAGP GRFRDNRMDR REHGHRDPNV VPGPPKPAKE KPPKKKAQDK 500
    ILSNEYEEKY DLSRPTASQL EDELQVGNVP LKKAKESKKH EKLEKPEKEK 550
    KKKMKNENAD KLLKSEKQMK KSEKKSKQEK EKSKKKKGGK TEQDGYQKPT 600
    NKHFTQSPKK SVADLLGSFE GKRRLLLITA PKAENNMYVQ QRDEYLESFC 650
    KMATRKISVI TIFGPVNNST MKIDHFQLDN EKPMRVVDDE DLVDQRLISE 700
    LRKEYGMTYN DFFMVLTDVD LRVKQYYEVP ITMKSVFDLI DTFQSRIKDM 750
    EKQKKEGIVC KEDKKQSLEN FLSRFRWRRR LLVISAPNDE DWAYSQQLSA 800
    LSGQACNFGL RHITILKLLG VGEEVGGVLE LFPINGSSVV EREDVPAHLV 850
    KDIRNYFQVS PEYFSMLLVG KDGNVKSWYP SPMWSMVIVY DLIDSMQLRR 900
    QEMAIQQSLG MRCPEDEYAG YGYHSYHQGY QDGYQDDYRH HESYHHGYPY 950
    Length:950
    Mass (Da):108,174
    Last modified:July 5, 2004 - v1
    Checksum:i67A1D4A7DD907AA0
    GO
    Isoform 2 (identifier: Q76M96-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MTSVHRKVDYTM

    Show »
    Length:961
    Mass (Da):109,492
    Checksum:i9EAE839A541AADF3
    GO
    Isoform 3 (identifier: Q76M96-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-865: Missing.

    Show »
    Length:85
    Mass (Da):10,174
    Checksum:iF43811D3541675A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti411 – 4111S → L in BAC11475. (PubMed:14702039)Curated
    Sequence conflicti549 – 5491E → K in AAH86876. (PubMed:15489334)Curated
    Sequence conflicti551 – 5511K → E in AAH86876. (PubMed:15489334)Curated
    Sequence conflicti837 – 8371S → G in AAH73164. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 865865Missing in isoform 3. 1 PublicationVSP_024135Add
    BLAST
    Alternative sequencei1 – 11M → MTSVHRKVDYTM in isoform 2. 1 PublicationVSP_024136

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY333429 mRNA. Translation: AAQ96742.1.
    AY548106 mRNA. Translation: AAS66643.1.
    AY548107 mRNA. Translation: AAS66644.1.
    AY526612 mRNA. Translation: AAS92235.1.
    AB052098 mRNA. Translation: BAD05134.1.
    AF506819 mRNA. Translation: AAM33633.1.
    BX647817 mRNA. Translation: CAH56167.1.
    BX647117 mRNA. Translation: CAH56178.1.
    AL833034 mRNA. Translation: CAH56325.1.
    CH471052 Genomic DNA. Translation: EAW79663.1.
    CH471052 Genomic DNA. Translation: EAW79665.1.
    BC042105 mRNA. Translation: AAH42105.1.
    BC073164 mRNA. Translation: AAH73164.1.
    BC086876 mRNA. Translation: AAH86876.1.
    BC110842 mRNA. Translation: AAI10843.1.
    BC116178 mRNA. Translation: AAI16179.1.
    AK075210 mRNA. Translation: BAC11475.1.
    CCDSiCCDS2968.1. [Q76M96-1]
    RefSeqiNP_955805.1. NM_199511.2. [Q76M96-1]
    NP_955806.1. NM_199512.2. [Q76M96-1]
    XP_005247192.1. XM_005247135.1. [Q76M96-2]
    UniGeneiHs.477128.

    Genome annotation databases

    EnsembliENST00000206423; ENSP00000206423; ENSG00000091986. [Q76M96-1]
    ENST00000439685; ENSP00000411814; ENSG00000091986. [Q76M96-1]
    GeneIDi151887.
    KEGGihsa:151887.
    UCSCiuc003dzf.3. human. [Q76M96-1]

    Polymorphism databases

    DMDMi74712933.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY333429 mRNA. Translation: AAQ96742.1 .
    AY548106 mRNA. Translation: AAS66643.1 .
    AY548107 mRNA. Translation: AAS66644.1 .
    AY526612 mRNA. Translation: AAS92235.1 .
    AB052098 mRNA. Translation: BAD05134.1 .
    AF506819 mRNA. Translation: AAM33633.1 .
    BX647817 mRNA. Translation: CAH56167.1 .
    BX647117 mRNA. Translation: CAH56178.1 .
    AL833034 mRNA. Translation: CAH56325.1 .
    CH471052 Genomic DNA. Translation: EAW79663.1 .
    CH471052 Genomic DNA. Translation: EAW79665.1 .
    BC042105 mRNA. Translation: AAH42105.1 .
    BC073164 mRNA. Translation: AAH73164.1 .
    BC086876 mRNA. Translation: AAH86876.1 .
    BC110842 mRNA. Translation: AAI10843.1 .
    BC116178 mRNA. Translation: AAI16179.1 .
    AK075210 mRNA. Translation: BAC11475.1 .
    CCDSi CCDS2968.1. [Q76M96-1 ]
    RefSeqi NP_955805.1. NM_199511.2. [Q76M96-1 ]
    NP_955806.1. NM_199512.2. [Q76M96-1 ]
    XP_005247192.1. XM_005247135.1. [Q76M96-2 ]
    UniGenei Hs.477128.

    3D structure databases

    ProteinModelPortali Q76M96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127410. 1 interaction.
    IntActi Q76M96. 1 interaction.
    STRINGi 9606.ENSP00000206423.

    PTM databases

    PhosphoSitei Q76M96.

    Polymorphism databases

    DMDMi 74712933.

    Proteomic databases

    MaxQBi Q76M96.
    PaxDbi Q76M96.
    PeptideAtlasi Q76M96.
    PRIDEi Q76M96.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000206423 ; ENSP00000206423 ; ENSG00000091986 . [Q76M96-1 ]
    ENST00000439685 ; ENSP00000411814 ; ENSG00000091986 . [Q76M96-1 ]
    GeneIDi 151887.
    KEGGi hsa:151887.
    UCSCi uc003dzf.3. human. [Q76M96-1 ]

    Organism-specific databases

    CTDi 151887.
    GeneCardsi GC03M112323.
    H-InvDB HIX0003550.
    HGNCi HGNC:30649. CCDC80.
    HPAi CAB025158.
    HPA002266.
    MIMi 608298. gene.
    neXtProti NX_Q76M96.
    PharmGKBi PA144596470.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42473.
    HOVERGENi HBG104210.
    InParanoidi Q76M96.
    OMAi AMYEVID.
    OrthoDBi EOG72G170.
    PhylomeDBi Q76M96.
    TreeFami TF332926.

    Miscellaneous databases

    ChiTaRSi CCDC80. human.
    GeneWikii CCDC80.
    GenomeRNAii 151887.
    NextBioi 86811.
    PROi Q76M96.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q76M96.
    Bgeei Q76M96.
    CleanExi HS_CCDC80.
    Genevestigatori Q76M96.

    Family and domain databases

    InterProi IPR025232. DUF4174.
    [Graphical view ]
    Pfami PF13778. DUF4174. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "URB expression in human bone marrow stromal cells and during mouse development."
      Liu Y., Monticone M., Tonachini L., Mastrogiacomo M., Marigo V., Cancedda R., Castagnola P.
      Biochem. Biophys. Res. Commun. 322:497-507(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, TISSUE SPECIFICITY.
      Tissue: Hair follicle dermal papilla.
    2. "DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells."
      Bommer G.T., Jaeger C., Duerr E.M., Baehs S., Eichhorst S.T., Brabletz T., Hu G., Froehlich T., Arnold G., Kress D.C., Goeke B., Fearon E.R., Kolligs F.T.
      J. Biol. Chem. 280:7962-7975(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
      Tissue: Hair follicle dermal papilla.
    4. "A novel gene from human brain endothelial cell PCR select library."
      Yonezawa T., Ninomiya Y.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain endothelium.
    5. Guo J.H., Yu L.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon endothelium, Endometrium and Stomach.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain, Chondrosarcoma and PNS.
    9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-583 (ISOFORM 2).
      Tissue: Placenta.

    Entry informationi

    Entry nameiCCD80_HUMAN
    AccessioniPrimary (citable) accession number: Q76M96
    Secondary accession number(s): D3DN67
    , Q5PR20, Q6GPG9, Q8IVT6, Q8NBV1, Q8NHY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3