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Q76M96 (CCD80_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil domain-containing protein 80
Alternative name(s):
Down-regulated by oncogenes protein 1
Up-regulated in BRS-3 deficient mouse homolog
Gene names
Name:CCDC80
Synonyms:DRO1, URB
ORF Names:HBE245
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length950 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Promotes cell adhesion and matrix assembly By similarity.

Subunit structure

Binds to various extracellular matrix proteins By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity Ref.2.

Tissue specificity

Expressed in dermal papilla and dermal fibroblasts (at protein level). Expressed in heart, thymus, placenta, pancreas, colon, epithelium, spleen and osteoblasts. Ref.1 Ref.2 Ref.3

Induction

Down-regulated in cancer and after osteoblastic differentiation. Up-regulated by dihydrotestosterone (DHT). Ref.1 Ref.3

Post-translational modification

Phosphorylated. Ref.2

Sequence similarities

Belongs to the CCDC80 family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q76M96-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q76M96-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTSVHRKVDYTM
Isoform 3 (identifier: Q76M96-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-865: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 950929Coiled-coil domain-containing protein 80
PRO_0000282418

Regions

Coiled coil560 – 58728 Potential
Compositional bias347 – 40458Thr-rich
Compositional bias486 – 610125Lys-rich

Natural variations

Alternative sequence1 – 865865Missing in isoform 3.
VSP_024135
Alternative sequence11M → MTSVHRKVDYTM in isoform 2.
VSP_024136

Experimental info

Sequence conflict4111S → L in BAC11475. Ref.9
Sequence conflict5491E → K in AAH86876. Ref.8
Sequence conflict5511K → E in AAH86876. Ref.8
Sequence conflict8371S → G in AAH73164. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 67A1D4A7DD907AA0

FASTA950108,174
        10         20         30         40         50         60 
MTWRMGPRFT MLLAMWLVCG SEPHPHATIR GSHGGRKVPL VSPDSSRPAR FLRHTGRSRG 

        70         80         90        100        110        120 
IERSTLEEPN LQPLQRRRSV PVLRLARPTE PPARSDINGA AVRPEQRPAA RGSPREMIRD 

       130        140        150        160        170        180 
EGSSARSRML RFPSGSSSPN ILASFAGKNR VWVISAPHAS EGYYRLMMSL LKDDVYCELA 

       190        200        210        220        230        240 
ERHIQQIVLF HQAGEEGGKV RRITSEGQIL EQPLDPSLIP KLMSFLKLEK GKFGMVLLKK 

       250        260        270        280        290        300 
TLQVEERYPY PVRLEAMYEV IDQGPIRRIE KIRQKGFVQK CKASGVEGQV VAEGNDGGGG 

       310        320        330        340        350        360 
AGRPSLGSEK KKEDPRRAQV PPTRESRVKV LRKLAATAPA LPQPPSTPRA TTLPPAPATT 

       370        380        390        400        410        420 
VTRSTSRAVT VAARPMTTTA FPTTQRPWTP SPSHRPPTTT EVITARRPSV SENLYPPSRK 

       430        440        450        460        470        480 
DQHRERPQTT RRPSKATSLE SFTNAPPTTI SEPSTRAAGP GRFRDNRMDR REHGHRDPNV 

       490        500        510        520        530        540 
VPGPPKPAKE KPPKKKAQDK ILSNEYEEKY DLSRPTASQL EDELQVGNVP LKKAKESKKH 

       550        560        570        580        590        600 
EKLEKPEKEK KKKMKNENAD KLLKSEKQMK KSEKKSKQEK EKSKKKKGGK TEQDGYQKPT 

       610        620        630        640        650        660 
NKHFTQSPKK SVADLLGSFE GKRRLLLITA PKAENNMYVQ QRDEYLESFC KMATRKISVI 

       670        680        690        700        710        720 
TIFGPVNNST MKIDHFQLDN EKPMRVVDDE DLVDQRLISE LRKEYGMTYN DFFMVLTDVD 

       730        740        750        760        770        780 
LRVKQYYEVP ITMKSVFDLI DTFQSRIKDM EKQKKEGIVC KEDKKQSLEN FLSRFRWRRR 

       790        800        810        820        830        840 
LLVISAPNDE DWAYSQQLSA LSGQACNFGL RHITILKLLG VGEEVGGVLE LFPINGSSVV 

       850        860        870        880        890        900 
EREDVPAHLV KDIRNYFQVS PEYFSMLLVG KDGNVKSWYP SPMWSMVIVY DLIDSMQLRR 

       910        920        930        940        950 
QEMAIQQSLG MRCPEDEYAG YGYHSYHQGY QDGYQDDYRH HESYHHGYPY 

« Hide

Isoform 2 [UniParc].

Checksum: 9EAE839A541AADF3
Show »

FASTA961109,492
Isoform 3 [UniParc].

Checksum: F43811D3541675A0
Show »

FASTA8510,174

References

« Hide 'large scale' references
[1]"URB expression in human bone marrow stromal cells and during mouse development."
Liu Y., Monticone M., Tonachini L., Mastrogiacomo M., Marigo V., Cancedda R., Castagnola P.
Biochem. Biophys. Res. Commun. 322:497-507(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, TISSUE SPECIFICITY.
Tissue: Hair follicle dermal papilla.
[2]"DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells."
Bommer G.T., Jaeger C., Duerr E.M., Baehs S., Eichhorst S.T., Brabletz T., Hu G., Froehlich T., Arnold G., Kress D.C., Goeke B., Fearon E.R., Kolligs F.T.
J. Biol. Chem. 280:7962-7975(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION.
[3]"URB expression in human dermal papilla cells."
Cha S.-Y., Sung Y.K., Im S., Kwack M.H., Kim M.K., Kim J.C.
J. Dermatol. Sci. 39:128-130(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
Tissue: Hair follicle dermal papilla.
[4]"A novel gene from human brain endothelial cell PCR select library."
Yonezawa T., Ninomiya Y.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain endothelium.
[5]Guo J.H., Yu L.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Colon endothelium, Endometrium and Stomach.
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Brain, Chondrosarcoma and PNS.
[9]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-583 (ISOFORM 2).
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY333429 mRNA. Translation: AAQ96742.1.
AY548106 mRNA. Translation: AAS66643.1.
AY548107 mRNA. Translation: AAS66644.1.
AY526612 mRNA. Translation: AAS92235.1.
AB052098 mRNA. Translation: BAD05134.1.
AF506819 mRNA. Translation: AAM33633.1.
BX647817 mRNA. Translation: CAH56167.1.
BX647117 mRNA. Translation: CAH56178.1.
AL833034 mRNA. Translation: CAH56325.1.
CH471052 Genomic DNA. Translation: EAW79663.1.
CH471052 Genomic DNA. Translation: EAW79665.1.
BC042105 mRNA. Translation: AAH42105.1.
BC073164 mRNA. Translation: AAH73164.1.
BC086876 mRNA. Translation: AAH86876.1.
BC110842 mRNA. Translation: AAI10843.1.
BC116178 mRNA. Translation: AAI16179.1.
AK075210 mRNA. Translation: BAC11475.1.
CCDSCCDS2968.1. [Q76M96-1]
RefSeqNP_955805.1. NM_199511.2. [Q76M96-1]
NP_955806.1. NM_199512.2. [Q76M96-1]
XP_005247192.1. XM_005247135.1. [Q76M96-2]
UniGeneHs.477128.

3D structure databases

ProteinModelPortalQ76M96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127410. 1 interaction.
IntActQ76M96. 1 interaction.
STRING9606.ENSP00000206423.

PTM databases

PhosphoSiteQ76M96.

Polymorphism databases

DMDM74712933.

Proteomic databases

MaxQBQ76M96.
PaxDbQ76M96.
PeptideAtlasQ76M96.
PRIDEQ76M96.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000206423; ENSP00000206423; ENSG00000091986. [Q76M96-1]
ENST00000439685; ENSP00000411814; ENSG00000091986. [Q76M96-1]
GeneID151887.
KEGGhsa:151887.
UCSCuc003dzf.3. human. [Q76M96-1]

Organism-specific databases

CTD151887.
GeneCardsGC03M112323.
H-InvDBHIX0003550.
HGNCHGNC:30649. CCDC80.
HPACAB025158.
HPA002266.
MIM608298. gene.
neXtProtNX_Q76M96.
PharmGKBPA144596470.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42473.
HOVERGENHBG104210.
InParanoidQ76M96.
OMAAMYEVID.
OrthoDBEOG72G170.
PhylomeDBQ76M96.
TreeFamTF332926.

Gene expression databases

ArrayExpressQ76M96.
BgeeQ76M96.
CleanExHS_CCDC80.
GenevestigatorQ76M96.

Family and domain databases

InterProIPR025232. DUF4174.
[Graphical view]
PfamPF13778. DUF4174. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCCDC80. human.
GeneWikiCCDC80.
GenomeRNAi151887.
NextBio86811.
PROQ76M96.
SOURCESearch...

Entry information

Entry nameCCD80_HUMAN
AccessionPrimary (citable) accession number: Q76M96
Secondary accession number(s): D3DN67 expand/collapse secondary AC list , Q5PR20, Q6GPG9, Q8IVT6, Q8NBV1, Q8NHY8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM