Q76M96 (CCD80_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 80

Alternative name(s):
Down-regulated by oncogenes protein 1
Up-regulated in BRS-3 deficient mouse homolog

Gene names

Name:	CCDC80
Synonyms:	DRO1, URB
ORF Names:	HBE245

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	950 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Promotes cell adhesion and matrix assembly By similarity.
Subunit structure	Binds to various extracellular matrix proteins By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity Ref.2.
Tissue specificity	Expressed in dermal papilla and dermal fibroblasts (at protein level). Expressed in heart, thymus, placenta, pancreas, colon, epithelium, spleen and osteoblasts. Ref.1 Ref.2 Ref.3
Induction	Down-regulated in cancer and after osteoblastic differentiation. Up-regulated by dihydrotestosterone (DHT). Ref.1 Ref.3
Post-translational modification	Phosphorylated. Ref.2
Sequence similarities	Belongs to the CCDC80 family.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Signal
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	extracellular matrix organization Inferred from electronic annotation. Source: Compara positive regulation of cell-substrate adhesion Inferred from electronic annotation. Source: Compara
Cellular_component	basement membrane Inferred from electronic annotation. Source: Compara interstitial matrix Inferred from electronic annotation. Source: Compara
Molecular_function	heparin binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q76M96-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q76M96-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTSVHRKVDYTM

Isoform 3 (identifier: Q76M96-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-865: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 950	929	Coiled-coil domain-containing protein 80		PRO_0000282418
Regions
	Coiled coil	560 – 587	28	Potential
	Compositional bias	347 – 404	58	Thr-rich
	Compositional bias	486 – 610	125	Lys-rich
Natural variations
	Alternative sequence	1 – 865	865	Missing in isoform 3.		VSP_024135
	Alternative sequence	1	1	M → MTSVHRKVDYTM in isoform 2.		VSP_024136
Experimental info
	Sequence conflict	411	1	S → L in BAC11475. Ref.9
	Sequence conflict	549	1	E → K in AAH86876. Ref.8
	Sequence conflict	551	1	K → E in AAH86876. Ref.8
	Sequence conflict	837	1	S → G in AAH73164. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 67A1D4A7DD907AA0	FASTA	950	108,174
	10 20 30 40 50 60 MTWRMGPRFT MLLAMWLVCG SEPHPHATIR GSHGGRKVPL VSPDSSRPAR FLRHTGRSRG 70 80 90 100 110 120 IERSTLEEPN LQPLQRRRSV PVLRLARPTE PPARSDINGA AVRPEQRPAA RGSPREMIRD 130 140 150 160 170 180 EGSSARSRML RFPSGSSSPN ILASFAGKNR VWVISAPHAS EGYYRLMMSL LKDDVYCELA 190 200 210 220 230 240 ERHIQQIVLF HQAGEEGGKV RRITSEGQIL EQPLDPSLIP KLMSFLKLEK GKFGMVLLKK 250 260 270 280 290 300 TLQVEERYPY PVRLEAMYEV IDQGPIRRIE KIRQKGFVQK CKASGVEGQV VAEGNDGGGG 310 320 330 340 350 360 AGRPSLGSEK KKEDPRRAQV PPTRESRVKV LRKLAATAPA LPQPPSTPRA TTLPPAPATT 370 380 390 400 410 420 VTRSTSRAVT VAARPMTTTA FPTTQRPWTP SPSHRPPTTT EVITARRPSV SENLYPPSRK 430 440 450 460 470 480 DQHRERPQTT RRPSKATSLE SFTNAPPTTI SEPSTRAAGP GRFRDNRMDR REHGHRDPNV 490 500 510 520 530 540 VPGPPKPAKE KPPKKKAQDK ILSNEYEEKY DLSRPTASQL EDELQVGNVP LKKAKESKKH 550 560 570 580 590 600 EKLEKPEKEK KKKMKNENAD KLLKSEKQMK KSEKKSKQEK EKSKKKKGGK TEQDGYQKPT 610 620 630 640 650 660 NKHFTQSPKK SVADLLGSFE GKRRLLLITA PKAENNMYVQ QRDEYLESFC KMATRKISVI 670 680 690 700 710 720 TIFGPVNNST MKIDHFQLDN EKPMRVVDDE DLVDQRLISE LRKEYGMTYN DFFMVLTDVD 730 740 750 760 770 780 LRVKQYYEVP ITMKSVFDLI DTFQSRIKDM EKQKKEGIVC KEDKKQSLEN FLSRFRWRRR 790 800 810 820 830 840 LLVISAPNDE DWAYSQQLSA LSGQACNFGL RHITILKLLG VGEEVGGVLE LFPINGSSVV 850 860 870 880 890 900 EREDVPAHLV KDIRNYFQVS PEYFSMLLVG KDGNVKSWYP SPMWSMVIVY DLIDSMQLRR 910 920 930 940 950 QEMAIQQSLG MRCPEDEYAG YGYHSYHQGY QDGYQDDYRH HESYHHGYPY
	Isoform 2 [UniParc]. Checksum: 9EAE839A541AADF3	FASTA	961	109,492
	10 20 30 40 50 60 MTSVHRKVDY TMTWRMGPRF TMLLAMWLVC GSEPHPHATI RGSHGGRKVP LVSPDSSRPA 70 80 90 100 110 120 RFLRHTGRSR GIERSTLEEP NLQPLQRRRS VPVLRLARPT EPPARSDING AAVRPEQRPA 130 140 150 160 170 180 ARGSPREMIR DEGSSARSRM LRFPSGSSSP NILASFAGKN RVWVISAPHA SEGYYRLMMS 190 200 210 220 230 240 LLKDDVYCEL AERHIQQIVL FHQAGEEGGK VRRITSEGQI LEQPLDPSLI PKLMSFLKLE 250 260 270 280 290 300 KGKFGMVLLK KTLQVEERYP YPVRLEAMYE VIDQGPIRRI EKIRQKGFVQ KCKASGVEGQ 310 320 330 340 350 360 VVAEGNDGGG GAGRPSLGSE KKKEDPRRAQ VPPTRESRVK VLRKLAATAP ALPQPPSTPR 370 380 390 400 410 420 ATTLPPAPAT TVTRSTSRAV TVAARPMTTT AFPTTQRPWT PSPSHRPPTT TEVITARRPS 430 440 450 460 470 480 VSENLYPPSR KDQHRERPQT TRRPSKATSL ESFTNAPPTT ISEPSTRAAG PGRFRDNRMD 490 500 510 520 530 540 RREHGHRDPN VVPGPPKPAK EKPPKKKAQD KILSNEYEEK YDLSRPTASQ LEDELQVGNV 550 560 570 580 590 600 PLKKAKESKK HEKLEKPEKE KKKKMKNENA DKLLKSEKQM KKSEKKSKQE KEKSKKKKGG 610 620 630 640 650 660 KTEQDGYQKP TNKHFTQSPK KSVADLLGSF EGKRRLLLIT APKAENNMYV QQRDEYLESF 670 680 690 700 710 720 CKMATRKISV ITIFGPVNNS TMKIDHFQLD NEKPMRVVDD EDLVDQRLIS ELRKEYGMTY 730 740 750 760 770 780 NDFFMVLTDV DLRVKQYYEV PITMKSVFDL IDTFQSRIKD MEKQKKEGIV CKEDKKQSLE 790 800 810 820 830 840 NFLSRFRWRR RLLVISAPND EDWAYSQQLS ALSGQACNFG LRHITILKLL GVGEEVGGVL 850 860 870 880 890 900 ELFPINGSSV VEREDVPAHL VKDIRNYFQV SPEYFSMLLV GKDGNVKSWY PSPMWSMVIV 910 920 930 940 950 960 YDLIDSMQLR RQEMAIQQSL GMRCPEDEYA GYGYHSYHQG YQDGYQDDYR HHESYHHGYP Y
	Isoform 3 [UniParc]. Checksum: F43811D3541675A0	FASTA	85	10,174
	10 20 30 40 50 60 MLLVGKDGNV KSWYPSPMWS MVIVYDLIDS MQLRRQEMAI QQSLGMRCPE DEYAGYGYHS 70 80 YHQGYQDGYQ DDYRHHESYH HGYPY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"URB expression in human bone marrow stromal cells and during mouse development." Liu Y., Monticone M., Tonachini L., Mastrogiacomo M., Marigo V., Cancedda R., Castagnola P. Biochem. Biophys. Res. Commun. 322:497-507(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, TISSUE SPECIFICITY. Tissue: Hair follicle dermal papilla.
[2]	"DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells." Bommer G.T., Jaeger C., Duerr E.M., Baehs S., Eichhorst S.T., Brabletz T., Hu G., Froehlich T., Arnold G., Kress D.C., Goeke B., Fearon E.R., Kolligs F.T. J. Biol. Chem. 280:7962-7975(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION.
[3]	"URB expression in human dermal papilla cells." Cha S.-Y., Sung Y.K., Im S., Kwack M.H., Kim M.K., Kim J.C. J. Dermatol. Sci. 39:128-130(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION. Tissue: Hair follicle dermal papilla.
[4]	"A novel gene from human brain endothelial cell PCR select library." Yonezawa T., Ninomiya Y. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain endothelium.
[5]	Guo J.H., Yu L. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon endothelium, Endometrium and Stomach.
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain, Chondrosarcoma and PNS.
[9]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-583 (ISOFORM 2). Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY333429 mRNA. Translation: AAQ96742.1. AY548106 mRNA. Translation: AAS66643.1. AY548107 mRNA. Translation: AAS66644.1. AY526612 mRNA. Translation: AAS92235.1. AB052098 mRNA. Translation: BAD05134.1. AF506819 mRNA. Translation: AAM33633.1. BX647817 mRNA. Translation: CAH56167.1. BX647117 mRNA. Translation: CAH56178.1. AL833034 mRNA. Translation: CAH56325.1. CH471052 Genomic DNA. Translation: EAW79663.1. CH471052 Genomic DNA. Translation: EAW79665.1. BC042105 mRNA. Translation: AAH42105.1. BC073164 mRNA. Translation: AAH73164.1. BC086876 mRNA. Translation: AAH86876.1. BC110842 mRNA. Translation: AAI10843.1. BC116178 mRNA. Translation: AAI16179.1. AK075210 mRNA. Translation: BAC11475.1.
IPI	IPI00260630. IPI00795085. IPI00844310.
RefSeq	NP_955805.1. NM_199511.1. NP_955806.1. NM_199512.1.
UniGene	Hs.477128.
3D structure databases
ProteinModelPortal	Q76M96.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000206423.
PTM databases
PhosphoSite	Q76M96.
Polymorphism databases
DMDM	74712933.
Proteomic databases
PaxDb	Q76M96.
PeptideAtlas	Q76M96.
PRIDE	Q76M96.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000206423; ENSP00000206423; ENSG00000091986. ENST00000439685; ENSP00000411814; ENSG00000091986.
GeneID	151887.
KEGG	hsa:151887.
UCSC	uc003dzf.3. human.
Organism-specific databases
CTD	151887.
GeneCards	GC03M112323.
H-InvDB	HIX0003550.
HGNC	HGNC:30649. CCDC80.
HPA	CAB025158. HPA002266.
MIM	608298. gene.
neXtProt	NX_Q76M96.
PharmGKB	PA144596470.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42473.
HOVERGEN	HBG104210.
InParanoid	Q76M96.
OMA	AMYEVID.
OrthoDB	EOG4N30NC.
PhylomeDB	Q76M96.
Gene expression databases
ArrayExpress	Q76M96.
Bgee	Q76M96.
CleanEx	HS_CCDC80.
Genevestigator	Q76M96.
Family and domain databases
InterPro	IPR025232. DUF4174. IPR024856. Equarin. [Graphical view]
PANTHER	PTHR19325:SF2. PTHR19325:SF2. 1 hit.
Pfam	PF13778. DUF4174. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CCDC80. human.
GenomeRNAi	151887.
NextBio	86811.
SOURCE	Search...

Entry information

Entry name

CCD80_HUMAN

Accession

Primary (citable) accession number: Q76M96
Secondary accession number(s): D3DN67 , Q5PR20, Q6GPG9, Q8IVT6, Q8NBV1, Q8NHY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.