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Protein
Submitted name:

MNTK1

Gene

Kcnk12

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotationImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Submitted name:
MNTK1Imported
Submitted name:
Potassium channel, subfamily K, member 12Imported
Gene namesi
Name:Kcnk12Imported
Synonyms:mntk1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2684043 Kcnk12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 60HelicalSequence analysisAdd BLAST22
Transmembranei119 – 140HelicalSequence analysisAdd BLAST22
Transmembranei146 – 176HelicalSequence analysisAdd BLAST31
Transmembranei213 – 234HelicalSequence analysisAdd BLAST22
Transmembranei246 – 263HelicalSequence analysisAdd BLAST18
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000050138

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053595

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 168Ion_trans_2InterPro annotationAdd BLAST58
Domaini224 – 302Ion_trans_2InterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4404 Eukaryota
ENOG410XRZJ LUCA
GeneTreeiENSGT00860000133807
HOGENOMiHOG000013227
HOVERGENiHBG052238
KOiK04921
OMAiNGYPRTV
OrthoDBiEOG091G06SB
TreeFamiTF313947

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR005410 2pore_dom_K_chnl_THIK
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PRINTSiPR01333 2POREKCHANEL
PR01588 THIKCHANNEL

Sequencei

Sequence statusi: Complete.

Q76M80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRSPRPPP RRCRRRLPRP SCCCCCCRRS HLNEDTGRFV LLAALIGLYL
60 70 80 90 100
VAGATVFSAL ESPGEAEARA RWGATLRNFS AAHGVAEPEL RAFLRHYEAA
110 120 130 140 150
LAAGVRADAL RPRWDFPGAF YFVGTVVSTI GFGMTTPATV GGKAFLIAYG
160 170 180 190 200
LFGCAGTILF FNLFLERIIS LLAFIMRACR ERQLRRSGLL PATFRRGSAL
210 220 230 240 250
SEADSLAGWK PSVYHVLLIL GLFAVLLACC ASAMYTSVEG WDYVDSLYFC
260 270 280 290 300
FVTFSTIGFG DLVSSQHAAY RNQGLYRLGN FLFILLGVCC IYSLFNVISI
310 320 330 340 350
LIKQVLNWML RKLSCRCCTR CCPAPGAPLA RRNAITPGSR LRRRLAALGA
360 370 380 390 400
DPATRDSDAE GRRLSGELIS MRDLTASNKV SLALLQKQLS ETANGYPRSV
410 420 430
CVNTRQNGFS GGVGALGIMN NRLAETSASR
Length:430
Mass (Da):46,949
Last modified:July 5, 2004 - v1
Checksum:iA33771BD78A0B977
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124316 Genomic DNA No translation available.
BC138133 mRNA Translation: AAI38134.1
BC138134 mRNA Translation: AAI38135.1
AB052939 mRNA Translation: BAD06001.1
RefSeqiNP_954859.1, NM_199251.1
UniGeneiMm.312046

Genome annotation databases

EnsembliENSMUST00000055221; ENSMUSP00000053595; ENSMUSG00000050138
GeneIDi210741
KEGGimmu:210741
UCSCiuc008dvc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ76M80_MOUSE
AccessioniPrimary (citable) accession number: Q76M80
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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