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Protein
Submitted name:

MNTK1

Gene

Kcnk12

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
MNTK1Imported
Submitted name:
Potassium channel, subfamily K, member 12Imported
Submitted name:
Protein Kcnk12Imported
Gene namesi
Name:Kcnk12Imported
Synonyms:mntk1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2684043. Kcnk12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 6022HelicalSequence analysisAdd
BLAST
Transmembranei119 – 14022HelicalSequence analysisAdd
BLAST
Transmembranei146 – 17631HelicalSequence analysisAdd
BLAST
Transmembranei213 – 23422HelicalSequence analysisAdd
BLAST
Transmembranei246 – 26318HelicalSequence analysisAdd
BLAST
Transmembranei275 – 29521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

PTM databases

PhosphoSiteiQ76M80.

Expressioni

Gene expression databases

BgeeiENSMUSG00000050138.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053595.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 16858Ion_trans_2InterPro annotationAdd
BLAST
Domaini224 – 30279Ion_trans_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013227.
HOVERGENiHBG052238.
KOiK04921.
OMAiMISMRDL.
OrthoDBiEOG091G06SB.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR005410. 2pore_dom_K_chnl_THIK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q76M80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRSPRPPP RRCRRRLPRP SCCCCCCRRS HLNEDTGRFV LLAALIGLYL
60 70 80 90 100
VAGATVFSAL ESPGEAEARA RWGATLRNFS AAHGVAEPEL RAFLRHYEAA
110 120 130 140 150
LAAGVRADAL RPRWDFPGAF YFVGTVVSTI GFGMTTPATV GGKAFLIAYG
160 170 180 190 200
LFGCAGTILF FNLFLERIIS LLAFIMRACR ERQLRRSGLL PATFRRGSAL
210 220 230 240 250
SEADSLAGWK PSVYHVLLIL GLFAVLLACC ASAMYTSVEG WDYVDSLYFC
260 270 280 290 300
FVTFSTIGFG DLVSSQHAAY RNQGLYRLGN FLFILLGVCC IYSLFNVISI
310 320 330 340 350
LIKQVLNWML RKLSCRCCTR CCPAPGAPLA RRNAITPGSR LRRRLAALGA
360 370 380 390 400
DPATRDSDAE GRRLSGELIS MRDLTASNKV SLALLQKQLS ETANGYPRSV
410 420 430
CVNTRQNGFS GGVGALGIMN NRLAETSASR
Length:430
Mass (Da):46,949
Last modified:July 5, 2004 - v1
Checksum:iA33771BD78A0B977
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124316 Genomic DNA. No translation available.
BC138133 mRNA. Translation: AAI38134.1.
BC138134 mRNA. Translation: AAI38135.1.
AB052939 mRNA. Translation: BAD06001.1.
RefSeqiNP_954859.1. NM_199251.1.
UniGeneiMm.312046.

Genome annotation databases

EnsembliENSMUST00000055221; ENSMUSP00000053595; ENSMUSG00000050138.
GeneIDi210741.
KEGGimmu:210741.
UCSCiuc008dvc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124316 Genomic DNA. No translation available.
BC138133 mRNA. Translation: AAI38134.1.
BC138134 mRNA. Translation: AAI38135.1.
AB052939 mRNA. Translation: BAD06001.1.
RefSeqiNP_954859.1. NM_199251.1.
UniGeneiMm.312046.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053595.

PTM databases

PhosphoSiteiQ76M80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055221; ENSMUSP00000053595; ENSMUSG00000050138.
GeneIDi210741.
KEGGimmu:210741.
UCSCiuc008dvc.1. mouse.

Organism-specific databases

CTDi56660.
MGIiMGI:2684043. Kcnk12.

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013227.
HOVERGENiHBG052238.
KOiK04921.
OMAiMISMRDL.
OrthoDBiEOG091G06SB.
TreeFamiTF313947.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050138.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR005410. 2pore_dom_K_chnl_THIK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiQ76M80_MOUSE
AccessioniPrimary (citable) accession number: Q76M80
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.