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Protein

Solute carrier family 22 member 27

Gene

Slc22a27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Isoform 1: Does not appear to have transporter activity.1 Publication
Isoform 2: Sodium-independent organic anion transporter which exhibits high specificity for L-carnitine. Can also transport salicylic acid and the drug cimetidine.1 Publication

Kineticsi

  1. KM=2.8 µM for L-carnitine (isoform 2)1 Publication
  2. KM=16.1 µM for cimetidine (isoform 2)1 Publication
  3. KM=175.5 µM for salicylic acid (isoform 2)1 Publication

    GO - Molecular functioni

    GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.1.19.40. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 27Imported
    Alternative name(s):
    Organic anion transporter 91 Publication
    Gene namesi
    Name:Slc22a27Imported
    Synonyms:Oat91 Publication
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    Proteomesi
    • UP000000589 Componenti: Chromosome 19

    Organism-specific databases

    MGIiMGI:3042283. Slc22a27.

    Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 15CytoplasmicCuratedAdd BLAST15
    Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
    Topological domaini37 – 145ExtracellularCuratedAdd BLAST109
    Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
    Topological domaini167 – 173CytoplasmicCurated7
    Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
    Topological domaini195 – 203ExtracellularCurated9
    Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
    Topological domaini225 – 234CytoplasmicCurated10
    Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
    Topological domaini256 – 258ExtracellularCurated3
    Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
    Topological domaini280 – 348CytoplasmicCuratedAdd BLAST69
    Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
    Topological domaini370 – 376ExtracellularCurated7
    Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
    Topological domaini398 – 405CytoplasmicCurated8
    Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
    Topological domaini427 – 432ExtracellularCurated6
    Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
    Topological domaini454 – 467CytoplasmicCuratedAdd BLAST14
    Transmembranei468 – 488HelicalSequence analysisAdd BLAST21
    Topological domaini489 – 494ExtracellularCurated6
    Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
    Topological domaini516 – 551CytoplasmicCuratedAdd BLAST36

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00004367751 – 551Solute carrier family 22 member 27Add BLAST551

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
    Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
    Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
    Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
    Glycosylationi107N-linked (GlcNAc...)Sequence analysis1

    Keywords - PTMi

    Glycoprotein

    PTM databases

    PhosphoSitePlusiQ76M72.

    Expressioni

    Tissue specificityi

    Expressed in proximal kidney tubules, and in liver hepatocytes (at protein level).1 Publication

    Gene expression databases

    BgeeiENSMUSG00000067656.
    ExpressionAtlasiQ76M72. baseline and differential.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000093991.

    Structurei

    3D structure databases

    ProteinModelPortaliQ76M72.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0255. Eukaryota.
    COG0477. LUCA.
    GeneTreeiENSGT00760000118852.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    KOiK08206.
    OMAiCHGSELI.
    OrthoDBiEOG091G04GS.
    PhylomeDBiQ76M72.
    TreeFamiTF315847.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport-like.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q76M72-1) [UniParc]FASTAAdd to basket
    Also known as: L1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MSFQELLNQV GSLGRFQILQ IVFLLLLNAI VVPHIAMENF TAAIPNHRCW
    60 70 80 90 100
    VPILDNDTAS DNGSRILSQD DLLRISIPLD SNLRPEKCRR FAQPQWHLLH
    110 120 130 140 150
    LNGTFSNVSE PDTEPCVDGW VYDRSNFLST IVTEWDLVCE SQALNSVTKF
    160 170 180 190 200
    SFMIGLFIGG IICGHLSDRL GRKFILTCAL LQFAITETCV AFAPSFFIYC
    210 220 230 240 250
    SLRFLAGLSV EPILVNSHLL MLEWTSPKFL TMMAALLSCA PNIGYMISAG
    260 270 280 290 300
    LAFLFRIWHH LQLTMSVPIF FFLILTRWLS ESARWLIVTN KPQKGLKELR
    310 320 330 340 350
    KVAHMNGMKN SGDLTMEIVR TSMKAELEAA KTKPSLRDLF HTSILRKRIC
    360 370 380 390 400
    VLSFMRLFFT VSIFGLAVHL QHLSSNIILL QFLISALAIL VSVIGPFVLN
    410 420 430 440 450
    HIGRRITYLV LMSLRGIFIL IAVFVPQEMQ TLRIIMATLA EGISSLCVGV
    460 470 480 490 500
    SRLHTNELLP TTLRATAVGV IGFFGNSGSF LSPLFMLLAT YYANMPWIFY
    510 520 530 540 550
    GGFSIFNAFT VFLLPETKNQ PLPDSTHDVG NDWKESRKGK KEDPIIKVTR

    F
    Length:551
    Mass (Da):62,045
    Last modified:July 5, 2004 - v1
    Checksum:iCA81960DC4C3393F
    GO
    Isoform 2 (identifier: Q76M72-2) [UniParc]FASTAAdd to basket
    Also known as: S1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         170-277: Missing.

    Show »
    Length:443
    Mass (Da):49,840
    Checksum:iBB13860241AF549B
    GO

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_058421170 – 277Missing in isoform 2. Add BLAST108

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB056442 mRNA. Translation: BAB85630.1.
    AB056443 mRNA. Translation: BAB85631.1.
    AC115715 Genomic DNA. No translation available.
    AC122119 Genomic DNA. No translation available.
    CCDSiCCDS50380.1. [Q76M72-1]
    RefSeqiNP_599017.1. NM_134256.1. [Q76M72-1]
    XP_006526791.1. XM_006526728.1. [Q76M72-1]
    UniGeneiMm.326517.

    Genome annotation databases

    EnsembliENSMUST00000075619; ENSMUSP00000093991; ENSMUSG00000067656. [Q76M72-1]
    ENSMUST00000182102; ENSMUSP00000138475; ENSMUSG00000067656. [Q76M72-2]
    GeneIDi171405.
    KEGGimmu:171405.
    UCSCiuc008gls.1. mouse. [Q76M72-1]
    uc012bhz.1. mouse.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB056442 mRNA. Translation: BAB85630.1.
    AB056443 mRNA. Translation: BAB85631.1.
    AC115715 Genomic DNA. No translation available.
    AC122119 Genomic DNA. No translation available.
    CCDSiCCDS50380.1. [Q76M72-1]
    RefSeqiNP_599017.1. NM_134256.1. [Q76M72-1]
    XP_006526791.1. XM_006526728.1. [Q76M72-1]
    UniGeneiMm.326517.

    3D structure databases

    ProteinModelPortaliQ76M72.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000093991.

    Protein family/group databases

    TCDBi2.A.1.19.40. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitePlusiQ76M72.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSMUST00000075619; ENSMUSP00000093991; ENSMUSG00000067656. [Q76M72-1]
    ENSMUST00000182102; ENSMUSP00000138475; ENSMUSG00000067656. [Q76M72-2]
    GeneIDi171405.
    KEGGimmu:171405.
    UCSCiuc008gls.1. mouse. [Q76M72-1]
    uc012bhz.1. mouse.

    Organism-specific databases

    CTDi171405.
    MGIiMGI:3042283. Slc22a27.

    Phylogenomic databases

    eggNOGiKOG0255. Eukaryota.
    COG0477. LUCA.
    GeneTreeiENSGT00760000118852.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    KOiK08206.
    OMAiCHGSELI.
    OrthoDBiEOG091G04GS.
    PhylomeDBiQ76M72.
    TreeFamiTF315847.

    Miscellaneous databases

    PROiQ76M72.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSMUSG00000067656.
    ExpressionAtlasiQ76M72. baseline and differential.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport-like.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiS22AR_MOUSE
    AccessioniPrimary (citable) accession number: Q76M72
    Secondary accession number(s): Q76M71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 6, 2016
    Last sequence update: July 5, 2004
    Last modified: November 30, 2016
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.