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Protein

DAN domain family member 5

Gene

Dand5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, and tissue growth and differentiation.1 Publication

GO - Molecular functioni

  • morphogen activity Source: BHF-UCL

GO - Biological processi

  • atrial septum development Source: BHF-UCL
  • determination of heart left/right asymmetry Source: BHF-UCL
  • determination of left/right asymmetry in lateral mesoderm Source: BHF-UCL
  • determination of left/right symmetry Source: MGI
  • negative regulation of BMP signaling pathway Source: BHF-UCL
  • negative regulation of nodal signaling pathway Source: BHF-UCL
  • negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: GO_Central
  • negative regulation of nodal signaling pathway involved in determination of left/right asymmetry Source: BHF-UCL
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: BHF-UCL
  • regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • sequestering of BMP in extracellular matrix Source: GO_Central
  • sequestering of nodal from receptor via nodal binding Source: BHF-UCL
  • signal transduction involved in regulation of gene expression Source: GO_Central
  • ventricular septum development Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
DAN domain family member 5
Alternative name(s):
Cerberus-like protein 2
Short name:
Cerl-2
Gene namesi
Name:Dand5
Synonyms:Cerl2, Sp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1344365. Dand5.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: BHF-UCL
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice display multiple laterality defects including randomization of the L/R axis, left pulmonary isomerism thoracic situs inversus and cardiovascular malformations.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 185162DAN domain family member 5PRO_0000311805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 144By similarity
Disulfide bondi111 ↔ 158By similarity
Disulfide bondi121 ↔ 179By similarity
Disulfide bondi125 ↔ 181By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ76LW6.
PRIDEiQ76LW6.

PTM databases

PhosphoSiteiQ76LW6.

Expressioni

Developmental stagei

At E7.0 (early head-fold stage) expressed in perinodal region. At E7.5 (late head-fold stage) expression begins to decrease in intensity on the left side and starts to be asymmetrically up-regulated on the right side of the node. By early E8.0 (somitogenesis), highly expressed in the right side of the node. No expression seen in later stages of development.1 Publication

Gene expression databases

BgeeiENSMUSG00000053226.
CleanExiMM_DAND5.
MM_SP1.
GenevisibleiQ76LW6. MM.

Interactioni

Protein-protein interaction databases

BioGridi204764. 1 interaction.
STRINGi10090.ENSMUSP00000070057.

Structurei

3D structure databases

ProteinModelPortaliQ76LW6.
SMRiQ76LW6. Positions 97-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 18286CTCKAdd
BLAST

Sequence similaritiesi

Belongs to the DAN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYA9. Eukaryota.
ENOG410Y6UJ. LUCA.
GeneTreeiENSGT00530000063926.
HOGENOMiHOG000112140.
HOVERGENiHBG094958.
InParanoidiQ76LW6.
OMAiHLCFGRC.
OrthoDBiEOG091G0PRJ.
PhylomeDBiQ76LW6.
TreeFamiTF106445.

Family and domain databases

InterProiIPR016860. Cerberus.
IPR006207. Cys_knot_C.
IPR004133. DAN.
[Graphical view]
PfamiPF03045. DAN. 1 hit.
[Graphical view]
PIRSFiPIRSF027807. Cerberus. 1 hit.
SMARTiSM00041. CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q76LW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRSQFTTLL GLFSGAWLPT GSGRPGAPAT PVQSGTAINQ SWTLDPLVPI
60 70 80 90 100
SALGSWEAFL GLQNKQQGTG ELQGGGQRVA AGVPLPLAPQ EVLQETCKAL
110 120 130 140 150
SFVQVISRPG CTSARVLNHL CFGRCSSFYI PSSDPTPVVF CNSCVPARKR
160 170 180
WTSVTLWCGA GQLASPRRVR ISTVLVQKCQ CRPKL
Length:185
Mass (Da):19,772
Last modified:July 5, 2004 - v1
Checksum:i520A745E246AF4DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY387409 mRNA. Translation: AAR25615.1.
AB070694 mRNA. Translation: BAC82439.1.
BC115659 mRNA. Translation: AAI15660.1.
CCDSiCCDS22477.1.
RefSeqiNP_957679.1. NM_201227.3.
UniGeneiMm.304252.

Genome annotation databases

EnsembliENSMUST00000065539; ENSMUSP00000070057; ENSMUSG00000053226.
GeneIDi23863.
KEGGimmu:23863.
UCSCiuc009mnh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY387409 mRNA. Translation: AAR25615.1.
AB070694 mRNA. Translation: BAC82439.1.
BC115659 mRNA. Translation: AAI15660.1.
CCDSiCCDS22477.1.
RefSeqiNP_957679.1. NM_201227.3.
UniGeneiMm.304252.

3D structure databases

ProteinModelPortaliQ76LW6.
SMRiQ76LW6. Positions 97-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204764. 1 interaction.
STRINGi10090.ENSMUSP00000070057.

PTM databases

PhosphoSiteiQ76LW6.

Proteomic databases

PaxDbiQ76LW6.
PRIDEiQ76LW6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065539; ENSMUSP00000070057; ENSMUSG00000053226.
GeneIDi23863.
KEGGimmu:23863.
UCSCiuc009mnh.1. mouse.

Organism-specific databases

CTDi199699.
MGIiMGI:1344365. Dand5.

Phylogenomic databases

eggNOGiENOG410IYA9. Eukaryota.
ENOG410Y6UJ. LUCA.
GeneTreeiENSGT00530000063926.
HOGENOMiHOG000112140.
HOVERGENiHBG094958.
InParanoidiQ76LW6.
OMAiHLCFGRC.
OrthoDBiEOG091G0PRJ.
PhylomeDBiQ76LW6.
TreeFamiTF106445.

Miscellaneous databases

PROiQ76LW6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053226.
CleanExiMM_DAND5.
MM_SP1.
GenevisibleiQ76LW6. MM.

Family and domain databases

InterProiIPR016860. Cerberus.
IPR006207. Cys_knot_C.
IPR004133. DAN.
[Graphical view]
PfamiPF03045. DAN. 1 hit.
[Graphical view]
PIRSFiPIRSF027807. Cerberus. 1 hit.
SMARTiSM00041. CT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDAND5_MOUSE
AccessioniPrimary (citable) accession number: Q76LW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.