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Q76LW2

- H6ST2_CHICK

UniProt

Q76LW2 - H6ST2_CHICK

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Protein

Heparan-sulfate 6-O-sulfotransferase 2

Gene

HS6ST2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate (By similarity). May also play a role in limb development.By similarity1 Publication

Catalytic activityi

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.

GO - Molecular functioni

  1. sulfotransferase activity Source: InterPro

GO - Biological processi

  1. limb development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Heparan-sulfate 6-O-sulfotransferase 2 (EC:2.8.2.-)
Short name:
HS6ST-2
Short name:
cHS6ST-2
Gene namesi
Name:HS6ST2
ORF Names:RCJMB04_19a20
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Heparan-sulfate 6-O-sulfotransferase 2PRO_0000190807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ76LW2.

Expressioni

Developmental stagei

Expressed in the developing wing bud. At stage 31, widely expressed with a higher level in limb and head.1 Publication

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence Analysis
Topological domaini29 – 403375LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni91 – 9775'-phosphosulfate-bindingSequence Analysis
Regioni180 – 18893'-phosphate bindingSequence Analysis

Sequence similaritiesi

Belongs to the sulfotransferase 6 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302961.
HOGENOMiHOG000007772.
HOVERGENiHBG083012.
InParanoidiQ76LW2.
KOiK08102.
PhylomeDBiQ76LW2.

Family and domain databases

InterProiIPR010635. Heparan_SO4-6-sulfoTrfase.
IPR027417. P-loop_NTPase.
IPR005331. Sulfotransferase.
[Graphical view]
PANTHERiPTHR12812. PTHR12812. 1 hit.
PfamiPF03567. Sulfotransfer_2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q76LW2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDRSHKVLL ALVMLFLFAV IVLQYVCPGT ECQLLRLRAL SPAAAADPYR
60 70 80 90 100
AEDETPARFV PRFNFSAGDL LRRVDFNIKG DDLIVFLHIQ KTGGTTFGRH
110 120 130 140 150
LVRNIQLEQP CECRAGQKKC TCHRPGKRET WLFSRFSTGW SCGLHADWTE
160 170 180 190 200
LTNCVPSVVD SKKEVRLRPS RNFYYITILR DPVSRYLSEW RHVQRGATWK
210 220 230 240 250
ASLHVCDGRS PTTEELPSCY TGDDWSGCSL QEFMDCPYNL ANNRQVRMLS
260 270 280 290 300
DLSLVGCYNL SVMPEEQRNK VLLDSAKENL KRMAFFGLTE FQRKTQYLFE
310 320 330 340 350
KTFNMNFISP FTQYNSTRAS SVEIDEQTQQ RIEALNFLDM ELYDYAKDLF
360 370 380 390 400
LQRYQYMRQK EHQEARRKRQ EQRKILRAKQ AHLREQGENS SSTDYLGNVE

RWR
Length:403
Mass (Da):47,175
Last modified:July 5, 2004 - v1
Checksum:i03BEE030927BF3BF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381R → H in CAG32152. (PubMed:15642098)Curated
Sequence conflicti215 – 2239Missing in CAG32152. (PubMed:15642098)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB071190 mRNA. Translation: BAD02830.1.
AJ720493 mRNA. Translation: CAG32152.1.
RefSeqiNP_989821.1. NM_204490.1.
UniGeneiGga.2632.

Genome annotation databases

GeneIDi395150.
KEGGigga:395150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB071190 mRNA. Translation: BAD02830.1 .
AJ720493 mRNA. Translation: CAG32152.1 .
RefSeqi NP_989821.1. NM_204490.1.
UniGenei Gga.2632.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q76LW2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395150.
KEGGi gga:395150.

Organism-specific databases

CTDi 90161.

Phylogenomic databases

eggNOGi NOG302961.
HOGENOMi HOG000007772.
HOVERGENi HBG083012.
InParanoidi Q76LW2.
KOi K08102.
PhylomeDBi Q76LW2.

Miscellaneous databases

NextBioi 20815242.

Family and domain databases

InterProi IPR010635. Heparan_SO4-6-sulfoTrfase.
IPR027417. P-loop_NTPase.
IPR005331. Sulfotransferase.
[Graphical view ]
PANTHERi PTHR12812. PTHR12812. 1 hit.
Pfami PF03567. Sulfotransfer_2. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Distinctive expression patterns of heparan sulfate O-sulfotransferases and regional differences in heparan sulfate structure in chick limb buds."
    Nogami K., Suzuki H., Habuchi H., Ishiguro N., Iwata H., Kimata K.
    J. Biol. Chem. 279:8219-8229(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.
  3. "Functional analysis of chick heparan sulfate 6-O-sulfotransferases in limb bud development."
    Kobayashi T., Habuchi H., Nogami K., Ashikari-Hada S., Tamura K., Ide H., Kimata K.
    Dev. Growth Differ. 52:146-156(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN LIMB BUD DEVELOPMENT.

Entry informationi

Entry nameiH6ST2_CHICK
AccessioniPrimary (citable) accession number: Q76LW2
Secondary accession number(s): Q5ZJE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3