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Q76LW2

- H6ST2_CHICK

UniProt

Q76LW2 - H6ST2_CHICK

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Protein
Heparan-sulfate 6-O-sulfotransferase 2
Gene
HS6ST2, RCJMB04_19a20
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate By similarity. May also play a role in limb development.1 Publication

Catalytic activityi

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.

GO - Molecular functioni

  1. sulfotransferase activity Source: InterPro

GO - Biological processi

  1. limb development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Heparan-sulfate 6-O-sulfotransferase 2 (EC:2.8.2.-)
Short name:
HS6ST-2
Short name:
cHS6ST-2
Gene namesi
Name:HS6ST2
ORF Names:RCJMB04_19a20
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Cytoplasmic Reviewed prediction
Transmembranei8 – 2821Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini29 – 403375Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Heparan-sulfate 6-O-sulfotransferase 2
PRO_0000190807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi259 – 2591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi315 – 3151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi389 – 3891N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ76LW2.

Expressioni

Developmental stagei

Expressed in the developing wing bud. At stage 31, widely expressed with a higher level in limb and head.1 Publication

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni91 – 9775'-phosphosulfate-binding Reviewed prediction
Regioni180 – 18893'-phosphate binding Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302961.
HOGENOMiHOG000007772.
HOVERGENiHBG083012.
InParanoidiQ76LW2.
KOiK08102.
PhylomeDBiQ76LW2.

Family and domain databases

InterProiIPR010635. Heparan_SO4-6-sulfoTrfase.
IPR027417. P-loop_NTPase.
IPR005331. Sulfotransferase.
[Graphical view]
PANTHERiPTHR12812. PTHR12812. 1 hit.
PfamiPF03567. Sulfotransfer_2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q76LW2-1 [UniParc]FASTAAdd to Basket

« Hide

MEDRSHKVLL ALVMLFLFAV IVLQYVCPGT ECQLLRLRAL SPAAAADPYR    50
AEDETPARFV PRFNFSAGDL LRRVDFNIKG DDLIVFLHIQ KTGGTTFGRH 100
LVRNIQLEQP CECRAGQKKC TCHRPGKRET WLFSRFSTGW SCGLHADWTE 150
LTNCVPSVVD SKKEVRLRPS RNFYYITILR DPVSRYLSEW RHVQRGATWK 200
ASLHVCDGRS PTTEELPSCY TGDDWSGCSL QEFMDCPYNL ANNRQVRMLS 250
DLSLVGCYNL SVMPEEQRNK VLLDSAKENL KRMAFFGLTE FQRKTQYLFE 300
KTFNMNFISP FTQYNSTRAS SVEIDEQTQQ RIEALNFLDM ELYDYAKDLF 350
LQRYQYMRQK EHQEARRKRQ EQRKILRAKQ AHLREQGENS SSTDYLGNVE 400
RWR 403
Length:403
Mass (Da):47,175
Last modified:July 5, 2004 - v1
Checksum:i03BEE030927BF3BF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381R → H in CAG32152. 1 Publication
Sequence conflicti215 – 2239Missing in CAG32152. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB071190 mRNA. Translation: BAD02830.1.
AJ720493 mRNA. Translation: CAG32152.1.
RefSeqiNP_989821.1. NM_204490.1.
UniGeneiGga.2632.

Genome annotation databases

GeneIDi395150.
KEGGigga:395150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB071190 mRNA. Translation: BAD02830.1 .
AJ720493 mRNA. Translation: CAG32152.1 .
RefSeqi NP_989821.1. NM_204490.1.
UniGenei Gga.2632.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q76LW2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395150.
KEGGi gga:395150.

Organism-specific databases

CTDi 90161.

Phylogenomic databases

eggNOGi NOG302961.
HOGENOMi HOG000007772.
HOVERGENi HBG083012.
InParanoidi Q76LW2.
KOi K08102.
PhylomeDBi Q76LW2.

Miscellaneous databases

NextBioi 20815242.

Family and domain databases

InterProi IPR010635. Heparan_SO4-6-sulfoTrfase.
IPR027417. P-loop_NTPase.
IPR005331. Sulfotransferase.
[Graphical view ]
PANTHERi PTHR12812. PTHR12812. 1 hit.
Pfami PF03567. Sulfotransfer_2. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Distinctive expression patterns of heparan sulfate O-sulfotransferases and regional differences in heparan sulfate structure in chick limb buds."
    Nogami K., Suzuki H., Habuchi H., Ishiguro N., Iwata H., Kimata K.
    J. Biol. Chem. 279:8219-8229(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.
  3. "Functional analysis of chick heparan sulfate 6-O-sulfotransferases in limb bud development."
    Kobayashi T., Habuchi H., Nogami K., Ashikari-Hada S., Tamura K., Ide H., Kimata K.
    Dev. Growth Differ. 52:146-156(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN LIMB BUD DEVELOPMENT.

Entry informationi

Entry nameiH6ST2_CHICK
AccessioniPrimary (citable) accession number: Q76LW2
Secondary accession number(s): Q5ZJE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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