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Protein

Glutathione peroxidase

Gene

Gpx4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, PeroxidaseUniRule annotationSAAS annotationImported

Keywords - Ligandi

SeleniumImported

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidaseUniRule annotation
Gene namesi
Name:Gpx4Imported
Synonyms:GPx4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:104767. Gpx4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

PTM databases

SwissPalmiQ76LV0.

Expressioni

Gene expression databases

ExpressionAtlasiQ76LV0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094863.

Structurei

3D structure databases

SMRiQ76LV0. Positions 89-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOVERGENiHBG004333.
KOiK05361.
TreeFamiTF338735.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q76LV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRAAARKRG RCRQRGGSPR GRRRRGPGRQ SPRKRPGPRR RKARARRRRR
60 70 80 90 100
ARPRRMEPIP EPFNPGPLLQ EPPQYCNSSE FLGLCASRDD WRCARSMHEF
110 120 130 140 150
SAKDIDGHMV CLDKYRGFVC IVTNVASQUG KTDVNYTQLV DLHARYAECG
160 170 180 190 200
LRILAFPCNQ FGRQEPGSNQ EIKEFAAGYN VKFDMYSKIC VNGDDAHPLW
210 220 230 240 250
KWMKVQPKGR GMLGNAIKWN FTKFLIDKNG CVVKRYGPME EPQVIEKDLP

CYL
Length:253
Mass (Da):29,194
Last modified:February 26, 2008 - v2
Checksum:iC55E2827533CDBF3
GO

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei129 – 1291SelenocysteineImported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159999 Genomic DNA. No translation available.
AC161120 Genomic DNA. No translation available.
AB072797 mRNA. Translation: BAC87835.1.
RefSeqiNP_001032830.2. NM_001037741.3.
UniGeneiMm.332810.
Mm.359573.

Genome annotation databases

EnsembliENSMUST00000097227; ENSMUSP00000094863; ENSMUSG00000075706.
GeneIDi625249.
KEGGimmu:625249.
UCSCiuc007gbl.2. mouse.

Keywords - Coding sequence diversityi

SelenocysteineImported

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159999 Genomic DNA. No translation available.
AC161120 Genomic DNA. No translation available.
AB072797 mRNA. Translation: BAC87835.1.
RefSeqiNP_001032830.2. NM_001037741.3.
UniGeneiMm.332810.
Mm.359573.

3D structure databases

SMRiQ76LV0. Positions 89-253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094863.

PTM databases

SwissPalmiQ76LV0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097227; ENSMUSP00000094863; ENSMUSG00000075706.
GeneIDi625249.
KEGGimmu:625249.
UCSCiuc007gbl.2. mouse.

Organism-specific databases

CTDi2879.
MGIiMGI:104767. Gpx4.

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOVERGENiHBG004333.
KOiK05361.
TreeFamiTF338735.

Miscellaneous databases

ChiTaRSiGpx4. mouse.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ76LV0. baseline and differential.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of nucleolar phospholipid hydroperoxide glutathione peroxidase in mammalian cells."
    Nakamura T., Imai H., Tsunashima N., Nakagawa Y.
    Biochem. Biophys. Res. Commun. 311:139-148(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Balb/cImported.
    Tissue: TestisImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ76LV0_MOUSE
AccessioniPrimary (citable) accession number: Q76LV0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: February 26, 2008
Last modified: June 8, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.