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Protein

Interleukin-21

Gene

IL21

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-21
Short name:
IL-21
Gene namesi
Name:IL21
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000001550318 – 146Interleukin-21Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 115Sequence analysis
Disulfide bondi71 ↔ 118Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ76LU5.
PRIDEiQ76LU5.

Expressioni

Tissue specificityi

Expressed in spleen, but not in the brain, heart, kidney, liver, and lung.1 Publication

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016413.

Structurei

3D structure databases

ProteinModelPortaliQ76LU5.
SMRiQ76LU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWTD. Eukaryota.
ENOG411198G. LUCA.
HOGENOMiHOG000113039.
HOVERGENiHBG052106.
InParanoidiQ76LU5.
KOiK05434.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
PANTHERiPTHR14356. PTHR14356. 1 hit.
PfamiView protein in Pfam
PF02372. IL15. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q76LU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERIVICLMV IFSGTVAHKS SSQGQDRLFI RLRQLIDIVD QLKNYVNDLD
60 70 80 90 100
PEFLPAPEDV KRHCERSAFS CFQKVQLKSA NNGDNEKIIN ILTKQLKRKL
110 120 130 140
PATNTGRRQK HEVTCPSCDS YEKKPPKEYL ERLKSLIQKM IHQHLS
Length:146
Mass (Da):16,948
Last modified:November 23, 2004 - v2
Checksum:i696566DA73F4B8BC
GO

Sequence cautioni

The sequence BAC87747 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073021 mRNA. Translation: BAC87747.1. Different initiation.
RefSeqiNP_942129.1. NM_198832.1.
UniGeneiBt.23583.

Genome annotation databases

GeneIDi378475.
KEGGibta:378475.

Similar proteinsi

Entry informationi

Entry nameiIL21_BOVIN
AccessioniPrimary (citable) accession number: Q76LU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: August 30, 2017
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families