Q76LU5 (IL21_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-21
Short name=IL-21

Gene names

Name:

IL21

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells By similarity. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation By similarity.
Subcellular location	Secreted Ref.1.
Tissue specificity	Expressed in spleen, but not in the brain, heart, kidney, liver, and lung. Ref.1
Sequence similarities	Belongs to the IL-15/IL-21 family.
Sequence caution	The sequence BAC87747.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell maturation Inferred from electronic annotation. Source: Compara immune response Inferred from electronic annotation. Source: InterPro positive regulation of T cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of interferon-gamma biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of interleukin-10 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-17 production Inferred from electronic annotation. Source: Compara positive regulation of natural killer cell cytokine production Inferred from electronic annotation. Source: Compara positive regulation of natural killer cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of natural killer cell mediated cytotoxicity Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Probable
	Chain	18 – 146	129	Interleukin-21		PRO_0000015503
Amino acid modifications
	Disulfide bond	64 ↔ 115		Potential
	Disulfide bond	71 ↔ 118		Potential

Sequences

	Sequence		Length	Mass (Da)
	Q76LU5 [UniParc]. Last modified November 23, 2004. Version 2. Checksum: 696566DA73F4B8BC	FASTA	146	16,948
	10 20 30 40 50 60 MERIVICLMV IFSGTVAHKS SSQGQDRLFI RLRQLIDIVD QLKNYVNDLD PEFLPAPEDV 70 80 90 100 110 120 KRHCERSAFS CFQKVQLKSA NNGDNEKIIN ILTKQLKRKL PATNTGRRQK HEVTCPSCDS 130 140 YEKKPPKEYL ERLKSLIQKM IHQHLS

References

[1]

"Cloning, expression, and tissue distribution of bovine interleukin-21." Muneta Y., Kikuma R., Yoshihara K., Mori Y. Vet. Immunol. Immunopathol. 95:73-80(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-32, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB073021 mRNA. Translation: BAC87747.1. Different initiation.
IPI	IPI00903592.
RefSeq	NP_942129.1. NM_198832.1.
UniGene	Bt.23583.
3D structure databases
ProteinModelPortal	Q76LU5.
SMR	Q76LU5. Positions 23-146.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000016413.
Proteomic databases
PRIDE	Q76LU5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	378475.
KEGG	bta:378475.
Organism-specific databases
CTD	59067.
Phylogenomic databases
eggNOG	NOG40525.
HOGENOM	HOG000113039.
HOVERGEN	HBG052106.
InParanoid	Q76LU5.
KO	K05434.
OrthoDB	EOG4DJJXM.
Gene expression databases
ArrayExpress	Q76LU5.
Family and domain databases
InterPro	IPR003443. Interleukin_15-like. [Graphical view]
Pfam	PF02372. IL15. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20813782.

Entry information

Entry name

IL21_BOVIN

Accession

Primary (citable) accession number: Q76LU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	November 23, 2004
Last modified:	April 3, 2013
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program