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Protein

Interleukin-21

Gene

IL21

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).By similarity

GO - Biological processi

  1. cell maturation Source: Ensembl
  2. immune response Source: InterPro
  3. positive regulation of B cell proliferation Source: Ensembl
  4. positive regulation of interferon-gamma biosynthetic process Source: Ensembl
  5. positive regulation of interleukin-10 production Source: Ensembl
  6. positive regulation of interleukin-17 production Source: Ensembl
  7. positive regulation of natural killer cell cytokine production Source: Ensembl
  8. positive regulation of natural killer cell differentiation Source: Ensembl
  9. positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
  10. positive regulation of T cell proliferation Source: Ensembl
  11. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  12. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-21
Short name:
IL-21
Gene namesi
Name:IL21
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 PublicationAdd
BLAST
Chaini18 – 146129Interleukin-21PRO_0000015503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 115Sequence Analysis
Disulfide bondi71 ↔ 118Sequence Analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ76LU5.

Expressioni

Tissue specificityi

Expressed in spleen, but not in the brain, heart, kidney, liver, and lung.1 Publication

Gene expression databases

ExpressionAtlasiQ76LU5. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016413.

Structurei

3D structure databases

ProteinModelPortaliQ76LU5.
SMRiQ76LU5. Positions 23-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40525.
HOGENOMiHOG000113039.
HOVERGENiHBG052106.
InParanoidiQ76LU5.
KOiK05434.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view]
PANTHERiPTHR14356. PTHR14356. 1 hit.
PfamiPF02372. IL15. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q76LU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERIVICLMV IFSGTVAHKS SSQGQDRLFI RLRQLIDIVD QLKNYVNDLD
60 70 80 90 100
PEFLPAPEDV KRHCERSAFS CFQKVQLKSA NNGDNEKIIN ILTKQLKRKL
110 120 130 140
PATNTGRRQK HEVTCPSCDS YEKKPPKEYL ERLKSLIQKM IHQHLS
Length:146
Mass (Da):16,948
Last modified:November 23, 2004 - v2
Checksum:i696566DA73F4B8BC
GO

Sequence cautioni

The sequence BAC87747.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073021 mRNA. Translation: BAC87747.1. Different initiation.
RefSeqiNP_942129.1. NM_198832.1.
UniGeneiBt.23583.

Genome annotation databases

GeneIDi378475.
KEGGibta:378475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073021 mRNA. Translation: BAC87747.1. Different initiation.
RefSeqiNP_942129.1. NM_198832.1.
UniGeneiBt.23583.

3D structure databases

ProteinModelPortaliQ76LU5.
SMRiQ76LU5. Positions 23-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016413.

Proteomic databases

PRIDEiQ76LU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378475.
KEGGibta:378475.

Organism-specific databases

CTDi59067.

Phylogenomic databases

eggNOGiNOG40525.
HOGENOMiHOG000113039.
HOVERGENiHBG052106.
InParanoidiQ76LU5.
KOiK05434.

Miscellaneous databases

NextBioi20813782.

Gene expression databases

ExpressionAtlasiQ76LU5. baseline.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view]
PANTHERiPTHR14356. PTHR14356. 1 hit.
PfamiPF02372. IL15. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning, expression, and tissue distribution of bovine interleukin-21."
    Muneta Y., Kikuma R., Yoshihara K., Mori Y.
    Vet. Immunol. Immunopathol. 95:73-80(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-32, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiIL21_BOVIN
AccessioniPrimary (citable) accession number: Q76LU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: January 7, 2015
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.