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Q76LU5

- IL21_BOVIN

UniProt

Q76LU5 - IL21_BOVIN

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Protein

Interleukin-21

Gene

IL21

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).By similarity

GO - Biological processi

  1. cell maturation Source: Ensembl
  2. immune response Source: InterPro
  3. positive regulation of B cell proliferation Source: Ensembl
  4. positive regulation of interferon-gamma biosynthetic process Source: Ensembl
  5. positive regulation of interleukin-10 production Source: Ensembl
  6. positive regulation of interleukin-17 production Source: Ensembl
  7. positive regulation of natural killer cell cytokine production Source: Ensembl
  8. positive regulation of natural killer cell differentiation Source: Ensembl
  9. positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
  10. positive regulation of T cell proliferation Source: Ensembl
  11. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  12. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-21
Short name:
IL-21
Gene namesi
Name:IL21
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 PublicationAdd
BLAST
Chaini18 – 146129Interleukin-21PRO_0000015503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 115Sequence Analysis
Disulfide bondi71 ↔ 118Sequence Analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ76LU5.

Expressioni

Tissue specificityi

Expressed in spleen, but not in the brain, heart, kidney, liver, and lung.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016413.

Structurei

3D structure databases

ProteinModelPortaliQ76LU5.
SMRiQ76LU5. Positions 23-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40525.
HOGENOMiHOG000113039.
HOVERGENiHBG052106.
InParanoidiQ76LU5.
KOiK05434.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view]
PANTHERiPTHR14356. PTHR14356. 1 hit.
PfamiPF02372. IL15. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q76LU5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERIVICLMV IFSGTVAHKS SSQGQDRLFI RLRQLIDIVD QLKNYVNDLD
60 70 80 90 100
PEFLPAPEDV KRHCERSAFS CFQKVQLKSA NNGDNEKIIN ILTKQLKRKL
110 120 130 140
PATNTGRRQK HEVTCPSCDS YEKKPPKEYL ERLKSLIQKM IHQHLS
Length:146
Mass (Da):16,948
Last modified:November 23, 2004 - v2
Checksum:i696566DA73F4B8BC
GO

Sequence cautioni

The sequence BAC87747.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073021 mRNA. Translation: BAC87747.1. Different initiation.
RefSeqiNP_942129.1. NM_198832.1.
UniGeneiBt.23583.

Genome annotation databases

GeneIDi378475.
KEGGibta:378475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073021 mRNA. Translation: BAC87747.1 . Different initiation.
RefSeqi NP_942129.1. NM_198832.1.
UniGenei Bt.23583.

3D structure databases

ProteinModelPortali Q76LU5.
SMRi Q76LU5. Positions 23-146.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000016413.

Proteomic databases

PRIDEi Q76LU5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 378475.
KEGGi bta:378475.

Organism-specific databases

CTDi 59067.

Phylogenomic databases

eggNOGi NOG40525.
HOGENOMi HOG000113039.
HOVERGENi HBG052106.
InParanoidi Q76LU5.
KOi K05434.

Miscellaneous databases

NextBioi 20813782.

Family and domain databases

InterProi IPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view ]
PANTHERi PTHR14356. PTHR14356. 1 hit.
Pfami PF02372. IL15. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning, expression, and tissue distribution of bovine interleukin-21."
    Muneta Y., Kikuma R., Yoshihara K., Mori Y.
    Vet. Immunol. Immunopathol. 95:73-80(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-32, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiIL21_BOVIN
AccessioniPrimary (citable) accession number: Q76LU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: October 1, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3