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Q76LU5

- IL21_BOVIN

UniProt

Q76LU5 - IL21_BOVIN

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Protein

Interleukin-21

Gene
IL21
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells By similarity. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation By similarity.

GO - Biological processi

  1. cell maturation Source: Ensembl
  2. immune response Source: InterPro
  3. positive regulation of B cell proliferation Source: Ensembl
  4. positive regulation of interferon-gamma biosynthetic process Source: Ensembl
  5. positive regulation of interleukin-10 production Source: Ensembl
  6. positive regulation of interleukin-17 production Source: Ensembl
  7. positive regulation of natural killer cell cytokine production Source: Ensembl
  8. positive regulation of natural killer cell differentiation Source: Ensembl
  9. positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
  10. positive regulation of T cell proliferation Source: Ensembl
  11. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  12. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-21
Short name:
IL-21
Gene namesi
Name:IL21
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 InferredAdd
BLAST
Chaini18 – 146129Interleukin-21PRO_0000015503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 115 Reviewed prediction
Disulfide bondi71 ↔ 118 Reviewed prediction

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ76LU5.

Expressioni

Tissue specificityi

Expressed in spleen, but not in the brain, heart, kidney, liver, and lung.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016413.

Structurei

3D structure databases

ProteinModelPortaliQ76LU5.
SMRiQ76LU5. Positions 23-146.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40525.
HOGENOMiHOG000113039.
HOVERGENiHBG052106.
InParanoidiQ76LU5.
KOiK05434.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view]
PANTHERiPTHR14356. PTHR14356. 1 hit.
PfamiPF02372. IL15. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q76LU5-1 [UniParc]FASTAAdd to Basket

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MERIVICLMV IFSGTVAHKS SSQGQDRLFI RLRQLIDIVD QLKNYVNDLD    50
PEFLPAPEDV KRHCERSAFS CFQKVQLKSA NNGDNEKIIN ILTKQLKRKL 100
PATNTGRRQK HEVTCPSCDS YEKKPPKEYL ERLKSLIQKM IHQHLS 146
Length:146
Mass (Da):16,948
Last modified:November 23, 2004 - v2
Checksum:i696566DA73F4B8BC
GO

Sequence cautioni

The sequence BAC87747.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB073021 mRNA. Translation: BAC87747.1. Different initiation.
RefSeqiNP_942129.1. NM_198832.1.
UniGeneiBt.23583.

Genome annotation databases

GeneIDi378475.
KEGGibta:378475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB073021 mRNA. Translation: BAC87747.1 . Different initiation.
RefSeqi NP_942129.1. NM_198832.1.
UniGenei Bt.23583.

3D structure databases

ProteinModelPortali Q76LU5.
SMRi Q76LU5. Positions 23-146.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000016413.

Proteomic databases

PRIDEi Q76LU5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 378475.
KEGGi bta:378475.

Organism-specific databases

CTDi 59067.

Phylogenomic databases

eggNOGi NOG40525.
HOGENOMi HOG000113039.
HOVERGENi HBG052106.
InParanoidi Q76LU5.
KOi K05434.

Miscellaneous databases

NextBioi 20813782.

Family and domain databases

InterProi IPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view ]
PANTHERi PTHR14356. PTHR14356. 1 hit.
Pfami PF02372. IL15. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning, expression, and tissue distribution of bovine interleukin-21."
    Muneta Y., Kikuma R., Yoshihara K., Mori Y.
    Vet. Immunol. Immunopathol. 95:73-80(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-32, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiIL21_BOVIN
AccessioniPrimary (citable) accession number: Q76LU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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