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Q76LU5

- IL21_BOVIN

UniProt

Q76LU5 - IL21_BOVIN

Protein

Interleukin-21

Gene

IL21

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells By similarity. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation By similarity.By similarity

    GO - Biological processi

    1. cell maturation Source: Ensembl
    2. immune response Source: InterPro
    3. positive regulation of B cell proliferation Source: Ensembl
    4. positive regulation of interferon-gamma biosynthetic process Source: Ensembl
    5. positive regulation of interleukin-10 production Source: Ensembl
    6. positive regulation of interleukin-17 production Source: Ensembl
    7. positive regulation of natural killer cell cytokine production Source: Ensembl
    8. positive regulation of natural killer cell differentiation Source: Ensembl
    9. positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
    10. positive regulation of T cell proliferation Source: Ensembl
    11. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
    12. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-21
    Short name:
    IL-21
    Gene namesi
    Name:IL21
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 17171 PublicationAdd
    BLAST
    Chaini18 – 146129Interleukin-21PRO_0000015503Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi64 ↔ 115Sequence Analysis
    Disulfide bondi71 ↔ 118Sequence Analysis

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ76LU5.

    Expressioni

    Tissue specificityi

    Expressed in spleen, but not in the brain, heart, kidney, liver, and lung.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000016413.

    Structurei

    3D structure databases

    ProteinModelPortaliQ76LU5.
    SMRiQ76LU5. Positions 23-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-15/IL-21 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40525.
    HOGENOMiHOG000113039.
    HOVERGENiHBG052106.
    InParanoidiQ76LU5.
    KOiK05434.

    Family and domain databases

    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR003443. IL-15/IL-21_fam.
    IPR028151. IL-21.
    [Graphical view]
    PANTHERiPTHR14356. PTHR14356. 1 hit.
    PfamiPF02372. IL15. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q76LU5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERIVICLMV IFSGTVAHKS SSQGQDRLFI RLRQLIDIVD QLKNYVNDLD    50
    PEFLPAPEDV KRHCERSAFS CFQKVQLKSA NNGDNEKIIN ILTKQLKRKL 100
    PATNTGRRQK HEVTCPSCDS YEKKPPKEYL ERLKSLIQKM IHQHLS 146
    Length:146
    Mass (Da):16,948
    Last modified:November 23, 2004 - v2
    Checksum:i696566DA73F4B8BC
    GO

    Sequence cautioni

    The sequence BAC87747.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB073021 mRNA. Translation: BAC87747.1. Different initiation.
    RefSeqiNP_942129.1. NM_198832.1.
    UniGeneiBt.23583.

    Genome annotation databases

    GeneIDi378475.
    KEGGibta:378475.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB073021 mRNA. Translation: BAC87747.1 . Different initiation.
    RefSeqi NP_942129.1. NM_198832.1.
    UniGenei Bt.23583.

    3D structure databases

    ProteinModelPortali Q76LU5.
    SMRi Q76LU5. Positions 23-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000016413.

    Proteomic databases

    PRIDEi Q76LU5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 378475.
    KEGGi bta:378475.

    Organism-specific databases

    CTDi 59067.

    Phylogenomic databases

    eggNOGi NOG40525.
    HOGENOMi HOG000113039.
    HOVERGENi HBG052106.
    InParanoidi Q76LU5.
    KOi K05434.

    Miscellaneous databases

    NextBioi 20813782.

    Family and domain databases

    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR003443. IL-15/IL-21_fam.
    IPR028151. IL-21.
    [Graphical view ]
    PANTHERi PTHR14356. PTHR14356. 1 hit.
    Pfami PF02372. IL15. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression, and tissue distribution of bovine interleukin-21."
      Muneta Y., Kikuma R., Yoshihara K., Mori Y.
      Vet. Immunol. Immunopathol. 95:73-80(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-32, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiIL21_BOVIN
    AccessioniPrimary (citable) accession number: Q76LU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3