Q76LU2 (Q76LU2_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
LDL receptor-related protein 4 EMBL BAD18061.2

Gene names

Name:	Lrp4 RGD 619731
Synonyms:	LRP4 EMBL BAD18061.2

Organism

Rattus norvegicus (Rat) EMBL BAD18061.2

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1905 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Cellular component	Membrane
Domain	EGF-like domain RuleBase RU000459 SAAS SAAS018097 Repeat SAAS SAAS000033 Transmembrane Transmembrane helix SAAS SAAS000033
Molecular function	Receptor EMBL BAD18061.2
PTM	Disulfide bond SAAS SAAS023415
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q76LU2 [UniParc]. Last modified June 28, 2011. Version 2. Checksum: E57CB3F1F12E35F8	FASTA	1,905	211,933
	10 20 30 40 50 60 MRRWWGALLL GALLCAHGTA SNLECACGRS HFTCAVSALG ECTCIPAQWQ CDGDNDCGDH 70 80 90 100 110 120 SDEDGCTLPT CSPLDFHCDN GKCIRRSWVC DGDNDCEDDS DEQDCPPREC EEDEFPCQNG 130 140 150 160 170 180 YCIRSLWHCD GDNDCGDNSD EQCDMRKCSD KEFRCSDGSC IAEHWYCDGD TDCKDGSDEE 190 200 210 220 230 240 SCPSAVPSPP CNLEEFQCAY GRRILDIYHC DGDDDCGDWS DESDCSSHQP CRSGEFMCDS 250 260 270 280 290 300 GLCVNAGWRC DGDADCDDQS DERNCTTSMC TAEQFRCRSG RCVRLSWRCD GEDDCADNSD 310 320 330 340 350 360 EENCENTGSP QCASDQFLCW NGRCIGQRKL CNGVNDCGDN SDESPQQNCR PRTGEENCNV 370 380 390 400 410 420 NNGGCAQKCQ MIRGAVQCTC HTGYRLTEDG RTCQDVNECA EEGYCSQGCT NSEGAFQCWC 430 440 450 460 470 480 EAGYELRPDR RSCKALGPEP VLLFANRIDI RQVLPHRSEY TLLLNNLENA IALDFHHRRE 490 500 510 520 530 540 LVFWSDVTLD RILRANLNGS NVEEVVSTGL ESPGGLAVDW VHDKLYWTDS GTSRIEVANL 550 560 570 580 590 600 DGAHRKVLLW QSLEKPRAIA LHPMEGTIYW TDWGNTPRIE ASSMDGSGRR IIADTHLFWP 610 620 630 640 650 660 NGLTIDYAGR RMYWVDAKHH VIERANLDGS HRKAVISQGL PHPFAITVFE DSLYWTDWHT 670 680 690 700 710 720 KSINSANKFT GKNQEIIRNK LHFPMDIHTL HPQRQPAGKN RCGDNNGGCT HLCLPSGQNY 730 740 750 760 770 780 TCACPTGFRK INSHACAQSL DKFLLFARRM DIRRISFDTE DLSDDVIPLA DVRSAVALDW 790 800 810 820 830 840 DSRDDHVYWT DVSTDTISRA KWDGTGQKVV VDTSLESPAG LAIDWVTNKL YWTDAGTDRI 850 860 870 880 890 900 EVANTDGSMR TVLIWENLDR PRDIVVEPMG GYMYWTDWGA SPKIERAGMD ASNRQVIISS 910 920 930 940 950 960 NLTWPNGLAI DYGSQRLYWA DAGMKTIEFA GLDGSKRKVL IGSQLPHPFG LTLYGQRIYW 970 980 990 1000 1010 1020 TDWQTKSIQS ADRLTGLDRE TLQENLENLM DIHVFHRQRP PVTTPCAVEN GGCSHLCLRS 1030 1040 1050 1060 1070 1080 PSPSGFSCTC PTGINLLLDG KTCSPGMNSF LIFARRIDVR MVSLDIPYFA DVVVPINMTM 1090 1100 1110 1120 1130 1140 KNTIAIGVDP LEGKVYWSDS TLHRISRASL DGSQHEDIIT TGLQTTDGLA VDAIGRKVYW 1150 1160 1170 1180 1190 1200 TDTGTNRIEV GNLDGSMRKV LVWQNLDSPR AIVLYHEMGF MYWTDWGENA KLERSGMDGS 1210 1220 1230 1240 1250 1260 DRTVLINNNL GWPNGLTVDK TSSQLLWADA HTERIEVADL NGANRHTLVS PVQHPYGLTL 1270 1280 1290 1300 1310 1320 LDSYIYWTDW QTRSIHRADK STGSNVILVR SNLPGLMDIQ AVDRAQPLGF NKCGSRNGGC 1330 1340 1350 1360 1370 1380 SHLCLPRPSG FSCACPTGIQ LKGDGKTCDP SPETYLLFSS RGSIRRISLD TDDHTDVHVP 1390 1400 1410 1420 1430 1440 VPGLNNVISL DYDSVDGKVY YTDVFLDVIR RADLNGSNME TVIGHGLKTT DGLAVDWVAR 1450 1460 1470 1480 1490 1500 NLYWTDTGRN TIEASRLDGS CRKVLINNSL DEPRAIAVFP RKGYLFWTDW GHIAKIERAN 1510 1520 1530 1540 1550 1560 LDGSERKVLI NADLGWPNGL TLDYDTRRIY WVDAHLDRIE SADLNGKLRQ VLVSHVSHPF 1570 1580 1590 1600 1610 1620 ALTQQDRWIY WTDWQTKSIQ RVDKYSGRNK ETVLANVEGL MDIIVVSPQR QTGTNACGVN 1630 1640 1650 1660 1670 1680 NGGCSHLCFA RASDFVCACP DEPDSHPCSL VPGLMPPAPR ATSLNEKSPV LPNTLPTTLH 1690 1700 1710 1720 1730 1740 SSTTRTRTSP EGAEGRCSER DAQLGLCAHS NEAVPAAPGE GLHVSYAVGG LLSVLLILLV 1750 1760 1770 1780 1790 1800 TAALMLYRHR KSKFTDPGMG NLTYSNPSYR TSTQEVKIEA APKPAMYNQL CYKKEGGPDH 1810 1820 1830 1840 1850 1860 SYTKEKIKIV EGIHLLAGHD AEWGDLKQLR SSRGGLLRDH VCMKTDTVSI QASSGSLDDT 1870 1880 1890 1900 ETEQLLQEEQ SECSSVHTAT TPERRGSLPD TGWKHERKLS SESQV

References

[1]	"Interaction of LDL receptor-related protein 4 (LRP4) with postsynaptic scaffold proteins via its C-terminal PDZ domain-binding motif, and its regulation by Ca2+/calmodulin-dependent protein kinase II." Tian Q.B., Suzuki T., Yamauchi T., Sakagami H., Yoshimura Y., Miyazawa S., Nakayama K., Saitoh F., Zhang J.P., Lu Y., Kondo H., Endo S. Eur. J. Neurosci. 23:2864-2876(2006) [PubMed: 16819975] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Tian Q., Suzuki T. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB073317 mRNA. Translation: BAD18061.2.
IPI	IPI00373645.
RefSeq	NP_112612.2. NM_031322.3.
UniGene	Rn.21381.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q76LU2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	83469.
KEGG	rno:83469.
Organism-specific databases
CTD	4038.
RGD	619731. Lrp4.
Family and domain databases
InterPro	IPR011042. 6-blade_b-propeller_TolB-like. IPR006210. EGF-like. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_reg_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR009030. Growth_fac_rcpt. IPR023415. LDLR_class-A_CS. IPR000033. LDLR_classB_rpt. IPR002172. LDrepeatLR_classA_rpt. [Graphical view]
Gene3D	G3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 4 hits. G3DSA:4.10.400.10. LDL_rcpt_classA_cys-rich. 8 hits.
Pfam	PF00057. Ldl_recept_a. 8 hits. PF00058. Ldl_recept_b. 16 hits. [Graphical view]
SMART	SM00181. EGF. 4 hits. SM00179. EGF_CA. 1 hit. SM00192. LDLa. 8 hits. SM00135. LY. 20 hits. [Graphical view]
SUPFAM	SSF57184. Grow_fac_recept. 1 hit. SSF57424. LDL_rcpt_classA_cys-rich. 8 hits.
PROSITE	PS00010. ASX_HYDROXYL. 1 hit. PS01186. EGF_2. 3 hits. PS01187. EGF_CA. 1 hit. PS01209. LDLRA_1. 7 hits. PS50068. LDLRA_2. 8 hits. PS51120. LDLRB. 20 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q76LU2_RAT

Accession

Primary (citable) accession number: Q76LU2

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	June 28, 2011
Last modified:	January 25, 2012
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)