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Protein
Submitted name:

Bcl-xL

Gene

bcl-xL

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Keywordsi

Biological processApoptosisPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-CFA-111453. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
R-CFA-844455. The NLRP1 inflammasome.

Names & Taxonomyi

Protein namesi
Submitted name:
Bcl-xLImported
Gene namesi
Name:bcl-xLImported
Synonyms:BCL2L1Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 24

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei213 – 231HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000010478.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 24BH4_2InterPro annotationAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 24BH4PROSITE-ProRule annotationAdd BLAST20

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00530000062935.
HOGENOMiHOG000056452.
HOVERGENiHBG004472.
KOiK04570.
OMAiNGSPSWH.
OrthoDBiEOG091G0OCU.
TreeFamiTF315834.

Family and domain databases

InterProiView protein in InterPro
IPR013279. Apop_reg_BclX.
IPR002475. Bcl2-like.
IPR004725. Bcl2/BclX.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF61. PTHR11256:SF61. 1 hit.
PfamiView protein in Pfam
PF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
PRINTSiPR01864. APOPREGBCLX.
PR01862. BCL2FAMILY.
SMARTiView protein in SMART
SM00265. BH4. 1 hit.
TIGRFAMsiTIGR00865. bcl-2. 1 hit.
PROSITEiView protein in PROSITE
PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q76LT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA
60 70 80 90 100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR
110 120 130 140 150
YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL
160 170 180 190 200
CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP WIQENGGWDT FVELYGNNAA
210 220 230
AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK
Length:233
Mass (Da):26,049
Last modified:July 5, 2004 - v1
Checksum:iE09D3CDD851AE9BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03013876 Genomic DNA. No translation available.
AB073983 mRNA. Translation: BAB71819.1.
RefSeqiNP_001003072.1. NM_001003072.1.
XP_005634731.1. XM_005634674.2.
XP_005634732.1. XM_005634675.2.
XP_005634733.1. XM_005634676.2.
XP_005634734.1. XM_005634677.2.
XP_013962308.1. XM_014106833.1.
XP_013962309.1. XM_014106834.1.
UniGeneiCfa.3481.

Genome annotation databases

EnsembliENSCAFT00000011308; ENSCAFP00000010478; ENSCAFG00000007053.
GeneIDi403618.
KEGGicfa:403618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03013876 Genomic DNA. No translation available.
AB073983 mRNA. Translation: BAB71819.1.
RefSeqiNP_001003072.1. NM_001003072.1.
XP_005634731.1. XM_005634674.2.
XP_005634732.1. XM_005634675.2.
XP_005634733.1. XM_005634676.2.
XP_005634734.1. XM_005634677.2.
XP_013962308.1. XM_014106833.1.
XP_013962309.1. XM_014106834.1.
UniGeneiCfa.3481.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000010478.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000011308; ENSCAFP00000010478; ENSCAFG00000007053.
GeneIDi403618.
KEGGicfa:403618.

Organism-specific databases

CTDi598.

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00530000062935.
HOGENOMiHOG000056452.
HOVERGENiHBG004472.
KOiK04570.
OMAiNGSPSWH.
OrthoDBiEOG091G0OCU.
TreeFamiTF315834.

Enzyme and pathway databases

ReactomeiR-CFA-111453. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
R-CFA-844455. The NLRP1 inflammasome.

Family and domain databases

InterProiView protein in InterPro
IPR013279. Apop_reg_BclX.
IPR002475. Bcl2-like.
IPR004725. Bcl2/BclX.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF61. PTHR11256:SF61. 1 hit.
PfamiView protein in Pfam
PF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
PRINTSiPR01864. APOPREGBCLX.
PR01862. BCL2FAMILY.
SMARTiView protein in SMART
SM00265. BH4. 1 hit.
TIGRFAMsiTIGR00865. bcl-2. 1 hit.
PROSITEiView protein in PROSITE
PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ76LT7_CANLF
AccessioniPrimary (citable) accession number: Q76LT7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 15, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.