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Q76LD0

- CRDL1_RAT

UniProt

Q76LD0 - CRDL1_RAT

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Protein

Chordin-like protein 1

Gene

Chrdl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. Plays a role during anterior segment eye development (By similarity).By similarity

GO - Biological processi

  1. cell fate determination Source: RGD
  2. compound eye development Source: UniProtKB
  3. eye development Source: UniProtKB
  4. neuron differentiation Source: RGD
  5. ossification Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Chordin-like protein 1
Alternative name(s):
Kohjirin
Neuralin-1
Neurogenesin-1
Ventroptin
Gene namesi
Name:Chrdl1
Synonyms:Kjr, Ng1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi735215. Chrdl1.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 447425Chordin-like protein 1PRO_0000223676Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ76LD0.
PRIDEiQ76LD0.

PTM databases

PhosphoSiteiQ76LD0.

Expressioni

Developmental stagei

Ubiquitously expressed in neurogenic regions of the embryonic brain.1 Publication

Gene expression databases

GenevestigatoriQ76LD0.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006008.

Structurei

3D structure databases

ProteinModelPortaliQ76LD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 9566VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini108 – 17467VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini253 – 31866VWFC 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi174 – 1763Cell attachment siteSequence Analysis

Sequence similaritiesi

Contains 3 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG147797.
HOGENOMiHOG000049211.
HOVERGENiHBG051113.
InParanoidiQ76LD0.
PhylomeDBiQ76LD0.

Family and domain databases

InterProiIPR001007. VWF_C.
[Graphical view]
PfamiPF00093. VWC. 3 hits.
[Graphical view]
SMARTiSM00214. VWC. 3 hits.
[Graphical view]
PROSITEiPS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q76LD0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGIKYIASL VFFFVFLEAS KTEPVKHSET YCMFQDKKYR VGEKWHPYLE
60 70 80 90 100
PYGLVYCVNC ICSENGNVLC SRVRCPTLHC LSPVHIPHLC CPRCPDSLPP
110 120 130 140 150
MNSKVTSKSC EYNGTTYQHG ELFIAEGLFQ NRQPNQCSQC SCSEGNVYCG
160 170 180 190 200
LKTCPKLTCA FPVSVPDSCC RVCRGDGELS WEHSDADIFR QPANREARHS
210 220 230 240 250
YLRSPYDPPP SRQAGGLPRF AGSRSHRGAV IDSQQASGTI VQIVINNKHK
260 270 280 290 300
HGQVCVSNGK TYSHGESWHP NLRAFGIVEC VLCTCNVTKQ ECKKIHCPNR
310 320 330 340 350
YPCKYPQKLD GKCCKVCPEE PPSQNFDSKG SFCGEETMPV YEAVLVEDGE
360 370 380 390 400
TARKVALETE KPPQVEVHVW TIRKGILQHF HIEKISKEMF GGLHHFKLVT
410 420 430 440
RTTMNQWKIF AEGEAQLSQM CSSRVCRTEL EDLVQVLYLE RPEKDHC
Length:447
Mass (Da):50,560
Last modified:February 21, 2006 - v2
Checksum:i5B76AC14008C0838
GO

Sequence cautioni

The sequence BAD06447.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080636 mRNA. Translation: BAD06447.1. Different initiation.
RefSeqiNP_955796.1. NM_199502.1.
UniGeneiRn.211154.

Genome annotation databases

GeneIDi363455.
KEGGirno:363455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080636 mRNA. Translation: BAD06447.1 . Different initiation.
RefSeqi NP_955796.1. NM_199502.1.
UniGenei Rn.211154.

3D structure databases

ProteinModelPortali Q76LD0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000006008.

PTM databases

PhosphoSitei Q76LD0.

Proteomic databases

PaxDbi Q76LD0.
PRIDEi Q76LD0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 363455.
KEGGi rno:363455.

Organism-specific databases

CTDi 91851.
RGDi 735215. Chrdl1.

Phylogenomic databases

eggNOGi NOG147797.
HOGENOMi HOG000049211.
HOVERGENi HBG051113.
InParanoidi Q76LD0.
PhylomeDBi Q76LD0.

Miscellaneous databases

NextBioi 683371.
PROi Q76LD0.

Gene expression databases

Genevestigatori Q76LD0.

Family and domain databases

InterProi IPR001007. VWF_C.
[Graphical view ]
Pfami PF00093. VWC. 3 hits.
[Graphical view ]
SMARTi SM00214. VWC. 3 hits.
[Graphical view ]
PROSITEi PS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel secretory factor, neurogenesin-1, provides neurogenic environmental cues for neural stem cells in the adult hippocampus."
    Ueki T., Tanaka M., Yamashita K., Mikawa S., Qiu Z., Maragakis N.J., Hevner R.F., Miura N., Sugimura H., Sato K.
    J. Neurosci. 23:11732-11740(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCRDL1_RAT
AccessioniPrimary (citable) accession number: Q76LD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 21, 2006
Last modified: October 1, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

The sequence shown has an N-terminus according to mammalian orthologs. The original sequence from PubMed:14684875 gives a longer N-terminus and suggests a signal sequence of 97 AA.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3