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Protein

Chordin-like protein 1

Gene

Chrdl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. Plays a role during anterior segment eye development (By similarity).By similarity

GO - Biological processi

  • cell fate determination Source: RGD
  • compound eye development Source: UniProtKB
  • eye development Source: UniProtKB
  • negative regulation of BMP signaling pathway Source: InterPro
  • neuron differentiation Source: RGD
  • ossification Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Chordin-like protein 1
Alternative name(s):
Kohjirin
Neuralin-1
Neurogenesin-1
Ventroptin
Gene namesi
Name:Chrdl1
Synonyms:Kjr, Ng1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735215. Chrdl1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 447425Chordin-like protein 1PRO_0000223676Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ76LD0.
PRIDEiQ76LD0.

PTM databases

PhosphoSiteiQ76LD0.

Expressioni

Developmental stagei

Ubiquitously expressed in neurogenic regions of the embryonic brain.1 Publication

Gene expression databases

GenevisibleiQ76LD0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006008.

Structurei

3D structure databases

ProteinModelPortaliQ76LD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 9566VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini108 – 17467VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini253 – 31866VWFC 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi174 – 1763Cell attachment siteSequence Analysis

Sequence similaritiesi

Contains 3 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG147797.
HOGENOMiHOG000049211.
HOVERGENiHBG051113.
InParanoidiQ76LD0.
PhylomeDBiQ76LD0.

Family and domain databases

InterProiIPR030114. Chordin-like_1.
IPR001007. VWF_C.
[Graphical view]
PANTHERiPTHR11339:SF249. PTHR11339:SF249. 1 hit.
PfamiPF00093. VWC. 3 hits.
[Graphical view]
SMARTiSM00214. VWC. 3 hits.
[Graphical view]
PROSITEiPS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q76LD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGIKYIASL VFFFVFLEAS KTEPVKHSET YCMFQDKKYR VGEKWHPYLE
60 70 80 90 100
PYGLVYCVNC ICSENGNVLC SRVRCPTLHC LSPVHIPHLC CPRCPDSLPP
110 120 130 140 150
MNSKVTSKSC EYNGTTYQHG ELFIAEGLFQ NRQPNQCSQC SCSEGNVYCG
160 170 180 190 200
LKTCPKLTCA FPVSVPDSCC RVCRGDGELS WEHSDADIFR QPANREARHS
210 220 230 240 250
YLRSPYDPPP SRQAGGLPRF AGSRSHRGAV IDSQQASGTI VQIVINNKHK
260 270 280 290 300
HGQVCVSNGK TYSHGESWHP NLRAFGIVEC VLCTCNVTKQ ECKKIHCPNR
310 320 330 340 350
YPCKYPQKLD GKCCKVCPEE PPSQNFDSKG SFCGEETMPV YEAVLVEDGE
360 370 380 390 400
TARKVALETE KPPQVEVHVW TIRKGILQHF HIEKISKEMF GGLHHFKLVT
410 420 430 440
RTTMNQWKIF AEGEAQLSQM CSSRVCRTEL EDLVQVLYLE RPEKDHC
Length:447
Mass (Da):50,560
Last modified:February 21, 2006 - v2
Checksum:i5B76AC14008C0838
GO

Sequence cautioni

The sequence BAD06447.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080636 mRNA. Translation: BAD06447.1. Different initiation.
RefSeqiNP_955796.1. NM_199502.1.
UniGeneiRn.211154.

Genome annotation databases

GeneIDi363455.
KEGGirno:363455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080636 mRNA. Translation: BAD06447.1. Different initiation.
RefSeqiNP_955796.1. NM_199502.1.
UniGeneiRn.211154.

3D structure databases

ProteinModelPortaliQ76LD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006008.

PTM databases

PhosphoSiteiQ76LD0.

Proteomic databases

PaxDbiQ76LD0.
PRIDEiQ76LD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi363455.
KEGGirno:363455.

Organism-specific databases

CTDi91851.
RGDi735215. Chrdl1.

Phylogenomic databases

eggNOGiNOG147797.
HOGENOMiHOG000049211.
HOVERGENiHBG051113.
InParanoidiQ76LD0.
PhylomeDBiQ76LD0.

Miscellaneous databases

NextBioi683371.
PROiQ76LD0.

Gene expression databases

GenevisibleiQ76LD0. RN.

Family and domain databases

InterProiIPR030114. Chordin-like_1.
IPR001007. VWF_C.
[Graphical view]
PANTHERiPTHR11339:SF249. PTHR11339:SF249. 1 hit.
PfamiPF00093. VWC. 3 hits.
[Graphical view]
SMARTiSM00214. VWC. 3 hits.
[Graphical view]
PROSITEiPS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel secretory factor, neurogenesin-1, provides neurogenic environmental cues for neural stem cells in the adult hippocampus."
    Ueki T., Tanaka M., Yamashita K., Mikawa S., Qiu Z., Maragakis N.J., Hevner R.F., Miura N., Sugimura H., Sato K.
    J. Neurosci. 23:11732-11740(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCRDL1_RAT
AccessioniPrimary (citable) accession number: Q76LD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 21, 2006
Last modified: June 24, 2015
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

The sequence shown has an N-terminus according to mammalian orthologs. The original sequence from PubMed:14684875 gives a longer N-terminus and suggests a signal sequence of 97 AA.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.