Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q76LD0 (CRDL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chordin-like protein 1
Alternative name(s):
Kohjirin
Neuralin-1
Neurogenesin-1
Ventroptin
Gene names
Name:Chrdl1
Synonyms:Kjr, Ng1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. Plays a role during anterior segment eye development By similarity. Ref.1

Subcellular location

Secreted Potential.

Developmental stage

Ubiquitously expressed in neurogenic regions of the embryonic brain. Ref.1

Sequence similarities

Contains 3 VWFC domains.

Caution

The sequence shown has an N-terminus according to mammalian orthologs. The original sequence from Ref.1 gives a longer N-terminus and suggests a signal sequence of 97 AA.

Sequence caution

The sequence BAD06447.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 447425Chordin-like protein 1
PRO_0000223676

Regions

Domain30 – 9566VWFC 1
Domain108 – 17467VWFC 2
Domain253 – 31866VWFC 3
Motif174 – 1763Cell attachment site Potential

Amino acid modifications

Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation2861N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q76LD0 [UniParc].

Last modified February 21, 2006. Version 2.
Checksum: 5B76AC14008C0838

FASTA44750,560
        10         20         30         40         50         60 
MEGIKYIASL VFFFVFLEAS KTEPVKHSET YCMFQDKKYR VGEKWHPYLE PYGLVYCVNC 

        70         80         90        100        110        120 
ICSENGNVLC SRVRCPTLHC LSPVHIPHLC CPRCPDSLPP MNSKVTSKSC EYNGTTYQHG 

       130        140        150        160        170        180 
ELFIAEGLFQ NRQPNQCSQC SCSEGNVYCG LKTCPKLTCA FPVSVPDSCC RVCRGDGELS 

       190        200        210        220        230        240 
WEHSDADIFR QPANREARHS YLRSPYDPPP SRQAGGLPRF AGSRSHRGAV IDSQQASGTI 

       250        260        270        280        290        300 
VQIVINNKHK HGQVCVSNGK TYSHGESWHP NLRAFGIVEC VLCTCNVTKQ ECKKIHCPNR 

       310        320        330        340        350        360 
YPCKYPQKLD GKCCKVCPEE PPSQNFDSKG SFCGEETMPV YEAVLVEDGE TARKVALETE 

       370        380        390        400        410        420 
KPPQVEVHVW TIRKGILQHF HIEKISKEMF GGLHHFKLVT RTTMNQWKIF AEGEAQLSQM 

       430        440 
CSSRVCRTEL EDLVQVLYLE RPEKDHC 

« Hide

References

[1]"A novel secretory factor, neurogenesin-1, provides neurogenic environmental cues for neural stem cells in the adult hippocampus."
Ueki T., Tanaka M., Yamashita K., Mikawa S., Qiu Z., Maragakis N.J., Hevner R.F., Miura N., Sugimura H., Sato K.
J. Neurosci. 23:11732-11740(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB080636 mRNA. Translation: BAD06447.1. Different initiation.
RefSeqNP_955796.1. NM_199502.1.
UniGeneRn.211154.

3D structure databases

ProteinModelPortalQ76LD0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000006008.

PTM databases

PhosphoSiteQ76LD0.

Proteomic databases

PaxDbQ76LD0.
PRIDEQ76LD0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID363455.
KEGGrno:363455.

Organism-specific databases

CTD91851.
RGD735215. Chrdl1.

Phylogenomic databases

eggNOGNOG147797.
HOGENOMHOG000049211.
HOVERGENHBG051113.
InParanoidQ76LD0.
PhylomeDBQ76LD0.

Gene expression databases

GenevestigatorQ76LD0.

Family and domain databases

InterProIPR001007. VWF_C.
[Graphical view]
PfamPF00093. VWC. 3 hits.
[Graphical view]
SMARTSM00214. VWC. 3 hits.
[Graphical view]
PROSITEPS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio683371.
PROQ76LD0.

Entry information

Entry nameCRDL1_RAT
AccessionPrimary (citable) accession number: Q76LD0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 21, 2006
Last modified: April 16, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families