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Q76LD0

- CRDL1_RAT

UniProt

Q76LD0 - CRDL1_RAT

Protein

Chordin-like protein 1

Gene

Chrdl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (21 Feb 2006)
      Previous versions | rss
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    Functioni

    Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. Plays a role during anterior segment eye development By similarity.By similarity

    GO - Biological processi

    1. cell fate determination Source: RGD
    2. compound eye development Source: UniProtKB
    3. eye development Source: UniProtKB
    4. neuron differentiation Source: RGD
    5. ossification Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chordin-like protein 1
    Alternative name(s):
    Kohjirin
    Neuralin-1
    Neurogenesin-1
    Ventroptin
    Gene namesi
    Name:Chrdl1
    Synonyms:Kjr, Ng1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi735215. Chrdl1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 447425Chordin-like protein 1PRO_0000223676Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ76LD0.
    PRIDEiQ76LD0.

    PTM databases

    PhosphoSiteiQ76LD0.

    Expressioni

    Developmental stagei

    Ubiquitously expressed in neurogenic regions of the embryonic brain.1 Publication

    Gene expression databases

    GenevestigatoriQ76LD0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000006008.

    Structurei

    3D structure databases

    ProteinModelPortaliQ76LD0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 9566VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini108 – 17467VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini253 – 31866VWFC 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi174 – 1763Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Contains 3 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG147797.
    HOGENOMiHOG000049211.
    HOVERGENiHBG051113.
    InParanoidiQ76LD0.
    PhylomeDBiQ76LD0.

    Family and domain databases

    InterProiIPR001007. VWF_C.
    [Graphical view]
    PfamiPF00093. VWC. 3 hits.
    [Graphical view]
    SMARTiSM00214. VWC. 3 hits.
    [Graphical view]
    PROSITEiPS01208. VWFC_1. 3 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q76LD0-1 [UniParc]FASTAAdd to Basket

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    MEGIKYIASL VFFFVFLEAS KTEPVKHSET YCMFQDKKYR VGEKWHPYLE    50
    PYGLVYCVNC ICSENGNVLC SRVRCPTLHC LSPVHIPHLC CPRCPDSLPP 100
    MNSKVTSKSC EYNGTTYQHG ELFIAEGLFQ NRQPNQCSQC SCSEGNVYCG 150
    LKTCPKLTCA FPVSVPDSCC RVCRGDGELS WEHSDADIFR QPANREARHS 200
    YLRSPYDPPP SRQAGGLPRF AGSRSHRGAV IDSQQASGTI VQIVINNKHK 250
    HGQVCVSNGK TYSHGESWHP NLRAFGIVEC VLCTCNVTKQ ECKKIHCPNR 300
    YPCKYPQKLD GKCCKVCPEE PPSQNFDSKG SFCGEETMPV YEAVLVEDGE 350
    TARKVALETE KPPQVEVHVW TIRKGILQHF HIEKISKEMF GGLHHFKLVT 400
    RTTMNQWKIF AEGEAQLSQM CSSRVCRTEL EDLVQVLYLE RPEKDHC 447
    Length:447
    Mass (Da):50,560
    Last modified:February 21, 2006 - v2
    Checksum:i5B76AC14008C0838
    GO

    Sequence cautioni

    The sequence BAD06447.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB080636 mRNA. Translation: BAD06447.1. Different initiation.
    RefSeqiNP_955796.1. NM_199502.1.
    UniGeneiRn.211154.

    Genome annotation databases

    GeneIDi363455.
    KEGGirno:363455.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB080636 mRNA. Translation: BAD06447.1 . Different initiation.
    RefSeqi NP_955796.1. NM_199502.1.
    UniGenei Rn.211154.

    3D structure databases

    ProteinModelPortali Q76LD0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000006008.

    PTM databases

    PhosphoSitei Q76LD0.

    Proteomic databases

    PaxDbi Q76LD0.
    PRIDEi Q76LD0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 363455.
    KEGGi rno:363455.

    Organism-specific databases

    CTDi 91851.
    RGDi 735215. Chrdl1.

    Phylogenomic databases

    eggNOGi NOG147797.
    HOGENOMi HOG000049211.
    HOVERGENi HBG051113.
    InParanoidi Q76LD0.
    PhylomeDBi Q76LD0.

    Miscellaneous databases

    NextBioi 683371.
    PROi Q76LD0.

    Gene expression databases

    Genevestigatori Q76LD0.

    Family and domain databases

    InterProi IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00093. VWC. 3 hits.
    [Graphical view ]
    SMARTi SM00214. VWC. 3 hits.
    [Graphical view ]
    PROSITEi PS01208. VWFC_1. 3 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel secretory factor, neurogenesin-1, provides neurogenic environmental cues for neural stem cells in the adult hippocampus."
      Ueki T., Tanaka M., Yamashita K., Mikawa S., Qiu Z., Maragakis N.J., Hevner R.F., Miura N., Sugimura H., Sato K.
      J. Neurosci. 23:11732-11740(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCRDL1_RAT
    AccessioniPrimary (citable) accession number: Q76LD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: February 21, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    The sequence shown has an N-terminus according to mammalian orthologs. The original sequence from PubMed:14684875 gives a longer N-terminus and suggests a signal sequence of 97 AA.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3