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Protein

Putative Polycomb group protein ASXL2

Gene

ASXL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1397 – 143438PHD-type; atypicalAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • peroxisome proliferator activated receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative Polycomb group protein ASXL2
Alternative name(s):
Additional sex combs-like protein 2
Gene namesi
Name:ASXL2
Synonyms:ASXH2, KIAA1685
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:23805. ASXL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving ASXL2 is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with KAT6A generates a KAT6A-ASXL2 fusion protein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei20 – 212Breakpoint for translocation to form KAT6A-ASXL2 protein

Organism-specific databases

PharmGKBiPA134884863.

Polymorphism and mutation databases

BioMutaiASXL2.
DMDMi74712929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14351435Putative Polycomb group protein ASXL2PRO_0000313826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei146 – 1461PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ76L83.
MaxQBiQ76L83.
PaxDbiQ76L83.
PRIDEiQ76L83.

PTM databases

iPTMnetiQ76L83.
PhosphoSiteiQ76L83.

Expressioni

Gene expression databases

BgeeiQ76L83.
CleanExiHS_ASXL2.
ExpressionAtlasiQ76L83. baseline and differential.
GenevisibleiQ76L83. HS.

Interactioni

Subunit structurei

Interacts with PPARA and PPARG.1 Publication

GO - Molecular functioni

  • peroxisome proliferator activated receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120543. 14 interactions.
IntActiQ76L83. 5 interactions.
MINTiMINT-1198991.
STRINGi9606.ENSP00000391447.

Structurei

3D structure databases

ProteinModelPortaliQ76L83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi174 – 1785Nuclear localization signalSequence analysis
Motifi303 – 3075LXXLL motif 1
Motifi887 – 8915LXXLL motif 2

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 235141Ser-richAdd
BLAST
Compositional biasi303 – 3075Poly-Leu
Compositional biasi654 – 68431Ala-richAdd
BLAST
Compositional biasi687 – 73953Gly-richAdd
BLAST
Compositional biasi1173 – 11764Poly-Ser

Domaini

Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which may be required for an association with nuclear receptors.By similarity

Sequence similaritiesi

Belongs to the Asx family.Curated
Contains 1 PHD-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1397 – 143438PHD-type; atypicalAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIF3. Eukaryota.
ENOG4111F3G. LUCA.
GeneTreeiENSGT00520000055578.
HOVERGENiHBG106941.
InParanoidiQ76L83.
KOiK11471.
OMAiQGKDVPM.
OrthoDBiEOG7SXW2P.
PhylomeDBiQ76L83.
TreeFamiTF328464.

Family and domain databases

InterProiIPR026905. ASX-like_PHD.
IPR024811. ASX/ASX-like.
IPR028020. ASXH.
IPR024817. ASXL2.
IPR007759. HB1/Asxl_HTH.
[Graphical view]
PANTHERiPTHR13578. PTHR13578. 2 hits.
PTHR13578:SF11. PTHR13578:SF11. 2 hits.
PfamiPF13919. ASXH. 1 hit.
PF05066. HARE-HTH. 1 hit.
PF13922. PHD_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q76L83-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MREKGRRKKG RTWAEAAKTV LEKYPNTPMS HKEILQVIQR EGLKEIRSGT
60 70 80 90 100
SPLACLNAML HTNSRGEEGI FYKVPGRMGV YTLKKDVPDG VKELSEGSEE
110 120 130 140 150
SSDGQSDSQS SENSSSSSDG GSNKEGKKSR WKRKVSSSSP QSGCPSPTIP
160 170 180 190 200
AGKVISPSQK HSKKALKQAL KQQQQKKQQQ QCRPSISISS NQHLSLKTVK
210 220 230 240 250
AASDSVPAKP ATWEGKQSDG QTGSPQNSNS SFSSSVKVEN TLLGLGKKSF
260 270 280 290 300
QRSERLHTRQ MKRTKCADID VETPDSILVN TNLRALINKH TFSVLPGDCQ
310 320 330 340 350
QRLLLLLPEV DRQVGPDGLM KLNGSALNNE FFTSAAQGWK ERLSEGEFTP
360 370 380 390 400
EMQVRIRQEI EKEKKVEPWK EQFFESYYGQ SSGLSLEDSK KLTASPSDPK
410 420 430 440 450
VKKTPAEQPK SMPVSEASLI RIVPVVSQSE CKEEALQMSS PGRKEECESQ
460 470 480 490 500
GEVQPNFSTS SEPLLSSALN THELSSILPI KCPKDEDLLE QKPVTSAEQE
510 520 530 540 550
SEKNHLTTAS NYNKSESQES LVTSPSKPKS PGVEKPIVKP TAGAGPQETN
560 570 580 590 600
MKEPLATLVD QSPESLKRKS SLTQEEAPVS WEKRPRVTEN RQHQQPFQVS
610 620 630 640 650
PQPFLNRGDR IQVRKVPPLK IPVSRISPMP FHPSQVSPRA RFPVSITSPN
660 670 680 690 700
RTGARTLADI KAKAQLVKAQ RAAAAAAAAA AAAASVGGTI PGPGPGGGQG
710 720 730 740 750
PGEGGEGQTA RGGSPGSDRV SETGKGPTLE LAGTGSRGGT RELLPCGPET
760 770 780 790 800
QPQSETKTTP SQAQPHSVSG AQLQQTPPVP PTPAVSGACT SVPSPAHIEK
810 820 830 840 850
LDNEKLNPTR ATATVASVSH PQGPSSCRQE KAPSPTGPAL ISGASPVHCA
860 870 880 890 900
ADGTVELKAG PSKNIPNPSA SSKTDASVPV AVTPSPLTSL LTTATLEKLP
910 920 930 940 950
VPQVSATTAP AGSAPPSSTL PAASSLKTPG TSLNMNGPTL RPTSSIPANN
960 970 980 990 1000
PLVTQLLQGK DVPMEQILPK PLTKVEMKTV PLTAKEERGM GALIATNTTE
1010 1020 1030 1040 1050
NSTREEVNER QSHPATQQQL GKTLQSKQLP QVPRPLQLFS AKELRDSSID
1060 1070 1080 1090 1100
THQYHEGLSK ATQDQILQTL IQRVRRQNLL SVVPPSQFNF AHSGFQLEDI
1110 1120 1130 1140 1150
STSQRFMLGF AGRRTSKPAM AGHYLLNIST YGRGSESFRR THSVNPEDRF
1160 1170 1180 1190 1200
CLSSPTEALK MGYTDCKNAT GESSSSKEDD TDEESTGDEQ ESVTVKEEPQ
1210 1220 1230 1240 1250
VSQSAGKGDT SSGPHSRETL STSDCLASKN VKAEIPLNEQ TTLSKENYLF
1260 1270 1280 1290 1300
TRGQTFDEKT LARDLIQAAQ KQMAHAVRGK AIRSSPELFS STVLPLPADS
1310 1320 1330 1340 1350
PTHQPLLLPP LQTPKLYGSP TQIGPSYRGM INVSTSSDMD HNSAVPGSQV
1360 1370 1380 1390 1400
SSNVGDVMSF SVTVTTIPAS QAMNPSSHGQ TIPVQAFSEE NSIEGTPSKC
1410 1420 1430
YCRLKAMIMC KGCGAFCHDD CIGPSKLCVS CLVVR
Length:1,435
Mass (Da):153,820
Last modified:July 5, 2004 - v1
Checksum:iA01026E3C2D1035D
GO
Isoform 2 (identifier: Q76L83-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-260: Missing.
     838-1094: Missing.

Note: No experimental confirmation available.
Show »
Length:918
Mass (Da):98,359
Checksum:iB923F0E5C7B5FEC6
GO

Sequence cautioni

The sequence BAA91889.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB21776.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD00088.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti473 – 4731E → G in CAI45930 (Ref. 3) Curated
Sequence conflicti651 – 6511R → K in CAI45930 (Ref. 3) Curated
Sequence conflicti1334 – 13341S → P in BAA91889 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti731 – 7311L → P.
Corresponds to variant rs13385963 [ dbSNP | Ensembl ].
VAR_037773
Natural varianti796 – 7961A → V.1 Publication
Corresponds to variant rs17854251 [ dbSNP | Ensembl ].
VAR_037774
Natural varianti1210 – 12101T → P.
Corresponds to variant rs12991178 [ dbSNP | Ensembl ].
VAR_037775
Natural varianti1242 – 12421T → P.
Corresponds to variant rs12990978 [ dbSNP | Ensembl ].
VAR_037776

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 260260Missing in isoform 2. 1 PublicationVSP_030163Add
BLAST
Alternative sequencei838 – 1094257Missing in isoform 2. 1 PublicationVSP_030164Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084279 mRNA. Translation: BAD00086.1.
AB084281 mRNA. Translation: BAD00088.1. Different initiation.
AB051472 mRNA. Translation: BAB21776.2. Different initiation.
CR933613 mRNA. Translation: CAI45930.1.
AC010150 Genomic DNA. Translation: AAY14841.1.
BC042999 mRNA. Translation: AAH42999.1.
AK001760 mRNA. Translation: BAA91889.1. Different initiation.
RefSeqiNP_060733.4. NM_018263.4. [Q76L83-1]
UniGeneiHs.119815.

Genome annotation databases

EnsembliENST00000404843; ENSP00000383920; ENSG00000143970. [Q76L83-2]
ENST00000435504; ENSP00000391447; ENSG00000143970. [Q76L83-1]
GeneIDi55252.
KEGGihsa:55252.
UCSCiuc002rgt.2. human. [Q76L83-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084279 mRNA. Translation: BAD00086.1.
AB084281 mRNA. Translation: BAD00088.1. Different initiation.
AB051472 mRNA. Translation: BAB21776.2. Different initiation.
CR933613 mRNA. Translation: CAI45930.1.
AC010150 Genomic DNA. Translation: AAY14841.1.
BC042999 mRNA. Translation: AAH42999.1.
AK001760 mRNA. Translation: BAA91889.1. Different initiation.
RefSeqiNP_060733.4. NM_018263.4. [Q76L83-1]
UniGeneiHs.119815.

3D structure databases

ProteinModelPortaliQ76L83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120543. 14 interactions.
IntActiQ76L83. 5 interactions.
MINTiMINT-1198991.
STRINGi9606.ENSP00000391447.

PTM databases

iPTMnetiQ76L83.
PhosphoSiteiQ76L83.

Polymorphism and mutation databases

BioMutaiASXL2.
DMDMi74712929.

Proteomic databases

EPDiQ76L83.
MaxQBiQ76L83.
PaxDbiQ76L83.
PRIDEiQ76L83.

Protocols and materials databases

DNASUi55252.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404843; ENSP00000383920; ENSG00000143970. [Q76L83-2]
ENST00000435504; ENSP00000391447; ENSG00000143970. [Q76L83-1]
GeneIDi55252.
KEGGihsa:55252.
UCSCiuc002rgt.2. human. [Q76L83-1]

Organism-specific databases

CTDi55252.
GeneCardsiASXL2.
HGNCiHGNC:23805. ASXL2.
MIMi612991. gene.
neXtProtiNX_Q76L83.
PharmGKBiPA134884863.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIF3. Eukaryota.
ENOG4111F3G. LUCA.
GeneTreeiENSGT00520000055578.
HOVERGENiHBG106941.
InParanoidiQ76L83.
KOiK11471.
OMAiQGKDVPM.
OrthoDBiEOG7SXW2P.
PhylomeDBiQ76L83.
TreeFamiTF328464.

Miscellaneous databases

ChiTaRSiASXL2. human.
GenomeRNAii55252.
NextBioi59320.
PROiQ76L83.
SOURCEiSearch...

Gene expression databases

BgeeiQ76L83.
CleanExiHS_ASXL2.
ExpressionAtlasiQ76L83. baseline and differential.
GenevisibleiQ76L83. HS.

Family and domain databases

InterProiIPR026905. ASX-like_PHD.
IPR024811. ASX/ASX-like.
IPR028020. ASXH.
IPR024817. ASXL2.
IPR007759. HB1/Asxl_HTH.
[Graphical view]
PANTHERiPTHR13578. PTHR13578. 2 hits.
PTHR13578:SF11. PTHR13578:SF11. 2 hits.
PfamiPF13919. ASXH. 1 hit.
PF05066. HARE-HTH. 1 hit.
PF13922. PHD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MOZ is fused to a novel Polycomb group gene in a therapy-related myelodysplastic syndrome with t(2;8)(p23;p11.2)."
    Hosoda F., Kitabayashi I., Kakazu N., Fukushima M., Aikawa Y., Abe T., Hibi S., Yagi T., Ohki M.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHROMOSOMAL TRANSLOCATION WITH KAT6A.
    Tissue: Bone marrow.
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. Ohara O., Nagase T., Kikuno R.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-796.
    Tissue: Testis.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 890-1435 (ISOFORM 1).
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}."
    Park U.H., Yoon S.K., Park T., Kim E.J., Um S.J.
    J. Biol. Chem. 286:1354-1363(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PPARA AND PPARG.
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiASXL2_HUMAN
AccessioniPrimary (citable) accession number: Q76L83
Secondary accession number(s): Q53TC9
, Q5H9U4, Q76L81, Q86XM1, Q9C0H8, Q9NV67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.