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Protein

Zinc finger protein 534

Gene

ZNF534

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri199 – 22123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27723C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri283 – 30523C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri339 – 36123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri367 – 38923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri395 – 41723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri479 – 50123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri507 – 52923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri535 – 55723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri563 – 58523C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri591 – 61323C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri619 – 64123C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri647 – 66923C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 534
Alternative name(s):
KRAB domain only protein 3
Gene namesi
Name:ZNF534
Synonyms:KRBO3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26337. ZNF534.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134911920.

Polymorphism and mutation databases

BioMutaiZNF534.
DMDMi74749834.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 674674Zinc finger protein 534PRO_0000394145Add
BLAST

Proteomic databases

PaxDbiQ76KX8.
PRIDEiQ76KX8.

PTM databases

iPTMnetiQ76KX8.
PhosphoSiteiQ76KX8.

Expressioni

Gene expression databases

BgeeiQ76KX8.
ExpressionAtlasiQ76KX8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327538.

Structurei

3D structure databases

ProteinModelPortaliQ76KX8.
SMRiQ76KX8. Positions 8-48, 137-674.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 9285KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 17 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri199 – 22123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27723C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri283 – 30523C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri339 – 36123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri367 – 38923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri395 – 41723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri479 – 50123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri507 – 52923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri535 – 55723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri563 – 58523C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri591 – 61323C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri619 – 64123C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri647 – 66923C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ76KX8.
KOiK09228.
OMAiQHRNIHT.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ76KX8.
TreeFamiTF341892.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q76KX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALTQGQLSF SDVAIEFSQE EWKCLDPGQK ALYRDVMLEN YRNLVSLGED
60 70 80 90 100
NVRPEACICS GICLPDLSVT SMLEQKRDPW TLQSEVKIIN NPDGRECIKG
110 120 130 140 150
VNTEKSSKLG SSAGNKSLKN QHGLTLQLHL TEWQPFQAVR NIYGCKHVEK
160 170 180 190 200
SISDNSSVSP VQISFFSVKT HIFNNYRNDF LFSTLLPQEQ KVHIREKPYG
210 220 230 240 250
CNEHGKVFRV SSSLTNRQVI HIADKTYKCS DCGEIFSSNS NFAQHQRIHT
260 270 280 290 300
GEKPYKYNEC GKVFNQNSHL AQHQKIHTGQ KPYNNKECGK VFSHHAYLAQ
310 320 330 340 350
HRKIHTGEKP YKCSECGKAF SVCSSLTAHL VIHTGEKPYD CKECGKVFRH
360 370 380 390 400
KSSLTTHQTV HTGERPYKCN ECGKGFSRIA FLARHRKVHT GEKPYKCNEC
410 420 430 440 450
GKVFIGNSRL ARHRKIHTGG RRYKCNECGK AFRTCSDLTA HLLIHTGEKP
460 470 480 490 500
YECIDCGKVF RHKSSLTYHC RIHTGEKPYK CNECGKVFSQ NSNLQRHRKI
510 520 530 540 550
HTGEKLYKCN ECGKVFRQNS HLAQHRDIHT GEKPYSCNEC GKVFRRNSHL
560 570 580 590 600
VRHRNVHTGE KPYSCNECGK VFSRNSHLAR HRNIHTGEKP HSCNECGKVF
610 620 630 640 650
SRNSHLARHR KIHTGEKLYK CNECSKVFSR NSRLAQHRNI HTGVKPYSCN
660 670
ECGKVFSKNS ILVQHCSIHT REKP
Length:674
Mass (Da):77,167
Last modified:July 5, 2004 - v1
Checksum:iA1E6226FC4FE55EE
GO
Isoform 2 (identifier: Q76KX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-60: Missing.

Show »
Length:661
Mass (Da):75,792
Checksum:iE7029A8B1B99F190
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei48 – 6013Missing in isoform 2. 1 PublicationVSP_039177Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB086839 mRNA. Translation: BAD13515.1.
AB086840 mRNA. Translation: BAD13516.1.
AC010332 Genomic DNA. No translation available.
CCDSiCCDS46165.1. [Q76KX8-1]
CCDS46166.1. [Q76KX8-2]
RefSeqiNP_001137410.1. NM_001143938.1. [Q76KX8-2]
NP_001137411.1. NM_001143939.1. [Q76KX8-1]
UniGeneiHs.447583.

Genome annotation databases

EnsembliENST00000332323; ENSP00000327538; ENSG00000198633. [Q76KX8-1]
ENST00000433050; ENSP00000391358; ENSG00000198633. [Q76KX8-2]
GeneIDi147658.
KEGGihsa:147658.
UCSCiuc002pzk.4. human. [Q76KX8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB086839 mRNA. Translation: BAD13515.1.
AB086840 mRNA. Translation: BAD13516.1.
AC010332 Genomic DNA. No translation available.
CCDSiCCDS46165.1. [Q76KX8-1]
CCDS46166.1. [Q76KX8-2]
RefSeqiNP_001137410.1. NM_001143938.1. [Q76KX8-2]
NP_001137411.1. NM_001143939.1. [Q76KX8-1]
UniGeneiHs.447583.

3D structure databases

ProteinModelPortaliQ76KX8.
SMRiQ76KX8. Positions 8-48, 137-674.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000327538.

PTM databases

iPTMnetiQ76KX8.
PhosphoSiteiQ76KX8.

Polymorphism and mutation databases

BioMutaiZNF534.
DMDMi74749834.

Proteomic databases

PaxDbiQ76KX8.
PRIDEiQ76KX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332323; ENSP00000327538; ENSG00000198633. [Q76KX8-1]
ENST00000433050; ENSP00000391358; ENSG00000198633. [Q76KX8-2]
GeneIDi147658.
KEGGihsa:147658.
UCSCiuc002pzk.4. human. [Q76KX8-1]

Organism-specific databases

CTDi147658.
GeneCardsiZNF534.
HGNCiHGNC:26337. ZNF534.
neXtProtiNX_Q76KX8.
PharmGKBiPA134911920.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ76KX8.
KOiK09228.
OMAiQHRNIHT.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ76KX8.
TreeFamiTF341892.

Miscellaneous databases

GenomeRNAii147658.
PROiQ76KX8.

Gene expression databases

BgeeiQ76KX8.
ExpressionAtlasiQ76KX8. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel Kruppel-like zinc finger protein."
    Maegawa S., Shiraishi M., Otsuka S., Meguro M., Mitsuya K., Nanba E., Oshimura M.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZN534_HUMAN
AccessioniPrimary (citable) accession number: Q76KX8
Secondary accession number(s): Q76KX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.