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Protein

N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1

Gene

B4GALNT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.4.1.244 2681
2.4.1.92 2681

Protein family/group databases

CAZyiGT7 Glycosyltransferase Family 7

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 (EC:2.4.1.244)
Short name:
NGalNAc-T1
Alternative name(s):
Beta-1,4-N-acetylgalactosaminyltransferase IV
Short name:
Beta4GalNAc-T4
Short name:
Beta4GalNAcT4
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000182272.11
HGNCiHGNC:26315 B4GALNT4
neXtProtiNX_Q76KP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini37 – 1039LumenalSequence analysisAdd BLAST1003

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182272
PharmGKBiPA142672565

Polymorphism and mutation databases

BioMutaiB4GALNT4
DMDMi74712926

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002523701 – 1039N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1Add BLAST1039

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ76KP1
PeptideAtlasiQ76KP1
PRIDEiQ76KP1

PTM databases

iPTMnetiQ76KP1
PhosphoSitePlusiQ76KP1

Expressioni

Tissue specificityi

Highly expressed in ovary, adult and fetal brain. Also expressed in fetal kidney and lung.1 Publication

Gene expression databases

BgeeiENSG00000182272
CleanExiHS_B4GALNT4
ExpressionAtlasiQ76KP1 baseline and differential
GenevisibleiQ76KP1 HS

Organism-specific databases

HPAiHPA053126

Interactioni

Protein-protein interaction databases

BioGridi130784, 5 interactors
STRINGi9606.ENSP00000328277

Structurei

3D structure databases

ProteinModelPortaliQ76KP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 278PA14PROSITE-ProRule annotationAdd BLAST171

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi449 – 590Pro-richAdd BLAST142

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3588 Eukaryota
ENOG410XNYM LUCA
GeneTreeiENSGT00760000119143
HOGENOMiHOG000071102
HOVERGENiHBG080886
InParanoidiQ76KP1
KOiK09657
OMAiKMDHVAH
OrthoDBiEOG091G011K
PhylomeDBiQ76KP1
TreeFamiTF318303

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR008428 Chond_GalNAc
IPR029044 Nucleotide-diphossugar_trans
IPR037524 PA14/GLEYA
IPR011658 PA14_dom
PfamiView protein in Pfam
PF05679 CHGN, 1 hit
PF07691 PA14, 1 hit
SMARTiView protein in SMART
SM00758 PA14, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS51820 PA14, 1 hit

Sequencei

Sequence statusi: Complete.

Q76KP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLPVKKIR KQMKLLLLLL LLSCAAWLTY VHLGLVRQGR ALRQRLGYGR
60 70 80 90 100
DGEKLTSETD GRGVHAAPST QRAEDSSESR EEEQAPEGRD LDMLFPGGAG
110 120 130 140 150
RLPLNFTHQT PPWREEYKGQ VNLHVFEDWC GGAVGHLRRN LHFPLFPHTR
160 170 180 190 200
TTVKKLAVSP KWKNYGLRIF GFIHPARDGD VQFSVASDDN SEFWLSLDES
210 220 230 240 250
PAAAQLVAFV GKTGSEWTAP GEFTKFSSQV SKPRRLMASR RYYFELLHKQ
260 270 280 290 300
DDRGSDHVEV GWRAFLPGLK FEVISSAHIS LYTDESALKM DHVAHVPQSP
310 320 330 340 350
ASHVGGRPPQ EETSADMLRP DPRDTFFLTP RMESSSLENV LEPCAYAPTY
360 370 380 390 400
VVKDFPIARY QGLQFVYLSF VYPNDYTRLT HMETDNKCFY RESPLYLERF
410 420 430 440 450
GFYKYMKMDK EEGDEDEEDE VQRRAFLFLN PDDFLDDEDE GELLDSLEPT
460 470 480 490 500
EAAPPRSGPQ SPAPAAPAQP GATLAPPTPP RPRDGGTPRH SRALSWAARA
510 520 530 540 550
ARPLPLFLGR APPPRPAVEQ PPPKVYVTRV RPGQRASPRA PAPRAPWPPF
560 570 580 590 600
PGVFLHPRPL PRVQLRAPPR PPRPHGRRTG GPQATQPRPP ARAQATQGGR
610 620 630 640 650
EGQARTLGPA APTVDSNLSS EARPVTSFLS LSQVSGPQLP GEGEEEEEGE
660 670 680 690 700
DDGAPGDEAA SEDSEEAAGP ALGRWREDAI DWQRTFSVGA VDFELLRSDW
710 720 730 740 750
NDLRCNVSGN LQLPEAEAVD VTAQYMERLN ARHGGRFALL RIVNVEKRRD
760 770 780 790 800
SARGSRFLLE LELQERGGGR LRLSEYVFLR LPGARVGDAD GESPEPAPAA
810 820 830 840 850
SVRPDGRPEL CRPLRLAWRQ DVMVHFIVPV KNQARWVAQF LADMAALHAR
860 870 880 890 900
TGDSRFSVVL VDFESEDMDV ERALRAARLP RYQYLRRTGN FERSAGLQAG
910 920 930 940 950
VDAVEDASSI VFLCDLHIHF PPNILDGIRK HCVEGRLAFA PVVMRLSCGS
960 970 980 990 1000
SPRDPHGYWE VNGFGLFGIY KSDFDRVGGM NTEEFRDQWG GEDWELLDRV
1010 1020 1030
LQAGLEVERL RLRNFYHHYH SKRGMWSVRS RKGSRTGAS
Length:1,039
Mass (Da):116,513
Last modified:July 5, 2004 - v1
Checksum:i1D8D9E07AFC8DF70
GO

Sequence cautioni

The sequence BAB71566 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti942V → M in BAB71566 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06109667A → V. Corresponds to variant dbSNP:rs34063493Ensembl.1
Natural variantiVAR_06109788G → V. Corresponds to variant dbSNP:rs11822725Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089939 mRNA Translation: BAD06471.1
AK057774 mRNA Translation: BAB71566.1 Different initiation.
CCDSiCCDS7694.1
RefSeqiNP_848632.2, NM_178537.4
UniGeneiHs.148074

Genome annotation databases

EnsembliENST00000329962; ENSP00000328277; ENSG00000182272
GeneIDi338707
KEGGihsa:338707
UCSCiuc001lpb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiB4GN4_HUMAN
AccessioniPrimary (citable) accession number: Q76KP1
Secondary accession number(s): Q96LV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health