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Protein

Speriolin

Gene

SPATC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Speriolin
Alternative name(s):
Spermatogenesis and centriole-associated protein 1
Spermatogenesis-associated protein 15
Spermatogenic cell-specific Cdc20-binding protein
Gene namesi
Name:SPATC1
Synonyms:SPATA15, SPRN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:30510. SPATC1.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: MGI
  • cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134907641.

Polymorphism and mutation databases

BioMutaiSPATC1.
DMDMi162416255.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591SperiolinPRO_0000312300Add
BLAST

Proteomic databases

PaxDbiQ76KD6.
PRIDEiQ76KD6.

PTM databases

PhosphoSiteiQ76KD6.

Expressioni

Tissue specificityi

Detected only in testis.1 Publication

Gene expression databases

BgeeiQ76KD6.
CleanExiHS_SPATC1.
HS_SPRN.
GenevisibleiQ76KD6. HS.

Organism-specific databases

HPAiHPA039590.
HPA040220.

Interactioni

Subunit structurei

Found in a complex with CDC20, CDC27 and TUBG1. Interacts with CDC20 (By similarity).By similarity

Protein-protein interaction databases

BioGridi131991. 3 interactions.
STRINGi9606.ENSP00000366690.

Structurei

3D structure databases

ProteinModelPortaliQ76KD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7878Necessary for targeting centrosomesBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 4242Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the speriolin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKZX. Eukaryota.
ENOG410Y05H. LUCA.
GeneTreeiENSGT00520000055666.
HOGENOMiHOG000035107.
HOVERGENiHBG103626.
InParanoidiQ76KD6.
OMAiRKTSKFP.
OrthoDBiEOG7F7W91.
PhylomeDBiQ76KD6.
TreeFamiTF329273.

Family and domain databases

InterProiIPR026715. SPATC1.
IPR029384. Speriolin_C.
IPR029385. Speriolin_N.
[Graphical view]
PANTHERiPTHR22192. PTHR22192. 1 hit.
PfamiPF15059. Speriolin_C. 1 hit.
PF15058. Speriolin_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q76KD6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLLTNYEGL RHQIERLVRE NEELKKLVRL IRENHELKSA IKTQAGGLGI
60 70 80 90 100
SGFTSGLGEA TAGLSSRQNN GVFLPPSPAV ANERVLEEVG IMALAPLAEM
110 120 130 140 150
LTSLQPSATP GSLMSPLTGT LSTLLSGPAP TSQSSPLTSF LTSPIAGPLT
160 170 180 190 200
GTLASSLGLP STGTLTPSSL VAGPVAMSQS SPLIAPVMGT VAVSLSSPLL
210 220 230 240 250
SSTATPPGVS QNLLANPMSN LVLPEAPRLR LAEPLRGGPT GPQSPACVVP
260 270 280 290 300
TATTKVPLST EPPQSTQDPE PLSMAFAGAP LQTSTPIGAM GTPAPKTAFS
310 320 330 340 350
FNTSDTQAQP SAAQEQVVPA SVPTSPTTSP TVTVLASAPA LAPQVATSYT
360 370 380 390 400
PSSTTHIAQG APHPPSRMHN SPTQNLPVPH CPPHNAHSPP RTSSSPASVN
410 420 430 440 450
DSRGPRTTEP STKSMMEVER KLAHRKTSKF PENPRESKQL AWERLVGEIA
460 470 480 490 500
FQLDRRILSS IFPERVRLYG FTVSNIPEKI IQASLNPSDH KLDEKLCQRL
510 520 530 540 550
TQRYVSVMNR LQSLGYNGRV HPALTEQLVN AYGILRERPE LAASEGGPYT
560 570 580 590
VDFLQRVVVE TVHPGMLADA LLLLSCLSQL AHDDGKPMFI W
Length:591
Mass (Da):62,399
Last modified:December 4, 2007 - v2
Checksum:i3604434BB5A6C20F
GO
Isoform 2 (identifier: Q76KD6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-441: ESKQLA → GFPEPQ
     442-591: Missing.

Note: No experimental confirmation available.
Show »
Length:441
Mass (Da):45,355
Checksum:i1AC83F62F2983B03
GO

Sequence cautioni

The sequence AAH50390.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH53547.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651S → P in BAD08232 (PubMed:15280373).Curated
Sequence conflicti65 – 651S → P in AAH50390 (PubMed:15489334).Curated
Sequence conflicti473 – 4731V → A in AAH53547 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei436 – 4416ESKQLA → GFPEPQ in isoform 2. 1 PublicationVSP_042815
Alternative sequencei442 – 591150Missing in isoform 2. 1 PublicationVSP_042816Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB092352 mRNA. Translation: BAD08232.1.
AK301710 mRNA. Translation: BAG63181.1.
AC109322 Genomic DNA. No translation available.
BC050390 mRNA. Translation: AAH50390.1. Different initiation.
BC053547 mRNA. Translation: AAH53547.1. Different initiation.
CCDSiCCDS47937.1. [Q76KD6-2]
CCDS6413.2. [Q76KD6-1]
RefSeqiNP_001127846.1. NM_001134374.1. [Q76KD6-2]
NP_940974.2. NM_198572.2. [Q76KD6-1]
UniGeneiHs.97726.

Genome annotation databases

EnsembliENST00000377470; ENSP00000366690; ENSG00000186583. [Q76KD6-1]
ENST00000447830; ENSP00000387613; ENSG00000186583. [Q76KD6-2]
GeneIDi375686.
KEGGihsa:375686.
UCSCiuc011lkw.3. human. [Q76KD6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB092352 mRNA. Translation: BAD08232.1.
AK301710 mRNA. Translation: BAG63181.1.
AC109322 Genomic DNA. No translation available.
BC050390 mRNA. Translation: AAH50390.1. Different initiation.
BC053547 mRNA. Translation: AAH53547.1. Different initiation.
CCDSiCCDS47937.1. [Q76KD6-2]
CCDS6413.2. [Q76KD6-1]
RefSeqiNP_001127846.1. NM_001134374.1. [Q76KD6-2]
NP_940974.2. NM_198572.2. [Q76KD6-1]
UniGeneiHs.97726.

3D structure databases

ProteinModelPortaliQ76KD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131991. 3 interactions.
STRINGi9606.ENSP00000366690.

PTM databases

PhosphoSiteiQ76KD6.

Polymorphism and mutation databases

BioMutaiSPATC1.
DMDMi162416255.

Proteomic databases

PaxDbiQ76KD6.
PRIDEiQ76KD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377470; ENSP00000366690; ENSG00000186583. [Q76KD6-1]
ENST00000447830; ENSP00000387613; ENSG00000186583. [Q76KD6-2]
GeneIDi375686.
KEGGihsa:375686.
UCSCiuc011lkw.3. human. [Q76KD6-1]

Organism-specific databases

CTDi375686.
GeneCardsiSPATC1.
HGNCiHGNC:30510. SPATC1.
HPAiHPA039590.
HPA040220.
MIMi610874. gene.
neXtProtiNX_Q76KD6.
PharmGKBiPA134907641.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKZX. Eukaryota.
ENOG410Y05H. LUCA.
GeneTreeiENSGT00520000055666.
HOGENOMiHOG000035107.
HOVERGENiHBG103626.
InParanoidiQ76KD6.
OMAiRKTSKFP.
OrthoDBiEOG7F7W91.
PhylomeDBiQ76KD6.
TreeFamiTF329273.

Miscellaneous databases

GenomeRNAii375686.
NextBioi100565.
PROiQ76KD6.
SOURCEiSearch...

Gene expression databases

BgeeiQ76KD6.
CleanExiHS_SPATC1.
HS_SPRN.
GenevisibleiQ76KD6. HS.

Family and domain databases

InterProiIPR026715. SPATC1.
IPR029384. Speriolin_C.
IPR029385. Speriolin_N.
[Graphical view]
PANTHERiPTHR22192. PTHR22192. 1 hit.
PfamiPF15059. Speriolin_C. 1 hit.
PF15058. Speriolin_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20."
    Goto M., Eddy E.M.
    J. Biol. Chem. 279:42128-42138(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Speriolin is a novel human and mouse sperm centrosome protein."
    Goto M., O'Brien D.A., Eddy E.M.
    Hum. Reprod. 25:1884-1894(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSPERI_HUMAN
AccessioniPrimary (citable) accession number: Q76KD6
Secondary accession number(s): B4DWW9, Q5U5I8, Q7Z6L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: March 16, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.