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Protein

Beta-galactoside alpha-2,6-sialyltransferase 2

Gene

St6gal2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.

Catalytic activityi

CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-4085001 Sialic acid metabolism

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactoside alpha-2,6-sialyltransferase 2 (EC:2.4.99.11 Publication)
Short name:
Alpha 2,6-ST 2
Alternative name(s):
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
ST6Gal II
Short name:
ST6GalII
Sialyltransferase 2
Gene namesi
Name:St6gal2
Synonyms:Kiaa1877
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2445190 St6gal2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini33 – 524LumenalSequence analysisAdd BLAST492

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147861 – 524Beta-galactoside alpha-2,6-sialyltransferase 2Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi248 ↔ 514By similarity
Disulfide bondi291 ↔ 443By similarity
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi461 ↔ 472By similarity
Glycosylationi520N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ76K27
PRIDEiQ76K27

PTM databases

PhosphoSitePlusiQ76K27

Expressioni

Tissue specificityi

Mainly expressed in brain and embryo. Very low expression is also detected in spleen, oviduct, lung and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000024172
CleanExiMM_ST6GAL2
ExpressionAtlasiQ76K27 baseline and differential
GenevisibleiQ76K27 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084091

Structurei

3D structure databases

ProteinModelPortaliQ76K27
SMRiQ76K27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi230 – 262Arg-richAdd BLAST33

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
GeneTreeiENSGT00550000074444
HOGENOMiHOG000013206
HOVERGENiHBG052853
InParanoidiQ76K27
KOiK00779
OMAiRLWKGNV
OrthoDBiEOG091G07C7
TreeFamiTF323961

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit
SUPFAMiSSF88713 SSF88713, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q76K27-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPHLKQWRQ RMLFGIFVWG LLFLAIFIYF TNSNPAAPMP SSFSFLERRG
60 70 80 90 100
LLPLQGKQRV IMGALQEPSL PRSLDASKVL LDSHPENPFH PWPGDPQKWD
110 120 130 140 150
QAPNGFDNGD EFFTSQVGRK SQSAFYPEED SYFFVADQPE LYHHRQGALE
160 170 180 190 200
LPSPGETSWR SGPVQPKQKL LHPRRGSLPE EAYDSDMLSA SMSRAFLYRL
210 220 230 240 250
WKGAVSSKML NPRLQKAMRY YMSFNKHGVR FRRRGRREAT RTGPELLCEM
260 270 280 290 300
RRRVRVRTLD GREAPFSGLG WRPLVPGVPL SQLHPRGLSS CAVVMSAGAI
310 320 330 340 350
LNSSLGEEID SHDAVLRFNS APTRGYEKDV GNKTTVRIIN SQILANPSHH
360 370 380 390 400
FIDSALYKDV ILVAWDPAPY SANLNLWYKK PDYNLFTPYI QHRRKYPTQP
410 420 430 440 450
FYILHPKFIW QLWDIIQENT REKIQPNPPS SGFIGILIMM SMCKEVHVYE
460 470 480 490 500
YIPSVRQTEL CHYHELYYDA ACTLGAYHPL LYEKLLVQRL NTGTQADLHH
510 520
KGKVVLPGFQ TLRCPVTSPN NTHS
Length:524
Mass (Da):60,192
Last modified:July 27, 2011 - v2
Checksum:i9EB27CB3B901124F
GO
Isoform 2 (identifier: Q76K27-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-438: ILI → TCV
     439-524: Missing.

Show »
Length:438
Mass (Da):50,283
Checksum:i70189C34D6DFF59A
GO

Sequence cautioni

The sequence BAC98272 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48R → S in BAC87752 (PubMed:12966079).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030357436 – 438ILI → TCV in isoform 2. 2 Publications3
Alternative sequenceiVSP_030358439 – 524Missing in isoform 2. 2 PublicationsAdd BLAST86

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095093 Genomic DNA Translation: BAC87752.1
AK082566 mRNA Translation: BAC38534.1
CT009635 Genomic DNA Translation: CAP19181.1
CT009635 Genomic DNA Translation: CAP19182.1
BC125586 mRNA Translation: AAI25587.1
AK129462 mRNA Translation: BAC98272.1 Different initiation.
CCDSiCCDS84324.1 [Q76K27-1]
RefSeqiNP_001334332.1, NM_001347403.1 [Q76K27-1]
NP_766417.1, NM_172829.2 [Q76K27-2]
XP_006524330.1, XM_006524267.2 [Q76K27-1]
XP_006524331.1, XM_006524268.2 [Q76K27-1]
XP_006524332.1, XM_006524269.2 [Q76K27-1]
UniGeneiMm.311687

Genome annotation databases

EnsembliENSMUST00000025000; ENSMUSP00000025000; ENSMUSG00000024172 [Q76K27-1]
ENSMUST00000086878; ENSMUSP00000084091; ENSMUSG00000024172 [Q76K27-2]
ENSMUST00000183712; ENSMUSP00000139036; ENSMUSG00000098633 [Q76K27-1]
ENSMUST00000184253; ENSMUSP00000139138; ENSMUSG00000098633 [Q76K27-2]
GeneIDi240119
KEGGimmu:240119

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSIAT2_MOUSE
AccessioniPrimary (citable) accession number: Q76K27
Secondary accession number(s): A9C434, Q6ZPG5, Q8BUU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health