Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Folliculin

Gene

Flcn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a tumor suppressor (PubMed:14769940). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Folliculin
Alternative name(s):
Birt-Hogg-Dube syndrome protein homolog
Gene namesi
Name:Flcn
Synonyms:Bhd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi735088 Flcn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Flcn may be involved in renal cell carcinoma.1 Publication

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239421 – 579FolliculinAdd BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineBy similarity1
Modified residuei73PhosphoserineBy similarity1
Modified residuei302PhosphoserineCombined sources1
Modified residuei571PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ76JQ2
PRIDEiQ76JQ2

PTM databases

iPTMnetiQ76JQ2
PhosphoSitePlusiQ76JQ2

Expressioni

Tissue specificityi

Expressed in kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000003302
ExpressionAtlasiQ76JQ2 baseline and differential
GenevisibleiQ76JQ2 RN

Interactioni

Subunit structurei

Interacts (via C-terminus) with FNIP1 and FNIP2 (via C-terminus). This mediates indirect interaction with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase. Interacts with HSP90AA1 in the presence of FNIP1. Interacts with HSP70, STUB1, CDC37, AHSA1, CCT2, STIP1, PTGES3 and PPP5C.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Prkaa1P546452EBI-7596839,EBI-7596967

GO - Molecular functioni

Protein-protein interaction databases

BioGridi257434, 3 interactors
IntActiQ76JQ2, 4 interactors
MINTiQ76JQ2
STRINGi10116.ENSRNOP00000004412

Structurei

3D structure databases

SMRiQ76JQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 242uDENN FLCN/SMCR8-typePROSITE-ProRule annotationAdd BLAST157
Domaini339 – 491cDENN FLCN/SMCR8-typePROSITE-ProRule annotationAdd BLAST153
Domaini493 – 558dDENN FLCN/SMCR8-typePROSITE-ProRule annotationAdd BLAST66

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili287 – 310Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the folliculin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3715 Eukaryota
ENOG410XQ9Y LUCA
GeneTreeiENSGT00390000009864
HOGENOMiHOG000052507
HOVERGENiHBG081531
InParanoidiQ76JQ2
KOiK09594
OMAiCYCALTG
OrthoDBiEOG091G0C9Z
PhylomeDBiQ76JQ2
TreeFamiTF315084

Family and domain databases

InterProiView protein in InterPro
IPR037521 FLCN/SMCR8_DENN
IPR021713 Folliculin
IPR032035 Folliculin_C
IPR037520 Folliculin_N
PANTHERiPTHR31441 PTHR31441, 1 hit
PfamiView protein in Pfam
PF11704 Folliculin, 1 hit
PF16692 Folliculin_C, 1 hit
PROSITEiView protein in PROSITE
PS51834 DENN_FLCN_SMCR8, 1 hit

Sequencei

Sequence statusi: Complete.

Q76JQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAIVALCHF CELHGPRTLF CTEVLHAPLP QGAGSGDSPG QVEQAEEEEG
60 70 80 90 100
GIQMSSRVRA HSPAEGASTD SSSPGPKKSD MCEGCRSLAV GHPGYISHDK
110 120 130 140 150
ETSIKYVSHQ HPNHPQLFSI VRQACVRSLS CEVCPGREGP IFFGDEQHGF
160 170 180 190 200
VFSHTFFIKD SLARGFQRWY SIIAIMMDRI YLINSWPFLL GKIRGIISEL
210 220 230 240 250
QGKALKVFEA EQFGCPQRAQ RMNTAFTPFL HQRNGNAARS LTSLTSDDNL
260 270 280 290 300
WACLHTSFAW LLKACGSRLT EKLLEGAPTE DTLVQMEKLA DLEEESESWD
310 320 330 340 350
NSEAEEEEKA PATAEGAEGR ELASCPTESS FLSACGSWQP PKLSVFKSLR
360 370 380 390 400
HMRQVLGAPS FRMLAWHVLM GNQVIWKSRD VNLVHSAFEV LRTMLPVGCV
410 420 430 440 450
RIIPYSSQYE EAYRCNFLGL SPPVPIPAHV LASEFVVVVE VHTATRSNPH
460 470 480 490 500
PAGCEDDQSL SKYEFVVTSG SPVAADRVGP TILNKMEAAL TNQNLSVDVV
510 520 530 540 550
DQCLVCLKEE WMNKVKVLFK FTKVDSRPKE DTQKLLSVLG ASEEDNVKLL
560 570
KFWMTGLSKT YKSHLMSTVR SPTAAESRN
Length:579
Mass (Da):64,122
Last modified:July 5, 2004 - v1
Checksum:iA31D13BBC598296A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096213 mRNA Translation: BAD01656.1
BC085848 mRNA Translation: AAH85848.1
RefSeqiNP_955422.1, NM_199390.2
XP_006246551.1, XM_006246489.3
XP_006246552.1, XM_006246490.3
XP_017452756.1, XM_017597267.1
UniGeneiRn.12799

Genome annotation databases

EnsembliENSRNOT00000004412; ENSRNOP00000004412; ENSRNOG00000003302
GeneIDi303185
KEGGirno:303185
UCSCiRGD:735088 rat

Similar proteinsi

Entry informationi

Entry nameiFLCN_RAT
AccessioniPrimary (citable) accession number: Q76JQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health