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Protein

Folliculin

Gene

Flcn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Folliculin
Alternative name(s):
Birt-Hogg-Dube syndrome protein homolog
Gene namesi
Name:Flcn
Synonyms:Bhd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi735088. Flcn.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Flcn may be involved in renal cell carcinoma.

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579FolliculinPRO_0000223942Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621PhosphoserineBy similarity
Modified residuei73 – 731PhosphoserineBy similarity
Modified residuei302 – 3021PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ76JQ2.
PRIDEiQ76JQ2.

PTM databases

PhosphoSiteiQ76JQ2.

Expressioni

Tissue specificityi

Expressed in kidney.1 Publication

Gene expression databases

ExpressionAtlasiQ76JQ2. baseline and differential.
GenevisibleiQ76JQ2. RN.

Interactioni

Subunit structurei

Interacts (via C-terminus) with FNIP1 and FNIP2 (via C-terminus). This mediates indirect interaction with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Prkaa1P546452EBI-7596839,EBI-7596967

GO - Molecular functioni

Protein-protein interaction databases

BioGridi257434. 3 interactions.
IntActiQ76JQ2. 4 interactions.
STRINGi10116.ENSRNOP00000004412.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili287 – 31024Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the folliculin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3715. Eukaryota.
ENOG410XQ9Y. LUCA.
GeneTreeiENSGT00390000009864.
HOGENOMiHOG000052507.
HOVERGENiHBG081531.
InParanoidiQ76JQ2.
KOiK09594.
OMAiVKLLKFW.
OrthoDBiEOG7PS1FX.
PhylomeDBiQ76JQ2.
TreeFamiTF315084.

Family and domain databases

InterProiIPR021713. Folliculin.
IPR032035. Folliculin_C.
[Graphical view]
PANTHERiPTHR31441. PTHR31441. 1 hit.
PfamiPF16692. Folliculin_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q76JQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAIVALCHF CELHGPRTLF CTEVLHAPLP QGAGSGDSPG QVEQAEEEEG
60 70 80 90 100
GIQMSSRVRA HSPAEGASTD SSSPGPKKSD MCEGCRSLAV GHPGYISHDK
110 120 130 140 150
ETSIKYVSHQ HPNHPQLFSI VRQACVRSLS CEVCPGREGP IFFGDEQHGF
160 170 180 190 200
VFSHTFFIKD SLARGFQRWY SIIAIMMDRI YLINSWPFLL GKIRGIISEL
210 220 230 240 250
QGKALKVFEA EQFGCPQRAQ RMNTAFTPFL HQRNGNAARS LTSLTSDDNL
260 270 280 290 300
WACLHTSFAW LLKACGSRLT EKLLEGAPTE DTLVQMEKLA DLEEESESWD
310 320 330 340 350
NSEAEEEEKA PATAEGAEGR ELASCPTESS FLSACGSWQP PKLSVFKSLR
360 370 380 390 400
HMRQVLGAPS FRMLAWHVLM GNQVIWKSRD VNLVHSAFEV LRTMLPVGCV
410 420 430 440 450
RIIPYSSQYE EAYRCNFLGL SPPVPIPAHV LASEFVVVVE VHTATRSNPH
460 470 480 490 500
PAGCEDDQSL SKYEFVVTSG SPVAADRVGP TILNKMEAAL TNQNLSVDVV
510 520 530 540 550
DQCLVCLKEE WMNKVKVLFK FTKVDSRPKE DTQKLLSVLG ASEEDNVKLL
560 570
KFWMTGLSKT YKSHLMSTVR SPTAAESRN
Length:579
Mass (Da):64,122
Last modified:July 5, 2004 - v1
Checksum:iA31D13BBC598296A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096213 mRNA. Translation: BAD01656.1.
BC085848 mRNA. Translation: AAH85848.1.
RefSeqiNP_955422.1. NM_199390.2.
XP_006246551.1. XM_006246489.2.
XP_006246552.1. XM_006246490.2.
XP_006246553.1. XM_006246491.1.
UniGeneiRn.12799.

Genome annotation databases

EnsembliENSRNOT00000004412; ENSRNOP00000004412; ENSRNOG00000003302.
GeneIDi303185.
KEGGirno:303185.
UCSCiRGD:735088. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096213 mRNA. Translation: BAD01656.1.
BC085848 mRNA. Translation: AAH85848.1.
RefSeqiNP_955422.1. NM_199390.2.
XP_006246551.1. XM_006246489.2.
XP_006246552.1. XM_006246490.2.
XP_006246553.1. XM_006246491.1.
UniGeneiRn.12799.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi257434. 3 interactions.
IntActiQ76JQ2. 4 interactions.
STRINGi10116.ENSRNOP00000004412.

PTM databases

PhosphoSiteiQ76JQ2.

Proteomic databases

PaxDbiQ76JQ2.
PRIDEiQ76JQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004412; ENSRNOP00000004412; ENSRNOG00000003302.
GeneIDi303185.
KEGGirno:303185.
UCSCiRGD:735088. rat.

Organism-specific databases

CTDi201163.
RGDi735088. Flcn.

Phylogenomic databases

eggNOGiKOG3715. Eukaryota.
ENOG410XQ9Y. LUCA.
GeneTreeiENSGT00390000009864.
HOGENOMiHOG000052507.
HOVERGENiHBG081531.
InParanoidiQ76JQ2.
KOiK09594.
OMAiVKLLKFW.
OrthoDBiEOG7PS1FX.
PhylomeDBiQ76JQ2.
TreeFamiTF315084.

Miscellaneous databases

NextBioi650815.
PROiQ76JQ2.

Gene expression databases

ExpressionAtlasiQ76JQ2. baseline and differential.
GenevisibleiQ76JQ2. RN.

Family and domain databases

InterProiIPR021713. Folliculin.
IPR032035. Folliculin_C.
[Graphical view]
PANTHERiPTHR31441. PTHR31441. 1 hit.
PfamiPF16692. Folliculin_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A germ-line insertion in the Birt-Hogg-Dube (BHD) gene gives rise to the Nihon rat model of inherited renal cancer."
    Okimoto K., Sakurai J., Kobayashi T., Mitani H., Hirayama Y., Nickerson M.L., Warren M.B., Zbar B., Schmidt L.S., Hino O.
    Proc. Natl. Acad. Sci. U.S.A. 101:2023-2027(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, POSSIBLE INVOLVEMENT IN RENAL CELL CARCINOMA.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-302, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFLCN_RAT
AccessioniPrimary (citable) accession number: Q76JQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.