Reviewed,
UniProtKB/Swiss-Prot Q76IQ3 (TY3H_CANFA)
Last modified
November 25, 2008.
Version 27.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tyrosine 3-monooxygenase EC=1.14.16.2 Alternative name(s): Tyrosine 3-hydroxylase Short name=TH | ||
| Gene names |
| ||
| Organism | Canis familiaris (Dog) | ||
| Taxonomic identifier | 9615 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis |
Protein attributes
| Sequence length | 495 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Plays an important role in the physiology of adrenergic neurons By similarity. |
| Catalytic activity | L-tyrosine + tetrahydrobiopterin + O(2) = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin. |
| Cofactor | Fe(2+) ion. |
| Enzyme regulation | Phosphorylation leads to an increase in the catalytic activity. |
| Pathway | Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2. |
| Sequence similarities | Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Catecholamine biosynthesis Neurotransmitter biosynthesis |
| Coding sequence diversity | Polymorphism |
| Ligand | Iron Metal-binding |
| Molecular function | Monooxygenase Oxidoreductase |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | aromatic amino acid family metabolic process Inferred from electronic annotation. Source: InterPro catecholamine biosynthetic processInferred from electronic annotation. Source: InterPro neurotransmitter biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | iron ion binding Inferred from electronic annotation. Source: InterPro tyrosine 3-monooxygenase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 495 | 494 | Tyrosine 3-monooxygenase | PRO_0000289577 | |||||
Sites | |||||||||
| Metal binding | 328 | 1 | Iron By similarity | ||||||
| Metal binding | 333 | 1 | Iron By similarity | ||||||
| Metal binding | 373 | 1 | Iron By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 19 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 31 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 40 | 1 | Phosphoserine; by PKA By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 33 | 1 | R → C | ||||||
Sequences
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References
| [1] | "Canine tyrosine hydroxylase (TH) gene and dopamine beta-hydroxylase (DBH) gene: their sequences, genetic polymorphisms, and diversities among five different dog breeds." Takeuchi Y., Hashizume C., Chon E.M.H., Momozawa Y., Masuda K., Kikusui T., Mori Y. J. Vet. Med. Sci. 67:861-867(2005) [PubMed: 16210796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT CYS-33. Strain: Beagle. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| AB097058 mRNA. Translation: BAC82588.1. | |
| RefSeq | NP_001002966.1. |
| UniGene | Cfa.3446 |
3D structure databases | |
| SMR | Q76IQ3. Positions 158-494. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSCAFG00000010099. Canis familiaris. [Contig view] |
| GeneID | 403444. |
| KEGG | cfa:403444. |
Phylogenomic databases | |
| HOVERGEN | Q76IQ3. |
Family and domain databases | |
| InterPro | IPR001273. Aaa_hydroxylase. IPR005962. Tyr_3_mOase. [Graphical view] |
| Gene3D | G3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit. |
| PANTHER | PTHR11473. Aaa_hydroxylase. 1 hit. |
| Pfam | PF00351. Biopterin_H. 1 hit. [Graphical view] |
| PRINTS | PR00372. FYWHYDRXLASE. |
| ProDom | PD002559. Aaa_hydroxylase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR01269. Tyr_3_monoox. 1 hit. |
| PROSITE | PS00367. BIOPTERIN_HYDROXYL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TY3H_CANFA | ||||||||
| Accession | Primary (citable) accession number: Q76IQ3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


