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Q76IQ2 (MPI_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannose-6-phosphate isomerase

EC=5.3.1.8
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name=PMI
Gene names
Name:PMI1
Synonyms:PMI40
Ordered Locus Names:CAGL0J02244g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activity

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the mannose-6-phosphate isomerase type 1 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
Zinc
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processGDP-mannose biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmannose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Mannose-6-phosphate isomerase
PRO_0000194242

Sites

Active site3011 By similarity
Metal binding1101Zinc By similarity
Metal binding1121Zinc By similarity
Metal binding1371Zinc By similarity
Metal binding2821Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q76IQ2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: BC444CC3F9A89FE7

FASTA42947,589
        10         20         30         40         50         60 
MTSDRFFRLD AGYQQYDWGK IGSSSAVAKF AAHSDPSVKI DETKPYAELW MGTHSKLPSV 

        70         80         90        100        110        120 
NHETKATLND ILAKNSQELI GEDVINKFKS TNELPFLFKV LSIEKVLSIQ AHPDKELGKK 

       130        140        150        160        170        180 
LHMEDPKNYP DDNHKPEMAV AITEFEGFCG FKPLEEIADE LETIPEFRDV VGDEVANEFI 

       190        200        210        220        230        240 
QNYKTGVENS SSACANNKKL LQKVFEKVMT APCDILEKNA DGMAKRANEN PSSFKSSDLP 

       250        260        270        280        290        300 
ELVVRLNRQF PKDVGLFCGC LMLNHCKLQP GQALFLEAKD PHAYICGDII ECMAASDNVV 

       310        320        330        340        350        360 
RAGFTPKFKD VKNLVEMLTY RYDPVEKQVM SAEEFPRAGG DGATIMYNPP IAEFSVLETT 

       370        380        390        400        410        420 
FKNKTGKATV EGLKGPSIVI TTAGEGYISA DGQKLKAEPG FVFFIGANVP VELETTDKDF 


TTYRAFVEA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB097082 Genomic DNA. Translation: BAD02470.1.
CR380956 Genomic DNA. Translation: CAG60751.1.
RefSeqXP_447802.1. XM_447802.1.

3D structure databases

ProteinModelPortalQ76IQ2.
SMRQ76IQ2. Positions 2-429.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2889794.
KEGGcgr:CAGL0J02244g.

Phylogenomic databases

HOGENOMHOG000241277.
KOK01809.
OMAFIDEFQP.
OrthoDBEOG7WDNCR.

Enzyme and pathway databases

UniPathwayUPA00126; UER00423.

Family and domain databases

Gene3D2.60.120.10. 3 hits.
InterProIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR10309. PTHR10309. 1 hit.
PfamPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSPR00714. MAN6PISMRASE.
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR00218. manA. 1 hit.
PROSITEPS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPI_CANGA
AccessionPrimary (citable) accession number: Q76IQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways