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Protein

Mannose-6-phosphate isomerase

Gene

PMI1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Mannose-6-phosphate isomerase (PMI1)
  2. Phosphomannomutase (SEC53)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi110ZincBy similarity1
Metal bindingi112ZincBy similarity1
Metal bindingi137ZincBy similarity1
Metal bindingi282ZincBy similarity1
Active sitei301By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00126; UER00423

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:PMI1
Synonyms:PMI40
Ordered Locus Names:CAGL0J02244g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome J

Organism-specific databases

CGDiCAL0133206 CAGL0J02244g
EuPathDBiFungiDB:CAGL0J02244g

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001942421 – 429Mannose-6-phosphate isomeraseAdd BLAST429

Proteomic databases

PRIDEiQ76IQ2

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_447802.1

Structurei

3D structure databases

ProteinModelPortaliQ76IQ2
SMRiQ76IQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2757 Eukaryota
COG1482 LUCA
HOGENOMiHOG000241277
InParanoidiQ76IQ2
KOiK01809
OMAiMGTHPSN
OrthoDBiEOG092C3NWF

Family and domain databases

Gene3Di2.60.120.10, 4 hits
InterProiView protein in InterPro
IPR001250 Man6P_Isoase-1
IPR016305 Mannose-6-P_Isomerase
IPR018050 Pmannose_isomerase-type1_CS
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR10309 PTHR10309, 1 hit
PfamiView protein in Pfam
PF01238 PMI_typeI, 1 hit
PIRSFiPIRSF001480 Mannose-6-phosphate_isomerase, 1 hit
PRINTSiPR00714 MAN6PISMRASE
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR00218 manA, 1 hit
PROSITEiView protein in PROSITE
PS00965 PMI_I_1, 1 hit
PS00966 PMI_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q76IQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSDRFFRLD AGYQQYDWGK IGSSSAVAKF AAHSDPSVKI DETKPYAELW
60 70 80 90 100
MGTHSKLPSV NHETKATLND ILAKNSQELI GEDVINKFKS TNELPFLFKV
110 120 130 140 150
LSIEKVLSIQ AHPDKELGKK LHMEDPKNYP DDNHKPEMAV AITEFEGFCG
160 170 180 190 200
FKPLEEIADE LETIPEFRDV VGDEVANEFI QNYKTGVENS SSACANNKKL
210 220 230 240 250
LQKVFEKVMT APCDILEKNA DGMAKRANEN PSSFKSSDLP ELVVRLNRQF
260 270 280 290 300
PKDVGLFCGC LMLNHCKLQP GQALFLEAKD PHAYICGDII ECMAASDNVV
310 320 330 340 350
RAGFTPKFKD VKNLVEMLTY RYDPVEKQVM SAEEFPRAGG DGATIMYNPP
360 370 380 390 400
IAEFSVLETT FKNKTGKATV EGLKGPSIVI TTAGEGYISA DGQKLKAEPG
410 420
FVFFIGANVP VELETTDKDF TTYRAFVEA
Length:429
Mass (Da):47,589
Last modified:July 5, 2004 - v1
Checksum:iBC444CC3F9A89FE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097082 Genomic DNA Translation: BAD02470.1
CR380956 Genomic DNA Translation: CAG60751.1
RefSeqiXP_447802.1, XM_447802.1

Genome annotation databases

EnsemblFungiiCAG60751; CAG60751; CAGL0J02244g
GeneIDi2889794
KEGGicgr:CAGL0J02244g

Similar proteinsi

Entry informationi

Entry nameiMPI_CANGA
AccessioniPrimary (citable) accession number: Q76IQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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