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Protein

Palmitoyltransferase ZDHHC23

Gene

Zdhhc23

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane (By similarity). May be involved in NOS1 regulation and targeting to the synaptic membrane.By similarity1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC23 (EC:2.3.1.225)
Alternative name(s):
NNOS-interacting DHHC domain-containing protein with dendritic mRNA
Zinc finger DHHC domain-containing protein 23
Short name:
DHHC-23
Short name:
zDHHC23
Gene namesi
Name:Zdhhc23
Synonyms:Nidd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1303254. Zdhhc23.

Subcellular locationi

  • Membrane Curated; Multi-pass membrane protein Curated

  • Note: Neuronal soma and dendrites.1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129141 – 429Palmitoyltransferase ZDHHC23Add BLAST429

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ76IC6.
PRIDEiQ76IC6.

PTM databases

iPTMnetiQ76IC6.
PhosphoSitePlusiQ76IC6.

Expressioni

Tissue specificityi

Expressed in the brain (at protein level), with highest levels in olfactory bulb, piriform cortex and hippocampus.1 Publication

Developmental stagei

Highly expressed during the first week after birth.1 Publication

Gene expression databases

BgeeiENSRNOG00000027179.

Interactioni

Subunit structurei

Interacts with NOS1.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036655.

Structurei

3D structure databases

SMRiQ76IC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini253 – 303DHHCPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni426 – 429Interaction with NOS11 Publication4

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000290638.
HOVERGENiHBG055654.
InParanoidiQ76IC6.
KOiK18932.
OMAiRWITCKS.
OrthoDBiEOG091G0BNH.
TreeFamiTF354316.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform L (identifier: Q76IC6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPVKKKKTE EPELEPLCCC EYIDRNGEKN HVAACLCDCQ DLDEGCDRWL
60 70 80 90 100
TCKSLRPETC ERITDTISDR LRIPWLRGAK KVNISILPPL VLLPVLLRVA
110 120 130 140 150
SWHFLLGVVV LTSLPMLALW YYYLTHRRKE QTLFFLSLGL FSLGYMYYVF
160 170 180 190 200
LQEVVPQGHV GPAQLALLTC GLFLILVALY RAKKNPGYLS NPACNDKSPS
210 220 230 240 250
NSQIECPIKK GQEKTKGFPG TDTSGSLNNR TLKDDAKGSS RVGLDSPAKS
260 270 280 290 300
KEDWCAKCQL VRPARAWHCR ICGICVRRMD HHCVWINSCV GESNHQAFIL
310 320 330 340 350
ALSIFLLTSV YGISLTLNTI CRDRSLFTAL FYCPGVYANY SSALSFTCVW
360 370 380 390 400
YSVIITAGMA YIFLIQLINI SYNVTEREVQ QALRQKTGRR LLCGLIVDTG
410 420
QYNRGFLRNW LQFSTLGTRT VHTPAEDIV
Length:429
Mass (Da):48,473
Last modified:October 16, 2013 - v2
Checksum:iC9E06073A39CB44D
GO
Isoform S (identifier: Q76IC6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-322: Missing.

Show »
Length:392
Mass (Da):44,478
Checksum:iA6E589033399FCEC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti260L → V in BAD16732 (PubMed:15105416).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016279286 – 322Missing in isoform S. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098078 mRNA. Translation: BAD16732.1.
AY886538 mRNA. Translation: AAX73400.1.
AABR06068599 Genomic DNA. No translation available.
RefSeqiNP_998792.2. NM_213627.2. [Q76IC6-1]
XP_008766961.1. XM_008768739.2. [Q76IC6-1]
XP_008766962.1. XM_008768740.2. [Q76IC6-1]
UniGeneiRn.43304.

Genome annotation databases

EnsembliENSRNOT00000079423; ENSRNOP00000075515; ENSRNOG00000060348. [Q76IC6-1]
ENSRNOT00000079521; ENSRNOP00000073720; ENSRNOG00000060348. [Q76IC6-1]
GeneIDi363783.
KEGGirno:363783.
UCSCiRGD:1303254. rat. [Q76IC6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098078 mRNA. Translation: BAD16732.1.
AY886538 mRNA. Translation: AAX73400.1.
AABR06068599 Genomic DNA. No translation available.
RefSeqiNP_998792.2. NM_213627.2. [Q76IC6-1]
XP_008766961.1. XM_008768739.2. [Q76IC6-1]
XP_008766962.1. XM_008768740.2. [Q76IC6-1]
UniGeneiRn.43304.

3D structure databases

SMRiQ76IC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036655.

PTM databases

iPTMnetiQ76IC6.
PhosphoSitePlusiQ76IC6.

Proteomic databases

PaxDbiQ76IC6.
PRIDEiQ76IC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000079423; ENSRNOP00000075515; ENSRNOG00000060348. [Q76IC6-1]
ENSRNOT00000079521; ENSRNOP00000073720; ENSRNOG00000060348. [Q76IC6-1]
GeneIDi363783.
KEGGirno:363783.
UCSCiRGD:1303254. rat. [Q76IC6-1]

Organism-specific databases

CTDi254887.
RGDi1303254. Zdhhc23.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000290638.
HOVERGENiHBG055654.
InParanoidiQ76IC6.
KOiK18932.
OMAiRWITCKS.
OrthoDBiEOG091G0BNH.
TreeFamiTF354316.

Miscellaneous databases

PROiPR:Q76IC6.

Gene expression databases

BgeeiENSRNOG00000027179.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZDH23_RAT
AccessioniPrimary (citable) accession number: Q76IC6
Secondary accession number(s): Q2TGI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 16, 2013
Last modified: April 12, 2017
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.