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Q76I76

- SSH2_HUMAN

UniProt

Q76I76 - SSH2_HUMAN

Protein

Protein phosphatase Slingshot homolog 2

Gene

SSH2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei392 – 3921Phosphocysteine intermediate1 PublicationPROSITE-ProRule annotation

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. DNA binding Source: InterPro
    3. phosphoprotein phosphatase activity Source: UniProtKB
    4. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    5. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. actin cytoskeleton organization Source: UniProtKB
    2. protein dephosphorylation Source: UniProtKB
    3. regulation of actin polymerization or depolymerization Source: RefGenome
    4. regulation of axonogenesis Source: RefGenome
    5. regulation of lamellipodium assembly Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase Slingshot homolog 2 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    SSH-like protein 2
    Short name:
    SSH-2L
    Short name:
    hSSH-2L
    Gene namesi
    Name:SSH2
    Synonyms:KIAA1725, SSH2L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:30580. SSH2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. cytoskeleton Source: UniProtKB-SubCell
    3. extracellular space Source: UniProt

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi392 – 3921C → S: Abrogates phosphatase activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA134861867.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14231423Protein phosphatase Slingshot homolog 2PRO_0000094843Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei36 – 361Phosphoserine1 Publication
    Modified residuei487 – 4871Phosphoserine1 Publication
    Modified residuei1422 – 14221Phosphothreonine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ76I76.
    PaxDbiQ76I76.
    PRIDEiQ76I76.

    PTM databases

    PhosphoSiteiQ76I76.

    Expressioni

    Gene expression databases

    ArrayExpressiQ76I76.
    BgeeiQ76I76.
    CleanExiHS_SSH2.
    GenevestigatoriQ76I76.

    Organism-specific databases

    HPAiCAB017189.

    Interactioni

    Subunit structurei

    Interacts with filamentous actin.1 Publication

    Protein-protein interaction databases

    BioGridi124548. 5 interactions.
    STRINGi9606.ENSP00000269033.

    Structurei

    Secondary structure

    1
    1423
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi309 – 3124
    Beta strandi315 – 3184
    Helixi320 – 3234
    Helixi326 – 3316
    Beta strandi334 – 3396
    Beta strandi342 – 3443
    Beta strandi352 – 3565
    Helixi368 – 3703
    Helixi371 – 38313
    Beta strandi387 – 3915
    Beta strandi393 – 3975
    Helixi398 – 41114
    Helixi415 – 42511
    Helixi433 – 44715

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2NT2X-ray2.10A/B/C305-449[»]
    ProteinModelPortaliQ76I76.
    SMRiQ76I76. Positions 307-448.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ76I76.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini307 – 447141Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    HOVERGENiHBG094002.
    InParanoidiQ76I76.
    KOiK05766.
    OrthoDBiEOG7B8S33.
    PhylomeDBiQ76I76.
    TreeFamiTF319444.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR014876. DEK_C.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR009057. Homeodomain-like.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF08766. DEK_C. 1 hit.
    PF00782. DSPc. 1 hit.
    [Graphical view]
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q76I76-1) [UniParc]FASTAAdd to Basket

    Also known as: L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALVTVQRSP TPSTTSSPCA SEADSGEEEC RSQPRSISES FLTVKGAALF     50
    LPRGNGSSTP RISHRRNKHA GDLQQHLQAM FILLRPEDNI RLAVRLESTY 100
    QNRTRYMVVV STNGRQDTEE SIVLGMDFSS NDSSTCTMGL VLPLWSDTLI 150
    HLDGDGGFSV STDNRVHIFK PVSVQAMWSA LQSLHKACEV ARAHNYYPGS 200
    LFLTWVSYYE SHINSDQSSV NEWNAMQDVQ SHRPDSPALF TDIPTERERT 250
    ERLIKTKLRE IMMQKDLENI TSKEIRTELE MQMVCNLREF KEFIDNEMIV 300
    ILGQMDSPTQ IFEHVFLGSE WNASNLEDLQ NRGVRYILNV TREIDNFFPG 350
    VFEYHNIRVY DEEATDLLAY WNDTYKFISK AKKHGSKCLV HCKMGVSRSA 400
    STVIAYAMKE YGWNLDRAYD YVKERRTVTK PNPSFMRQLE EYQGILLASK 450
    QRHNKLWRSH SDSDLSDHHE PICKPGLELN KKDITTSADQ IAEVKTMESH 500
    PPIPPVFVEH MVPQDANQKG LCTKERMICL EFTSREFHAG QIEDELNLND 550
    INGCSSGCCL NESKFPLDNC HASKALIQPG HVPEMANKFP DLTVEDLETD 600
    ALKADMNVHL LPMEELTSPL KDPPMSPDPE SPSPQPSCQT EISDFSTDRI 650
    DFFSALEKFV ELSQETRSRS FSHSRMEELG GGRNESCRLS VVEVAPSKVT 700
    ADDQRSSSLS NTPHASEESS MDEEQSKAIS ELVSPDIFMQ SHSENAISVK 750
    EIVTEIESIS QGVGQIQLKG DILPNPCHTP KKNSIHELLL ERAQTPENKP 800
    GHMEQDEDSC TAQPELAKDS GMCNPEGCLT THSSIADLEE GEPAEGEQEL 850
    QGSGMHPGAK WYPGSVRRAT LEFEERLRQE QEHHGAAPTC TSLSTRKNSK 900
    NDSSVADLAP KGKSDEAPPE HSFVLKEPEM SKGKGKYSGS EAGSLSHSEQ 950
    NATVPAPRVL EFDHLPDPQE GPGSDTGTQQ EGVLKDLRTV IPYQESETQA 1000
    VPLPLPKRVE IIEYTHIVTS PNHTGPGSEI ATSEKSGEQG LRKVNMEKSV 1050
    TVLCTLDENL NRTLDPNQVS LHPQVLPLPH SSSPEHNRPT DHPTSILSSP 1100
    EDRGSSLSTA LETAAPFVSH TTHLLSASLD YLHPQTMVHL EGFTEQSSTT 1150
    DEPSAEQVSW EESQESPLSS GSEVPYKDSQ LSSADLSLIS KLGDNTGELQ 1200
    EKMDPLPVAC RLPHSSSSEN IKSLSHSPGV VKERAKEIES RVVFQAGLTK 1250
    PSQMRRSASL AKLGYLDLCK DCLPEREPAS CESPHLKLLQ PFLRTDSGMH 1300
    AMEDQESLEN PGAPHNPEPT KSFVEQLTTT ECIVQSKPVE RPLVQYAKEF 1350
    GSSQQYLLPR AGLELTSSEG GLPVLQTQGL QCACPAPGLA VAPRQQHGRT 1400
    HPLRRLKKAN DKKRTTNPFY NTM 1423
    Length:1,423
    Mass (Da):158,216
    Last modified:July 5, 2004 - v1
    Checksum:i23D0B59C97D6BE38
    GO
    Isoform 2 (identifier: Q76I76-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-36: MALVTVQRSP...EEECRSQPRS → MTLSTLARKR...VISQNAINQL
         179-195: SALQSLHKACEVARAHN → VDRDSRNKHCYVLLVEE
         196-1423: Missing.

    Show »
    Length:202
    Mass (Da):22,470
    Checksum:i027BBBE4C2D6FE7B
    GO
    Isoform 3 (identifier: Q76I76-3) [UniParc]FASTAAdd to Basket

    Also known as: A

    The sequence of this isoform differs from the canonical sequence as follows:
         179-195: SALQSLHKACEVARAHN → VDRDSRNKHCYVLLVEE
         196-1423: Missing.

    Show »
    Length:195
    Mass (Da):21,685
    Checksum:i21EB60284CB3E961
    GO
    Isoform 4 (identifier: Q76I76-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         449-449: S → R
         450-1423: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:449
    Mass (Da):51,492
    Checksum:iAFD156098A92A04D
    GO

    Sequence cautioni

    The sequence AAH11636.2 differs from that shown. Reason: Erroneous initiation.
    The sequence AAL92027.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti743 – 7431S → L.
    Corresponds to variant rs2289629 [ dbSNP | Ensembl ].
    VAR_051758
    Natural varianti763 – 7631V → A.
    Corresponds to variant rs6505140 [ dbSNP | Ensembl ].
    VAR_051759
    Natural varianti1300 – 13001H → Q.
    Corresponds to variant rs8080046 [ dbSNP | Ensembl ].
    VAR_051760

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3636MALVT…SQPRS → MTLSTLARKRKAPLACTCSL GGPDMIPYFSANAVISQNAI NQL in isoform 2. 1 PublicationVSP_016321Add
    BLAST
    Alternative sequencei179 – 19517SALQS…ARAHN → VDRDSRNKHCYVLLVEE in isoform 2 and isoform 3. 2 PublicationsVSP_016322Add
    BLAST
    Alternative sequencei196 – 14231228Missing in isoform 2 and isoform 3. 2 PublicationsVSP_016323Add
    BLAST
    Alternative sequencei449 – 4491S → R in isoform 4. 1 PublicationVSP_016324
    Alternative sequencei450 – 1423974Missing in isoform 4. 1 PublicationVSP_016325Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB072358 mRNA. Translation: BAB84117.1.
    AB072359 mRNA. Translation: BAB84118.1.
    AB099290 mRNA. Translation: BAC97813.1.
    BC008941 mRNA. Translation: AAH08941.1.
    BC011636 mRNA. Translation: AAH11636.2. Different initiation.
    BC068223 mRNA. Translation: AAH68223.1.
    AF484838 mRNA. Translation: AAL92027.1. Different initiation.
    AB051512 mRNA. Translation: BAB21816.1.
    CCDSiCCDS11253.1. [Q76I76-1]
    RefSeqiNP_001269058.1. NM_001282129.1.
    NP_001269059.1. NM_001282130.1.
    NP_001269060.1. NM_001282131.1.
    NP_203747.2. NM_033389.3. [Q76I76-1]
    UniGeneiHs.654754.

    Genome annotation databases

    EnsembliENST00000269033; ENSP00000269033; ENSG00000141298. [Q76I76-1]
    GeneIDi85464.
    KEGGihsa:85464.
    UCSCiuc002heo.1. human. [Q76I76-1]
    uc002hep.1. human. [Q76I76-4]
    uc002her.3. human. [Q76I76-3]

    Polymorphism databases

    DMDMi74749833.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB072358 mRNA. Translation: BAB84117.1 .
    AB072359 mRNA. Translation: BAB84118.1 .
    AB099290 mRNA. Translation: BAC97813.1 .
    BC008941 mRNA. Translation: AAH08941.1 .
    BC011636 mRNA. Translation: AAH11636.2 . Different initiation.
    BC068223 mRNA. Translation: AAH68223.1 .
    AF484838 mRNA. Translation: AAL92027.1 . Different initiation.
    AB051512 mRNA. Translation: BAB21816.1 .
    CCDSi CCDS11253.1. [Q76I76-1 ]
    RefSeqi NP_001269058.1. NM_001282129.1.
    NP_001269059.1. NM_001282130.1.
    NP_001269060.1. NM_001282131.1.
    NP_203747.2. NM_033389.3. [Q76I76-1 ]
    UniGenei Hs.654754.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2NT2 X-ray 2.10 A/B/C 305-449 [» ]
    ProteinModelPortali Q76I76.
    SMRi Q76I76. Positions 307-448.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124548. 5 interactions.
    STRINGi 9606.ENSP00000269033.

    PTM databases

    PhosphoSitei Q76I76.

    Polymorphism databases

    DMDMi 74749833.

    Proteomic databases

    MaxQBi Q76I76.
    PaxDbi Q76I76.
    PRIDEi Q76I76.

    Protocols and materials databases

    DNASUi 85464.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000269033 ; ENSP00000269033 ; ENSG00000141298 . [Q76I76-1 ]
    GeneIDi 85464.
    KEGGi hsa:85464.
    UCSCi uc002heo.1. human. [Q76I76-1 ]
    uc002hep.1. human. [Q76I76-4 ]
    uc002her.3. human. [Q76I76-3 ]

    Organism-specific databases

    CTDi 85464.
    GeneCardsi GC17M027952.
    HGNCi HGNC:30580. SSH2.
    HPAi CAB017189.
    MIMi 606779. gene.
    neXtProti NX_Q76I76.
    PharmGKBi PA134861867.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2453.
    HOVERGENi HBG094002.
    InParanoidi Q76I76.
    KOi K05766.
    OrthoDBi EOG7B8S33.
    PhylomeDBi Q76I76.
    TreeFami TF319444.

    Miscellaneous databases

    ChiTaRSi SSH2. human.
    EvolutionaryTracei Q76I76.
    GeneWikii SSH2.
    GenomeRNAii 85464.
    NextBioi 76121.
    PROi Q76I76.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q76I76.
    Bgeei Q76I76.
    CleanExi HS_SSH2.
    Genevestigatori Q76I76.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR014876. DEK_C.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR009057. Homeodomain-like.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF08766. DEK_C. 1 hit.
    PF00782. DSPc. 1 hit.
    [Graphical view ]
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin."
      Niwa R., Nagata-Ohashi K., Takeichi M., Mizuno K., Uemura T.
      Cell 108:233-246(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), FUNCTION, INTERACTION WITH ACTIN, MUTAGENESIS OF CYS-392.
    2. "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin."
      Ohta Y., Kousaka K., Nagata-Ohashi K., Ohashi K., Muramoto A., Shima Y., Niwa R., Uemura T., Mizuno K.
      Genes Cells 8:811-824(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Brain and Lung.
    4. "Identification of genes expressed during myocardial development."
      Chan S.Y., Chan A.K.W., Cheung B.P.K., Liang Y., Leung M.P.
      Chin. Med. J. 116:1329-1332(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 282-409 (ISOFORMS 1/4).
    5. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 382-1423 (ISOFORM 1).
      Tissue: Brain.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36 AND THR-1422, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-487 AND THR-1422, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Crystal structure of human slingshot phosphatase 2."
      Jung S.K., Jeong D.G., Yoon T.S., Kim J.H., Ryu S.E., Kim S.J.
      Proteins 68:408-412(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 305-448, ACTIVE SITE.

    Entry informationi

    Entry nameiSSH2_HUMAN
    AccessioniPrimary (citable) accession number: Q76I76
    Secondary accession number(s): Q8TDB5
    , Q8WYL1, Q8WYL2, Q96F40, Q96H36, Q9C0D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Tyrosine phosphatase activity has not been demonstrated for this protein to date.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3