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Protein

Hyaluronidase-1

Gene

Hyal1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). Overexpression of HYAL1 suppressed the growth rate of colon carcinoma cell tumors in an experimental model.By similarity1 Publication

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei146 – 1461Proton donorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.35. 5301.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-1 (EC:3.2.1.35)
Short name:
Hyal-1
Alternative name(s):
Hyaluronoglucosaminidase-1
Gene namesi
Name:Hyal1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303060. Hyal1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence AnalysisAdd
BLAST
Chaini40 – 449410Hyaluronidase-1PRO_0000042626Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 348By similarity
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi222 ↔ 236By similarity
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi373 ↔ 384By similarity
Disulfide bondi378 ↔ 433By similarity
Disulfide bondi435 ↔ 444By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ76HN1.

Expressioni

Gene expression databases

GenevestigatoriQ76HN1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021408.

Structurei

3D structure databases

ProteinModelPortaliQ76HN1.
SMRiQ76HN1. Positions 38-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini433 – 44412EGF-likeAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiNOG77606.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ76HN1.
KOiK01197.
PhylomeDBiQ76HN1.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q76HN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPFSPEVSP DPCPATAAHL LRTYTLFLTL LELAQGCRGS MVSNRPFITV
60 70 80 90 100
WNADTHWCLK DHGVDVDVSV FDVVANKEQN FQGPNMTIFY REELGTYPYY
110 120 130 140 150
TPTGEPVFGG LPQNASLVTH LAHAFQDIKA AMPEPDFSGL AVIDWEAWRP
160 170 180 190 200
RWAFNWDSKD IYQQRSMELV RAEHPDWPET LVEAEAQGQF QEAAEAWMAG
210 220 230 240 250
TLQLGQVLRP RGLWGYYGFP DCYNYDFLSP NYTGQCSLSI HDQNDQLGWL
260 270 280 290 300
WNQSYALYPS IYLPAALMGT GKSQMYVRYR VQEAFRLALV SRDPHVPIMP
310 320 330 340 350
YVQIFYEKTD YLLPLEELEH SLGESAAQGA AGAVLWISSE KTSTKESCQA
360 370 380 390 400
IKAYMDSTLG PFILNVTSAA LLCSEALCSG RGRCVRHPSY PEALLTLSPA
410 420 430 440
SFSIEPTHDG RPLSLKGTLS LKDRAQMAMK FKCRCYRGWS GEWCKKQDM
Length:449
Mass (Da):50,645
Last modified:July 5, 2004 - v1
Checksum:iEEF42E46758398EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100600 mRNA. Translation: BAD14368.1.
RefSeqiNP_997499.1. NM_207616.1.
UniGeneiRn.124438.

Genome annotation databases

GeneIDi367166.
KEGGirno:367166.
UCSCiRGD:1303060. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100600 mRNA. Translation: BAD14368.1.
RefSeqiNP_997499.1. NM_207616.1.
UniGeneiRn.124438.

3D structure databases

ProteinModelPortaliQ76HN1.
SMRiQ76HN1. Positions 38-449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021408.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Proteomic databases

PRIDEiQ76HN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi367166.
KEGGirno:367166.
UCSCiRGD:1303060. rat.

Organism-specific databases

CTDi3373.
RGDi1303060. Hyal1.

Phylogenomic databases

eggNOGiNOG77606.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ76HN1.
KOiK01197.
PhylomeDBiQ76HN1.

Enzyme and pathway databases

BRENDAi3.2.1.35. 5301.

Miscellaneous databases

NextBioi690796.
PROiQ76HN1.

Gene expression databases

GenevestigatoriQ76HN1.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression and activity of rat hyaluronidase."
    Hanaki A., Ueno Y., Nakasa T., Okinaka O.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. "Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors."
    Jacobson A., Rahmanian M., Rubin K., Heldin P.
    Int. J. Cancer 102:212-219(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiHYAL1_RAT
AccessioniPrimary (citable) accession number: Q76HN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.