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Q76HN1

- HYAL1_RAT

UniProt

Q76HN1 - HYAL1_RAT

Protein

Hyaluronidase-1

Gene

Hyal1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth By similarity. Overexpression of HYAL1 suppressed the growth rate of colon carcinoma cell tumors in an experimental model.By similarity1 Publication

    Catalytic activityi

    Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei146 – 1461Proton donorBy similarity

    GO - Molecular functioni

    1. hyaluronan synthase activity Source: UniProtKB
    2. hyalurononglucosaminidase activity Source: RGD
    3. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cartilage development Source: UniProtKB
    3. cell death Source: RGD
    4. cellular response to interleukin-1 Source: UniProtKB
    5. cellular response to pH Source: UniProtKB
    6. cellular response to platelet-derived growth factor stimulus Source: UniProtKB
    7. cellular response to UV-B Source: UniProtKB
    8. hyaluronan biosynthetic process Source: UniProtKB
    9. hyaluronan catabolic process Source: RGD
    10. hyaluronan metabolic process Source: UniProtKB
    11. inflammatory response Source: UniProtKB
    12. negative regulation of cell growth Source: UniProtKB
    13. negative regulation of cell proliferation Source: RGD
    14. positive regulation of angiogenesis Source: UniProtKB
    15. positive regulation of cell adhesion Source: UniProtKB
    16. positive regulation of cell growth Source: UniProtKB
    17. positive regulation of epithelial cell migration Source: UniProtKB
    18. positive regulation of epithelial cell proliferation Source: UniProtKB
    19. positive regulation of growth Source: UniProtKB
    20. positive regulation of hyaluranon cable assembly Source: UniProtKB
    21. response to antibiotic Source: UniProtKB
    22. response to reactive oxygen species Source: UniProtKB
    23. response to virus Source: UniProtKB

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH56. Glycoside Hydrolase Family 56.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronidase-1 (EC:3.2.1.35)
    Short name:
    Hyal-1
    Alternative name(s):
    Hyaluronoglucosaminidase-1
    Gene namesi
    Name:Hyal1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1303060. Hyal1.

    Subcellular locationi

    Secreted By similarity. Lysosome By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoplasmic vesicle Source: UniProtKB
    3. extracellular space Source: UniProtKB
    4. hyaluranon cable Source: UniProtKB
    5. lysosome Source: UniProtKB

    Keywords - Cellular componenti

    Lysosome, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3939Sequence AnalysisAdd
    BLAST
    Chaini40 – 449410Hyaluronidase-1PRO_0000042626Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi58 ↔ 348By similarity
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi222 ↔ 236By similarity
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi373 ↔ 384By similarity
    Disulfide bondi378 ↔ 433By similarity
    Disulfide bondi435 ↔ 444By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ76HN1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ76HN1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000021408.

    Structurei

    3D structure databases

    ProteinModelPortaliQ76HN1.
    SMRiQ76HN1. Positions 38-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini433 – 44412EGF-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 56 family.Curated
    Contains 1 EGF-like domain.Curated

    Keywords - Domaini

    EGF-like domain, Signal

    Phylogenomic databases

    eggNOGiNOG77606.
    HOGENOMiHOG000015133.
    HOVERGENiHBG052053.
    InParanoidiQ76HN1.
    KOiK01197.
    PhylomeDBiQ76HN1.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    [Graphical view]
    PANTHERiPTHR11769. PTHR11769. 1 hit.
    PfamiPF01630. Glyco_hydro_56. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
    PRINTSiPR00846. GLHYDRLASE56.
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q76HN1-1 [UniParc]FASTAAdd to Basket

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    MKPFSPEVSP DPCPATAAHL LRTYTLFLTL LELAQGCRGS MVSNRPFITV    50
    WNADTHWCLK DHGVDVDVSV FDVVANKEQN FQGPNMTIFY REELGTYPYY 100
    TPTGEPVFGG LPQNASLVTH LAHAFQDIKA AMPEPDFSGL AVIDWEAWRP 150
    RWAFNWDSKD IYQQRSMELV RAEHPDWPET LVEAEAQGQF QEAAEAWMAG 200
    TLQLGQVLRP RGLWGYYGFP DCYNYDFLSP NYTGQCSLSI HDQNDQLGWL 250
    WNQSYALYPS IYLPAALMGT GKSQMYVRYR VQEAFRLALV SRDPHVPIMP 300
    YVQIFYEKTD YLLPLEELEH SLGESAAQGA AGAVLWISSE KTSTKESCQA 350
    IKAYMDSTLG PFILNVTSAA LLCSEALCSG RGRCVRHPSY PEALLTLSPA 400
    SFSIEPTHDG RPLSLKGTLS LKDRAQMAMK FKCRCYRGWS GEWCKKQDM 449
    Length:449
    Mass (Da):50,645
    Last modified:July 5, 2004 - v1
    Checksum:iEEF42E46758398EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB100600 mRNA. Translation: BAD14368.1.
    RefSeqiNP_997499.1. NM_207616.1.
    UniGeneiRn.124438.

    Genome annotation databases

    GeneIDi367166.
    KEGGirno:367166.
    UCSCiRGD:1303060. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB100600 mRNA. Translation: BAD14368.1 .
    RefSeqi NP_997499.1. NM_207616.1.
    UniGenei Rn.124438.

    3D structure databases

    ProteinModelPortali Q76HN1.
    SMRi Q76HN1. Positions 38-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000021408.

    Protein family/group databases

    CAZyi GH56. Glycoside Hydrolase Family 56.

    Proteomic databases

    PRIDEi Q76HN1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 367166.
    KEGGi rno:367166.
    UCSCi RGD:1303060. rat.

    Organism-specific databases

    CTDi 3373.
    RGDi 1303060. Hyal1.

    Phylogenomic databases

    eggNOGi NOG77606.
    HOGENOMi HOG000015133.
    HOVERGENi HBG052053.
    InParanoidi Q76HN1.
    KOi K01197.
    PhylomeDBi Q76HN1.

    Miscellaneous databases

    NextBioi 690796.
    PROi Q76HN1.

    Gene expression databases

    Genevestigatori Q76HN1.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    [Graphical view ]
    PANTHERi PTHR11769. PTHR11769. 1 hit.
    Pfami PF01630. Glyco_hydro_56. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
    PRINTSi PR00846. GLHYDRLASE56.
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression and activity of rat hyaluronidase."
      Hanaki A., Ueno Y., Nakasa T., Okinaka O.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
    2. "Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors."
      Jacobson A., Rahmanian M., Rubin K., Heldin P.
      Int. J. Cancer 102:212-219(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiHYAL1_RAT
    AccessioniPrimary (citable) accession number: Q76HN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3