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Q76HN1

- HYAL1_RAT

UniProt

Q76HN1 - HYAL1_RAT

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Protein

Hyaluronidase-1

Gene

Hyal1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). Overexpression of HYAL1 suppressed the growth rate of colon carcinoma cell tumors in an experimental model.By similarity1 Publication

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei146 – 1461Proton donorBy similarity

GO - Molecular functioni

  1. hyaluronan synthase activity Source: UniProtKB
  2. hyalurononglucosaminidase activity Source: RGD
  3. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cartilage development Source: UniProtKB
  3. cell death Source: RGD
  4. cellular response to interleukin-1 Source: UniProtKB
  5. cellular response to pH Source: UniProtKB
  6. cellular response to platelet-derived growth factor stimulus Source: UniProtKB
  7. cellular response to UV-B Source: UniProtKB
  8. hyaluronan biosynthetic process Source: UniProtKB
  9. hyaluronan catabolic process Source: RGD
  10. hyaluronan metabolic process Source: UniProtKB
  11. inflammatory response Source: UniProtKB
  12. negative regulation of cell growth Source: UniProtKB
  13. negative regulation of cell proliferation Source: RGD
  14. positive regulation of angiogenesis Source: UniProtKB
  15. positive regulation of cell adhesion Source: UniProtKB
  16. positive regulation of cell growth Source: UniProtKB
  17. positive regulation of epithelial cell migration Source: UniProtKB
  18. positive regulation of epithelial cell proliferation Source: UniProtKB
  19. positive regulation of growth Source: UniProtKB
  20. positive regulation of hyaluranon cable assembly Source: UniProtKB
  21. response to antibiotic Source: UniProtKB
  22. response to reactive oxygen species Source: UniProtKB
  23. response to virus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-1 (EC:3.2.1.35)
Short name:
Hyal-1
Alternative name(s):
Hyaluronoglucosaminidase-1
Gene namesi
Name:Hyal1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1303060. Hyal1.

Subcellular locationi

Secreted By similarity. Lysosome By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoplasmic vesicle Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. hyaluranon cable Source: UniProtKB
  5. lysosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence AnalysisAdd
BLAST
Chaini40 – 449410Hyaluronidase-1PRO_0000042626Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 348By similarity
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi222 ↔ 236By similarity
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi373 ↔ 384By similarity
Disulfide bondi378 ↔ 433By similarity
Disulfide bondi435 ↔ 444By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ76HN1.

Expressioni

Gene expression databases

GenevestigatoriQ76HN1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021408.

Structurei

3D structure databases

ProteinModelPortaliQ76HN1.
SMRiQ76HN1. Positions 38-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini433 – 44412EGF-likeAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiNOG77606.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ76HN1.
KOiK01197.
PhylomeDBiQ76HN1.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q76HN1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPFSPEVSP DPCPATAAHL LRTYTLFLTL LELAQGCRGS MVSNRPFITV
60 70 80 90 100
WNADTHWCLK DHGVDVDVSV FDVVANKEQN FQGPNMTIFY REELGTYPYY
110 120 130 140 150
TPTGEPVFGG LPQNASLVTH LAHAFQDIKA AMPEPDFSGL AVIDWEAWRP
160 170 180 190 200
RWAFNWDSKD IYQQRSMELV RAEHPDWPET LVEAEAQGQF QEAAEAWMAG
210 220 230 240 250
TLQLGQVLRP RGLWGYYGFP DCYNYDFLSP NYTGQCSLSI HDQNDQLGWL
260 270 280 290 300
WNQSYALYPS IYLPAALMGT GKSQMYVRYR VQEAFRLALV SRDPHVPIMP
310 320 330 340 350
YVQIFYEKTD YLLPLEELEH SLGESAAQGA AGAVLWISSE KTSTKESCQA
360 370 380 390 400
IKAYMDSTLG PFILNVTSAA LLCSEALCSG RGRCVRHPSY PEALLTLSPA
410 420 430 440
SFSIEPTHDG RPLSLKGTLS LKDRAQMAMK FKCRCYRGWS GEWCKKQDM
Length:449
Mass (Da):50,645
Last modified:July 5, 2004 - v1
Checksum:iEEF42E46758398EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB100600 mRNA. Translation: BAD14368.1.
RefSeqiNP_997499.1. NM_207616.1.
UniGeneiRn.124438.

Genome annotation databases

GeneIDi367166.
KEGGirno:367166.
UCSCiRGD:1303060. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB100600 mRNA. Translation: BAD14368.1 .
RefSeqi NP_997499.1. NM_207616.1.
UniGenei Rn.124438.

3D structure databases

ProteinModelPortali Q76HN1.
SMRi Q76HN1. Positions 38-449.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021408.

Protein family/group databases

CAZyi GH56. Glycoside Hydrolase Family 56.

Proteomic databases

PRIDEi Q76HN1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 367166.
KEGGi rno:367166.
UCSCi RGD:1303060. rat.

Organism-specific databases

CTDi 3373.
RGDi 1303060. Hyal1.

Phylogenomic databases

eggNOGi NOG77606.
HOGENOMi HOG000015133.
HOVERGENi HBG052053.
InParanoidi Q76HN1.
KOi K01197.
PhylomeDBi Q76HN1.

Miscellaneous databases

NextBioi 690796.
PROi Q76HN1.

Gene expression databases

Genevestigatori Q76HN1.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view ]
PANTHERi PTHR11769. PTHR11769. 1 hit.
Pfami PF01630. Glyco_hydro_56. 1 hit.
[Graphical view ]
PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
PRINTSi PR00846. GLHYDRLASE56.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression and activity of rat hyaluronidase."
    Hanaki A., Ueno Y., Nakasa T., Okinaka O.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. "Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors."
    Jacobson A., Rahmanian M., Rubin K., Heldin P.
    Int. J. Cancer 102:212-219(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiHYAL1_RAT
AccessioniPrimary (citable) accession number: Q76HN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3