SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q76HM9

- HYAL3_RAT

UniProt

Q76HM9 - HYAL3_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Hyaluronidase-3
Gene
Hyal3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Proton donor By similarity

GO - Molecular functioni

  1. hyaluronoglucuronidase activity Source: Ensembl
  2. hyalurononglucosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cartilage development Source: Ensembl
  3. cellular response to UV-B Source: Ensembl
  4. cellular response to interleukin-1 Source: Ensembl
  5. cellular response to tumor necrosis factor Source: Ensembl
  6. hyaluronan catabolic process Source: Ensembl
  7. inflammatory response Source: Ensembl
  8. response to antibiotic Source: Ensembl
  9. response to virus Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-3 (EC:3.2.1.35)
Short name:
Hyal-3
Alternative name(s):
Hyaluronoglucosaminidase-3
Gene namesi
Name:Hyal3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi1303334. Hyal3.

Subcellular locationi

Secreted By similarity. Lysosome By similarity

GO - Cellular componenti

  1. cytoplasmic vesicle Source: Ensembl
  2. extracellular region Source: UniProtKB-SubCell
  3. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 412390Hyaluronidase-3
PRO_0000248204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 332 By similarity
Glycosylationi69 – 691N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi206 ↔ 221 By similarity
Glycosylationi216 – 2161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi357 ↔ 368 By similarity
Disulfide bondi362 ↔ 396 By similarity
Disulfide bondi398 ↔ 407 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ76HM9.

Expressioni

Gene expression databases

GenevestigatoriQ76HM9.

Structurei

3D structure databases

ProteinModelPortaliQ76HM9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini353 – 40856EGF-like
Add
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiNOG69101.
GeneTreeiENSGT00550000074476.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ76HM9.
KOiK01197.
OrthoDBiEOG74J97S.
PhylomeDBiQ76HM9.
TreeFamiTF321598.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q76HM9-1 [UniParc]FASTAAdd to Basket

« Hide

MITQLGLTLV VGLTLCLVHV QALLQVPEFP FSVLWNVPSA RCKTRFGVHL    50
PLDALGIIAN HGQRFHGQNI TIFYKNQFGL YPYFGPRGTA HNGGIPQAVS 100
LDHHLAQAAH QILHNLGSSF AGLAVLDWEE WYPLWAGNWG THRQVYQAAS 150
WAWAQQMFPD LNPQEQLHKA QTGFEQAARA LMEHTLRLGQ MLRPHGLWGF 200
YRYPVCGNGW HNMASNYTGH CHPAIITRNT QLRWLWAASS ALFPSIYLPP 250
RLPPAYHQTF VRHRLEEAFR VALTGHAHPL PVLAYVRLTH RSSGRFLSLD 300
DLMQTIGVSA ALGAAGVVLW GDLSVSSSEE ECWRLHDYLV GTLGPYVINV 350
TKAATACSHQ RCHGHGRCSW KDPGQMEAFL HLQPDDNLGA WKSFRCRCYL 400
GWSGPTCLEP KP 412
Length:412
Mass (Da):46,207
Last modified:July 5, 2004 - v1
Checksum:iBB4949AADE4FB270
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291F → L in AAH97259. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB100602 mRNA. Translation: BAD14370.1.
BC097259 mRNA. Translation: AAH97259.1.
RefSeqiNP_997482.2. NM_207599.2.
UniGeneiRn.229321.

Genome annotation databases

EnsembliENSRNOT00000021590; ENSRNOP00000021590; ENSRNOG00000016093.
GeneIDi300993.
KEGGirno:300993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB100602 mRNA. Translation: BAD14370.1 .
BC097259 mRNA. Translation: AAH97259.1 .
RefSeqi NP_997482.2. NM_207599.2.
UniGenei Rn.229321.

3D structure databases

ProteinModelPortali Q76HM9.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH56. Glycoside Hydrolase Family 56.

Proteomic databases

PRIDEi Q76HM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021590 ; ENSRNOP00000021590 ; ENSRNOG00000016093 .
GeneIDi 300993.
KEGGi rno:300993.

Organism-specific databases

CTDi 8372.
RGDi 1303334. Hyal3.

Phylogenomic databases

eggNOGi NOG69101.
GeneTreei ENSGT00550000074476.
HOGENOMi HOG000015133.
HOVERGENi HBG052053.
InParanoidi Q76HM9.
KOi K01197.
OrthoDBi EOG74J97S.
PhylomeDBi Q76HM9.
TreeFami TF321598.

Miscellaneous databases

NextBioi 647866.
PROi Q76HM9.

Gene expression databases

Genevestigatori Q76HM9.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
[Graphical view ]
PANTHERi PTHR11769. PTHR11769. 1 hit.
Pfami PF01630. Glyco_hydro_56. 1 hit.
[Graphical view ]
PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSi PR00846. GLHYDRLASE56.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression and activity of rat hyaluronidase."
    Hanaki A., Ueno Y., Nakasa T., Okinaka O.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiHYAL3_RAT
AccessioniPrimary (citable) accession number: Q76HM9
Secondary accession number(s): Q4V8Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi