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Q76HM9

- HYAL3_RAT

UniProt

Q76HM9 - HYAL3_RAT

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Protein

Hyaluronidase-3

Gene

Hyal3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Proton donorBy similarity

GO - Molecular functioni

  1. hyaluronoglucuronidase activity Source: Ensembl
  2. hyalurononglucosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cartilage development Source: Ensembl
  3. cellular response to interleukin-1 Source: Ensembl
  4. cellular response to tumor necrosis factor Source: Ensembl
  5. cellular response to UV-B Source: Ensembl
  6. hyaluronan catabolic process Source: Ensembl
  7. inflammatory response Source: Ensembl
  8. response to antibiotic Source: Ensembl
  9. response to virus Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-3 (EC:3.2.1.35)
Short name:
Hyal-3
Alternative name(s):
Hyaluronoglucosaminidase-3
Gene namesi
Name:Hyal3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi1303334. Hyal3.

Subcellular locationi

Secreted By similarity. Lysosome By similarity

GO - Cellular componenti

  1. cytoplasmic vesicle Source: Ensembl
  2. extracellular region Source: UniProtKB-KW
  3. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 412390Hyaluronidase-3PRO_0000248204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 332By similarity
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi206 ↔ 221By similarity
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi357 ↔ 368By similarity
Disulfide bondi362 ↔ 396By similarity
Disulfide bondi398 ↔ 407By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ76HM9.

Expressioni

Gene expression databases

GenevestigatoriQ76HM9.

Structurei

3D structure databases

ProteinModelPortaliQ76HM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini353 – 40856EGF-likeAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiNOG69101.
GeneTreeiENSGT00550000074476.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ76HM9.
KOiK01197.
OrthoDBiEOG74J97S.
PhylomeDBiQ76HM9.
TreeFamiTF321598.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q76HM9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITQLGLTLV VGLTLCLVHV QALLQVPEFP FSVLWNVPSA RCKTRFGVHL
60 70 80 90 100
PLDALGIIAN HGQRFHGQNI TIFYKNQFGL YPYFGPRGTA HNGGIPQAVS
110 120 130 140 150
LDHHLAQAAH QILHNLGSSF AGLAVLDWEE WYPLWAGNWG THRQVYQAAS
160 170 180 190 200
WAWAQQMFPD LNPQEQLHKA QTGFEQAARA LMEHTLRLGQ MLRPHGLWGF
210 220 230 240 250
YRYPVCGNGW HNMASNYTGH CHPAIITRNT QLRWLWAASS ALFPSIYLPP
260 270 280 290 300
RLPPAYHQTF VRHRLEEAFR VALTGHAHPL PVLAYVRLTH RSSGRFLSLD
310 320 330 340 350
DLMQTIGVSA ALGAAGVVLW GDLSVSSSEE ECWRLHDYLV GTLGPYVINV
360 370 380 390 400
TKAATACSHQ RCHGHGRCSW KDPGQMEAFL HLQPDDNLGA WKSFRCRCYL
410
GWSGPTCLEP KP
Length:412
Mass (Da):46,207
Last modified:July 5, 2004 - v1
Checksum:iBB4949AADE4FB270
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291F → L in AAH97259. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100602 mRNA. Translation: BAD14370.1.
BC097259 mRNA. Translation: AAH97259.1.
RefSeqiNP_997482.2. NM_207599.2.
UniGeneiRn.229321.

Genome annotation databases

EnsembliENSRNOT00000021590; ENSRNOP00000021590; ENSRNOG00000016093.
GeneIDi300993.
KEGGirno:300993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100602 mRNA. Translation: BAD14370.1 .
BC097259 mRNA. Translation: AAH97259.1 .
RefSeqi NP_997482.2. NM_207599.2.
UniGenei Rn.229321.

3D structure databases

ProteinModelPortali Q76HM9.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH56. Glycoside Hydrolase Family 56.

Proteomic databases

PRIDEi Q76HM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021590 ; ENSRNOP00000021590 ; ENSRNOG00000016093 .
GeneIDi 300993.
KEGGi rno:300993.

Organism-specific databases

CTDi 8372.
RGDi 1303334. Hyal3.

Phylogenomic databases

eggNOGi NOG69101.
GeneTreei ENSGT00550000074476.
HOGENOMi HOG000015133.
HOVERGENi HBG052053.
InParanoidi Q76HM9.
KOi K01197.
OrthoDBi EOG74J97S.
PhylomeDBi Q76HM9.
TreeFami TF321598.

Miscellaneous databases

NextBioi 647866.
PROi Q76HM9.

Gene expression databases

Genevestigatori Q76HM9.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
[Graphical view ]
PANTHERi PTHR11769. PTHR11769. 1 hit.
Pfami PF01630. Glyco_hydro_56. 1 hit.
[Graphical view ]
PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSi PR00846. GLHYDRLASE56.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression and activity of rat hyaluronidase."
    Hanaki A., Ueno Y., Nakasa T., Okinaka O.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiHYAL3_RAT
AccessioniPrimary (citable) accession number: Q76HM9
Secondary accession number(s): Q4V8Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3