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Protein

Hyaluronidase-3

Gene

Hyal3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei129Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.35. 5301.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-3 (EC:3.2.1.35)
Short name:
Hyal-3
Alternative name(s):
Hyaluronoglucosaminidase-3
Gene namesi
Name:Hyal3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303334. Hyal3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000024820423 – 412Hyaluronidase-3Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 332By similarity
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi206 ↔ 221By similarity
Glycosylationi216N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi357 ↔ 368By similarity
Disulfide bondi362 ↔ 396By similarity
Disulfide bondi398 ↔ 407By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ76HM9.
PRIDEiQ76HM9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016093.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021590.

Structurei

3D structure databases

ProteinModelPortaliQ76HM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini353 – 408EGF-likeAdd BLAST56

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiENOG410IH0U. Eukaryota.
ENOG410XPZT. LUCA.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ76HM9.
KOiK01197.
PhylomeDBiQ76HM9.
TreeFamiTF321598.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR013032. EGF-like_CS.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PTHR11769:SF19. PTHR11769:SF19. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q76HM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITQLGLTLV VGLTLCLVHV QALLQVPEFP FSVLWNVPSA RCKTRFGVHL
60 70 80 90 100
PLDALGIIAN HGQRFHGQNI TIFYKNQFGL YPYFGPRGTA HNGGIPQAVS
110 120 130 140 150
LDHHLAQAAH QILHNLGSSF AGLAVLDWEE WYPLWAGNWG THRQVYQAAS
160 170 180 190 200
WAWAQQMFPD LNPQEQLHKA QTGFEQAARA LMEHTLRLGQ MLRPHGLWGF
210 220 230 240 250
YRYPVCGNGW HNMASNYTGH CHPAIITRNT QLRWLWAASS ALFPSIYLPP
260 270 280 290 300
RLPPAYHQTF VRHRLEEAFR VALTGHAHPL PVLAYVRLTH RSSGRFLSLD
310 320 330 340 350
DLMQTIGVSA ALGAAGVVLW GDLSVSSSEE ECWRLHDYLV GTLGPYVINV
360 370 380 390 400
TKAATACSHQ RCHGHGRCSW KDPGQMEAFL HLQPDDNLGA WKSFRCRCYL
410
GWSGPTCLEP KP
Length:412
Mass (Da):46,207
Last modified:July 5, 2004 - v1
Checksum:iBB4949AADE4FB270
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29F → L in AAH97259 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100602 mRNA. Translation: BAD14370.1.
BC097259 mRNA. Translation: AAH97259.1.
RefSeqiNP_997482.2. NM_207599.2.
UniGeneiRn.229321.

Genome annotation databases

GeneIDi300993.
KEGGirno:300993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100602 mRNA. Translation: BAD14370.1.
BC097259 mRNA. Translation: AAH97259.1.
RefSeqiNP_997482.2. NM_207599.2.
UniGeneiRn.229321.

3D structure databases

ProteinModelPortaliQ76HM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021590.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Proteomic databases

PaxDbiQ76HM9.
PRIDEiQ76HM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi300993.
KEGGirno:300993.

Organism-specific databases

CTDi8372.
RGDi1303334. Hyal3.

Phylogenomic databases

eggNOGiENOG410IH0U. Eukaryota.
ENOG410XPZT. LUCA.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ76HM9.
KOiK01197.
PhylomeDBiQ76HM9.
TreeFamiTF321598.

Enzyme and pathway databases

BRENDAi3.2.1.35. 5301.

Miscellaneous databases

PROiQ76HM9.

Gene expression databases

BgeeiENSRNOG00000016093.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR013032. EGF-like_CS.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PTHR11769:SF19. PTHR11769:SF19. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYAL3_RAT
AccessioniPrimary (citable) accession number: Q76HM9
Secondary accession number(s): Q4V8Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.