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Q76HM9

- HYAL3_RAT

UniProt

Q76HM9 - HYAL3_RAT

Protein

Hyaluronidase-3

Gene

Hyal3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291Proton donorBy similarity

    GO - Molecular functioni

    1. hyaluronoglucuronidase activity Source: Ensembl
    2. hyalurononglucosaminidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cartilage development Source: Ensembl
    3. cellular response to interleukin-1 Source: Ensembl
    4. cellular response to tumor necrosis factor Source: Ensembl
    5. cellular response to UV-B Source: Ensembl
    6. hyaluronan catabolic process Source: Ensembl
    7. inflammatory response Source: Ensembl
    8. response to antibiotic Source: Ensembl
    9. response to virus Source: Ensembl

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH56. Glycoside Hydrolase Family 56.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronidase-3 (EC:3.2.1.35)
    Short name:
    Hyal-3
    Alternative name(s):
    Hyaluronoglucosaminidase-3
    Gene namesi
    Name:Hyal3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi1303334. Hyal3.

    Subcellular locationi

    Secreted By similarity. Lysosome By similarity

    GO - Cellular componenti

    1. cytoplasmic vesicle Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell
    3. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 412390Hyaluronidase-3PRO_0000248204Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi42 ↔ 332By similarity
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi206 ↔ 221By similarity
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi357 ↔ 368By similarity
    Disulfide bondi362 ↔ 396By similarity
    Disulfide bondi398 ↔ 407By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ76HM9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ76HM9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ76HM9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini353 – 40856EGF-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 56 family.Curated
    Contains 1 EGF-like domain.Curated

    Keywords - Domaini

    EGF-like domain, Signal

    Phylogenomic databases

    eggNOGiNOG69101.
    GeneTreeiENSGT00550000074476.
    HOGENOMiHOG000015133.
    HOVERGENiHBG052053.
    InParanoidiQ76HM9.
    KOiK01197.
    OrthoDBiEOG74J97S.
    PhylomeDBiQ76HM9.
    TreeFamiTF321598.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    IPR027260. Hyaluronidase-3.
    [Graphical view]
    PANTHERiPTHR11769. PTHR11769. 1 hit.
    PfamiPF01630. Glyco_hydro_56. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
    PIRSF500776. Hyaluronidase_3. 1 hit.
    PRINTSiPR00846. GLHYDRLASE56.
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q76HM9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MITQLGLTLV VGLTLCLVHV QALLQVPEFP FSVLWNVPSA RCKTRFGVHL    50
    PLDALGIIAN HGQRFHGQNI TIFYKNQFGL YPYFGPRGTA HNGGIPQAVS 100
    LDHHLAQAAH QILHNLGSSF AGLAVLDWEE WYPLWAGNWG THRQVYQAAS 150
    WAWAQQMFPD LNPQEQLHKA QTGFEQAARA LMEHTLRLGQ MLRPHGLWGF 200
    YRYPVCGNGW HNMASNYTGH CHPAIITRNT QLRWLWAASS ALFPSIYLPP 250
    RLPPAYHQTF VRHRLEEAFR VALTGHAHPL PVLAYVRLTH RSSGRFLSLD 300
    DLMQTIGVSA ALGAAGVVLW GDLSVSSSEE ECWRLHDYLV GTLGPYVINV 350
    TKAATACSHQ RCHGHGRCSW KDPGQMEAFL HLQPDDNLGA WKSFRCRCYL 400
    GWSGPTCLEP KP 412
    Length:412
    Mass (Da):46,207
    Last modified:July 5, 2004 - v1
    Checksum:iBB4949AADE4FB270
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291F → L in AAH97259. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB100602 mRNA. Translation: BAD14370.1.
    BC097259 mRNA. Translation: AAH97259.1.
    RefSeqiNP_997482.2. NM_207599.2.
    UniGeneiRn.229321.

    Genome annotation databases

    EnsembliENSRNOT00000021590; ENSRNOP00000021590; ENSRNOG00000016093.
    GeneIDi300993.
    KEGGirno:300993.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB100602 mRNA. Translation: BAD14370.1 .
    BC097259 mRNA. Translation: AAH97259.1 .
    RefSeqi NP_997482.2. NM_207599.2.
    UniGenei Rn.229321.

    3D structure databases

    ProteinModelPortali Q76HM9.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH56. Glycoside Hydrolase Family 56.

    Proteomic databases

    PRIDEi Q76HM9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021590 ; ENSRNOP00000021590 ; ENSRNOG00000016093 .
    GeneIDi 300993.
    KEGGi rno:300993.

    Organism-specific databases

    CTDi 8372.
    RGDi 1303334. Hyal3.

    Phylogenomic databases

    eggNOGi NOG69101.
    GeneTreei ENSGT00550000074476.
    HOGENOMi HOG000015133.
    HOVERGENi HBG052053.
    InParanoidi Q76HM9.
    KOi K01197.
    OrthoDBi EOG74J97S.
    PhylomeDBi Q76HM9.
    TreeFami TF321598.

    Miscellaneous databases

    NextBioi 647866.
    PROi Q76HM9.

    Gene expression databases

    Genevestigatori Q76HM9.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    IPR027260. Hyaluronidase-3.
    [Graphical view ]
    PANTHERi PTHR11769. PTHR11769. 1 hit.
    Pfami PF01630. Glyco_hydro_56. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
    PIRSF500776. Hyaluronidase_3. 1 hit.
    PRINTSi PR00846. GLHYDRLASE56.
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression and activity of rat hyaluronidase."
      Hanaki A., Ueno Y., Nakasa T., Okinaka O.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiHYAL3_RAT
    AccessioniPrimary (citable) accession number: Q76HM9
    Secondary accession number(s): Q4V8Q0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3