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Q76HM9 (HYAL3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hyaluronidase-3

Short name=Hyal-3
EC=3.2.1.35
Alternative name(s):
Hyaluronoglucosaminidase-3
Gene names
Name:Hyal3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Subcellular location

Secreted By similarity. Lysosome By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 56 family.

Contains 1 EGF-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 412390Hyaluronidase-3
PRO_0000248204

Regions

Domain353 – 40856EGF-like

Sites

Active site1291Proton donor By similarity

Amino acid modifications

Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation2161N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 332 By similarity
Disulfide bond206 ↔ 221 By similarity
Disulfide bond357 ↔ 368 By similarity
Disulfide bond362 ↔ 396 By similarity
Disulfide bond398 ↔ 407 By similarity

Experimental info

Sequence conflict291F → L in AAH97259. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q76HM9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: BB4949AADE4FB270

FASTA41246,207
        10         20         30         40         50         60 
MITQLGLTLV VGLTLCLVHV QALLQVPEFP FSVLWNVPSA RCKTRFGVHL PLDALGIIAN 

        70         80         90        100        110        120 
HGQRFHGQNI TIFYKNQFGL YPYFGPRGTA HNGGIPQAVS LDHHLAQAAH QILHNLGSSF 

       130        140        150        160        170        180 
AGLAVLDWEE WYPLWAGNWG THRQVYQAAS WAWAQQMFPD LNPQEQLHKA QTGFEQAARA 

       190        200        210        220        230        240 
LMEHTLRLGQ MLRPHGLWGF YRYPVCGNGW HNMASNYTGH CHPAIITRNT QLRWLWAASS 

       250        260        270        280        290        300 
ALFPSIYLPP RLPPAYHQTF VRHRLEEAFR VALTGHAHPL PVLAYVRLTH RSSGRFLSLD 

       310        320        330        340        350        360 
DLMQTIGVSA ALGAAGVVLW GDLSVSSSEE ECWRLHDYLV GTLGPYVINV TKAATACSHQ 

       370        380        390        400        410 
RCHGHGRCSW KDPGQMEAFL HLQPDDNLGA WKSFRCRCYL GWSGPTCLEP KP 

« Hide

References

« Hide 'large scale' references
[1]"Expression and activity of rat hyaluronidase."
Hanaki A., Ueno Y., Nakasa T., Okinaka O.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB100602 mRNA. Translation: BAD14370.1.
BC097259 mRNA. Translation: AAH97259.1.
RefSeqNP_997482.2. NM_207599.2.
UniGeneRn.229321.

3D structure databases

ProteinModelPortalQ76HM9.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH56. Glycoside Hydrolase Family 56.

Proteomic databases

PRIDEQ76HM9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000021590; ENSRNOP00000021590; ENSRNOG00000016093.
GeneID300993.
KEGGrno:300993.

Organism-specific databases

CTD8372.
RGD1303334. Hyal3.

Phylogenomic databases

eggNOGNOG69101.
GeneTreeENSGT00550000074476.
HOGENOMHOG000015133.
HOVERGENHBG052053.
InParanoidQ76HM9.
KOK01197.
OrthoDBEOG74J97S.
PhylomeDBQ76HM9.
TreeFamTF321598.

Gene expression databases

GenevestigatorQ76HM9.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
[Graphical view]
PANTHERPTHR11769. PTHR11769. 1 hit.
PfamPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFPIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSPR00846. GLHYDRLASE56.
SMARTSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio647866.
PROQ76HM9.

Entry information

Entry nameHYAL3_RAT
AccessionPrimary (citable) accession number: Q76HM9
Secondary accession number(s): Q4V8Q0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries