Reviewed, UniProtKB/Swiss-Prot Q76G20 (EFP_THET8)

Names and origin

Protein names

Recommended name:
    Elongation factor P
      Short name=EF-P

Gene names

Name:	efp
Ordered Locus Names:	TTHA1125

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Complete proteome] [HAMAP]

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	184 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase By similarity.
Pathway	Protein biosynthesis; polypeptide chain elongation. HAMAP MF_00141
Subcellular location	Cytoplasm. HAMAP MF_00141
Sequence similarities	Belongs to the elongation factor P family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Elongation factor
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	translational elongation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	translation elongation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 184

184

Elongation factor P HAMAP MF_00141

PRO_0000094357

Secondary structure

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184

Helix Strand Turn

Details...

Helix

4 – 6

3

Beta strand

12 – 15

4

Beta strand

18 – 28

11

Beta strand

36 – 47

12

Beta strand

49 – 55

7

Beta strand

59 – 62

4

Beta strand

65 – 76

12

Beta strand

79 – 84

6

Turn

85 – 87

3

Beta strand

90 – 94

5

Helix

95 – 97

3

Helix

101 – 103

3

Beta strand

109 – 115

7

Beta strand

118 – 123

6

Beta strand

126 – 134

9

Beta strand

137 – 139

3

Beta strand

142 – 145

4

Beta strand

147 – 153

7

Beta strand

158 – 162

5

Beta strand

170 – 174

5

Turn

175 – 178

4

Beta strand

179 – 183

5

Sequences

	Sequence		Length	Mass (Da)
	Q76G20-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 962699782753CB30	FASTA	184	20,225
	10 20 30 40 50 60 MISVTDLRPG TKVKMDGGLW ECVEYQHQKL GRGGAKVVAK FKNLETGATV ERTFNSGEKL 70 80 90 100 110 120 EDIYVETREL QYLYPEGEEM VFMDLETYEQ FAVPRSRVVG AEFFKEGMTA LGDMYEGQPI 130 140 150 160 170 180 KVTPPTVVEL KVVDTPPGVR GDTVSGGSKP ATLETGAVVQ VPLFVEPGEV IKVDTRTGEY VGRA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Crystal structure of elongation factor P from Thermus thermophilus HB8." Hanawa-Suetsugu K., Sekine S., Sakai H., Hori-Takemoto C., Terada T., Unzai S., Tame J.R.H., Kuramitsu S., Shirouzu M., Yokoyama S. Proc. Natl. Acad. Sci. U.S.A. 101:9595-9600(2004) [PubMed: 15210970] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS).
[2]	"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBLGenBankDDBJ

AB103477 Genomic DNA. Translation: BAD14383.1.
AP008226 Genomic DNA. Translation: BAD70948.1.

RefSeq

YP_144391.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1UEB	X-ray	1.65	A/B	1-184	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

Q76G20.

Genome annotation databases

GeneID

3169027.

GenomeReviews

Gene locus TTHA1125 in contig AP008226_GR.

KEGG

ttj:TTHA1125.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

Q76G20.

OMA

GVKGDTA.

Enzyme and pathway databases

BioCyc

TTHE300852:TTHA1125-MON.

Family and domain databases

HAMAP

MF_00141.
[Tree]

InterPro

IPR015365. Elong-fact-P_C.
IPR012340. NA-bd_OB-fold.
IPR020599. Transl_elong_fac_P/YeiP.
IPR013185. Transl_elong_KOW-like.
IPR001059. Transl_elong_P/YeiP_cen.
IPR013852. Transl_elong_P/YeiP_CS.
IPR011768. Transl_elongation_fac_P.
IPR014722. Transl_SH3-like_sub.
[Graphical view]

Gene3D

G3DSA:2.40.50.140. OB_NA_bd_sub. 2 hits.
G3DSA:2.30.30.30. Ribosomal_L2. 1 hit.

Pfam

PF01132. EFP. 1 hit.
PF08207. EFP_N. 1 hit.
PF09285. Elong-fact-P_C. 1 hit.
[Graphical view]

PIRSF

PIRSF005901. EF-P. 1 hit.

TIGRFAMs

TIGR00038. efp. 1 hit.

PROSITE

PS01275. EFP. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

EFP_THET8

Accession

Primary (citable) accession number: Q76G20
Secondary accession number(s): Q5SJ89

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)