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Protein

Elongation factor P

Gene

efp

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).By similarity

Pathwayi: polypeptide chain elongation

This protein is involved in the pathway polypeptide chain elongation, which is part of Protein biosynthesis.
View all proteins of this organism that are known to be involved in the pathway polypeptide chain elongation and in Protein biosynthesis.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00345.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor P
Short name:
EF-P
Gene namesi
Name:efp
Ordered Locus Names:TTHA1125
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000943571 – 184Elongation factor PAdd BLAST184

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1125.

Structurei

Secondary structure

1184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Beta strandi12 – 15Combined sources4
Beta strandi18 – 30Combined sources13
Beta strandi36 – 47Combined sources12
Beta strandi49 – 55Combined sources7
Beta strandi59 – 62Combined sources4
Beta strandi65 – 76Combined sources12
Beta strandi79 – 84Combined sources6
Turni85 – 87Combined sources3
Beta strandi90 – 94Combined sources5
Helixi95 – 97Combined sources3
Helixi101 – 103Combined sources3
Beta strandi109 – 115Combined sources7
Beta strandi118 – 123Combined sources6
Beta strandi126 – 134Combined sources9
Beta strandi137 – 139Combined sources3
Beta strandi142 – 145Combined sources4
Beta strandi147 – 153Combined sources7
Beta strandi158 – 162Combined sources5
Beta strandi170 – 174Combined sources5
Turni175 – 178Combined sources4
Beta strandi179 – 183Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UEBX-ray1.65A/B1-184[»]
4V6AX-ray3.10AV/CV1-184[»]
ProteinModelPortaliQ76G20.
SMRiQ76G20.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ76G20.

Family & Domainsi

Sequence similaritiesi

Belongs to the elongation factor P family.Curated

Phylogenomic databases

eggNOGiENOG4105DRH. Bacteria.
COG0231. LUCA.
HOGENOMiHOG000010047.
KOiK02356.
OMAiDQINVPE.
PhylomeDBiQ76G20.

Family and domain databases

CDDicd04470. S1_EF-P_repeat_1. 1 hit.
cd05794. S1_EF-P_repeat_2. 1 hit.
Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_00141. EF_P. 1 hit.
InterProiIPR015365. Elong-fact-P_C.
IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR020599. Transl_elong_fac_P/YeiP.
IPR013185. Transl_elong_KOW-like.
IPR001059. Transl_elong_P/YeiP_cen.
IPR013852. Transl_elong_P/YeiP_CS.
IPR011768. Transl_elongation_fac_P.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF01132. EFP. 1 hit.
PF08207. EFP_N. 1 hit.
PF09285. Elong-fact-P_C. 1 hit.
[Graphical view]
PIRSFiPIRSF005901. EF-P. 1 hit.
SMARTiSM01185. EFP. 1 hit.
SM00841. Elong-fact-P_C. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 2 hits.
TIGRFAMsiTIGR00038. efp. 1 hit.
PROSITEiPS01275. EFP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q76G20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISVTDLRPG TKVKMDGGLW ECVEYQHQKL GRGGAKVVAK FKNLETGATV
60 70 80 90 100
ERTFNSGEKL EDIYVETREL QYLYPEGEEM VFMDLETYEQ FAVPRSRVVG
110 120 130 140 150
AEFFKEGMTA LGDMYEGQPI KVTPPTVVEL KVVDTPPGVR GDTVSGGSKP
160 170 180
ATLETGAVVQ VPLFVEPGEV IKVDTRTGEY VGRA
Length:184
Mass (Da):20,225
Last modified:July 5, 2004 - v1
Checksum:i962699782753CB30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB103477 Genomic DNA. Translation: BAD14383.1.
AP008226 Genomic DNA. Translation: BAD70948.1.
RefSeqiWP_011173195.1. NC_006461.1.
YP_144391.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70948; BAD70948; BAD70948.
GeneIDi3169027.
KEGGittj:TTHA1125.
PATRICi23957209. VBITheThe93045_1104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB103477 Genomic DNA. Translation: BAD14383.1.
AP008226 Genomic DNA. Translation: BAD70948.1.
RefSeqiWP_011173195.1. NC_006461.1.
YP_144391.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UEBX-ray1.65A/B1-184[»]
4V6AX-ray3.10AV/CV1-184[»]
ProteinModelPortaliQ76G20.
SMRiQ76G20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1125.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70948; BAD70948; BAD70948.
GeneIDi3169027.
KEGGittj:TTHA1125.
PATRICi23957209. VBITheThe93045_1104.

Phylogenomic databases

eggNOGiENOG4105DRH. Bacteria.
COG0231. LUCA.
HOGENOMiHOG000010047.
KOiK02356.
OMAiDQINVPE.
PhylomeDBiQ76G20.

Enzyme and pathway databases

UniPathwayiUPA00345.

Miscellaneous databases

EvolutionaryTraceiQ76G20.

Family and domain databases

CDDicd04470. S1_EF-P_repeat_1. 1 hit.
cd05794. S1_EF-P_repeat_2. 1 hit.
Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_00141. EF_P. 1 hit.
InterProiIPR015365. Elong-fact-P_C.
IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR020599. Transl_elong_fac_P/YeiP.
IPR013185. Transl_elong_KOW-like.
IPR001059. Transl_elong_P/YeiP_cen.
IPR013852. Transl_elong_P/YeiP_CS.
IPR011768. Transl_elongation_fac_P.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF01132. EFP. 1 hit.
PF08207. EFP_N. 1 hit.
PF09285. Elong-fact-P_C. 1 hit.
[Graphical view]
PIRSFiPIRSF005901. EF-P. 1 hit.
SMARTiSM01185. EFP. 1 hit.
SM00841. Elong-fact-P_C. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 2 hits.
TIGRFAMsiTIGR00038. efp. 1 hit.
PROSITEiPS01275. EFP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEFP_THET8
AccessioniPrimary (citable) accession number: Q76G20
Secondary accession number(s): Q5SJ89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.