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Q76G19 (PDZD4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
PDZ domain-containing protein 4
Alternative name(s):
PDZ domain-containing RING finger protein 4-like protein
Gene names
Name:PDZD4
Synonyms:KIAA1444, PDZK4, PDZRN4L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length769 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasmcell cortex. Note: Mainly localized under the plasma membrane. Ref.1

Tissue specificity

Brain-specific. Expressed in fetal and adult brain. Up-regulated in synovial carcinomas. Ref.1

Sequence similarities

Contains 1 PDZ (DHR) domain.

Sequence caution

The sequence BAC03666.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcell cortex

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 769769PDZ domain-containing protein 4
PRO_0000055921

Regions

Domain130 – 21485PDZ
Coiled coil389 – 41931 Potential

Amino acid modifications

Modified residue2361Phosphoserine Ref.7
Modified residue4541Phosphoserine Ref.7

Natural variations

Natural variant391R → C in a breast cancer sample; somatic mutation. Ref.8
VAR_035952

Experimental info

Sequence conflict3741G → D in BAC03666. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q76G19 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 9C6788FD289154CD

FASTA76986,171
        10         20         30         40         50         60 
MGCNMCVVQK PEEQYKVMLQ VNGKELSKLS QEQTLQALRS SKEPLVIQVL RRSPRLRGDS 

        70         80         90        100        110        120 
SCHDLQLVDS GTQTDITFEH IMALGKLRPP TPPMVILEPP PISHEYYDPA EFMEGGPQEA 

       130        140        150        160        170        180 
DRLDELEYEE VELYKSSHRD KLGLMVCYRT DDEEDLGIYV GEVNPNSIAA KDGRIREGDR 

       190        200        210        220        230        240 
IIQINGVDVQ NREEAVAILS QEENTNISLL VARPESQLAK RWKDSDRDDF LDDFGSENEG 

       250        260        270        280        290        300 
ELRARKLKSP PAQQPGNEEE KGAPDAGPGL SNSQELDSGV GRTDESTRNE ESSEHDLLGD 

       310        320        330        340        350        360 
EPPSSTNTPG SLRKFGLQGD ALQSRDFHFS MDSLLAEGAG LGGGDVPGLT DEEYERYREL 

       370        380        390        400        410        420 
LEIKCHLENG NQLGLLFPRA SGGNSALDVN RNESLGHEMA MLEEELRHLE FKCRNILRAQ 

       430        440        450        460        470        480 
KMQQLRERCM KAWLLEEESL YDLAASEPKK HELSDISELP EKSDKDSTSA YNTGESCRST 

       490        500        510        520        530        540 
PLLVEPLPES PLRRAMAGNS NLNRTPPGPA VATPAKAAPP PGSPAKFRSL SRDPEAGRRQ 

       550        560        570        580        590        600 
HAEERGRRNP KTGLTLERVG PESSPYLSRR HRGQGQEGEH YHSCVQLAPT RGLEELGHGP 

       610        620        630        640        650        660 
LSLAGGPRVG GVAAAATEAP RMEWKVKVRS DGTRYVAKRP VRDRLLKARA LKIREERSGM 

       670        680        690        700        710        720 
TTDDDAVSEM KMGRYWSKEE RKQHLIRARE QRKRREFMMQ SRLECLREQQ NGDSKPELNI 

       730        740        750        760 
IALSHRKTMK KRNKKILDNW ITIQEMLAHG ARSADGKRVY NPLLSVTTV 

« Hide

References

« Hide 'large scale' references
[1]"Identification of PDZK4, a novel human gene with PDZ domains, that is upregulated in synovial sarcomas."
Nagayama S., Iiizumi M., Katagiri T., Toguchida J., Nakamura Y.
Oncogene 23:5551-5557(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 132-547.
Tissue: Brain.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 535-769.
Tissue: Brain.
[6]"Identification and characterization of human PDZRN4L gene and mouse Pdzrn4l gene in silico."
Katoh M., Katoh M.
Int. J. Mol. Med. 13:923-927(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236 AND SER-454, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-39.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB103478 mRNA. Translation: BAD16631.1.
AK091444 mRNA. Translation: BAC03666.1. Different initiation.
AK127016 mRNA. Translation: BAG54423.1.
CH471172 Genomic DNA. Translation: EAW72805.1.
AB040877 mRNA. Translation: BAA95968.1.
BC002606 mRNA. Translation: AAH02606.2.
BC080584 mRNA. Translation: AAH80584.1.
RefSeqNP_115901.2. NM_032512.2.
UniGeneHs.92732.

3D structure databases

ProteinModelPortalQ76G19.
SMRQ76G19. Positions 11-52, 118-226.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121646. 2 interactions.
IntActQ76G19. 2 interactions.
MINTMINT-2875333.
STRING9606.ENSP00000164640.

PTM databases

PhosphoSiteQ76G19.

Polymorphism databases

DMDM62288846.

Proteomic databases

PaxDbQ76G19.
PRIDEQ76G19.

Protocols and materials databases

DNASU57595.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000164640; ENSP00000164640; ENSG00000067840.
ENST00000595215; ENSP00000470548; ENSG00000267915.
GeneID57595.
KEGGhsa:57595.
UCSCuc004fiz.1. human.

Organism-specific databases

CTD57595.
GeneCardsGC0XM153067.
HGNCHGNC:21167. PDZD4.
HPAHPA003878.
MIM300634. gene.
neXtProtNX_Q76G19.
PharmGKBPA134896313.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG318730.
HOGENOMHOG000231379.
HOVERGENHBG053554.
KOK15682.
OMACLREQQN.
PhylomeDBQ76G19.
TreeFamTF315909.

Gene expression databases

ArrayExpressQ76G19.
BgeeQ76G19.
CleanExHS_PDZD4.
GenevestigatorQ76G19.

Family and domain databases

Gene3D2.30.42.10. 2 hits.
InterProIPR001478. PDZ.
[Graphical view]
PfamPF00595. PDZ. 1 hit.
[Graphical view]
SMARTSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
PROSITEPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPDZD4.
GenomeRNAi57595.
NextBio64198.
PROQ76G19.
SOURCESearch...

Entry information

Entry namePDZD4_HUMAN
AccessionPrimary (citable) accession number: Q76G19
Secondary accession number(s): B3KXB1 expand/collapse secondary AC list , Q8NB75, Q9BUH9, Q9P284
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM