Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q76FK4

- NOL8_HUMAN

UniProt

Q76FK4 - NOL8_HUMAN

Protein

Nucleolar protein 8

Gene

NOL8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.3 Publications

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. DNA replication Source: HGNC
    2. positive regulation of cell growth Source: HGNC
    3. rRNA processing Source: UniProtKB

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleolar protein 8
    Alternative name(s):
    Nucleolar protein Nop132
    Gene namesi
    Name:NOL8Imported
    Synonyms:C9orf34, NOP132
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:23387. NOL8.

    Subcellular locationi

    Nucleusnucleolus 2 Publications
    Note: Localizes in the nucleolar-organizing region during ribosome biogenesis.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleolus Source: UniProtKB
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134918056.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11671167Nucleolar protein 8PRO_0000239443Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei298 – 2981Phosphoserine3 Publications
    Modified residuei302 – 3021Phosphothreonine3 Publications
    Modified residuei304 – 3041Phosphoserine3 Publications
    Modified residuei365 – 3651Phosphoserine5 Publications
    Modified residuei376 – 3761Phosphotyrosine2 Publications
    Modified residuei378 – 3781Phosphoserine4 Publications
    Modified residuei381 – 3811Phosphothreonine4 Publications
    Modified residuei801 – 8011PhosphoserineBy similarity
    Modified residuei837 – 8371Phosphoserine3 Publications
    Modified residuei838 – 8381Phosphoserine2 Publications
    Modified residuei843 – 8431Phosphoserine3 Publications
    Modified residuei845 – 8451Phosphoserine3 Publications
    Modified residuei888 – 8881Phosphothreonine5 Publications
    Modified residuei890 – 8901Phosphoserine5 Publications
    Modified residuei1036 – 10361Phosphoserine2 Publications
    Modified residuei1082 – 10821Phosphoserine4 Publications
    Modified residuei1083 – 10831Phosphoserine4 Publications
    Modified residuei1084 – 10841Phosphoserine4 Publications
    Modified residuei1099 – 10991Phosphoserine3 Publications

    Post-translational modificationi

    Phosphorylated.1 Publication5 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ76FK4.
    PaxDbiQ76FK4.
    PRIDEiQ76FK4.

    PTM databases

    PhosphoSiteiQ76FK4.

    Expressioni

    Tissue specificityi

    Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle.1 Publication

    Inductioni

    Up-regulated in diffuse-type gastric cancers.1 Publication

    Gene expression databases

    ArrayExpressiQ76FK4.
    BgeeiQ76FK4.
    GenevestigatoriQ76FK4.

    Organism-specific databases

    HPAiHPA044440.

    Interactioni

    Subunit structurei

    Interacts with the GTP form of RRAGA, RRAGC and RRAGD. Interacts with NIP7. Interacts with DDX18; the interaction is RNA-dependent. Interacts with DDX47; the interaction is RNA-dependent.2 Publications

    Protein-protein interaction databases

    BioGridi120364. 4 interactions.
    IntActiQ76FK4. 3 interactions.
    MINTiMINT-4539421.

    Structurei

    3D structure databases

    ProteinModelPortaliQ76FK4.
    SMRiQ76FK4. Positions 8-88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 8982RRMPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili753 – 77927Sequence AnalysisAdd
    BLAST
    Coiled coili886 – 92439Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1113 – 11164Poly-PheSequence Analysis

    Sequence similaritiesi

    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG73280.
    HOVERGENiHBG057565.
    InParanoidiQ76FK4.
    OMAiFQAFKGI.
    OrthoDBiEOG70CR60.
    PhylomeDBiQ76FK4.
    TreeFamiTF323283.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 12 Publications (identifier: Q76FK4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKVNRETKRL YVGGLSQDIS EADLQNQFSR FGEVSDVEII TRKDDQGNPQ     50
    KVFAYINISV AEADLKKCMS VLNKTKWKGG TLQIQLAKES FLHRLAQERE 100
    AAKAKKEEST TGNANLLEKT GGVDFHMKAV PGTEVPGHKN WVVSKFGRVL 150
    PVLHLKNQHK RKIIKYDPSK YCHNLKKIGE DFSNTIPISS LTWELEGGND 200
    PMSKKRRGEF SDFHGPPKKI IKVQKDESST GSLAMSTRPR RVIERPPLTQ 250
    QQAAQKRTCD SITPSKSSPV PVSDTQKLKN LPFKTSGLET AKKRNSISDD 300
    DTDSEDELRM MIAKEENLQR TTQPSINESE SDPFEVVRDD FKSGVHKLHS 350
    LIGLGIKNRV SCHDSDDDIM RNDREYDSGD TDEIIAMKKN VAKVKNSTEF 400
    SQMEKSTKKT SFKNRENCEL SDHCIKLQKR KSNVESALSH GLKSLNRKSP 450
    SHSSSSEDAD SASELADSEG GEEYNAMMKN CLRVNLTLAD LEQLAGSDLK 500
    VPNEDTKSDG PETTTQCKFD RGSKSPKTPT GLRRGRQCIR PAEIVASLLE 550
    GEENTCGKQK PKENNLKPKF QAFKGVGCLY EKESMKKSLK DSVASNNKDQ 600
    NSMKHEDPSI ISMEDGSPYV NGSLGEVTPC QHAKKANGPN YIQPQKRQTT 650
    FESQDRKAVS PSSSEKRSKN PISRPLEGKK SLSLSAKTHN IGFDKDSCHS 700
    TTKTEASQEE RSDSSGLTSL KKSPKVSSKD TREIKTDFSL SISNSSDVSA 750
    KDKHAEDNEK RLAALEARQK AKEVQKKLVH NALANLDGHP EDKPTHIIFG 800
    SDSECETEET STQEQSHPGE EWVKESMGKT SGKLFDSSDD DESDSEDDSN 850
    RFKIKPQFEG RAGQKLMDLQ SHFGTDDRFR MDSRFLETDS EEEQEEVNEK 900
    KTAEEEELAE EKKKALNVVQ SVLQINLSNS TNRGSVAAKK FKDIIHYDPT 950
    KQDHATYERK RDDKPKESKA KRKKKREEAE KLPEVSKEMY YNIAMDLKEI 1000
    FQTTKYTSEK EEGTPWNEDC GKEKPEEIQD PAALTSDAEQ PSGFTFSFFD 1050
    SDTKDIKEET YRVETVKPGK IVWQEDPRLQ DSSSEEEDVT EETDHRNSSP 1100
    GEASLLEKET TRFFFFSKND ERLQGSDLFW RGVGSNMSRN SWEARTTNLR 1150
    MDCRKKHKDA KRKMKPK 1167
    Length:1,167
    Mass (Da):131,616
    Last modified:July 5, 2004 - v1
    Checksum:i6E64780D6F0E7415
    GO
    Isoform 21 Publication (identifier: Q76FK4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-68: Missing.

    Note: No experimental confirmation available. Gene prediction based on EST data.

    Show »
    Length:1,099
    Mass (Da):123,927
    Checksum:iBED9401AC2D5ABE8
    GO
    Isoform 41 Publication (identifier: Q76FK4-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         787-824: Missing.

    Note: No experimental confirmation available. Gene prediction based on EST data.

    Show »
    Length:1,129
    Mass (Da):127,337
    Checksum:iCF4642596A282A1A
    GO

    Sequence cautioni

    The sequence BAA91356.1 differs from that shown. Reason: Frameshift at position 1136.
    The sequence BAA91356.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB14229.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB15003.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti69 – 691M → I in BAC99315. (PubMed:14660641)Curated
    Sequence conflicti69 – 691M → I in BAA91479. (PubMed:14702039)Curated
    Sequence conflicti454 – 4541S → G in BAB14857. (PubMed:14702039)Curated
    Sequence conflicti479 – 4791K → E in BAB14857. (PubMed:14702039)Curated
    Sequence conflicti630 – 6301C → W in BAC99315. (PubMed:14660641)Curated
    Sequence conflicti630 – 6301C → W in BAA91356. (PubMed:14702039)Curated
    Sequence conflicti733 – 7331E → G in BAB14857. (PubMed:14702039)Curated
    Sequence conflicti749 – 7491S → G in BAB14857. (PubMed:14702039)Curated
    Sequence conflicti945 – 9451I → L in BAC99315. (PubMed:14660641)Curated
    Sequence conflicti945 – 9451I → L in BAA91356. (PubMed:14702039)Curated
    Sequence conflicti966 – 9661K → R in BAC99315. (PubMed:14660641)Curated
    Sequence conflicti966 – 9661K → R in BAA91356. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti470 – 4701G → E.
    Corresponds to variant rs58545014 [ dbSNP | Ensembl ].
    VAR_061830
    Natural varianti748 – 7481V → L.
    Corresponds to variant rs2236344 [ dbSNP | Ensembl ].
    VAR_052211
    Natural varianti841 – 8411D → E.
    Corresponds to variant rs15717 [ dbSNP | Ensembl ].
    VAR_052212
    Natural varianti988 – 9881E → D.
    Corresponds to variant rs34224798 [ dbSNP | Ensembl ].
    VAR_052213
    Natural varianti1021 – 10211G → S.
    Corresponds to variant rs921122 [ dbSNP | Ensembl ].
    VAR_052214

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6868Missing in isoform 2. 1 PublicationVSP_052055Add
    BLAST
    Alternative sequencei787 – 82438Missing in isoform 4. 1 PublicationVSP_052056Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB105104 mRNA. Translation: BAD12268.1.
    AB109030 mRNA. Translation: BAC99315.1.
    AK000743 mRNA. Translation: BAA91356.1. Sequence problems.
    AK001049 mRNA. Translation: BAA91479.1.
    AK022755 mRNA. Translation: BAB14229.1. Different initiation.
    AK024245 mRNA. Translation: BAB14857.1.
    AK024786 mRNA. Translation: BAB15003.1. Different initiation.
    AL136097 Genomic DNA. No translation available.
    BC013788 mRNA. Translation: AAH13788.2.
    CCDSiCCDS47993.1. [Q76FK4-1]
    CCDS59135.1. [Q76FK4-2]
    RefSeqiNP_001243323.1. NM_001256394.1. [Q76FK4-2]
    NP_060418.4. NM_017948.5. [Q76FK4-1]
    XP_006717229.1. XM_006717166.1. [Q76FK4-1]
    XP_006717230.1. XM_006717167.1. [Q76FK4-1]
    XP_006717231.1. XM_006717168.1. [Q76FK4-4]
    XP_006717232.1. XM_006717169.1. [Q76FK4-2]
    XP_006717233.1. XM_006717170.1. [Q76FK4-2]
    UniGeneiHs.442199.

    Genome annotation databases

    EnsembliENST00000358855; ENSP00000351723; ENSG00000198000. [Q76FK4-2]
    ENST00000442668; ENSP00000401177; ENSG00000198000. [Q76FK4-1]
    ENST00000535387; ENSP00000441300; ENSG00000198000. [Q76FK4-4]
    ENST00000542053; ENSP00000440709; ENSG00000198000. [Q76FK4-2]
    ENST00000545558; ENSP00000441140; ENSG00000198000. [Q76FK4-1]
    GeneIDi55035.
    KEGGihsa:55035.
    UCSCiuc022bjw.1. human. [Q76FK4-1]

    Polymorphism databases

    DMDMi74758950.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB105104 mRNA. Translation: BAD12268.1 .
    AB109030 mRNA. Translation: BAC99315.1 .
    AK000743 mRNA. Translation: BAA91356.1 . Sequence problems.
    AK001049 mRNA. Translation: BAA91479.1 .
    AK022755 mRNA. Translation: BAB14229.1 . Different initiation.
    AK024245 mRNA. Translation: BAB14857.1 .
    AK024786 mRNA. Translation: BAB15003.1 . Different initiation.
    AL136097 Genomic DNA. No translation available.
    BC013788 mRNA. Translation: AAH13788.2 .
    CCDSi CCDS47993.1. [Q76FK4-1 ]
    CCDS59135.1. [Q76FK4-2 ]
    RefSeqi NP_001243323.1. NM_001256394.1. [Q76FK4-2 ]
    NP_060418.4. NM_017948.5. [Q76FK4-1 ]
    XP_006717229.1. XM_006717166.1. [Q76FK4-1 ]
    XP_006717230.1. XM_006717167.1. [Q76FK4-1 ]
    XP_006717231.1. XM_006717168.1. [Q76FK4-4 ]
    XP_006717232.1. XM_006717169.1. [Q76FK4-2 ]
    XP_006717233.1. XM_006717170.1. [Q76FK4-2 ]
    UniGenei Hs.442199.

    3D structure databases

    ProteinModelPortali Q76FK4.
    SMRi Q76FK4. Positions 8-88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120364. 4 interactions.
    IntActi Q76FK4. 3 interactions.
    MINTi MINT-4539421.

    PTM databases

    PhosphoSitei Q76FK4.

    Polymorphism databases

    DMDMi 74758950.

    Proteomic databases

    MaxQBi Q76FK4.
    PaxDbi Q76FK4.
    PRIDEi Q76FK4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358855 ; ENSP00000351723 ; ENSG00000198000 . [Q76FK4-2 ]
    ENST00000442668 ; ENSP00000401177 ; ENSG00000198000 . [Q76FK4-1 ]
    ENST00000535387 ; ENSP00000441300 ; ENSG00000198000 . [Q76FK4-4 ]
    ENST00000542053 ; ENSP00000440709 ; ENSG00000198000 . [Q76FK4-2 ]
    ENST00000545558 ; ENSP00000441140 ; ENSG00000198000 . [Q76FK4-1 ]
    GeneIDi 55035.
    KEGGi hsa:55035.
    UCSCi uc022bjw.1. human. [Q76FK4-1 ]

    Organism-specific databases

    CTDi 55035.
    GeneCardsi GC09M095059.
    HGNCi HGNC:23387. NOL8.
    HPAi HPA044440.
    MIMi 611534. gene.
    neXtProti NX_Q76FK4.
    PharmGKBi PA134918056.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG73280.
    HOVERGENi HBG057565.
    InParanoidi Q76FK4.
    OMAi FQAFKGI.
    OrthoDBi EOG70CR60.
    PhylomeDBi Q76FK4.
    TreeFami TF323283.

    Miscellaneous databases

    GeneWikii NOL8.
    GenomeRNAii 55035.
    NextBioi 58463.
    PROi Q76FK4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q76FK4.
    Bgeei Q76FK4.
    Genevestigatori Q76FK4.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer."
      Jinawath N., Furukawa Y., Nakamura Y.
      Cancer Sci. 95:430-435(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, PHOSPHORYLATION.
    2. "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D."
      Sekiguchi T., Todaka Y., Wang Y., Hirose E., Nakashima N., Nishimoto T.
      J. Biol. Chem. 279:8343-8350(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 946-964, FUNCTION, INTERACTION WITH NIP7; RRAGA; RRAGC AND RRAGD.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Embryonic headImported, HepatomaImported, Smooth muscleImported and TeratocarcinomaImported.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 473-1167 (ISOFORMS 1/2).
      Tissue: ColonImported.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365; THR-888 AND SER-890, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47."
      Sekiguchi T., Hayano T., Yanagida M., Takahashi N., Nishimoto T.
      Nucleic Acids Res. 34:4593-4608(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH DDX18 AND DDX47, SUBCELLULAR LOCATION.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365; SER-378; THR-381; SER-837; SER-838; SER-843; SER-845; SER-1036; SER-1082; SER-1083; SER-1084 AND SER-1099, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298; THR-302; SER-304; SER-378; THR-381; SER-837; SER-843; SER-845; THR-888; SER-890; SER-1082; SER-1083 AND SER-1084, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365; THR-888 AND SER-890, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298; THR-302; SER-304; SER-365; TYR-376; SER-378; THR-381; THR-888; SER-890; SER-1082; SER-1083; SER-1084 AND SER-1099, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNOL8_HUMAN
    AccessioniPrimary (citable) accession number: Q76FK4
    Secondary accession number(s): Q5TCC7
    , Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3