Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q76FK4

- NOL8_HUMAN

UniProt

Q76FK4 - NOL8_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Nucleolar protein 8

Gene

NOL8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.3 Publications

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. DNA replication Source: HGNC
  2. positive regulation of cell growth Source: HGNC
  3. rRNA processing Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 8
Alternative name(s):
Nucleolar protein Nop132
Gene namesi
Name:NOL8Imported
Synonyms:C9orf34, NOP132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:23387. NOL8.

Subcellular locationi

Nucleusnucleolus 2 Publications
Note: Localizes in the nucleolar-organizing region during ribosome biogenesis.

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleolus Source: UniProtKB
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134918056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11671167Nucleolar protein 8PRO_0000239443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei298 – 2981Phosphoserine2 Publications
Modified residuei302 – 3021Phosphothreonine2 Publications
Modified residuei304 – 3041Phosphoserine2 Publications
Modified residuei365 – 3651Phosphoserine4 Publications
Modified residuei376 – 3761Phosphotyrosine1 Publication
Modified residuei378 – 3781Phosphoserine3 Publications
Modified residuei381 – 3811Phosphothreonine3 Publications
Modified residuei801 – 8011PhosphoserineBy similarity
Modified residuei837 – 8371Phosphoserine2 Publications
Modified residuei838 – 8381Phosphoserine1 Publication
Modified residuei843 – 8431Phosphoserine2 Publications
Modified residuei845 – 8451Phosphoserine2 Publications
Modified residuei888 – 8881Phosphothreonine4 Publications
Modified residuei890 – 8901Phosphoserine4 Publications
Modified residuei1036 – 10361Phosphoserine1 Publication
Modified residuei1082 – 10821Phosphoserine3 Publications
Modified residuei1083 – 10831Phosphoserine3 Publications
Modified residuei1084 – 10841Phosphoserine3 Publications
Modified residuei1099 – 10991Phosphoserine2 Publications

Post-translational modificationi

Phosphorylated.1 Publication5 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ76FK4.
PaxDbiQ76FK4.
PRIDEiQ76FK4.

PTM databases

PhosphoSiteiQ76FK4.

Expressioni

Tissue specificityi

Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle.1 Publication

Inductioni

Up-regulated in diffuse-type gastric cancers.1 Publication

Gene expression databases

BgeeiQ76FK4.
ExpressionAtlasiQ76FK4. baseline and differential.
GenevestigatoriQ76FK4.

Organism-specific databases

HPAiHPA044440.

Interactioni

Subunit structurei

Interacts with the GTP form of RRAGA, RRAGC and RRAGD. Interacts with NIP7. Interacts with DDX18; the interaction is RNA-dependent. Interacts with DDX47; the interaction is RNA-dependent.2 Publications

Protein-protein interaction databases

BioGridi120364. 6 interactions.
IntActiQ76FK4. 3 interactions.
MINTiMINT-4539421.

Structurei

3D structure databases

ProteinModelPortaliQ76FK4.
SMRiQ76FK4. Positions 5-100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8982RRMPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili753 – 77927Sequence AnalysisAdd
BLAST
Coiled coili886 – 92439Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1113 – 11164Poly-PheSequence Analysis

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG73280.
GeneTreeiENSGT00390000004860.
HOVERGENiHBG057565.
InParanoidiQ76FK4.
OMAiFQAFKGI.
OrthoDBiEOG70CR60.
PhylomeDBiQ76FK4.
TreeFamiTF323283.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 12 Publications (identifier: Q76FK4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVNRETKRL YVGGLSQDIS EADLQNQFSR FGEVSDVEII TRKDDQGNPQ
60 70 80 90 100
KVFAYINISV AEADLKKCMS VLNKTKWKGG TLQIQLAKES FLHRLAQERE
110 120 130 140 150
AAKAKKEEST TGNANLLEKT GGVDFHMKAV PGTEVPGHKN WVVSKFGRVL
160 170 180 190 200
PVLHLKNQHK RKIIKYDPSK YCHNLKKIGE DFSNTIPISS LTWELEGGND
210 220 230 240 250
PMSKKRRGEF SDFHGPPKKI IKVQKDESST GSLAMSTRPR RVIERPPLTQ
260 270 280 290 300
QQAAQKRTCD SITPSKSSPV PVSDTQKLKN LPFKTSGLET AKKRNSISDD
310 320 330 340 350
DTDSEDELRM MIAKEENLQR TTQPSINESE SDPFEVVRDD FKSGVHKLHS
360 370 380 390 400
LIGLGIKNRV SCHDSDDDIM RNDREYDSGD TDEIIAMKKN VAKVKNSTEF
410 420 430 440 450
SQMEKSTKKT SFKNRENCEL SDHCIKLQKR KSNVESALSH GLKSLNRKSP
460 470 480 490 500
SHSSSSEDAD SASELADSEG GEEYNAMMKN CLRVNLTLAD LEQLAGSDLK
510 520 530 540 550
VPNEDTKSDG PETTTQCKFD RGSKSPKTPT GLRRGRQCIR PAEIVASLLE
560 570 580 590 600
GEENTCGKQK PKENNLKPKF QAFKGVGCLY EKESMKKSLK DSVASNNKDQ
610 620 630 640 650
NSMKHEDPSI ISMEDGSPYV NGSLGEVTPC QHAKKANGPN YIQPQKRQTT
660 670 680 690 700
FESQDRKAVS PSSSEKRSKN PISRPLEGKK SLSLSAKTHN IGFDKDSCHS
710 720 730 740 750
TTKTEASQEE RSDSSGLTSL KKSPKVSSKD TREIKTDFSL SISNSSDVSA
760 770 780 790 800
KDKHAEDNEK RLAALEARQK AKEVQKKLVH NALANLDGHP EDKPTHIIFG
810 820 830 840 850
SDSECETEET STQEQSHPGE EWVKESMGKT SGKLFDSSDD DESDSEDDSN
860 870 880 890 900
RFKIKPQFEG RAGQKLMDLQ SHFGTDDRFR MDSRFLETDS EEEQEEVNEK
910 920 930 940 950
KTAEEEELAE EKKKALNVVQ SVLQINLSNS TNRGSVAAKK FKDIIHYDPT
960 970 980 990 1000
KQDHATYERK RDDKPKESKA KRKKKREEAE KLPEVSKEMY YNIAMDLKEI
1010 1020 1030 1040 1050
FQTTKYTSEK EEGTPWNEDC GKEKPEEIQD PAALTSDAEQ PSGFTFSFFD
1060 1070 1080 1090 1100
SDTKDIKEET YRVETVKPGK IVWQEDPRLQ DSSSEEEDVT EETDHRNSSP
1110 1120 1130 1140 1150
GEASLLEKET TRFFFFSKND ERLQGSDLFW RGVGSNMSRN SWEARTTNLR
1160
MDCRKKHKDA KRKMKPK
Length:1,167
Mass (Da):131,616
Last modified:July 5, 2004 - v1
Checksum:i6E64780D6F0E7415
GO
Isoform 21 Publication (identifier: Q76FK4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »
Length:1,099
Mass (Da):123,927
Checksum:iBED9401AC2D5ABE8
GO
Isoform 41 Publication (identifier: Q76FK4-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     787-824: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »
Length:1,129
Mass (Da):127,337
Checksum:iCF4642596A282A1A
GO

Sequence cautioni

The sequence BAA91356.1 differs from that shown. Reason: Frameshift at position 1136. Curated
The sequence BAA91356.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14229.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15003.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691M → I in BAC99315. (PubMed:14660641)Curated
Sequence conflicti69 – 691M → I in BAA91479. (PubMed:14702039)Curated
Sequence conflicti454 – 4541S → G in BAB14857. (PubMed:14702039)Curated
Sequence conflicti479 – 4791K → E in BAB14857. (PubMed:14702039)Curated
Sequence conflicti630 – 6301C → W in BAC99315. (PubMed:14660641)Curated
Sequence conflicti630 – 6301C → W in BAA91356. (PubMed:14702039)Curated
Sequence conflicti733 – 7331E → G in BAB14857. (PubMed:14702039)Curated
Sequence conflicti749 – 7491S → G in BAB14857. (PubMed:14702039)Curated
Sequence conflicti945 – 9451I → L in BAC99315. (PubMed:14660641)Curated
Sequence conflicti945 – 9451I → L in BAA91356. (PubMed:14702039)Curated
Sequence conflicti966 – 9661K → R in BAC99315. (PubMed:14660641)Curated
Sequence conflicti966 – 9661K → R in BAA91356. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti470 – 4701G → E.
Corresponds to variant rs58545014 [ dbSNP | Ensembl ].
VAR_061830
Natural varianti748 – 7481V → L.
Corresponds to variant rs2236344 [ dbSNP | Ensembl ].
VAR_052211
Natural varianti841 – 8411D → E.
Corresponds to variant rs15717 [ dbSNP | Ensembl ].
VAR_052212
Natural varianti988 – 9881E → D.
Corresponds to variant rs34224798 [ dbSNP | Ensembl ].
VAR_052213
Natural varianti1021 – 10211G → S.
Corresponds to variant rs921122 [ dbSNP | Ensembl ].
VAR_052214

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6868Missing in isoform 2. 1 PublicationVSP_052055Add
BLAST
Alternative sequencei787 – 82438Missing in isoform 4. 1 PublicationVSP_052056Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB105104 mRNA. Translation: BAD12268.1.
AB109030 mRNA. Translation: BAC99315.1.
AK000743 mRNA. Translation: BAA91356.1. Sequence problems.
AK001049 mRNA. Translation: BAA91479.1.
AK022755 mRNA. Translation: BAB14229.1. Different initiation.
AK024245 mRNA. Translation: BAB14857.1.
AK024786 mRNA. Translation: BAB15003.1. Different initiation.
AL136097 Genomic DNA. No translation available.
BC013788 mRNA. Translation: AAH13788.2.
CCDSiCCDS47993.1. [Q76FK4-1]
CCDS59135.1. [Q76FK4-2]
RefSeqiNP_001243323.1. NM_001256394.1. [Q76FK4-2]
NP_060418.4. NM_017948.5. [Q76FK4-1]
XP_006717229.1. XM_006717166.1. [Q76FK4-1]
XP_006717230.1. XM_006717167.1. [Q76FK4-1]
XP_006717231.1. XM_006717168.1. [Q76FK4-4]
XP_006717232.1. XM_006717169.1. [Q76FK4-2]
XP_006717233.1. XM_006717170.1. [Q76FK4-2]
UniGeneiHs.442199.

Genome annotation databases

EnsembliENST00000358855; ENSP00000351723; ENSG00000198000. [Q76FK4-2]
ENST00000442668; ENSP00000401177; ENSG00000198000. [Q76FK4-1]
ENST00000535387; ENSP00000441300; ENSG00000198000. [Q76FK4-4]
ENST00000542053; ENSP00000440709; ENSG00000198000. [Q76FK4-2]
ENST00000545558; ENSP00000441140; ENSG00000198000. [Q76FK4-1]
GeneIDi55035.
KEGGihsa:55035.
UCSCiuc022bjw.1. human. [Q76FK4-1]

Polymorphism databases

DMDMi74758950.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB105104 mRNA. Translation: BAD12268.1 .
AB109030 mRNA. Translation: BAC99315.1 .
AK000743 mRNA. Translation: BAA91356.1 . Sequence problems.
AK001049 mRNA. Translation: BAA91479.1 .
AK022755 mRNA. Translation: BAB14229.1 . Different initiation.
AK024245 mRNA. Translation: BAB14857.1 .
AK024786 mRNA. Translation: BAB15003.1 . Different initiation.
AL136097 Genomic DNA. No translation available.
BC013788 mRNA. Translation: AAH13788.2 .
CCDSi CCDS47993.1. [Q76FK4-1 ]
CCDS59135.1. [Q76FK4-2 ]
RefSeqi NP_001243323.1. NM_001256394.1. [Q76FK4-2 ]
NP_060418.4. NM_017948.5. [Q76FK4-1 ]
XP_006717229.1. XM_006717166.1. [Q76FK4-1 ]
XP_006717230.1. XM_006717167.1. [Q76FK4-1 ]
XP_006717231.1. XM_006717168.1. [Q76FK4-4 ]
XP_006717232.1. XM_006717169.1. [Q76FK4-2 ]
XP_006717233.1. XM_006717170.1. [Q76FK4-2 ]
UniGenei Hs.442199.

3D structure databases

ProteinModelPortali Q76FK4.
SMRi Q76FK4. Positions 5-100.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120364. 6 interactions.
IntActi Q76FK4. 3 interactions.
MINTi MINT-4539421.

PTM databases

PhosphoSitei Q76FK4.

Polymorphism databases

DMDMi 74758950.

Proteomic databases

MaxQBi Q76FK4.
PaxDbi Q76FK4.
PRIDEi Q76FK4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358855 ; ENSP00000351723 ; ENSG00000198000 . [Q76FK4-2 ]
ENST00000442668 ; ENSP00000401177 ; ENSG00000198000 . [Q76FK4-1 ]
ENST00000535387 ; ENSP00000441300 ; ENSG00000198000 . [Q76FK4-4 ]
ENST00000542053 ; ENSP00000440709 ; ENSG00000198000 . [Q76FK4-2 ]
ENST00000545558 ; ENSP00000441140 ; ENSG00000198000 . [Q76FK4-1 ]
GeneIDi 55035.
KEGGi hsa:55035.
UCSCi uc022bjw.1. human. [Q76FK4-1 ]

Organism-specific databases

CTDi 55035.
GeneCardsi GC09M095059.
HGNCi HGNC:23387. NOL8.
HPAi HPA044440.
MIMi 611534. gene.
neXtProti NX_Q76FK4.
PharmGKBi PA134918056.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG73280.
GeneTreei ENSGT00390000004860.
HOVERGENi HBG057565.
InParanoidi Q76FK4.
OMAi FQAFKGI.
OrthoDBi EOG70CR60.
PhylomeDBi Q76FK4.
TreeFami TF323283.

Miscellaneous databases

ChiTaRSi NOL8. human.
GeneWikii NOL8.
GenomeRNAii 55035.
NextBioi 58463.
PROi Q76FK4.
SOURCEi Search...

Gene expression databases

Bgeei Q76FK4.
ExpressionAtlasi Q76FK4. baseline and differential.
Genevestigatori Q76FK4.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer."
    Jinawath N., Furukawa Y., Nakamura Y.
    Cancer Sci. 95:430-435(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, PHOSPHORYLATION.
  2. "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D."
    Sekiguchi T., Todaka Y., Wang Y., Hirose E., Nakashima N., Nishimoto T.
    J. Biol. Chem. 279:8343-8350(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 946-964, FUNCTION, INTERACTION WITH NIP7; RRAGA; RRAGC AND RRAGD.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryonic headImported, HepatomaImported, Smooth muscleImported and TeratocarcinomaImported.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 473-1167 (ISOFORMS 1/2).
    Tissue: ColonImported.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365; THR-888 AND SER-890, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47."
    Sekiguchi T., Hayano T., Yanagida M., Takahashi N., Nishimoto T.
    Nucleic Acids Res. 34:4593-4608(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DDX18 AND DDX47, SUBCELLULAR LOCATION.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365; SER-378; THR-381; SER-837; SER-838; SER-843; SER-845; SER-1036; SER-1082; SER-1083; SER-1084 AND SER-1099, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298; THR-302; SER-304; SER-378; THR-381; SER-837; SER-843; SER-845; THR-888; SER-890; SER-1082; SER-1083 AND SER-1084, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365; THR-888 AND SER-890, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298; THR-302; SER-304; SER-365; TYR-376; SER-378; THR-381; THR-888; SER-890; SER-1082; SER-1083; SER-1084 AND SER-1099, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNOL8_HUMAN
AccessioniPrimary (citable) accession number: Q76FK4
Secondary accession number(s): Q5TCC7
, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3