Q76FK4 (NOL8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleolar protein 8

Alternative name(s):
Nucleolar protein Nop132

Gene names

Name:	NOL8
Synonyms:	C9orf34, NOP132

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1167 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. Ref.1 Ref.2 Ref.7
Subunit structure	Interacts with the GTP form of RRAGA, RRAGC and RRAGD. Interacts with NIP7. Interacts with DDX18; the interaction is RNA-dependent. Interacts with DDX47; the interaction is RNA-dependent. Ref.2 Ref.7
Subcellular location	Nucleus › nucleolus. Note: Localizes in the nucleolar-organizing region during ribosome biogenesis. Ref.1 Ref.7
Tissue specificity	Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle. Ref.1
Induction	Up-regulated in diffuse-type gastric cancers. Ref.1
Post-translational modification	Phosphorylated Probable. Ref.1
Sequence similarities	Contains 1 RRM (RNA recognition motif) domain.
Sequence caution	The sequence BAA91356.1 differs from that shown. Reason: Frameshift at position 1136. The sequence BAB14229.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB15003.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from mutant phenotype Ref.2. Source: HGNC positive regulation of cell growth Inferred from mutant phenotype Ref.2. Source: HGNC rRNA processing Inferred from mutant phenotype Ref.7. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleolus Inferred from direct assay Ref.1Ref.7. Source: UniProtKB
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 Ref.2 (identifier: Q76FK4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.4 (identifier: Q76FK4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Note: No experimental confirmation available.

Isoform 3 Ref.4 (identifier: Q76FK4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Note: No experimental confirmation available.

Isoform 4 Ref.4 (identifier: Q76FK4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     787-824: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1167	1167	Nucleolar protein 8		PRO_0000239443
Regions
	Domain	8 – 89	82	RRM
	Coiled coil	753 – 779	27	Potential
	Coiled coil	886 – 924	39	Potential
	Compositional bias	1113 – 1116	4	Poly-Phe
Amino acid modifications
	Modified residue	298	1	Phosphoserine Ref.10 Ref.12
	Modified residue	302	1	Phosphothreonine Ref.10 Ref.12
	Modified residue	304	1	Phosphoserine Ref.10 Ref.12
	Modified residue	365	1	Phosphoserine Ref.6 Ref.9 Ref.11 Ref.12
	Modified residue	376	1	Phosphotyrosine Ref.12
	Modified residue	378	1	Phosphoserine Ref.9 Ref.10 Ref.12
	Modified residue	381	1	Phosphothreonine Ref.9 Ref.10 Ref.12
	Modified residue	801	1	Phosphoserine By similarity
	Modified residue	837	1	Phosphoserine Ref.9 Ref.10
	Modified residue	838	1	Phosphoserine Ref.9
	Modified residue	843	1	Phosphoserine Ref.9 Ref.10
	Modified residue	845	1	Phosphoserine Ref.9 Ref.10
	Modified residue	888	1	Phosphothreonine Ref.6 Ref.10 Ref.11 Ref.12
	Modified residue	890	1	Phosphoserine Ref.6 Ref.10 Ref.11 Ref.12
	Modified residue	1036	1	Phosphoserine Ref.9
	Modified residue	1082	1	Phosphoserine Ref.9 Ref.10 Ref.12
	Modified residue	1083	1	Phosphoserine Ref.9 Ref.10 Ref.12
	Modified residue	1084	1	Phosphoserine Ref.9 Ref.10 Ref.12
	Modified residue	1099	1	Phosphoserine Ref.9 Ref.12
Natural variations
	Alternative sequence	1 – 126	126	Missing in isoform 3. Ref.4		VSP_052054
	Alternative sequence	1 – 68	68	Missing in isoform 2. Ref.4		VSP_052055
	Alternative sequence	787 – 824	38	Missing in isoform 4. Ref.4		VSP_052056
	Natural variant	470	1	G → E. Corresponds to variant rs58545014 [ dbSNP | Ensembl ].		VAR_061830
	Natural variant	748	1	V → L. Corresponds to variant rs2236344 [ dbSNP | Ensembl ].		VAR_052211
	Natural variant	841	1	D → E. Corresponds to variant rs15717 [ dbSNP | Ensembl ].		VAR_052212
	Natural variant	988	1	E → D. Corresponds to variant rs34224798 [ dbSNP | Ensembl ].		VAR_052213
	Natural variant	1021	1	G → S. Corresponds to variant rs921122 [ dbSNP | Ensembl ].		VAR_052214
Experimental info
	Sequence conflict	69	1	M → I in BAC99315. Ref.2
	Sequence conflict	69	1	M → I in BAA91479. Ref.3
	Sequence conflict	454	1	S → G in BAB14857. Ref.3
	Sequence conflict	479	1	K → E in BAB14857. Ref.3
	Sequence conflict	630	1	C → W in BAC99315. Ref.2
	Sequence conflict	630	1	C → W in BAA91356. Ref.3
	Sequence conflict	733	1	E → G in BAB14857. Ref.3
	Sequence conflict	749	1	S → G in BAB14857. Ref.3
	Sequence conflict	945	1	I → L in BAC99315. Ref.2
	Sequence conflict	945	1	I → L in BAA91356. Ref.3
	Sequence conflict	966	1	K → R in BAC99315. Ref.2
	Sequence conflict	966	1	K → R in BAA91356. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 6E64780D6F0E7415	FASTA	1,167	131,616
	10 20 30 40 50 60 MKVNRETKRL YVGGLSQDIS EADLQNQFSR FGEVSDVEII TRKDDQGNPQ KVFAYINISV 70 80 90 100 110 120 AEADLKKCMS VLNKTKWKGG TLQIQLAKES FLHRLAQERE AAKAKKEEST TGNANLLEKT 130 140 150 160 170 180 GGVDFHMKAV PGTEVPGHKN WVVSKFGRVL PVLHLKNQHK RKIIKYDPSK YCHNLKKIGE 190 200 210 220 230 240 DFSNTIPISS LTWELEGGND PMSKKRRGEF SDFHGPPKKI IKVQKDESST GSLAMSTRPR 250 260 270 280 290 300 RVIERPPLTQ QQAAQKRTCD SITPSKSSPV PVSDTQKLKN LPFKTSGLET AKKRNSISDD 310 320 330 340 350 360 DTDSEDELRM MIAKEENLQR TTQPSINESE SDPFEVVRDD FKSGVHKLHS LIGLGIKNRV 370 380 390 400 410 420 SCHDSDDDIM RNDREYDSGD TDEIIAMKKN VAKVKNSTEF SQMEKSTKKT SFKNRENCEL 430 440 450 460 470 480 SDHCIKLQKR KSNVESALSH GLKSLNRKSP SHSSSSEDAD SASELADSEG GEEYNAMMKN 490 500 510 520 530 540 CLRVNLTLAD LEQLAGSDLK VPNEDTKSDG PETTTQCKFD RGSKSPKTPT GLRRGRQCIR 550 560 570 580 590 600 PAEIVASLLE GEENTCGKQK PKENNLKPKF QAFKGVGCLY EKESMKKSLK DSVASNNKDQ 610 620 630 640 650 660 NSMKHEDPSI ISMEDGSPYV NGSLGEVTPC QHAKKANGPN YIQPQKRQTT FESQDRKAVS 670 680 690 700 710 720 PSSSEKRSKN PISRPLEGKK SLSLSAKTHN IGFDKDSCHS TTKTEASQEE RSDSSGLTSL 730 740 750 760 770 780 KKSPKVSSKD TREIKTDFSL SISNSSDVSA KDKHAEDNEK RLAALEARQK AKEVQKKLVH 790 800 810 820 830 840 NALANLDGHP EDKPTHIIFG SDSECETEET STQEQSHPGE EWVKESMGKT SGKLFDSSDD 850 860 870 880 890 900 DESDSEDDSN RFKIKPQFEG RAGQKLMDLQ SHFGTDDRFR MDSRFLETDS EEEQEEVNEK 910 920 930 940 950 960 KTAEEEELAE EKKKALNVVQ SVLQINLSNS TNRGSVAAKK FKDIIHYDPT KQDHATYERK 970 980 990 1000 1010 1020 RDDKPKESKA KRKKKREEAE KLPEVSKEMY YNIAMDLKEI FQTTKYTSEK EEGTPWNEDC 1030 1040 1050 1060 1070 1080 GKEKPEEIQD PAALTSDAEQ PSGFTFSFFD SDTKDIKEET YRVETVKPGK IVWQEDPRLQ 1090 1100 1110 1120 1130 1140 DSSSEEEDVT EETDHRNSSP GEASLLEKET TRFFFFSKND ERLQGSDLFW RGVGSNMSRN 1150 1160 SWEARTTNLR MDCRKKHKDA KRKMKPK
	Isoform 2 [UniParc]. Checksum: BED9401AC2D5ABE8	FASTA	1,099	123,927
	10 20 30 40 50 60 MSVLNKTKWK GGTLQIQLAK ESFLHRLAQE REAAKAKKEE STTGNANLLE KTGGVDFHMK 70 80 90 100 110 120 AVPGTEVPGH KNWVVSKFGR VLPVLHLKNQ HKRKIIKYDP SKYCHNLKKI GEDFSNTIPI 130 140 150 160 170 180 SSLTWELEGG NDPMSKKRRG EFSDFHGPPK KIIKVQKDES STGSLAMSTR PRRVIERPPL 190 200 210 220 230 240 TQQQAAQKRT CDSITPSKSS PVPVSDTQKL KNLPFKTSGL ETAKKRNSIS DDDTDSEDEL 250 260 270 280 290 300 RMMIAKEENL QRTTQPSINE SESDPFEVVR DDFKSGVHKL HSLIGLGIKN RVSCHDSDDD 310 320 330 340 350 360 IMRNDREYDS GDTDEIIAMK KNVAKVKNST EFSQMEKSTK KTSFKNRENC ELSDHCIKLQ 370 380 390 400 410 420 KRKSNVESAL SHGLKSLNRK SPSHSSSSED ADSASELADS EGGEEYNAMM KNCLRVNLTL 430 440 450 460 470 480 ADLEQLAGSD LKVPNEDTKS DGPETTTQCK FDRGSKSPKT PTGLRRGRQC IRPAEIVASL 490 500 510 520 530 540 LEGEENTCGK QKPKENNLKP KFQAFKGVGC LYEKESMKKS LKDSVASNNK DQNSMKHEDP 550 560 570 580 590 600 SIISMEDGSP YVNGSLGEVT PCQHAKKANG PNYIQPQKRQ TTFESQDRKA VSPSSSEKRS 610 620 630 640 650 660 KNPISRPLEG KKSLSLSAKT HNIGFDKDSC HSTTKTEASQ EERSDSSGLT SLKKSPKVSS 670 680 690 700 710 720 KDTREIKTDF SLSISNSSDV SAKDKHAEDN EKRLAALEAR QKAKEVQKKL VHNALANLDG 730 740 750 760 770 780 HPEDKPTHII FGSDSECETE ETSTQEQSHP GEEWVKESMG KTSGKLFDSS DDDESDSEDD 790 800 810 820 830 840 SNRFKIKPQF EGRAGQKLMD LQSHFGTDDR FRMDSRFLET DSEEEQEEVN EKKTAEEEEL 850 860 870 880 890 900 AEEKKKALNV VQSVLQINLS NSTNRGSVAA KKFKDIIHYD PTKQDHATYE RKRDDKPKES 910 920 930 940 950 960 KAKRKKKREE AEKLPEVSKE MYYNIAMDLK EIFQTTKYTS EKEEGTPWNE DCGKEKPEEI 970 980 990 1000 1010 1020 QDPAALTSDA EQPSGFTFSF FDSDTKDIKE ETYRVETVKP GKIVWQEDPR LQDSSSEEED 1030 1040 1050 1060 1070 1080 VTEETDHRNS SPGEASLLEK ETTRFFFFSK NDERLQGSDL FWRGVGSNMS RNSWEARTTN 1090 LRMDCRKKHK DAKRKMKPK
	Isoform 3 [UniParc]. Checksum: 62E1E4B071F418BA	FASTA	1,041	117,504
	10 20 30 40 50 60 MKAVPGTEVP GHKNWVVSKF GRVLPVLHLK NQHKRKIIKY DPSKYCHNLK KIGEDFSNTI 70 80 90 100 110 120 PISSLTWELE GGNDPMSKKR RGEFSDFHGP PKKIIKVQKD ESSTGSLAMS TRPRRVIERP 130 140 150 160 170 180 PLTQQQAAQK RTCDSITPSK SSPVPVSDTQ KLKNLPFKTS GLETAKKRNS ISDDDTDSED 190 200 210 220 230 240 ELRMMIAKEE NLQRTTQPSI NESESDPFEV VRDDFKSGVH KLHSLIGLGI KNRVSCHDSD 250 260 270 280 290 300 DDIMRNDREY DSGDTDEIIA MKKNVAKVKN STEFSQMEKS TKKTSFKNRE NCELSDHCIK 310 320 330 340 350 360 LQKRKSNVES ALSHGLKSLN RKSPSHSSSS EDADSASELA DSEGGEEYNA MMKNCLRVNL 370 380 390 400 410 420 TLADLEQLAG SDLKVPNEDT KSDGPETTTQ CKFDRGSKSP KTPTGLRRGR QCIRPAEIVA 430 440 450 460 470 480 SLLEGEENTC GKQKPKENNL KPKFQAFKGV GCLYEKESMK KSLKDSVASN NKDQNSMKHE 490 500 510 520 530 540 DPSIISMEDG SPYVNGSLGE VTPCQHAKKA NGPNYIQPQK RQTTFESQDR KAVSPSSSEK 550 560 570 580 590 600 RSKNPISRPL EGKKSLSLSA KTHNIGFDKD SCHSTTKTEA SQEERSDSSG LTSLKKSPKV 610 620 630 640 650 660 SSKDTREIKT DFSLSISNSS DVSAKDKHAE DNEKRLAALE ARQKAKEVQK KLVHNALANL 670 680 690 700 710 720 DGHPEDKPTH IIFGSDSECE TEETSTQEQS HPGEEWVKES MGKTSGKLFD SSDDDESDSE 730 740 750 760 770 780 DDSNRFKIKP QFEGRAGQKL MDLQSHFGTD DRFRMDSRFL ETDSEEEQEE VNEKKTAEEE 790 800 810 820 830 840 ELAEEKKKAL NVVQSVLQIN LSNSTNRGSV AAKKFKDIIH YDPTKQDHAT YERKRDDKPK 850 860 870 880 890 900 ESKAKRKKKR EEAEKLPEVS KEMYYNIAMD LKEIFQTTKY TSEKEEGTPW NEDCGKEKPE 910 920 930 940 950 960 EIQDPAALTS DAEQPSGFTF SFFDSDTKDI KEETYRVETV KPGKIVWQED PRLQDSSSEE 970 980 990 1000 1010 1020 EDVTEETDHR NSSPGEASLL EKETTRFFFF SKNDERLQGS DLFWRGVGSN MSRNSWEART 1030 1040 TNLRMDCRKK HKDAKRKMKP K
	Isoform 4 [UniParc]. Checksum: CF4642596A282A1A	FASTA	1,129	127,337
	10 20 30 40 50 60 MKVNRETKRL YVGGLSQDIS EADLQNQFSR FGEVSDVEII TRKDDQGNPQ KVFAYINISV 70 80 90 100 110 120 AEADLKKCMS VLNKTKWKGG TLQIQLAKES FLHRLAQERE AAKAKKEEST TGNANLLEKT 130 140 150 160 170 180 GGVDFHMKAV PGTEVPGHKN WVVSKFGRVL PVLHLKNQHK RKIIKYDPSK YCHNLKKIGE 190 200 210 220 230 240 DFSNTIPISS LTWELEGGND PMSKKRRGEF SDFHGPPKKI IKVQKDESST GSLAMSTRPR 250 260 270 280 290 300 RVIERPPLTQ QQAAQKRTCD SITPSKSSPV PVSDTQKLKN LPFKTSGLET AKKRNSISDD 310 320 330 340 350 360 DTDSEDELRM MIAKEENLQR TTQPSINESE SDPFEVVRDD FKSGVHKLHS LIGLGIKNRV 370 380 390 400 410 420 SCHDSDDDIM RNDREYDSGD TDEIIAMKKN VAKVKNSTEF SQMEKSTKKT SFKNRENCEL 430 440 450 460 470 480 SDHCIKLQKR KSNVESALSH GLKSLNRKSP SHSSSSEDAD SASELADSEG GEEYNAMMKN 490 500 510 520 530 540 CLRVNLTLAD LEQLAGSDLK VPNEDTKSDG PETTTQCKFD RGSKSPKTPT GLRRGRQCIR 550 560 570 580 590 600 PAEIVASLLE GEENTCGKQK PKENNLKPKF QAFKGVGCLY EKESMKKSLK DSVASNNKDQ 610 620 630 640 650 660 NSMKHEDPSI ISMEDGSPYV NGSLGEVTPC QHAKKANGPN YIQPQKRQTT FESQDRKAVS 670 680 690 700 710 720 PSSSEKRSKN PISRPLEGKK SLSLSAKTHN IGFDKDSCHS TTKTEASQEE RSDSSGLTSL 730 740 750 760 770 780 KKSPKVSSKD TREIKTDFSL SISNSSDVSA KDKHAEDNEK RLAALEARQK AKEVQKKLVH 790 800 810 820 830 840 NALANLESMG KTSGKLFDSS DDDESDSEDD SNRFKIKPQF EGRAGQKLMD LQSHFGTDDR 850 860 870 880 890 900 FRMDSRFLET DSEEEQEEVN EKKTAEEEEL AEEKKKALNV VQSVLQINLS NSTNRGSVAA 910 920 930 940 950 960 KKFKDIIHYD PTKQDHATYE RKRDDKPKES KAKRKKKREE AEKLPEVSKE MYYNIAMDLK 970 980 990 1000 1010 1020 EIFQTTKYTS EKEEGTPWNE DCGKEKPEEI QDPAALTSDA EQPSGFTFSF FDSDTKDIKE 1030 1040 1050 1060 1070 1080 ETYRVETVKP GKIVWQEDPR LQDSSSEEED VTEETDHRNS SPGEASLLEK ETTRFFFFSK 1090 1100 1110 1120 NDERLQGSDL FWRGVGSNMS RNSWEARTTN LRMDCRKKHK DAKRKMKPK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer." Jinawath N., Furukawa Y., Nakamura Y. Cancer Sci. 95:430-435(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, PHOSPHORYLATION.
[2]	"A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D." Sekiguchi T., Todaka Y., Wang Y., Hirose E., Nakashima N., Nishimoto T. J. Biol. Chem. 279:8343-8350(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 946-964, FUNCTION, INTERACTION WITH NIP7; RRAGA; RRAGC AND RRAGD.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Embryonic head, Hepatoma, Smooth muscle and Teratocarcinoma.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2; 3 AND 4).
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 473-1167 (ISOFORMS 1/2). Tissue: Colon.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365; THR-888 AND SER-890, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47." Sekiguchi T., Hayano T., Yanagida M., Takahashi N., Nishimoto T. Nucleic Acids Res. 34:4593-4608(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH DDX18 AND DDX47, SUBCELLULAR LOCATION.
[8]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365; SER-378; THR-381; SER-837; SER-838; SER-843; SER-845; SER-1036; SER-1082; SER-1083; SER-1084 AND SER-1099, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298; THR-302; SER-304; SER-378; THR-381; SER-837; SER-843; SER-845; THR-888; SER-890; SER-1082; SER-1083 AND SER-1084, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365; THR-888 AND SER-890, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298; THR-302; SER-304; SER-365; TYR-376; SER-378; THR-381; THR-888; SER-890; SER-1082; SER-1083; SER-1084 AND SER-1099, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB105104 mRNA. Translation: BAD12268.1. AB109030 mRNA. Translation: BAC99315.1. AK000743 mRNA. Translation: BAA91356.1. Sequence problems. AK001049 mRNA. Translation: BAA91479.1. AK022755 mRNA. Translation: BAB14229.1. Different initiation. AK024245 mRNA. Translation: BAB14857.1. AK024786 mRNA. Translation: BAB15003.1. Different initiation. AL136097 Genomic DNA. Translation: CAC12712.1. AL136097 Genomic DNA. Translation: CAI16204.1. AL136097 Genomic DNA. Translation: CAI16205.1. AL136097 Genomic DNA. Translation: CAI16206.1. AL136097 Genomic DNA. Translation: CAI16207.1. AL136097 Genomic DNA. Translation: CAI16208.1. AL136097 Genomic DNA. Translation: CAI16209.1. BC013788 mRNA. Translation: AAH13788.2.
IPI	IPI00161085. IPI00480054. IPI00645407. IPI01014020.
RefSeq	NP_001243323.1. NM_001256394.1. NP_060418.4. NM_017948.5.
UniGene	Hs.442199.
3D structure databases
ProteinModelPortal	Q76FK4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q76FK4. 2 interactions.
PTM databases
PhosphoSite	Q76FK4.
Polymorphism databases
DMDM	74758950.
Proteomic databases
PaxDb	Q76FK4.
PRIDE	Q76FK4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358855; ENSP00000351723; ENSG00000198000. ENST00000442668; ENSP00000401177; ENSG00000198000. ENST00000535387; ENSP00000441300; ENSG00000198000. ENST00000542053; ENSP00000440709; ENSG00000198000. ENST00000545558; ENSP00000441140; ENSG00000198000.
GeneID	55035.
KEGG	hsa:55035.
UCSC	uc022bjw.1. human.
Organism-specific databases
CTD	55035.
GeneCards	GC09M095059.
HGNC	HGNC:23387. NOL8.
HPA	HPA044440.
MIM	611534. gene.
neXtProt	NX_Q76FK4.
PharmGKB	PA134918056.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG73280.
HOVERGEN	HBG057565.
InParanoid	Q76FK4.
OMA	DDSNRFK.
Gene expression databases
ArrayExpress	Q76FK4.
Bgee	Q76FK4.
Genevestigator	Q76FK4.
GermOnline	ENSG00000198000. Homo sapiens.
Family and domain databases
Gene3D	3.30.70.330. 1 hit.
InterPro	IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. [Graphical view]
SMART	SM00360. RRM. 1 hit. [Graphical view]
PROSITE	PS50102. RRM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55035.
NextBio	58463.
SOURCE	Search...

Entry information

Entry name

NOL8_HUMAN

Accession

Primary (citable) accession number: Q76FK4
Secondary accession number(s): Q5TCC7 , Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.