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Protein

Deleted in azoospermia-like

Gene

dazl

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

RNA-binding protein that is required for primordial germ cell (PGC) differentiation and indirectly necessary for the migration of PGCs through the endoderm. May promote meiotic cell division during spermatogenesis. Shows a preference for G- and U-rich RNAs and probably binds the 3'-UTR of target mRNAs. Stimulates the initiation of translation of mRNAs through the recruitment of poly(A)-binding proteins (PABPs) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Oogenesis, Spermatogenesis, Translation regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deleted in azoospermia-like
Short name:
DAZ-like protein
Alternative name(s):
Xtdazl
Gene namesi
Name:dazlImported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1006218. dazl.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • mitochondrial cloud Source: UniProtKB
  • pole plasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002488511 – 286Deleted in azoospermia-likeAdd BLAST286

Proteomic databases

PaxDbiQ76CY5.

Expressioni

Tissue specificityi

Germ-line specific; expressed in adult testis and ovary. Localized specifically to the oocyte and embryonic germ plasm and to migrating primordial germ cells (PGCs).1 Publication

Developmental stagei

Expressed constantly during oogenesis from the previtellogenic (stage I) oocyte to the mature (stage VI) oocyte, and after fertilization until the early tadpole stage.1 Publication

Gene expression databases

BgeeiENSXETG00000025199.

Interactioni

Subunit structurei

Interacts with the C-terminus of pabp1 and with epabp. Prior to oocyte maturation, found in a complex with epabp and pum2 proteins and spdy1 mRNA; pum2 dissociates from the complex during maturation (By similarity).By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000053944.

Structurei

3D structure databases

ProteinModelPortaliQ76CY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 105RRMPROSITE-ProRule annotationAdd BLAST76
Domaini155 – 180DAZ-likeSequence analysisAdd BLAST26

Sequence similaritiesi

Belongs to the RRM DAZ family.Curated
Contains 1 DAZ-like domain.Sequence analysis
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00530000063480.
HOGENOMiHOG000246400.
HOVERGENiHBG000573.
InParanoidiQ76CY5.
OMAiRSYVIPP.
OrthoDBiEOG091G02CS.
TreeFamiTF324396.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q76CY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATEASAGE EAASATSQAF VLPEGKVIPN TVFVGGIDIT MDEMAIGNLF
60 70 80 90 100
EKYGKVKDLK IITDRTGVSK GYGFVSFYDE VDVQKIVKSQ INFHGKKLKL
110 120 130 140 150
GPAIRKMQRI CTYVQTSPVV ISPPTQFHPT WNSQNADSYI QHSPIISPVT
160 170 180 190 200
QYVQACPYPS SPPMAIQQIP VGCQQPSYFQ VSPQWPTDQR NYMFPSPAFT
210 220 230 240 250
FNYNCCEIDP NGGEPMPREY HIDQAVSASG ANLQKRYVDM STQTIISCLF
260 270 280
DPAKKVRLFA SQEDYIQDDS VHQFRRSKSV IKRVSN
Length:286
Mass (Da):31,927
Last modified:July 5, 2004 - v1
Checksum:i257DB58428FB39B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB109328 mRNA. Translation: BAC99992.1.
BC067947 mRNA. Translation: AAH67947.1.
RefSeqiNP_989079.1. NM_203748.1.
UniGeneiStr.6165.

Genome annotation databases

EnsembliENSXETT00000053944; ENSXETP00000053944; ENSXETG00000025199.
GeneIDi394676.
KEGGixtr:394676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB109328 mRNA. Translation: BAC99992.1.
BC067947 mRNA. Translation: AAH67947.1.
RefSeqiNP_989079.1. NM_203748.1.
UniGeneiStr.6165.

3D structure databases

ProteinModelPortaliQ76CY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000053944.

Proteomic databases

PaxDbiQ76CY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000053944; ENSXETP00000053944; ENSXETG00000025199.
GeneIDi394676.
KEGGixtr:394676.

Organism-specific databases

CTDi1618.
XenbaseiXB-GENE-1006218. dazl.

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00530000063480.
HOGENOMiHOG000246400.
HOVERGENiHBG000573.
InParanoidiQ76CY5.
OMAiRSYVIPP.
OrthoDBiEOG091G02CS.
TreeFamiTF324396.

Gene expression databases

BgeeiENSXETG00000025199.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDAZL_XENTR
AccessioniPrimary (citable) accession number: Q76CY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.