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Protein

Pleiotropic drug resistance protein 1

Gene

PDR1

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a general defense protein.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi194 – 201ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi882 – 889ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pleiotropic drug resistance protein 1
Alternative name(s):
NtPDR1
Gene namesi
Name:PDR1
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
Proteomesi
  • UP000084051 Componenti: Genome assembly

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei530 – 550HelicalSequence analysisAdd BLAST21
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21
Transmembranei618 – 638HelicalSequence analysisAdd BLAST21
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21
Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
Transmembranei702 – 722HelicalSequence analysisAdd BLAST21
Transmembranei760 – 780HelicalSequence analysisAdd BLAST21
Transmembranei1181 – 1201HelicalSequence analysisAdd BLAST21
Transmembranei1221 – 1241HelicalSequence analysisAdd BLAST21
Transmembranei1269 – 1289HelicalSequence analysisAdd BLAST21
Transmembranei1296 – 1316HelicalSequence analysisAdd BLAST21
Transmembranei1326 – 1346HelicalSequence analysisAdd BLAST21
Transmembranei1357 – 1377HelicalSequence analysisAdd BLAST21
Transmembranei1406 – 1426HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002346551 – 1434Pleiotropic drug resistance protein 1Add BLAST1434

Proteomic databases

PRIDEiQ76CU2.

Expressioni

Inductioni

By the phytohormone methyl jasmonate (MeJA), defense elicitors (INF1 elicitin of P.infestans, flagellin of P.syringae and yeast extract), and protein phosphatase inhibitor (cantharidin). Repressed by protein kinase inhibitor (K252a) and cycloheximide.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ76CU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 434ABC transporter 1PROSITE-ProRule annotationAdd BLAST274
Domaini512 – 725ABC transmembrane type-2 1Add BLAST214
Domaini837 – 1089ABC transporter 2PROSITE-ProRule annotationAdd BLAST253
Domaini1162 – 1376ABC transmembrane type-2 2Add BLAST215

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

CDDicd03233. ABCG_PDR_domain1. 1 hit.
cd03232. ABCG_PDR_domain2. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR029481. ABC_trans_N.
IPR003439. ABC_transporter-like.
IPR034001. ABCG_PDR_1.
IPR034003. ABCG_PDR_2.
IPR027417. P-loop_NTPase.
IPR013581. PDR_assoc.
PfamiView protein in Pfam
PF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF14510. ABC_trans_N. 1 hit.
PF08370. PDR_assoc. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q76CU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPANLSNLR GSSLRGSTRG SLRANSNSIW RNNGVEIFSR SSRDEDDEEA
60 70 80 90 100
LKWAALEKLP TFDRLRKGLL FGSQGAAAEV DINDLGFQER KNLLERLVKV
110 120 130 140 150
ADEDNEKFLL KLKNRIDRVG IDLPTIEVRY EHLNIDADAY VGSRSLPTFM
160 170 180 190 200
NFMTNFVETL LNSLHILSSR KRQLTILKDI SGIIKPCRMT LLLGPPSSGK
210 220 230 240 250
TTLLLALAGK LDPALKVTGK VSYNGHELHE FVPQRTAAYI SQHDLHIGEM
260 270 280 290 300
TVRETLEFSA RCQGVGSRFE MLAELSRREK AANIKPDADI DIYMKAAATE
310 320 330 340 350
GQEANVVTDY VLKILGLDIC ADTMVGDDMI RGISGGQKKR VTTGEMLVGP
360 370 380 390 400
SKALFMDEIS TGLDSSTTYS IVNSLRQSVQ ILKGTAVISL LQPAPETYNL
410 420 430 440 450
FDDIILLSDG YIVYQGPRDD VLEFFESMGF KCPQRKGVAD FLQEVTSKKD
460 470 480 490 500
QQQYWSKRNE PYRFITSKEF AEAYQSFHVG RKLGDELATP FDKTKCHPAA
510 520 530 540 550
LTNEKYGIGK KELLKVCTER ELLLMKRNSF VYMFKFSQLT IMALITMTLF
560 570 580 590 600
FRTEMPRDTT DDGGIYAGAL FFVVIMIMFN GMSELAMTIF KLPVFYKQRD
610 620 630 640 650
LLFFPSWAYA IPSWILKIPV TLVEVGLWVI LTYYVIGFDP NITRFLKQFL
660 670 680 690 700
LLIVVNQMAS GMFRFIGAVG RTMGVASTFG SFALLLQFAL GGFVLSRDDV
710 720 730 740 750
KSWWIWGYWI SPMMYSVNSI LVNEFDGKKW NHIVPGGNET LGSTVVKSRG
760 770 780 790 800
FFPEAYWYWI GVGALVGFTV VFNFCYSLAL AYLNPFDKPQ AVLPEDGENA
810 820 830 840 850
ENGEVSSQIT STDGGDSISE SQNNKKGMVL PFEPHSITFD DVVYSVDMPQ
860 870 880 890 900
EMKEQGAGED RLVLLKGVSG AFRPGVLTAL MGVSGAGKTT LMDVLAGRKT
910 920 930 940 950
GGYIDGEIKI SGYPKKQETF ARISGYCEQN DIHSPYVTVY ESLVYSAWLR
960 970 980 990 1000
LPQDVDEKTR KMFVDEVMEL VELGPLRSAL VGLPGVNGLS TEQRKRLTIA
1010 1020 1030 1040 1050
VELVANPSII FMDEPTSGLD ARAAAIVMRT VRNTVDTGRT VVCTIHQPSI
1060 1070 1080 1090 1100
DIFEAFDELF LMKRGGQEIY VGPLGRHSCH LIKYFESNPG VAKIKEGYNP
1110 1120 1130 1140 1150
ATWMLEVTAS AQEMMLGIDF TEVYKNSDLY RRNKALISEL GVPRPGSKDL
1160 1170 1180 1190 1200
HFETQYSQSF WTQCVACLWK QHWSYWRNPA YTAVRFIFTT FIALIFGTMF
1210 1220 1230 1240 1250
WDLGTKVSKS QDLLNAMGSM YAAVLFLGVQ NASSVQPVVA IERTVFYRER
1260 1270 1280 1290 1300
AAGMYSAIPY AFGQVSIEIP YIFVQSVFYG IIVYAMIGFE WDVGKFFWYL
1310 1320 1330 1340 1350
FIMFFTLLYF TFYGMMGVAV TPNQNVASIV AAFFYGVWNL FSGFIIPRPR
1360 1370 1380 1390 1400
MPVWWRWYYW ANPVAWTLYG LVASQFGDIQ TKLSDNETVE QFLRRYFGFK
1410 1420 1430
HDFLGVVAAV LTAYVFMFAF TFAFAIKAFN FQRR
Length:1,434
Mass (Da):161,683
Last modified:July 5, 2004 - v1
Checksum:i041F2DCDD4D3239A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti810T → P in BAB92011 (PubMed:11997039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075550 mRNA. Translation: BAB92011.1.
AB109388 Genomic DNA. Translation: BAD07483.1.
RefSeqiNP_001312599.1. NM_001325670.1.
XP_016478140.1. XM_016622654.1.
UniGeneiNta.3864.

Genome annotation databases

GeneIDi107799533.
KEGGinta:107799533.

Similar proteinsi

Entry informationi

Entry nameiPDR1_TOBAC
AccessioniPrimary (citable) accession number: Q76CU2
Secondary accession number(s): Q8LP45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families